Comparing GFF2771 FitnessBrowser__Marino:GFF2771 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 15 hits to proteins with known functional sites (download)
O50584 Low specificity L-threonine aldolase; Low specificity L-TA; EC 4.1.2.48 from Pseudomonas sp. (strain NCIMB 10558) (see paper)
63% identity, 99% coverage: 3:343/343 of query aligns to 4:345/346 of O50584
5vyeB Crystal structure of l-threonine aldolase from pseudomonas putida
63% identity, 99% coverage: 3:343/343 of query aligns to 2:343/344 of 5vyeB
1v72A Crystal structure of phenylserine aldolase from pseudomonas putida
43% identity, 97% coverage: 7:339/343 of query aligns to 7:342/345 of 1v72A
O07051 L-allo-threonine aldolase; L-allo-TA; L-allo-threonine acetaldehyde-lyase; EC 4.1.2.49 from Aeromonas jandaei (see paper)
27% identity, 88% coverage: 33:335/343 of query aligns to 43:329/338 of O07051
3wgcB Aeromonas jandaei l-allo-threonine aldolase h128y/s292r double mutant (see paper)
27% identity, 88% coverage: 33:335/343 of query aligns to 42:326/333 of 3wgcB
Sites not aligning to the query:
1lw5B X-ray structure of l-threonine aldolase (low-specificity) in complex with glycine (see paper)
28% identity, 66% coverage: 9:236/343 of query aligns to 6:225/343 of 1lw5B
Sites not aligning to the query:
1lw4B X-ray structure of l-threonine aldolase (low-specificity) in complex with l-allo-threonine (see paper)
28% identity, 66% coverage: 9:236/343 of query aligns to 6:225/343 of 1lw4B
Sites not aligning to the query:
1jg8D Crystal structure of threonine aldolase (low-specificity)
28% identity, 66% coverage: 9:236/343 of query aligns to 7:226/344 of 1jg8D
Sites not aligning to the query:
3wgbD Crystal structure of aeromonas jandaei l-allo-threonine aldolase (see paper)
29% identity, 81% coverage: 33:310/343 of query aligns to 41:298/324 of 3wgbD
Sites not aligning to the query:
4lnmA Structure of escherichia coli threonine aldolase in complex with serine (see paper)
28% identity, 68% coverage: 9:242/343 of query aligns to 6:240/331 of 4lnmA
4rjyA Crystal structure of e. Coli l-threonine aldolase in complex with a non-covalently uncleaved bound l-serine substrate (see paper)
28% identity, 68% coverage: 9:242/343 of query aligns to 6:240/332 of 4rjyA
4lnlA Structure of escherichia coli threonine aldolase in complex with allo- thr (see paper)
28% identity, 68% coverage: 9:242/343 of query aligns to 6:240/332 of 4lnlA
Sites not aligning to the query:
4lnjA Structure of escherichia coli threonine aldolase in unliganded form (see paper)
28% identity, 68% coverage: 9:242/343 of query aligns to 6:240/332 of 4lnjA
3wlxA Crystal structure of low-specificity l-threonine aldolase from escherichia coli
28% identity, 68% coverage: 9:242/343 of query aligns to 6:240/331 of 3wlxA
Sites not aligning to the query:
Q8RXU4 Low-specificity L-threonine aldolase 1; Threonine aldolase 1; EC 4.1.2.48 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
25% identity, 90% coverage: 29:336/343 of query aligns to 29:343/358 of Q8RXU4
>GFF2771 FitnessBrowser__Marino:GFF2771
MSQSEQFASDNYSGVCPQAWKAMEAANRMDEPAYGEDSWTQKAADGLRTLFDTDCDVYFV
FNGTAANSLALASIGQSFHSVICHELAHIETDECGGPEYASNGAKLLLGQGENGKLTPES
IEHLVTKRTDIHYPKPKALSLTQATEVGTVYTPEELKVIRSVADRHKLNIHMDGARFANA
VAALDVHPAEITWKAGVDVLCFSGTKNGLALGEAVVFFNRSLAEDFEWRCKQAGQLASKM
RYISAPWCGLLEGDVWLQNARHANACAQRLAAGLEGLPGIQLRYPRQVNGVFVEMPEPLQ
AALRAKGWRFYNFIGGSARLMCSWATTNEQVDRFLSDVRALVS
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory