SitesBLAST

S109 (≠ E6) to W: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; dbSNP:rs142050154
N127 (≠ S23) to K: in D2HGA1; unknown pathological significance; complete loss of catalytic activity; dbSNP:rs762857195
G131 (= G26) to V: in D2HGA1; unknown pathological significance; complete loss of catalytic activity
I147 (≠ T36) to S: in D2HGA1; severe phenotype; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs121434361
M153 (≠ L42) to T: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; to V: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; dbSNP:rs1432270139
C172 (≠ T61) to Y: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs773735172
P189 (= P81) to L: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs587783517
A205 (= A101) to V: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs750889931
A231 (≠ G127) to V: in D2HGA1; unknown pathological significance; significant loss of catalytic activity
G233 (= G129) to S: in D2HGA1; unknown pathological significance; no effect on catalytic activity; dbSNP:rs374535734

Sites not aligning to the query:

15 R → G: in dbSNP:rs4675887
169:521 natural variant: Missing (in D2HGA1; unknown pathological significance)
375 D → Y: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs267606759
386 binding ; binding ; binding ; R→A: Loss of catalytic activity.
390 binding ; binding ; T→A: Significantly reduced catalytic activity.
399 V → M: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs746519212
400:521 natural variant: Missing (in D2HGA1; unknown pathological significance; complete loss of catalytic activity)
401 binding ; binding ; K→A: Loss of catalytic activity.
419 R → H: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs199908032
426 A → T: in D2HGA1; unknown pathological significance; no effect on catalytic activity; dbSNP:rs146578303
434 binding ; H→A: Loss of catalytic activity.
436 G → V: slight reduction in catalytic activity
439 N → D: in D2HGA1; mild phenotype; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs121434362
441 binding ; H→A: Loss of catalytic activity.
443 binding ; N→A: Significantly reduced catalytic activity.
444 V → A: in D2HGA1; severe phenotype; unknown pathological significance; significant reduction in catalytic activity; dbSNP:rs121434360
446 A → V: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs746956176
475 binding ; E→A: Loss of catalytic activity.
476 binding ; binding ; binding ; H→A: Loss of catalytic activity.
477 G → R: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs1453924640

6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
31% identity, 54% coverage: 1:197/366 of query aligns to 51:248/466 of 6lpxA

query
sites
6lpxA

M

L

T

R

P

P

Q

R

S

T

E

S

A

E

E

E

L

V

A

S

Q

H

I

I

I

L

V

R

G

H

A

C

T

H

A

E

-

R

P

N

L

L

A

A

V

V

S

N

-
x
P

G
x
Q

G
|
G

T
x
N

R
x
T

G
|
G

L
x
M

S

V

T

G

G
|
G

G
x
S

E

V

-

P

-

V

-

F

-

D

-

E

-

I

T

I

L

L

S

S

V

T

A

A

G

R

L

M

N

N

G

R

V

V

T

L

L

S

Y

F

E

H

P

S

G

V

A

S

L

G

T

I

L

L

V

V

V

C

Q

Q

A

A

G

G

T

C

S

V

V

L

E

E

V

L

Q

S

A

R

L

Y

L

V

A

-

G

-

E

-

N

E

Q

E

R

R

L

D

A

F

F

I

E

M

P

P

M

L

D

D

H

-

R

-

G

-

L

-

L
|
L

G
|
G

T
x
A

K

K

G

G

T

S

P
x
C

T
x
H

I

I

G
|
G

V
x
N

F

V

A
|
A

A
x
T

N

N

V
x
A

S
x
G

G
|
G

P

L

R

R

R

F

I

L

Q

R

C

Y

G

G

A

S

A

L

R

H

D

G

F

T

L

V

L

L

G

G

V

L

R

E

F

V

V

V

D

L

G

A

R

D

G

G

D

T

V

V

L

L

S

D

N

C

G

L

G

T

R

S

V

L

M

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

V

K

K

Q

L

L

M

F

A

I

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G

G

V
x
I

L
x
I

S

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

C

K

S

P

E

R

A

A

C

V

A

N

T

V

V

A

T

F

V

L

H

G

V

C

A

P

D

G

L

F

T

A

S

E

A

V

V

L

A

Q

A

T

M

F

S

S

T

T

A

C

L

K

G

G

binding flavin-adenine dinucleotide: P75 (vs. gap), Q76 (≠ G24), G77 (= G25), G78 (= G26), N79 (≠ T27), T80 (≠ R28), G81 (= G29), M82 (≠ L30), G85 (= G33), S86 (≠ G34), L139 (= L88), G140 (= G89), A141 (≠ T90), C145 (≠ P94), H146 (≠ T95), G148 (= G97), G149 (= G98), N150 (≠ V99), A152 (= A101), T153 (≠ A102), A155 (≠ V104), G156 (≠ S105), G157 (= G106), E206 (≠ H155), G207 (= G156), I211 (≠ V160), I212 (≠ L161)

Sites not aligning to the query:

binding 2-oxoglutaric acid: 333, 337, 348, 379, 381, 388, 390, 423
binding flavin-adenine dinucleotide: 39, 381, 422, 423, 459
binding zinc ion: 381, 388, 422

6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
31% identity, 54% coverage: 1:197/366 of query aligns to 51:248/466 of 6lpuA

query
sites
6lpuA

M

L

T

R

P

P

Q

R

S

T

E

S

A

E

E

E

L

V

A

S

Q

H

I

I

I

L

V

R

G

H

A

C

T

H

A

E

-

R

P

N

L

L

A

A

V

V

S

N

-
x
P

G
x
Q

G
|
G

T
x
N

R
x
T

G
|
G

L
x
M

S

V

T

G

G
|
G

G
x
S

E

V

-

P

-

V

-

F

-

D

-

E

-

I

T

I

L

L

S

S

V

T

A

A

G

R

L

M

N

N

G

R

V

V

T

L

L

S

Y

F

E

H

P

S

G

V

A

S

L

G

T

I

L

L

V

V

V

C

Q

Q

A

A

G

G

T

C

S

V

V

L

E

E

V

L

Q

S

A

R

L

Y

L

V

A

-

G

-

E

-

N

E

Q

E

R

R

L

D

A

F

F

I

E

M

P

P

M

L

D

D

H

-

R

-

G

-

L

-

L
|
L

G
|
G

T
x
A

K

K

G

G

T

S

P
x
C

T
x
H

I

I

G
|
G

V
x
N

F

V

A
|
A

A
x
T

N

N

V
x
A

S
x
G

G
|
G

P

L

R

R

R

F

I

L

Q

R

C

Y

G

G

A

S

A

L

R

H

D

G

F

T

L

V

L

L

G

G

V

L

R

E

F

V

V

V

D

L

G

A

R

D

G

G

D

T

V

V

L

L

S

D

N

C

G

L

G

T

R

S

V

L

M

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

V

K

K

Q

L

L

M

F

A

I

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G

G

V
x
I

L
x
I

S

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

C

K

S

P

E

R

A

A

C

V

A

N

T

V

V

A

T

F

V

L

H

G

V

C

A

P

D

G

L

F

T

A

S

E

A

V

V

L

A

Q

A

T

M

F

S

S

T

T

A

C

L

K

G

G

binding flavin-adenine dinucleotide: P75 (vs. gap), Q76 (≠ G24), G77 (= G25), G78 (= G26), N79 (≠ T27), T80 (≠ R28), G81 (= G29), M82 (≠ L30), G85 (= G33), S86 (≠ G34), L139 (= L88), G140 (= G89), A141 (≠ T90), C145 (≠ P94), H146 (≠ T95), G148 (= G97), G149 (= G98), N150 (≠ V99), A152 (= A101), T153 (≠ A102), A155 (≠ V104), G156 (≠ S105), G157 (= G106), E206 (≠ H155), G207 (= G156), I211 (≠ V160), I212 (≠ L161)
binding (2s)-2-hydroxypentanedioic acid: M82 (≠ L30)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 381, 422, 423, 459
binding (2s)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 390, 423
binding zinc ion: 381, 388, 422

6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal) (see paper)
31% identity, 54% coverage: 1:197/366 of query aligns to 51:248/466 of 6lpqA

query
sites
6lpqA

M

L

T

R

P

P

Q

R

S

T

E

S

A

E

E

E

L

V

A

S

Q

H

I

I

I

L

V

R

G

H

A

C

T

H

A

E

-

R

P

N

L

L

A

A

V

V

S

N

-
x
P

G
x
Q

G
|
G

T
x
N

R
x
T

G
|
G

L
x
M

S

V

T

G

G
|
G

G
x
S

E

V

-

P

-

V

-

F

-

D

-

E

-

I

T

I

L

L

S

S

V

T

A

A

G

R

L

M

N

N

G

R

V

V

T

L

L

S

Y

F

E

H

P

S

G

V

A

S

L

G

T

I

L

L

V

V

V

C

Q

Q

A

A

G

G

T

C

S

V

V

L

E

E

V

L

Q

S

A

R

L

Y

L

V

A

-

G

-

E

-

N

E

Q

E

R

R

L

D

A

F

F

I

E

M

P

P

M

L

D

D

H

-

R

-

G

-

L

-

L
|
L

G
|
G

T
x
A

K

K

G

G

T

S

P
x
C

T
x
H

I

I

G
|
G

V
x
N

F

V

A
|
A

A
x
T

N

N

V
x
A

S
x
G

G
|
G

P

L

R

R

R

F

I

L

Q

R

C

Y

G

G

A

S

A

L

R

H

D

G

F

T

L

V

L

L

G

G

V

L

R

E

F

V

V

V

D

L

G

A

R

D

G

G

D

T

V

V

L

L

S

D

N

C

G

L

G

T

R

S

V

L

M

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

V

K

K

Q

L

L

M

F

A

I

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
x
I

L
x
I

S

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

C

K

S

P

E

R

A

A

C

V

A

N

T

V

V

A

T

F

V

L

H

G

V

C

A

P

D

G

L

F

T

A

S

E

A

V

V

L

A

Q

A

T

M

F

S

S

T

T

A

C

L

K

G

G

binding flavin-adenine dinucleotide: P75 (vs. gap), Q76 (≠ G24), G77 (= G25), G78 (= G26), N79 (≠ T27), T80 (≠ R28), G81 (= G29), G85 (= G33), S86 (≠ G34), L139 (= L88), G140 (= G89), A141 (≠ T90), C145 (≠ P94), H146 (≠ T95), G148 (= G97), G149 (= G98), N150 (≠ V99), A152 (= A101), T153 (≠ A102), A155 (≠ V104), G156 (≠ S105), G157 (= G106), E206 (≠ H155), G207 (= G156), G210 (= G159), I211 (≠ V160), I212 (≠ L161)
binding d-malate: M82 (≠ L30)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 381, 422, 423, 459
binding d-malate: 333, 337, 348, 379, 381, 388, 422, 423
binding zinc ion: 381, 388, 422

6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg) (see paper)
31% identity, 54% coverage: 1:197/366 of query aligns to 51:248/466 of 6lppA

query
sites
6lppA

M

L

T

R

P

P

Q

R

S

T

E

S

A

E

E

E

L

V

A

S

Q

H

I

I

I

L

V

R

G

H

A

C

T

H

A

E

-

R

P

N

L

L

A

A

V

V

S

N

-
x
P

G
x
Q

G
|
G

T
x
N

R
x
T

G
|
G

L
x
M

S

V

T

G

G
|
G

G
x
S

E

V

-

P

-

V

-

F

-

D

-

E

-

I

T

I

L

L

S

S

V

T

A

A

G

R

L

M

N

N

G

R

V

V

T

L

L

S

Y

F

E

H

P

S

G

V

A

S

L

G

T

I

L

L

V

V

V

C

Q

Q

A

A

G

G

T

C

S

V

V

L

E

E

V

L

Q

S

A

R

L

Y

L

V

A

-

G

-

E

-

N

E

Q

E

R

R

L

D

A

F

F

I

E

M

P

P

M

L

D

D

H

-

R

-

G

-

L

-

L
|
L

G
|
G

T
x
A

K

K

G

G

T

S

P
x
C

T
x
H

I

I

G
|
G

V
x
N

F

V

A
|
A

A
x
T

N

N

V
x
A

S
x
G

G
|
G

P

L

R

R

R

F

I

L

Q

R

C

Y

G

G

A

S

A

L

R

H

D

G

F

T

L

V

L

L

G

G

V

L

R

E

F

V

V

V

D

L

G

A

R

D

G

G

D

T

V

V

L

L

S

D

N

C

G

L

G

T

R

S

V

L

M

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

V

K

K

Q

L

L

M

F

A

I

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G

G

V
x
I

L
x
I

S

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

C

K

S

P

E

R

A

A

C

V

A

N

T

V

V

A

T

F

V

L

H

G

V

C

A

P

D

G

L

F

T

A

S

E

A

V

V

L

A

Q

A

T

M

F

S

S

T

T

A

C

L

K

G

G

binding (2R)-2-hydroxypentanedioic acid: M82 (≠ L30)
binding flavin-adenine dinucleotide: P75 (vs. gap), Q76 (≠ G24), G77 (= G25), G78 (= G26), N79 (≠ T27), T80 (≠ R28), G81 (= G29), M82 (≠ L30), G85 (= G33), S86 (≠ G34), L139 (= L88), G140 (= G89), A141 (≠ T90), C145 (≠ P94), H146 (≠ T95), G148 (= G97), G149 (= G98), N150 (≠ V99), A152 (= A101), T153 (≠ A102), A155 (≠ V104), G156 (≠ S105), G157 (= G106), E206 (≠ H155), G207 (= G156), I211 (≠ V160), I212 (≠ L161)

Sites not aligning to the query:

binding (2R)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 390, 422, 423
binding flavin-adenine dinucleotide: 39, 381, 422, 423, 459
binding zinc ion: 381, 388, 422

6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
31% identity, 54% coverage: 1:197/366 of query aligns to 52:249/467 of 6lpnB

query
sites
6lpnB

M

L

T

R

P

P

Q

R

S

T

E

S

A

E

E

E

L

V

A

S

Q

H

I

I

I

L

V

R

G

H

A

C

T

H

A

E

-

R

P

N

L

L

A

A

V

V

S

N

-
x
P

G
x
Q

G
|
G

T
x
N

R
x
T

G
|
G

L
x
M

S

V

T

G

G
|
G

G
x
S

E

V

-

P

-

V

-

F

-

D

-

E

-

I

T

I

L

L

S

S

V

T

A

A

G

R

L

M

N

N

G

R

V

V

T

L

L

S

Y

F

E

H

P

S

G

V

A

S

L

G

T

I

L

L

V

V

V

C

Q

Q

A

A

G

G

T

C

S

V

V

L

E

E

V

L

Q

S

A

R

L

Y

L

V

A

-

G

-

E

-

N

E

Q

E

R

R

L

D

A

F

F

I

E

M

P

P

M

L

D

D

H

-

R

-

G

-

L

-

L
|
L

G
|
G

T
x
A

K

K

G

G

T

S

P
x
C

T
x
H

I

I

G
|
G

V
x
N

F

V

A
|
A

A
x
T

N

N

V
x
A

S
x
G

G
|
G

P

L

R

R

R

F

I

L

Q

R

C

Y

G

G

A

S

A

L

R

H

D

G

F

T

L

V

L

L

G

G

V

L

R

E

F

V

V

V

D

L

G

A

R

D

G

G

D

T

V

V

L

L

S

D

N

C

G

L

G

T

R

S

V

L

M

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

V

K

K

Q

L

L

M

F

A

I

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G

G

V
x
I

L
x
I

S

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

C

K

S

P

E

R

A

A

C

V

A

N

T

V

V

A

T

F

V

L

H

G

V

C

A

P

D

G

L

F

T

A

S

E

A

V

V

L

A

Q

A

T

M

F

S

S

T

T

A

C

L

K

G

G

binding flavin-adenine dinucleotide: P76 (vs. gap), Q77 (≠ G24), G78 (= G25), G79 (= G26), N80 (≠ T27), T81 (≠ R28), G82 (= G29), M83 (≠ L30), G86 (= G33), S87 (≠ G34), L140 (= L88), G141 (= G89), A142 (≠ T90), C146 (≠ P94), H147 (≠ T95), G149 (= G97), G150 (= G98), N151 (≠ V99), A153 (= A101), T154 (≠ A102), A156 (≠ V104), G157 (≠ S105), G158 (= G106), E207 (≠ H155), G208 (= G156), I212 (≠ V160), I213 (≠ L161)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 40, 338, 382, 423, 424, 460

P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 36% coverage: 37:166/366 of query aligns to 116:238/496 of P39976

query
sites
P39976

L

L

S

S

V

L

A

R

G

N

L

M

N

N

G

K

V

V

T

R

L

D

Y

F

E

D

P

P

G

V

A

S

L

G

T

T

L

F

V

K

V

C

Q

D

A

A

G

G

T

V

S

V

V

M

E

R

E

D

V

A

Q

H

A

Q

L

F

L

L

A

H

G

D

E

H

N

D

Q

H

R

I

L

F

A

-

F

-

E

-

P

P

M

L

D

D

H

-

R

-

G

-

L

-

L

L

G

P

T

S

K

R

G

N

T

N

P

C

T

Q

I

V

G

G

V

V

F

V

A

S

A

T

N

N

V

A

S

G

G

G

P

L

R

N

R

F

I

L

Q

R

C

Y

G

G

A

S

A

L

R

H

D

G

F

N

L

V

L

L

G

G

V

L

R

E

F

V

V

V

D

L

G

P

R

N

G

G

D

E

V

I

L

I

S

S

N

N

G

I

G

N

R

A

V

L

M

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

V

K

K

Q

L

L

M

F

A

I

G

G

S

A

H

E

G

G

T

T

L

I

G

G

V

V

L

V

S

T

E

G

V

V

S

S

L

I

Sites not aligning to the query:

17 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

4bc7B Mammalian alkyldihydroxyacetonephosphate synthase: arg419his mutant (see paper)
25% identity, 43% coverage: 36:192/366 of query aligns to 163:311/543 of 4bc7B

query
sites
4bc7B

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P
|
P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K

L

G

E

T

F

P
x
S

T
|
T

I

V

G
|
G

V
x
W

F

I

A
x
S

A
x
T

N

R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

binding flavin-adenine dinucleotide: P208 (= P81), D209 (≠ G89), S210 (≠ T90), S214 (≠ P94), T215 (= T95), G217 (= G97), G218 (= G98), W219 (≠ V99), S221 (≠ A101), T222 (≠ A102), A224 (≠ V104), S225 (= S105), E274 (≠ H155), G275 (= G156), G278 (= G159), V279 (= V160), I280 (≠ L161)

Sites not aligning to the query:

binding 1-dodecanol: 400, 410, 411, 412, 463, 467
binding flavin-adenine dinucleotide: 16, 140, 141, 142, 143, 144, 145, 146, 147, 150, 151, 501, 502, 539

P97275 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Cavia porcellus (Guinea pig) (see 4 papers)
25% identity, 43% coverage: 36:192/366 of query aligns to 257:405/658 of P97275

query
sites
P97275

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F
x
H

E

E

P

P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K
x
L

G
x
E

T
x
F

P
x
S

T
|
T

I

V

G

G

V

W

F

I

A

S

A
x
T

N
x
R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S
|
S

H
x
E

G
|
G

T
|
T

L
|
L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

H300 (≠ F79) mutation to A: Loss of activity.
303:309 (vs. 89:95, 14% identical) binding
T309 (= T95) mutation to I: Impaired FAD binding and protein stability. Loss of activity.
TRAS 316:319 (≠ ANVS 102:105) binding
S367 (= S154) mutation to A: Strongly reduced activity.
368:374 (vs. 155:161, 71% identical) binding

Sites not aligning to the query:

1:58 modified: transit peptide, Peroxisome
234:240 binding
419 Important for enzyme activity; R→H: Loss of activity.; R→K: Strongly reduced activity.
469 L→P: Impaired FAD binding and protein stability. Loss of activity.
515 binding ; R→L: Impaired FAD binding and protein stability. Loss of activity.
576 C→A: No effect on activity.
578 active site, Proton donor/acceptor; Y→F: Loss of activity.
615 H→A: Loss of activity.
615:617 Important for enzyme activity
616 H→A: Loss of activity.
617 H→A: Loss of activity.
654:658 Important for enzyme activity

5adzC Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
25% identity, 43% coverage: 36:192/366 of query aligns to 177:325/557 of 5adzC

query
sites
5adzC

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P
|
P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K

L

G

E

T

F

P
x
S

T
|
T

I

V

G
|
G

V
x
W

F

I

A
x
S

A
x
T

N

R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

binding flavin-adenine dinucleotide: P222 (= P81), D223 (≠ G89), S224 (≠ T90), S228 (≠ P94), T229 (= T95), G231 (= G97), G232 (= G98), W233 (≠ V99), S235 (≠ A101), T236 (≠ A102), A238 (≠ V104), S239 (= S105), E288 (≠ H155), G289 (= G156), G292 (= G159), V293 (= V160), I294 (≠ L161)
binding (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide): D223 (≠ G89)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 16, 109, 154, 155, 156, 157, 158, 159, 160, 161, 164, 165, 515, 553
binding (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide): 410, 411, 413, 414, 424, 425, 426, 477, 479, 480, 481, 515, 516

5ae2B Ether lipid-generating enzyme agps in complex with inhibitor 1e (see paper)
25% identity, 43% coverage: 36:192/366 of query aligns to 163:311/542 of 5ae2B

query
sites
5ae2B

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P
|
P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K

L

G

E

T

F

P
x
S

T
|
T

I

V

G
|
G

V
x
W

F

I

A
x
S

A
x
T

N

R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

binding flavin-adenine dinucleotide: P208 (= P81), D209 (≠ G89), S210 (≠ T90), S214 (≠ P94), T215 (= T95), G217 (= G97), G218 (= G98), W219 (≠ V99), S221 (≠ A101), T222 (≠ A102), A224 (≠ V104), S225 (= S105), E274 (≠ H155), G275 (= G156), G278 (= G159), V279 (= V160), I280 (≠ L161)
binding 3-(2-fluorophenyl)-2-methyl-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)acrylamide: D209 (≠ G89)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 16, 140, 141, 142, 143, 144, 145, 146, 147, 150, 151, 500, 538
binding 3-(2-fluorophenyl)-2-methyl-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)acrylamide: 395, 396, 399, 409, 410, 411, 462, 464, 465, 466, 500, 501

4bc9B Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl (see paper)
25% identity, 43% coverage: 36:192/366 of query aligns to 163:311/542 of 4bc9B

query
sites
4bc9B

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P
|
P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K

L

G

E

T

F

P
x
S

T
|
T

I

V

G
|
G

V
x
W

F

I

A
x
S

A
x
T

N

R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

binding propanenitrile: D209 (≠ G89)
binding flavin-adenine dinucleotide: P208 (= P81), D209 (≠ G89), S210 (≠ T90), S214 (≠ P94), T215 (= T95), G217 (= G97), G218 (= G98), W219 (≠ V99), S221 (≠ A101), T222 (≠ A102), A224 (≠ V104), S225 (= S105), E274 (≠ H155), G275 (= G156), G278 (= G159), V279 (= V160), I280 (≠ L161)

Sites not aligning to the query:

binding propanenitrile: 462, 500, 501
binding flavin-adenine dinucleotide: 16, 95, 140, 141, 142, 143, 144, 145, 146, 147, 150, 151, 500, 538

5ae1B Ether lipid-generating enzyme agps in complex with inhibitor zinc69435460 (see paper)
25% identity, 43% coverage: 36:192/366 of query aligns to 163:311/539 of 5ae1B

query
sites
5ae1B

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P
|
P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K

L

G

E

T

F

P
x
S

T
|
T

I

V

G
|
G

V
x
W

F

I

A
x
S

A
x
T

N

R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

binding (3-(2-fluorophenyl)-n-(1-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-5-yl)ethyl)butanamide): D209 (≠ G89)
binding flavin-adenine dinucleotide: P208 (= P81), D209 (≠ G89), S210 (≠ T90), S214 (≠ P94), T215 (= T95), G217 (= G97), G218 (= G98), W219 (≠ V99), S221 (≠ A101), T222 (≠ A102), A224 (≠ V104), S225 (= S105), E274 (≠ H155), G275 (= G156), G278 (= G159), V279 (= V160), I280 (≠ L161)

Sites not aligning to the query:

binding (3-(2-fluorophenyl)-n-(1-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-5-yl)ethyl)butanamide): 95, 392, 395, 396, 406, 407, 408, 459, 461, 462, 463, 497, 498
binding flavin-adenine dinucleotide: 16, 95, 140, 141, 142, 143, 144, 145, 146, 147, 150, 151, 497, 535

6gouA Development of alkyl glycerone phosphate synthase inhibitors: complex with inhibitor 2i (see paper)
25% identity, 43% coverage: 36:192/366 of query aligns to 177:325/554 of 6gouA

query
sites
6gouA

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P
|
P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K

L

G

E

T

F

P
x
S

T
|
T

I

V

G
|
G

V
x
W

F

I

A
x
S

A
x
T

N

R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

binding (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide: D223 (≠ G89)
binding flavin-adenine dinucleotide: P222 (= P81), D223 (≠ G89), S224 (≠ T90), S228 (≠ P94), T229 (= T95), G231 (= G97), G232 (= G98), W233 (≠ V99), S235 (≠ A101), T236 (≠ A102), A238 (≠ V104), S239 (= S105), E288 (≠ H155), G289 (= G156), G292 (= G159), V293 (= V160), I294 (≠ L161)

Sites not aligning to the query:

binding (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide: 407, 410, 411, 421, 422, 423, 474, 476, 477, 478, 512, 513
binding flavin-adenine dinucleotide: 16, 109, 154, 155, 156, 157, 158, 159, 160, 161, 164, 165, 512, 550

4bc9A Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl (see paper)
25% identity, 43% coverage: 36:192/366 of query aligns to 168:316/555 of 4bc9A

query
sites
4bc9A

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P
|
P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K

L

G

E

T

F

P
x
S

T
|
T

I

V

G
|
G

V
x
W

F

I

A
x
S

A
x
T

N

R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

binding propanenitrile: D214 (≠ G89)
binding flavin-adenine dinucleotide: P213 (= P81), D214 (≠ G89), S215 (≠ T90), S219 (≠ P94), T220 (= T95), G222 (= G97), G223 (= G98), W224 (≠ V99), S226 (≠ A101), T227 (≠ A102), A229 (≠ V104), S230 (= S105), E279 (≠ H155), G280 (= G156), G283 (= G159), V284 (= V160), I285 (≠ L161)

Sites not aligning to the query:

binding propanenitrile: 475, 513, 514
binding flavin-adenine dinucleotide: 16, 145, 146, 147, 148, 149, 150, 151, 152, 155, 156, 513, 551

5ae3A Ether lipid-generating enzyme agps in complex with antimycin a (see paper)
25% identity, 43% coverage: 36:192/366 of query aligns to 163:311/539 of 5ae3A

query
sites
5ae3A

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P
|
P

M

-

D

-

H

-

R

-

G

-

L

-

G
x
D

T
x
S

K

L

G

E

T

F

P
x
S

T
|
T

I

V

G
|
G

V
x
W

F

I

A
x
S

A
x
T

N

R

V
x
A

S
|
S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

M

R

K

F

V

V

V

D

T

G

P

R

R

G

G

D

-

V

V

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H
x
E

G
|
G

T

T

L

L

G
|
G

V
|
V

L
x
I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

T

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

binding flavin-adenine dinucleotide: P208 (= P81), D209 (≠ G89), S210 (≠ T90), S214 (≠ P94), T215 (= T95), G217 (= G97), G218 (= G98), W219 (≠ V99), S221 (≠ A101), T222 (≠ A102), A224 (≠ V104), S225 (= S105), E274 (≠ H155), G275 (= G156), G278 (= G159), V279 (= V160), I280 (≠ L161)

Sites not aligning to the query:

binding [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 3-methylbutanoate: 45, 48, 49, 53, 325, 327, 331, 334, 349, 386, 387, 389, 393, 396, 400, 407, 408, 443, 447, 461
binding flavin-adenine dinucleotide: 13, 95, 140, 141, 142, 143, 144, 145, 146, 147, 150, 151, 497, 498, 535

O00116 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Aging-associated gene 5 protein; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Homo sapiens (Human) (see 2 papers)
24% identity, 43% coverage: 36:192/366 of query aligns to 257:405/658 of O00116

query
sites
O00116

T

S

L

L

S

D

V

T

A

S

G

Q

L

M

N

N

G

R

V

I

T

L

L

W

Y

V

E

D

P

E

G

N

A

N

L

L

T

T

L

A

V

H

V

V

Q

E

A

A

G

G

T

I

S

T

V

G

E

Q

E

E

V

L

Q

E

A

R

L

Q

L

L

A

K

G

E

E

S

N

G

Q

Y

R

C

L

T

A

G

F

H

E

E

P

P

M

-

D

-

H

-

R

-

G

-

L

-

G

D

T

S

K

L

G

E

T

F

P

S

T

T

I

V

G

G

V

W

F

V

A

S

A

T

N

R

V

A

S

S

G

G

P

M

R

K

I

N

Q

I

C

Y

G

G

A

N

A

I

R

E

D

D

F

L

L

V

G

H

V

I

R

K

F

M

V

V

D

T

G

P

R

R

G

G

D

-

V

I

L

I

S

E

N

K

G

S

G

C

R

Q

V

G

M

P

K

R

N

M

V

S

T

T

G

G

Y

P

D

D

L

I

V

H

K

H

L

F

M

I

A

M

G

G

S

S

H

E

G

G

T

T

L

L

G

G

V

V

L

I

S

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

C

V

S

P

E

E

A

Y

C

Q

A

K

T

Y

V

G

T

S

V

V

H

A

V

F

A

P

D

N

L

F

T

E

S

Q

A

G

V

V

A

A

A

C

M

L

Sites not aligning to the query:

182 R → Q: in RCDP3; severely reduced protein levels
419 Important for enzyme activity; R → H: in RCDP3; loss of enzyme activity; dbSNP:rs121434411
471 E → K: in RCDP3; severely reduced protein levels
568 T → M: in RCDP3; does not affect protein levels; dbSNP:rs387907214

Query Sequence

>GFF2924 FitnessBrowser__Phaeo:GFF2924
MTPQSEAELAQIIVGATAPLAVSGGGTRGLSTGGETLSVAGLNGVTLYEPGALTLVVQAG
TSVEEVQALLAGENQRLAFEPMDHRGLLGTKGTPTIGGVFAANVSGPRRIQCGAARDFLL
GVRFVDGRGDVLSNGGRVMKNVTGYDLVKLMAGSHGTLGVLSEVSLKVLPCSEACATVTV
HVADLTSAVAAMSTALGSPYDVTGAAYDPEAGAVYIRVEGFEASVTYRAEALKMALGKFG
EVSLALGAGDALWEGIRNVAAFHDRPGDVWRISVKPSDAVALAPALEAEGLLFDWGGGLI
WALVPAGRDLRFRLTVPGHATLVRASAQTRAELGQFQPQPGPLAAISGGLRRQFDPRGIL
NPGLMG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory