SitesBLAST

M1 (= M38) modified: Initiator methionine, Removed
C2 (= C39) mutation C->A,S: Loss of glutamine-dependent activity but no effect on ammonia-dependent asparagine synthetase activity.
H30 (= H63) mutation to A: 4,5-fold decrease in glutamine affinity.
D34 (= D70) mutation D->N,E: Little effect on the kinetic properties.
H81 (≠ Y118) mutation to A: 5-fold decrease in glutamine affinity.
A105 (≠ K143) mutation to H: Little effect on the kinetic properties.
E349 (≠ Q409) mutation E->A,Q: Loss of glutamine- and ammonia-dependent synthetase activity, but still exhibits glutaminase activity.; mutation to D: 5-fold increase in affinity for aspartate when assaying both the glutamine- and ammonia-dependent synthetase reactions, and 2-fold decrease in kcat for these reactions. Modifies the product glutamate/asparagine stoichiometry.

P78753 Probable asparagine synthetase [glutamine-hydrolyzing]; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
27% identity, 80% coverage: 38:541/627 of query aligns to 1:443/557 of P78753

query
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P78753

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S391 (≠ V490) modified: Phosphoserine

Sites not aligning to the query:

489 modified: Phosphoserine

P08243 Asparagine synthetase [glutamine-hydrolyzing]; Cell cycle control protein TS11; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Homo sapiens (Human) (see 7 papers)
25% identity, 83% coverage: 38:558/627 of query aligns to 1:470/561 of P08243

query
sites
P08243

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C2 (= C39) active site, For GATase activity; mutation to A: Loss of the glutamine-dependent asparagine synthetase activity, while the ammonia-dependent activity remained unaffected.
A6 (≠ G43) to E: in ASNSD; dramatic reduction in protein abundance; dbSNP:rs398122975
V210 (= V248) to E: in dbSNP:rs1049674
F362 (≠ Q406) to V: in ASNSD; dramatic reduction in protein abundance; dbSNP:rs398122973

Sites not aligning to the query:

550 R → C: in ASNSD; increases level of protein abundance; dbSNP:rs398122974

6gq3A Human asparagine synthetase (asns) in complex with 6-diazo-5-oxo-l- norleucine (don) at 1.85 a resolution (see paper)
25% identity, 78% coverage: 64:554/627 of query aligns to 23:453/509 of 6gq3A

query
sites
6gq3A

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G

S

H

W

Y

M

E

R

V

V

L

D

D

-

L

-

K

A

P

N

N

G

G

A

K

T

V

T

A

T

S

Q

V

R

E

W

M

W

V

E

K

L

Y

Q

H

F

-

G

H

A

C

R

R

E

D

E

V

E

F

R

P

N

G

Y

F

S

E

F

I

E

E

D

T

W

V

K

K

Q

N

R

N

T

L

L

R

D

I

T

L

M

F

R

N

E

N

A

A

V

V

A

K

I

K

R

R

Q

L

R

M

A

T

A

D

V

R

D

R

V

I

G

G

V

C

L

L

S

S

G

G

V

L

D

D

S

S

L

L

-

V

-

A

-

T

L

L

V

L

G

K

L

Q

L

L

R

K

E

E

A

A

G

Q

V

V

A

Q

D

Y

N

P

L

L

L

Q

T

T

F

F

S

A

I

I

G

G

F

M

E

E

D

D

A

S

G

-

E

-

R

-

G

-

D

P

E

D

F

L

K

L

Y

A

S

A

D

R

L

K

I

V

A

A

K

D

H

H

Y

I

K

G

T

S

R

E

H

H

H

Y

Q

E

L

V

R

L

I

F

Q

N

E

S

K

E

E

E

I

G

L

I

E

Q

Q

A

L

L

P

D

A

E

A

V

F

I

Q

F

A

S

M

L

S

E

E

T

P

Y

M

D

V

I

S
x
T

-

T

-

V

H
x
R

D

A

C

S

I

V

A

G

F

M

Y

Y

L

L

L

I

S

S

R

K

E

Y

V

I

A

R

K

K

H

N

C

T

K

D

-

S

-

V

V

V

V

I

Q

F

S

S

G

G

Q

E

G

G

A

S

D

D

E

E

L

L

F

T

A

Q

G

G

Y

Y

H

I

W

Y

Y

F

P

-

L

-

V

-

D

-

G

-

A

-

E

-

D

-

P

-

V

-

A

-

Y

-

L

-

A

-

F

-

R

-

D

-

R

-

S

-

Y

-

E

-

Y

-

A

-

E

-

T

-

V

-

Q

-

W

-

V

-

Q

-

G

-

D

-

F

-

S

-

G

-

D

-

F

-

V

-

R

-

Q

-

H

H

F

K

A

A

Q

-

P

P

G

S

A

P

D

E

A

K

A

A

V

E

D

E

K

E

A

S

L

E

R

R

I

L

D

L

S

R

T

E

V

L

M

Y

L

L

V

F

D

D

D

-

P

-

V

V

K

L

R

R

V

A

D

D

N

R

M

T

T

T

M

A

A

A

W

H

G

G

L

L

E

E

A

L

R

R

T

V

P

P

F

F

L

L

D

D

Y

H

R

R

V

F

A

S

E

S

L

Y

S

Y

A

L

R

S

I

L

P

P

A

P

K

E

F

M

K

R

L

I

P

P

E

K

G

N

G

G

-

I

-

E

K

K

Y

H

V

L

L

L

K

R

E

E

A

T

A

F

R

E

-

D

-

S

Q

N

V

L

I

I

P

P

A

K

E

E

V

I

I

L

D

W

R

R

P

P

active site: L49 (= L87), N74 (= N112), G75 (= G113), T324 (≠ S385), R327 (≠ H386)
binding 5-oxo-l-norleucine: R48 (= R86), V51 (≠ I89), V52 (≠ M90), Y73 (≠ F111), N74 (= N112), G75 (= G113), E76 (≠ A114), V95 (≠ G136), D96 (= D137)

Sites not aligning to the query:

active site: 4
binding 5-oxo-l-norleucine: 1

1mc1A Beta-lactam synthetase with product (dgpc), amp and ppi (see paper)
27% identity, 57% coverage: 65:419/627 of query aligns to 11:342/491 of 1mc1A

query
sites
1mc1A

T

S

A

A

R

R

G

G

P

P

-

V

-

F

D

A

A

T

C

R

G

G

F

S

H

H

S

T

Q

D

G

I

P

D

L

T

A

P

L

Q

G

G

H

E

R

R

R

S

L

L

K

A

I

A

M

T

D

L

L

V

C

H

E

A

A

P

S

S

G

V

Q

A

P

P

M

-

I

-

D

D

S

R

A

A

L

V

G

A

L

R

S

S

M

L

-

T

-

G

-

A

-

P

-

T

-

A

V

V

F

L

N
x
A

G
|
G

A

E

I

I

Y

Y

N

N

Y

R

P

D

E

E

L

L

R

-

A

-

E

-

L

L

E

S

G

V

L

L

G

P

Y

A

R

G

F

P

F

A

S

P

E

E

G

G

D

D

T

A

E

E

V

L

L

V

L

L

K

R

G

L

F

L

H

E

A

R

W

Y

G

D

E

L

A

H

L

A

L

F

P

R

R

L

L

V

N

N

G

G

M

R

F

F

A

A

F

T

A

V

I

V

W

-

Q

-

R

R

D

T

T

G

Q

D

Q

R

L

V

F

L

I

L

A

A

R

T

D

D

R

H

L

A

G

G

V

S

K

V

P

P

L

L

Y

Y

L

T

S

C

R

V

T

A

D

P

Q

G

R

E

L

V

R

R

F

A

A

S

S

T

S

E

L

A

P

K

A

A

L

L

L

A

K

A

G

G

G

F

D

P

I

L

A

A

G

D

V

A

L

R

N

R

P

V

V

A

A

G

L

L

N

T

H

-

Y

-

M

-

S

-

F

-

H

-

A

-

V

-

P

-

A

-

P

-

D

-

T

-

L

-

I

-

A

-

G

G

I

V

E

Y

K

Q

L

V

P

P

P

A

A

G

S

A

W

V

M

M

R

D

V

I

D

D

-

L

A

G

N

S

G

G

A

T

T

A

T

V

T

T

Q

H

R

R

W

T

W

W

E

T

L

P

Q

G

F

L

G

S

A

R

R

R

E

I

E

L

E

P

R

E

N

G

Y

E

S

A

F

V

E

A

D

A

W

V

K

R

Q

A

R

-

T

-

L

-

D

-

T

A

M

L

R

E

E

K

A

A

V

V

A

A

I

Q

R

R

Q

V

R

T

A

P

A

G

V

D

D

T

V

P

G

L

V

V

L
x
V

L

L

S
|
S

G

G

G
|
G

V

I

D
|
D

S
|
S

S

S

L

G

L

V

V

A

G

A

L

C

L

A

R

H

E

R

A

A

G

-

V

-

A

A

D

G

N

E

L

L

L

D

T

T

F

V

S
|
S

I
x
M

G

G

F

T

E

D

D

T

A

S

G

-

E

-

R

-

G

-

D

N

E

E

F

F

K

R

Y

E

S

A

D

R

L

A

I

V

A

V

K

D

H

H

Y

L

K

R

T

T

R

R

H

H

H

R

Q

E

L

I

R

T

I

I

Q

P

E

T

K

T

E

E

I

L

L

L

E

A

Q

Q

L

L

P

P

A

Y

A

A

F

V

Q

W

A

A

M

S

S

E

E

S

P

-

M

-

V

V

S

D

H

P

D
|
D

C

I

I

I

A

E

F
x
Y

Y

L

L

L

-

P

-

L

-

T

-

A

L

L

S

Y

R

R

E

A

V

L

A

D

K

G

H

P

C

E

K

R

V

R

V

I

Q

L

S

T

G
|
G

Q
x
Y

G
|
G

A

A

D
|
D

E
x
I

L

P

F

L

A

G

G

G

Y

M

H

H

active site: A65 (≠ N112), G66 (= G113), D306 (= D387), Y332 (≠ Q409)
binding adenosine monophosphate: V231 (≠ L303), S233 (= S305), S238 (= S310), S256 (= S330), M257 (≠ I331), G331 (= G408)
binding magnesium ion: D237 (= D309), D335 (= D412)
binding deoxyguanidinoproclavaminic acid: Y310 (≠ F391), Y332 (≠ Q409), G333 (= G410), I336 (≠ E413)
binding pyrophosphate 2-: S233 (= S305), G235 (= G307), D237 (= D309), S238 (= S310), D335 (= D412)

Sites not aligning to the query:

active site: 366, 427
binding adenosine monophosphate: 427, 430
binding deoxyguanidinoproclavaminic acid: 357, 366, 427
binding pyrophosphate 2-: 407, 427, 428

1jgtB Crystal structure of beta-lactam synthetase (see paper)
27% identity, 50% coverage: 108:419/627 of query aligns to 69:355/500 of 1jgtB

query
sites
1jgtB

S

T

M

A

V

V

F

L

N
x
A

G
|
G

A

E

I

I

Y

Y

N

N

Y

R

P

D

E

E

L

L

R

-

A

-

E

-

L

L

E

S

G

V

L

L

G

P

Y

A

R

G

F

P

F

A

S

P

E

E

G

G

D

D

T

A

E

E

V

L

L

V

L

L

K

R

G

L

F

L

H

E

A

R

W

Y

G

D

E

L

A

H

L

A

L

F

P

R

R

L

L

V

N

N

G

G

M

R

F

F

A

A

F

T

A

V

I

V

W

-

Q

-

R

R

D

T

T

G

Q

D

Q

R

L

V

F

L

I

L

A

A

R

T

D

D

R

H

L

A

G

G

V

S

K

V

P

P

L

L

Y

Y

L

T

S

C

R

V

T

A

D

P

Q

G

R

E

L

V

R

R

F

A

A

S

S

T

S

E

L

A

P

K

A

A

L

L

L

A

K

A

G

H

G

R

D

D

I

P

A

K

G

G

V

F

L

-

N

-

P

P

V

L

A

A

L

D

N

A

H

R

Y

R

M

V

S

A

F

G

H

-

A

-

V

-

P

-

A

-

P

-

D

-

T

-

L

-

I

L

A

T

G

G

I

V

E

Y

K

Q

L

V

P

P

P

A

A

G

S

A

W

V

M

M

R

D

V

I

D

D

-

L

A

G

N

S

G

G

A

T

T

A

T

V

T

T

Q

H

R

R

W

T

W

W

E

T

L

P

Q

G

F

L

G

S

A

R

R

R

E

I

E

L

E

P

R

E

N

G

Y

E

S

A

F

V

E

A

D

A

W

V

K

R

Q

A

R

-

T

-

L

-

D

-

T

A

M

L

R

E

E

K

A

A

V

V

A

A

I

Q

R

R

Q

V

R

T

A

P

A

G

V

D

D

T

V

P

G

L

V

V

L
x
V

L
|
L

S
|
S

G

G

G
|
G

V
x
I

D
|
D

S
|
S

S

S

L

G

L

V

V

A

G

A

L

C

L

A

R

H

E

R

A

A

G

-

V

-

A

A

D

G

N

E

L

L

L

D

T

T

F

V

S
|
S

I
x
M

G

G

F

T

E

D

D

T

A

S

G

-

E

-

R

-

G

-

D

N

E

E

F

F

K

R

Y

E

S

A

D

R

L

A

I

V

A

V

K

D

H

H

Y

L

K

R

T

T

R

R

H

H

H

R

Q

E

L

I

R

T

I

I

Q

P

E

T

K

T

E

E

I

L

L

L

E

A

Q

Q

L

L

P

P

A

Y

A

A

F

V

Q

W

A

A

M

S

S

E

E

S

P

-

M

-

V

V

S

D

H

P

D
|
D

C

I

I

I

A

E

F
x
Y

Y

L

L

L

-

P

-
x
L

-

T

-

A

L

L

S

Y

R

R

E

A

V

L

A

D

K

G

H

P

C

E

K

R

V

R

V

I

Q

L

S

T

G
|
G

Q
x
Y

G
|
G

A

A

D
|
D

E
x
I

L

P

F

L

A

G

G

G

Y
x
M

H

H

active site: A73 (≠ N112), G74 (= G113), D319 (= D387), Y345 (≠ Q409)
binding diphosphomethylphosphonic acid adenosyl ester: V244 (≠ L303), L245 (= L304), S246 (= S305), G248 (= G307), I249 (≠ V308), D250 (= D309), S251 (= S310), S269 (= S330), M270 (≠ I331), L327 (vs. gap), G344 (= G408), Y345 (≠ Q409), D348 (= D412)
binding n2-(carboxyethyl)-l-arginine: Y323 (≠ F391), Y345 (≠ Q409), G346 (= G410), D348 (= D412), I349 (≠ E413), M354 (≠ Y418)
binding magnesium ion: D250 (= D309), D348 (= D412)

Sites not aligning to the query:

active site: 379, 440
binding diphosphomethylphosphonic acid adenosyl ester: 420, 440
binding n2-(carboxyethyl)-l-arginine: 370, 379

1mbzA Beta-lactam synthetase with trapped intermediate (see paper)
26% identity, 50% coverage: 108:419/627 of query aligns to 65:347/496 of 1mbzA

query
sites
1mbzA

S

T

M

A

V

V

F

L

N
x
A

G
|
G

A

E

I

I

Y

Y

N

N

Y

R

P

D

E

E

L

L

R

-

A

-

E

-

L

L

E

S

G

V

L

L

G

P

Y

A

R

G

F

P

F

A

S

P

E

E

G

G

D

D

T

A

E

E

V

L

L

V

L

L

K

R

G

L

F

L

H

E

A

R

W

Y

G

D

E

L

A

H

L

A

L

F

P

R

R

L

L

V

N

N

G

G

M

R

F

F

A

A

F

T

A

V

I

V

W

-

Q

-

R

R

D

T

T

G

Q

D

Q

R

L

V

F

L

I

L

A

A

R

T

D

D

R

H

L

A

G

G

V

S

K

V

P

P

L

L

Y

Y

L

T

S

C

R

V

T

A

D

P

Q

G

R

E

L

V

R

R

F

A

A

S

S

T

S

E

L

A

P

K

A

A

L

L

L

A

K

A

G

H

G

G

D

-

I

-

A

-

G

-

V

-

L

-

N

F

P

P

V

L

A

A

L

D

N

A

H

R

Y

R

M

V

S

A

F

G

H

-

A

-

V

-

P

-

A

-

P

-

D

-

T

-

L

-

I

L

A

T

G

G

I

V

E

Y

K

Q

L

V

P

P

P

A

A

G

S

A

W

V

M

M

R

D

V

I

D

D

-

L

A

G

N

S

G

G

A

T

T

A

T

V

T

T

Q

H

R

R

W

T

W

W

E

T

L

P

Q

G

F

L

G

S

A

R

R

R

E

I

E

L

E

P

R

E

N

G

Y

E

S

A

F

V

E

A

D

A

W

V

K

R

Q

A

R

-

T

-

L

-

D

-

T

A

M

L

R

E

E

K

A

A

V

V

A

A

I

Q

R

R

Q

V

R

T

A

P

A

G

V

D

D

T

V

P

G

L

V

V

L
x
V

L
|
L

S
|
S

G

G

G
|
G

V

I

D
|
D

S
|
S

S

S

L

G

L

V

V

A

G

A

L

C

L

A

R

H

E

R

A

A

G

-

V

-

A

A

D

G

N

E

L

L

L

D

T

T

F

V

S
|
S

I
x
M

G

G

F

T

E

D

D

T

A

S

G

-

E

-

R

-

G

-

D

N

E

E

F

F

K

R

Y

E

S

A

D

R

L

A

I

V

A

V

K

D

H

H

Y

L

K

R

T

T

R

R

H

H

H

R

Q

E

L

I

R

T

I

I

Q

P

E

T

K

T

E

E

I

L

L

L

E

A

Q

Q

L

L

P

P

A

Y

A

A

F

V

Q

W

A

A

M

S

S

E

E

S

P

-

M

-

V

V

S

D

H

P

D
|
D

C

I

I

I

A

E

F
x
Y

Y

L

L

L

-

P

-
x
L

-

T

-

A

L

L

S

Y

R

R

E

A

V

L

A

D

K

G

H

P

C

E

K

R

V

R

V

I

Q

L

S

T

G
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G

Q
x
Y

G
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G

A

A

D
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D

E
x
I

L

P

F

L

A

G

G

G

Y

M

H

H

active site: A69 (≠ N112), G70 (= G113), D311 (= D387), Y337 (≠ Q409)
binding arginine-n-methylcarbonyl phosphoric acid 5'-adenosine ester: V236 (≠ L303), L237 (= L304), S238 (= S305), S243 (= S310), S261 (= S330), M262 (≠ I331), Y315 (≠ F391), L319 (vs. gap), G336 (= G408), Y337 (≠ Q409), G338 (= G410), D340 (= D412), I341 (≠ E413)
binding magnesium ion: D242 (= D309), D340 (= D412)
binding pyrophosphate 2-: S238 (= S305), G240 (= G307), D242 (= D309), S243 (= S310), D340 (= D412)

Sites not aligning to the query:

active site: 371, 432
binding arginine-n-methylcarbonyl phosphoric acid 5'-adenosine ester: 362, 371, 432, 434, 435
binding pyrophosphate 2-: 412, 432, 433

1mb9A Beta-lactam synthetase complexed with atp (see paper)
26% identity, 50% coverage: 108:419/627 of query aligns to 66:346/485 of 1mb9A

query
sites
1mb9A

S

T

M

A

V

V

F

L

N
x
A

G
|
G

A

E

I

I

Y

Y

N

N

Y

R

P

D

E

E

L

L

R

-

A

-

E

-

L

L

E

S

G

V

L

L

G

P

Y

A

R

G

F

P

F

A

S

P

E

E

G

G

D

D

T

A

E

E

V

L

L

V

L

L

K

R

G

L

F

L

H

E

A

R

W

Y

G

D

E

L

A

H

L

A

L

F

P

R

R

L

L

V

N

N

G

G

M

R

F

F

A

A

F

T

A

V

I

V

W

-

Q

-

R

R

D

T

T

G

Q

D

Q

R

L

V

F

L

I

L

A

A

R

T

D

D

R

H

L

A

G

G

V

S

K

V

P

P

L

L

Y

Y

L

T

S

C

R

V

T

A

D

P

Q

G

R

E

L

V

R

R

F

A

A

S

S

T

S

E

L

A

P

K

A

A

L

L

L

-

K

-

G

-

D

-

I

-

A

-

G

-

V

-

L

-

N

-

P

-

V

-

A

-

L

-

N

-

H

-

Y

-

M

-

S

-

F

-

H

-

A

A

V

A

V

F

P

P

A

L

P

A

D

D

T

A

L

R

-

R

-

V

-

A

-

G

I

L

A

T

G

G

I

V

E

Y

K

Q

L

V

P

P

P

A

A

G

S

A

W

V

M

M

R

D

V

I

D

D

-

L

A

G

N

S

G

G

A

T

T

A

T

V

T

T

Q

H

R

R

W

T

W

W

E

T

L

P

Q

G

F

L

G

S

A

R

R

R

E

I

E

L

E

P

R

E

N

G

Y

E

S

A

F

V

E

A

D

A

W

V

K

R

Q

A

R

-

T

-

L

-

D

-

T

A

M

L

R

E

E

K

A

A

V

V

A

A

I

Q

R

R

Q

V

R

T

A

P

A

G

V

D

D

T

V

P

G

L

V

V

L
x
V

L
|
L

S
|
S

G

G

G
|
G

V

I

D
|
D

S
|
S

S

S

L

G

L

V

V

A

G

A

L

C

L

A

R

H

E

R

A

A

G

-

V

-

A

A

D

G

N

E

L

L

L

D

T

T

F

V

S
|
S

I
x
M

G

G

F

T

E

D

D

T

A

S

G

-

E

-

R

-

G

-

D

N

E

E

F

F

K

R

Y

E

S

A

D

R

L

A

I

V

A

V

K

D

H

H

Y

L

K

R

T

T

R

R

H

H

H

R

Q

E

L

I

R

T

I

I

Q

P

E

T

K

T

E

E

I

L

L

L

E

A

Q

Q

L

L

P

P

A

Y

A

A

F

V

Q

W

A

A

M

S

S

E

E

S

P

-

M

-

V

V

S

D

H

P

D
|
D

C

I

I

I

A

E

F
x
Y

Y

L

L

L

-

P

-
x
L

-

T

-

A

L

L

S

Y

R

R

E

A

V

L

A

D

K

G

H

P

C

E

K

R

V

R

V

I

Q

L

S

T

G
|
G

Q
x
Y

G

G

A

A

D
|
D

E

I

L

P

F

L

A

G

G

G

Y

M

H

H

active site: A70 (≠ N112), G71 (= G113), D310 (= D387), Y336 (≠ Q409)
binding adenosine monophosphate: V235 (≠ L303), L236 (= L304), S242 (= S310), S260 (= S330), M261 (≠ I331), Y314 (≠ F391), L318 (vs. gap), G335 (= G408), Y336 (≠ Q409)
binding adenosine-5'-triphosphate: V235 (≠ L303), L236 (= L304), S237 (= S305), G239 (= G307), D241 (= D309), S242 (= S310), S260 (= S330), M261 (≠ I331), L318 (vs. gap), G335 (= G408), D339 (= D412)
binding magnesium ion: D241 (= D309), D339 (= D412)
binding pyrophosphate 2-: S237 (= S305), G239 (= G307), D241 (= D309), S242 (= S310), D339 (= D412)

Sites not aligning to the query:

active site: 370, 431
binding adenosine-5'-triphosphate: 411, 431
binding pyrophosphate 2-: 411, 431

Query Sequence

>GFF2874 FitnessBrowser__psRCH2:GFF2874
MTEPSQAGSTPLRWSEKLNFARDGSVTLPNGKTGKDLMCGIAGELRFDNRPADLAAVERI
TQHLTARGPDACGFHSQGPLALGHRRLKIMDLCEASGQPMIDSALGLSMVFNGAIYNYPE
LRAELEGLGYRFFSEGDTEVLLKGFHAWGEALLPRLNGMFAFAIWQRDTQQLFIARDRLG
VKPLYLSRTDQRLRFASSLPALLKGGDIAGVLNPVALNHYMSFHAVVPAPDTLIAGIEKL
PPASWMRVDANGATTTQRWWELQFGAREEERNYSFEDWKQRTLDTMREAVAIRQRAAVDV
GVLLSGGVDSSLLVGLLREAGVADNLLTFSIGFEDAGGERGDEFKYSDLIAKHYKTRHHQ
LRIQEKEILEQLPAAFQAMSEPMVSHDCIAFYLLSREVAKHCKVVQSGQGADELFAGYHW
YPLVDGAEDPVAAYLAAFRDRSYEEYAETVQQQWVQGDFSGDFVRQHFAQPGADAAVDKA
LRIDSTVMLVDDPVKRVDNMTMAWGLEARTPFLDYRVAELSARIPAKFKLPEGGKYVLKE
AARQVIPAEVIDRPKGYFPVPGLKHLQGATLNWVREMLLDPSQERGLYNPQALEKLLADP
DGQLTPLRGSKLWQLAAVNLWLSEQGL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory