SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing GFF2781 FitnessBrowser__Phaeo:GFF2781 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
32% identity, 94% coverage: 27:467/467 of query aligns to 21:466/467 of 7qh2C

query
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binding flavin-adenine dinucleotide: D32 (≠ Q38), E37 (≠ T43), E37 (≠ T43), V73 (≠ P79), R74 (≠ Y80), G75 (= G81), S76 (≠ T82), G77 (= G83), T78 (= T84), T78 (= T84), G79 (≠ S85), L80 (= L86), A83 (≠ H89), C84 (≠ V90), P137 (= P143), G138 (= G144), E139 (vs. gap), E139 (vs. gap), A142 (= A147), T143 (≠ S148), A145 (≠ G150), G146 (= G151), N147 (≠ M152), S149 (≠ A154), T150 (= T155), A152 (= A157), G153 (≠ S158), E203 (= E208), G204 (= G209), C207 (≠ G212), V208 (≠ L213), I209 (= I214), L332 (≠ Y333), E422 (= E424), H423 (= H425), N459 (= N460)
binding fe (iii) ion: H377 (= H380), H384 (= H387), E422 (= E424)

P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
33% identity, 95% coverage: 21:465/467 of query aligns to 4:456/459 of P9WIT1

query
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P9WIT1

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K354 (≠ E359) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
30% identity, 88% coverage: 54:465/467 of query aligns to 44:465/465 of 3pm9A

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A

A

R

N

S

A

K

A

A

V

E

V

E

A

M

L

N

I

L

P

L

G

A

A

P

R

M

P

V

V

-

P

-

F

G

G

H

H

V

L

G

G

D

D

G

G

N

N

F

I

H

H

A

-

L

-

I

Y

N

N

M

V

D

S

S

Q

A

P

E

V

E

G

R

A

E

D

A

K

A

A

D

E

A

F

Y

L

V

A

G

R

W

W

L

H

N

D

-

V

-

S

-

Q

-

V

-

F

E

E

L

V

A

V

I

L

S

R

I

L

E

G

G

G

T

S

C

I

T

S

G

A

E
|
E

H
|
H

G

G

I

I

G

G

Q

V

G

M

K

K

R

R

P

D

Y

E

L

L

Q

A

Q

E

E

V

L

K

G

D

E

K

T

T

T

A

-

I

R

E

Y

L

M

M

A

R

A

S

I

I

K

K

A

A

A

L

L

L

D

D

P

P

E

H

N

G

I

I

L

M

N
|
N

P

P

G

G

K

K

I

V

L

V

active site: A149 (= A157), L159 (≠ T167)
binding flavin-adenine dinucleotide: P69 (= P79), Q70 (≠ Y80), G71 (= G81), G72 (≠ T82), N73 (≠ G83), T74 (= T84), G75 (≠ S85), L76 (= L86), G79 (≠ H89), Q80 (≠ V90), L91 (≠ M101), L133 (≠ P143), G134 (= G144), A135 (= A145), C139 (vs. gap), T140 (vs. gap), G142 (= G150), G143 (= G151), N144 (≠ M152), S146 (≠ A154), T147 (= T155), A149 (= A157), G150 (≠ S158), E200 (= E208), G201 (= G209), G204 (= G212), I205 (≠ L213), I206 (= I214), E423 (= E424), H424 (= H425), N460 (= N460)

6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
30% identity, 88% coverage: 57:465/467 of query aligns to 53:464/466 of 6lpxA

query
sites
6lpxA

P

P

T

R

S

T

T

S

D

E

E

E

V

V

A

S

D

H

I

I

V

L

R

R

T

H

C

C

A

H

D

E

Y

R

G

N

V

L

P

A

V

V

I

N

P
|
P

Y
x
Q

G
|
G

T
x
G

G
x
N

T
|
T

S
x
G

L
x
M

E

V

G

G

H
x
G

V
x
S

N

V

A

P

P

V

A

F

G

D

G

E

I

I

C

I

V

L

D

S

M

T

M

A

R

R

M

M

D

N

K

R

I

V

L

L

A

S

V

F

H

H

A

S

E

V

D

S

L

G

D

I

V

L

V

V

V

C

Q

Q

P

A

G

G

V

C

T

V

R

L

E

E

Q

E

L

L

N

S

T

R

Y

Y

L

V

R

E

D

E

Q

R

G

D

L

F

F

I

F

M

P

P

I

L

D

D

P
x
L

G
|
G

A
|
A

N

K

A

G

S

S

-
x
C

-
x
H

L

I

G
|
G

M
x
N

A

V

A
|
A

T
|
T

R

N

A
|
A

S
x
G

G
|
G

T

L

N

R

A

F

V

L

R

R

Y

Y

G

G

T

S

M

L

K

H

D

G

N

T

V

V

L

L

A

G

L

L

E

E

A

V

V

V

M

L

A

A

D

D

G

G

G

T

V

V

I

L

R

D

T

C

A

L

Q

T

R

S

A

L

K

R

K

K

S

D

S

N

A

T

G

G

Y

Y

D

D

M

L

T

K

R

Q

L

L

L

F

V

I

G

G

S

S

E
|
E

G
|
G

T

T

L

L

G

G

L
x
I

I
|
I

T

T

E

T

L

V

T

S

L

I

R

L

L

C

Q

P

G

P

I

K

P

P

E

R

A

A

I

V

R

N

S

V

A

A

R

F

C

L

-

G

-

C

-

P

A

G

F

F

R

A

S

E

V

V

-

L

-

Q

-

T

D

F

D

S

A

T

C

C

R

K

A

G

V

M

M

L

M

G

T

E

I

I

Q

-

Y

-

G

-

I

-

P

-

V

L

S

S

R

A

I

F

E

E

L

F

L

M

D

D

E

A

M

V

S

C

V

M

R

Q

A

L

A

V

N

G

A

R

Y

H

S

L

G

H

L

L

D

A

L

S

P

P

-

V

-

Q

E

E

M

S

P

P

L

F

-

Y

L

V

L

L

L

I

E

E

F

T

H

S

G

G

S

S

D

N

A

A

G

G

V

H

-

D

V

A

E

E

Q

K

A

L

D

G

T

H

F

F

A

L

Q

E

I

H

A

A

E

L

E

G

F

S

G

G

G

L

F

V

D

T

I

D

A

G

A

T

T

M

S

A

T

T

A

D

E

Q

E

R

R

K

S

V

K

K

-

M

L

L

W

W

Q

A

A

L

R
|
R

H

E

D

R

M

I

Y
x
T

W

E

A

A

S

-

L

-

Q

-

L

L

R

S

P

R

G

D

A

G

K

Y

G

V

I

Y

S
x
K

T

Y

D

D

V

L

C

S

V

L

P

P

I

V

S

E

K

R

L

L

A

Y

E

D

C

I

V

V

S

T

A

D

A

L

R

R

S

A

K

R

A

L

E

G

E

P

M

H

N

A

L

K

L

H

A

V

P

V

M

G

V
x
Y

G

G

H
|
H

V

L

G

G

D

D

G

G

N

N

F

L

H
|
H

A

L

L
x
N

L

V

L

T

I

A

N

E

M

A

D

F

S

S

A

P

E

S

E

L

R

L

E

A

A

A

A

L

D

E

A

P

Y

H

V

V

G

-

W

-

L

-

N

Y

E

E

L

W

A

T

I

A

S

G

I

Q

E

Q

G

G

T

S

C

V

T

S

G

A

E
|
E

H
|
H

G

G

I

V

G

G

Q

F

G

R

K

K

R

R

P

D

Y

V

L

L

-

G

Q

Y

Q

S

E

K

L

P

G

P

E

G

T

A

T

L

R

Q

Y

L

M

M

A

Q

I

L

K

K

A

A

A

L

L

L

D

D

P

P

E

K

N

G

I

I

L

L

N
|
N

P

P

G

Y

K

K

I

T

L

L

binding 2-oxoglutaric acid: R333 (= R329), T337 (≠ Y333), K348 (≠ S347), Y379 (≠ V378), H381 (= H380), H388 (= H387), N390 (≠ L389), H423 (= H425)
binding flavin-adenine dinucleotide: P75 (= P79), Q76 (≠ Y80), G77 (= G81), G78 (≠ T82), N79 (≠ G83), T80 (= T84), G81 (≠ S85), M82 (≠ L86), G85 (≠ H89), S86 (≠ V90), L139 (≠ P143), G140 (= G144), A141 (= A145), C145 (vs. gap), H146 (vs. gap), G148 (= G150), G149 (= G151), N150 (≠ M152), A152 (= A154), T153 (= T155), A155 (= A157), G156 (≠ S158), G157 (= G159), E206 (= E208), G207 (= G209), I211 (≠ L213), I212 (= I214), H381 (= H380), E422 (= E424), H423 (= H425), N459 (= N460)
binding zinc ion: H381 (= H380), H388 (= H387), E422 (= E424)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39

6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
30% identity, 88% coverage: 57:465/467 of query aligns to 53:464/466 of 6lpuA

query
sites
6lpuA

P

P

T

R

S

T

T

S

D

E

E

E

V

V

A

S

D

H

I

I

V

L

R

R

T

H

C

C

A

H

D

E

Y

R

G

N

V

L

P

A

V

V

I

N

P
|
P

Y
x
Q

G
|
G

T
x
G

G
x
N

T
|
T

S
x
G

L
x
M

E

V

G

G

H
x
G

V
x
S

N

V

A

P

P

V

A

F

G

D

G

E

I

I

C

I

V

L

D

S

M

T

M

A

R

R

M

M

D

N

K

R

I

V

L

L

A

S

V

F

H

H

A

S

E

V

D

S

L

G

D

I

V

L

V

V

V

C

Q

Q

P

A

G

G

V

C

T

V

R

L

E

E

Q

E

L

L

N

S

T

R

Y

Y

L

V

R

E

D

E

Q

R

G

D

L

F

F

I

F

M

P

P

I

L

D

D

P
x
L

G
|
G

A
|
A

N

K

A

G

S

S

-
x
C

-
x
H

L

I

G
|
G

M
x
N

A

V

A
|
A

T
|
T

R

N

A
|
A

S
x
G

G
|
G

T

L

N

R

A

F

V

L

R

R

Y

Y

G

G

T

S

M

L

K

H

D

G

N

T

V

V

L

L

A

G

L

L

E

E

A

V

V

V

M

L

A

A

D

D

G

G

G

T

V

V

I

L

R

D

T

C

A

L

Q

T

R

S

A

L

K

R

K

K

S

D

S

N

A

T

G

G

Y

Y

D

D

M

L

T

K

R

Q

L

L

L

F

V

I

G

G

S

S

E
|
E

G
|
G

T

T

L

L

G

G

L
x
I

I
|
I

T

T

E

T

L

V

T

S

L

I

R

L

L

C

Q

P

G

P

I

K

P

P

E

R

A

A

I

V

R

N

S

V

A

A

R

F

C

L

-

G

-

C

-

P

A

G

F

F

R

A

S

E

V

V

-

L

-

Q

-

T

D

F

D

S

A

T

C

C

R

K

A

G

V

M

M

L

M

G

T

E

I

I

Q

-

Y

-

G

-

I

-

P

-

V

L

S

S

R

A

I

F

E

E

L

F

L

M

D

D

E

A

M

V

S

C

V

M

R

Q

A

L

A

V

N

G

A

R

Y

H

S

L

G

H

L

L

D

A

L

S

P

P

-

V

-

Q

E

E

M

S

P

P

L

F

-

Y

L

V

L

L

L

I

E

E

F

T

H

S

G

G

S

S

D

N

A

A

G

G

V

H

-

D

V

A

E

E

Q

K

A

L

D

G

T

H

F

F

A

L

Q

E

I

H

A

A

E

L

E

G

F

S

G

G

G

L

F

V

D

T

I

D

A

G

A

T

T

M

S

A

T

T

A

D

E

Q

E

R

R

K

S

V

K

K

-

M

L

L

W

W

Q

A

A

L

R
|
R

H

E

D

R

M

I

Y
x
T

W

E

A

A

S

-

L

-

Q

-

L

L

R

S

P

R

G

D

A

G

K

Y

G

V

I

Y

S
x
K

T

Y

D

D

V

L

C

S

V

L

P

P

I

V

S

E

K

R

L

L

A

Y

E

D

C

I

V

V

S

T

A

D

A

L

R

R

S

A

K

R

A

L

E

G

E

P

M

H

N

A

L

K

L

H

A

V

P

V

M

G

V
x
Y

G

G

H
|
H

V

L

G

G

D

D

G

G

N

N

F

L

H
|
H

A

L

L
x
N

L

V

L

T

I

A

N

E

M

A

D

F

S

S

A

P

E

S

E

L

R

L

E

A

A

A

A

L

D

E

A

P

Y

H

V

V

G

-

W

-

L

-

N

Y

E

E

L

W

A

T

I

A

S

G

I

Q

E

Q

G

G

T

S

C

V

T

S

G

A

E
|
E

H
|
H

G

G

I

V

G

G

Q

F

G

R

K

K

R

R

P

D

Y

V

L

L

-

G

Q

Y

Q

S

E

K

L

P

G

P

E

G

T

A

T

L

R

Q

Y

L

M

M

A

Q

I

L

K

K

A

A

A

L

L

L

D

D

P

P

E

K

N

G

I

I

L

L

N
|
N

P

P

G

Y

K

K

I

T

L

L

binding flavin-adenine dinucleotide: P75 (= P79), Q76 (≠ Y80), G77 (= G81), G78 (≠ T82), N79 (≠ G83), T80 (= T84), G81 (≠ S85), M82 (≠ L86), G85 (≠ H89), S86 (≠ V90), L139 (≠ P143), G140 (= G144), A141 (= A145), C145 (vs. gap), H146 (vs. gap), G148 (= G150), G149 (= G151), N150 (≠ M152), A152 (= A154), T153 (= T155), A155 (= A157), G156 (≠ S158), G157 (= G159), E206 (= E208), G207 (= G209), I211 (≠ L213), I212 (= I214), H381 (= H380), E422 (= E424), H423 (= H425), N459 (= N460)
binding (2s)-2-hydroxypentanedioic acid: M82 (≠ L86), R333 (= R329), T337 (≠ Y333), K348 (≠ S347), Y379 (≠ V378), H381 (= H380), H388 (= H387), N390 (≠ L389), H423 (= H425)
binding zinc ion: H381 (= H380), H388 (= H387), E422 (= E424)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39

6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal) (see paper)
30% identity, 88% coverage: 57:465/467 of query aligns to 53:464/466 of 6lpqA

query
sites
6lpqA

P

P

T

R

S

T

T

S

D

E

E

E

V

V

A

S

D

H

I

I

V

L

R

R

T

H

C

C

A

H

D

E

Y

R

G

N

V

L

P

A

V

V

I

N

P
|
P

Y
x
Q

G
|
G

T
x
G

G
x
N

T
|
T

S
x
G

L
x
M

E

V

G

G

H
x
G

V
x
S

N

V

A

P

P

V

A

F

G

D

G

E

I

I

C

I

V

L

D

S

M

T

M

A

R

R

M

M

D

N

K

R

I

V

L

L

A

S

V

F

H

H

A

S

E

V

D

S

L

G

D

I

V

L

V

V

V

C

Q

Q

P

A

G

G

V

C

T

V

R

L

E

E

Q

E

L

L

N

S

T

R

Y

Y

L

V

R

E

D

E

Q

R

G

D

L

F

F

I

F

M

P

P

I

L

D

D

P
x
L

G
|
G

A
|
A

N

K

A

G

S

S

-
x
C

-
x
H

L

I

G
|
G

M
x
N

A

V

A
|
A

T
|
T

R

N

A
|
A

S
x
G

G
|
G

T

L

N

R

A

F

V

L

R

R

Y

Y

G

G

T

S

M

L

K

H

D

G

N

T

V

V

L

L

A

G

L

L

E

E

A

V

V

V

M

L

A

A

D

D

G

G

G

T

V

V

I

L

R

D

T

C

A

L

Q

T

R

S

A

L

K

R

K

K

S

D

S

N

A

T

G

G

Y

Y

D

D

M

L

T

K

R

Q

L

L

L

F

V

I

G

G

S

S

E
|
E

G
|
G

T

T

L

L

G
|
G

L
x
I

I
|
I

T

T

E

T

L

V

T

S

L

I

R

L

L

C

Q

P

G

P

I

K

P

P

E

R

A

A

I

V

R

N

S

V

A

A

R

F

C

L

-

G

-

C

-

P

A

G

F

F

R

A

S

E

V

V

-

L

-

Q

-

T

D

F

D

S

A

T

C

C

R

K

A

G

V

M

M

L

M

G

T

E

I

I

Q

-

Y

-

G

-

I

-

P

-

V

L

S

S

R

A

I

F

E

E

L

F

L

M

D

D

E

A

M

V

S

C

V

M

R

Q

A

L

A

V

N

G

A

R

Y

H

S

L

G

H

L

L

D

A

L

S

P

P

-

V

-

Q

E

E

M

S

P

P

L

F

-

Y

L

V

L

L

L

I

E

E

F

T

H

S

G

G

S

S

D

N

A

A

G

G

V

H

-

D

V

A

E

E

Q

K

A

L

D

G

T

H

F

F

A

L

Q

E

I

H

A

A

E

L

E

G

F

S

G

G

G

L

F

V

D

T

I

D

A

G

A

T

T

M

S

A

T

T

A

D

E

Q

E

R

R

K

S

V

K

K

-

M

L

L

W

W

Q

A

A

L

R
|
R

H

E

D

R

M

I

Y
x
T

W

E

A

A

S

-

L

-

Q

-

L

L

R

S

P

R

G

D

A

G

K

Y

G

V

I

Y

S
x
K

T

Y

D

D

V

L

C

S

V

L

P

P

I

V

S

E

K

R

L

L

A

Y

E

D

C

I

V

V

S

T

A

D

A

L

R

R

S

A

K

R

A

L

E

G

E

P

M

H

N

A

L

K

L

H

A

V

P

V

M

G

V
x
Y

G

G

H
|
H

V

L

G

G

D

D

G

G

N

N

F

L

H
|
H

A

L

L

N

L

V

L

T

I

A

N

E

M

A

D

F

S

S

A

P

E

S

E

L

R

L

E

A

A

A

A

L

D

E

A

P

Y

H

V

V

G

-

W

-

L

-

N

Y

E

E

L

W

A

T

I

A

S

G

I

Q

E

Q

G

G

T

S

C

V

T

S

G

A

E
|
E

H
|
H

G

G

I

V

G

G

Q

F

G

R

K

K

R

R

P

D

Y

V

L

L

-

G

Q

Y

Q

S

E

K

L

P

G

P

E

G

T

A

T

L

R

Q

Y

L

M

M

A

Q

I

L

K

K

A

A

A

L

L

L

D

D

P

P

E

K

N

G

I

I

L

L

N
|
N

P

P

G

Y

K

K

I

T

L

L

binding flavin-adenine dinucleotide: P75 (= P79), Q76 (≠ Y80), G77 (= G81), G78 (≠ T82), N79 (≠ G83), T80 (= T84), G81 (≠ S85), G85 (≠ H89), S86 (≠ V90), L139 (≠ P143), G140 (= G144), A141 (= A145), C145 (vs. gap), H146 (vs. gap), G148 (= G150), G149 (= G151), N150 (≠ M152), A152 (= A154), T153 (= T155), A155 (= A157), G156 (≠ S158), G157 (= G159), E206 (= E208), G207 (= G209), G210 (= G212), I211 (≠ L213), I212 (= I214), H381 (= H380), E422 (= E424), H423 (= H425), N459 (= N460)
binding d-malate: M82 (≠ L86), R333 (= R329), T337 (≠ Y333), K348 (≠ S347), Y379 (≠ V378), H381 (= H380), H388 (= H387), E422 (= E424), H423 (= H425)
binding zinc ion: H381 (= H380), H388 (= H387), E422 (= E424)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39

6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg) (see paper)
30% identity, 88% coverage: 57:465/467 of query aligns to 53:464/466 of 6lppA

query
sites
6lppA

P

P

T

R

S

T

T

S

D

E

E

E

V

V

A

S

D

H

I

I

V

L

R

R

T

H

C

C

A

H

D

E

Y

R

G

N

V

L

P

A

V

V

I

N

P
|
P

Y
x
Q

G
|
G

T
x
G

G
x
N

T
|
T

S
x
G

L
x
M

E

V

G

G

H
x
G

V
x
S

N

V

A

P

P

V

A

F

G

D

G

E

I

I

C

I

V

L

D

S

M

T

M

A

R

R

M

M

D

N

K

R

I

V

L

L

A

S

V

F

H

H

A

S

E

V

D

S

L

G

D

I

V

L

V

V

V

C

Q

Q

P

A

G

G

V

C

T

V

R

L

E

E

Q

E

L

L

N

S

T

R

Y

Y

L

V

R

E

D

E

Q

R

G

D

L

F

F

I

F

M

P

P

I

L

D

D

P
x
L

G
|
G

A
|
A

N

K

A

G

S

S

-
x
C

-
x
H

L

I

G
|
G

M
x
N

A

V

A
|
A

T
|
T

R

N

A
|
A

S
x
G

G
|
G

T

L

N

R

A

F

V

L

R

R

Y

Y

G

G

T

S

M

L

K

H

D

G

N

T

V

V

L

L

A

G

L

L

E

E

A

V

V

V

M

L

A

A

D

D

G

G

G

T

V

V

I

L

R

D

T

C

A

L

Q

T

R

S

A

L

K

R

K

K

S

D

S

N

A

T

G

G

Y

Y

D

D

M

L

T

K

R

Q

L

L

L

F

V

I

G

G

S

S

E
|
E

G
|
G

T

T

L

L

G

G

L
x
I

I
|
I

T

T

E

T

L

V

T

S

L

I

R

L

L

C

Q

P

G

P

I

K

P

P

E

R

A

A

I

V

R

N

S

V

A

A

R

F

C

L

-

G

-

C

-

P

A

G

F

F

R

A

S

E

V

V

-

L

-

Q

-

T

D

F

D

S

A

T

C

C

R

K

A

G

V

M

M

L

M

G

T

E

I

I

Q

-

Y

-

G

-

I

-

P

-

V

L

S

S

R

A

I

F

E

E

L

F

L

M

D

D

E

A

M

V

S

C

V

M

R

Q

A

L

A

V

N

G

A

R

Y

H

S

L

G

H

L

L

D

A

L

S

P

P

-

V

-

Q

E

E

M

S

P

P

L

F

-

Y

L

V

L

L

L

I

E

E

F

T

H

S

G

G

S

S

D

N

A

A

G

G

V

H

-

D

V

A

E

E

Q

K

A

L

D

G

T

H

F

F

A

L

Q

E

I

H

A

A

E

L

E

G

F

S

G

G

G

L

F

V

D

T

I

D

A

G

A

T

T

M

S

A

T

T

A

D

E

Q

E

R

R

K

S

V

K

K

-

M

L

L

W

W

Q

A

A

L

R
|
R

H

E

D

R

M

I

Y
x
T

W

E

A

A

S

-

L

-

Q

-

L

L

R

S

P

R

G

D

A

G

K

Y

G

V

I

Y

S
x
K

T

Y

D

D

V

L

C

S

V

L

P

P

I

V

S

E

K

R

L

L

A

Y

E

D

C

I

V

V

S

T

A

D

A

L

R

R

S

A

K

R

A

L

E

G

E

P

M

H

N

A

L

K

L

H

A

V

P

V

M

G

V
x
Y

G

G

H
|
H

V

L

G

G

D

D

G

G

N

N

F

L

H
|
H

A

L

L
x
N

L

V

L

T

I

A

N

E

M

A

D

F

S

S

A

P

E

S

E

L

R

L

E

A

A

A

A

L

D

E

A

P

Y

H

V

V

G

-

W

-

L

-

N

Y

E

E

L

W

A

T

I

A

S

G

I

Q

E

Q

G

G

T

S

C

V

T

S

G

A

E
|
E

H
|
H

G

G

I

V

G

G

Q

F

G

R

K

K

R

R

P

D

Y

V

L

L

-

G

Q

Y

Q

S

E

K

L

P

G

P

E

G

T

A

T

L

R

Q

Y

L

M

M

A

Q

I

L

K

K

A

A

A

L

L

L

D

D

P

P

E

K

N

G

I

I

L

L

N
|
N

P

P

G

Y

K

K

I

T

L

L

binding (2R)-2-hydroxypentanedioic acid: M82 (≠ L86), R333 (= R329), T337 (≠ Y333), K348 (≠ S347), Y379 (≠ V378), H381 (= H380), H388 (= H387), N390 (≠ L389), E422 (= E424), H423 (= H425)
binding flavin-adenine dinucleotide: P75 (= P79), Q76 (≠ Y80), G77 (= G81), G78 (≠ T82), N79 (≠ G83), T80 (= T84), G81 (≠ S85), M82 (≠ L86), G85 (≠ H89), S86 (≠ V90), L139 (≠ P143), G140 (= G144), A141 (= A145), C145 (vs. gap), H146 (vs. gap), G148 (= G150), G149 (= G151), N150 (≠ M152), A152 (= A154), T153 (= T155), A155 (= A157), G156 (≠ S158), G157 (= G159), E206 (= E208), G207 (= G209), I211 (≠ L213), I212 (= I214), H381 (= H380), E422 (= E424), H423 (= H425), N459 (= N460)
binding zinc ion: H381 (= H380), H388 (= H387), E422 (= E424)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39

6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
30% identity, 88% coverage: 57:465/467 of query aligns to 54:465/467 of 6lpnB

query
sites
6lpnB

P

P

T

R

S

T

T

S

D

E

E

E

V

V

A

S

D

H

I

I

V

L

R

R

T

H

C

C

A

H

D

E

Y

R

G

N

V

L

P

A

V

V

I

N

P
|
P

Y
x
Q

G
|
G

T
x
G

G
x
N

T
|
T

S
x
G

L
x
M

E

V

G

G

H
x
G

V
x
S

N

V

A

P

P

V

A

F

G

D

G

E

I

I

C

I

V

L

D

S

M

T

M

A

R

R

M

M

D

N

K

R

I

V

L

L

A

S

V

F

H

H

A

S

E

V

D

S

L

G

D

I

V

L

V

V

V

C

Q

Q

P

A

G

G

V

C

T

V

R

L

E

E

Q

E

L

L

N

S

T

R

Y

Y

L

V

R

E

D

E

Q

R

G

D

L

F

F

I

F

M

P

P

I

L

D

D

P
x
L

G
|
G

A
|
A

N

K

A

G

S

S

-
x
C

-
x
H

L

I

G
|
G

M
x
N

A

V

A
|
A

T
|
T

R

N

A
|
A

S
x
G

G
|
G

T

L

N

R

A

F

V

L

R

R

Y

Y

G

G

T

S

M

L

K

H

D

G

N

T

V

V

L

L

A

G

L

L

E

E

A

V

V

V

M

L

A

A

D

D

G

G

G

T

V

V

I

L

R

D

T

C

A

L

Q

T

R

S

A

L

K

R

K

K

S

D

S

N

A

T

G

G

Y

Y

D

D

M

L

T

K

R

Q

L

L

L

F

V

I

G

G

S

S

E
|
E

G
|
G

T

T

L

L

G

G

L
x
I

I
|
I

T

T

E

T

L

V

T

S

L

I

R

L

L

C

Q

P

G

P

I

K

P

P

E

R

A

A

I

V

R

N

S

V

A

A

R

F

C

L

-

G

-

C

-

P

A

G

F

F

R

A

S

E

V

V

-

L

-

Q

-

T

D

F

D

S

A

T

C

C

R

K

A

G

V

M

M

L

M

G

T

E

I

I

Q

-

Y

-

G

-

I

-

P

-

V

L

S

S

R

A

I

F

E

E

L

F

L

M

D

D

E

A

M

V

S

C

V

M

R

Q

A

L

A

V

N

G

A

R

Y

H

S

L

G

H

L

L

D

A

L

S

P

P

-

V

-

Q

E

E

M

S

P

P

L

F

-

Y

L

V

L

L

L

I

E

E

F

T

H

S

G

G

S

S

D

N

A

A

G

G

V

H

-

D

V

A

E

E

Q

K

A

L

D

G

T

H

F

F

A

L

Q

E

I

H

A

A

E

L

E

G

F

S

G

G

G

L

F

V

D

T

I

D

A

G

A

T

T

M

S

A

T

T

A

D

E

Q

E

R

R

K

S

V

K

K

-

M

L

L

W

W

Q

A

A

L

R

R

H

E

D

R

M

I

Y
x
T

W

E

A

A

S

-

L

-

Q

-

L

L

R

S

P

R

G

D

A

G

K

Y

G

V

I

Y

S

K

T

Y

D

D

V

L

C

S

V

L

P

P

I

V

S

E

K

R

L

L

A

Y

E

D

C

I

V

V

S

T

A

D

A

L

R

R

S

A

K

R

A

L

E

G

E

P

M

H

N

A

L

K

L

H

A

V

P

V

M

G

V

Y

G

G

H
|
H

V

L

G

G

D

D

G

G

N

N

F

L

H

H

A

L

L

N

L

V

L

T

I

A

N

E

M

A

D

F

S

S

A

P

E

S

E

L

R

L

E

A

A

A

A

L

D

E

A

P

Y

H

V

V

G

-

W

-

L

-

N

Y

E

E

L

W

A

T

I

A

S

G

I

Q

E

Q

G

G

T

S

C

V

T

S

G

A

E
|
E

H
|
H

G

G

I

V

G

G

Q

F

G

R

K

K

R

R

P

D

Y

V

L

L

-

G

Q

Y

Q

S

E

K

L

P

G

P

E

G

T

A

T

L

R

Q

Y

L

M

M

A

Q

I

L

K

K

A

A

A

L

L

L

D

D

P

P

E

K

N

G

I

I

L

L

N
|
N

P

P

G

Y

K

K

I

T

L

L

binding flavin-adenine dinucleotide: P76 (= P79), Q77 (≠ Y80), G78 (= G81), G79 (≠ T82), N80 (≠ G83), T81 (= T84), G82 (≠ S85), M83 (≠ L86), G86 (≠ H89), S87 (≠ V90), L140 (≠ P143), G141 (= G144), A142 (= A145), C146 (vs. gap), H147 (vs. gap), G149 (= G150), G150 (= G151), N151 (≠ M152), A153 (= A154), T154 (= T155), A156 (= A157), G157 (≠ S158), G158 (= G159), E207 (= E208), G208 (= G209), I212 (≠ L213), I213 (= I214), T338 (≠ Y333), H382 (= H380), E423 (= E424), H424 (= H425), N460 (= N460)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 40

Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
29% identity, 88% coverage: 57:465/467 of query aligns to 106:517/521 of Q8N465

query
sites
Q8N465

P

P

T

R

S

T

T
x
S

D

E

E

E

V

V

A

S

D

H

I

I

V

L

R

R

T

H

C

C

A

H

D

E

Y

R

G

N

V

L

P

A

V

V

I
x
N

P

P

Y

Q

G

G

T
x
G

G

N

T

T

S

G

L

M

E

V

G

G

H

G

V

S

N

V

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