SitesBLAST
Comparing GFF3080 FitnessBrowser__Marino:GFF3080 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
34% identity, 37% coverage: 51:180/355 of query aligns to 100:227/467 of 7qh2C
- binding flavin-adenine dinucleotide: P137 (≠ F91), G138 (= G92), E139 (≠ A93), A142 (vs. gap), T143 (= T96), G146 (= G99), N147 (≠ T100), S149 (≠ A102), T150 (≠ C103), A152 (≠ L105), G153 (≠ S106), E203 (≠ L156), G204 (= G157), I209 (= I162)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 73, 75, 76, 77, 78, 79, 80, 83, 84, 422, 423
- binding fe (iii) ion: 377, 384, 422
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
35% identity, 33% coverage: 62:178/355 of query aligns to 107:222/465 of 3pm9A
- active site: A149 (≠ L105), L159 (≠ S115)
- binding flavin-adenine dinucleotide: L133 (≠ F91), G134 (= G92), A135 (= A93), C139 (≠ S95), T140 (= T96), G142 (= G98), G143 (= G99), S146 (≠ A102), T147 (≠ C103), A149 (≠ L105), G150 (≠ S106), E200 (≠ L156), G201 (= G157), I205 (≠ V161), I206 (= I162)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 69, 70, 71, 72, 73, 74, 75, 76, 79, 80, 91, 423
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
27% identity, 61% coverage: 1:218/355 of query aligns to 59:269/466 of 6lpxA
- binding flavin-adenine dinucleotide: P75 (≠ D17), Q76 (≠ S18), G77 (= G19), G78 (≠ H20), N79 (≠ K21), T80 (≠ L22), G81 (≠ N23), M82 (≠ I24), G85 (= G27), S86 (≠ G28), L139 (≠ F91), G140 (= G92), A141 (= A93), C145 (vs. gap), G149 (= G99), N150 (≠ T100), A152 (= A102), T153 (≠ C103), G157 (= G107), G207 (= G157), I212 (= I162)
Sites not aligning to the query:
- binding 2-oxoglutaric acid: 333, 337, 348, 379, 381, 388, 423
- binding flavin-adenine dinucleotide: 39, 422, 459
- binding zinc ion: 381, 388, 422
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
27% identity, 61% coverage: 1:218/355 of query aligns to 59:269/466 of 6lpuA
- binding flavin-adenine dinucleotide: P75 (≠ D17), G77 (= G19), G78 (≠ H20), N79 (≠ K21), T80 (≠ L22), G81 (≠ N23), G85 (= G27), S86 (≠ G28), L139 (≠ F91), G140 (= G92), A141 (= A93), C145 (vs. gap), H146 (vs. gap), G148 (= G98), G149 (= G99), N150 (≠ T100), A152 (= A102), T153 (≠ C103), A155 (≠ L105), E206 (≠ L156), G207 (= G157), I211 (≠ V161), I212 (= I162)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 39, 422, 459
- binding (2s)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 423
- binding zinc ion: 381, 388, 422
6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal) (see paper)
27% identity, 61% coverage: 1:218/355 of query aligns to 59:269/466 of 6lpqA
- binding flavin-adenine dinucleotide: P75 (≠ D17), G77 (= G19), G78 (≠ H20), N79 (≠ K21), T80 (≠ L22), G81 (≠ N23), G85 (= G27), S86 (≠ G28), L139 (≠ F91), G140 (= G92), A141 (= A93), C145 (vs. gap), H146 (vs. gap), G149 (= G99), N150 (≠ T100), A152 (= A102), T153 (≠ C103), A155 (≠ L105), G157 (= G107), E206 (≠ L156), G207 (= G157), I211 (≠ V161), I212 (= I162)
- binding d-malate: M82 (≠ I24)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 39, 422, 459
- binding d-malate: 333, 337, 348, 379, 381, 388, 422, 423
- binding zinc ion: 381, 388, 422
6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg) (see paper)
27% identity, 61% coverage: 1:218/355 of query aligns to 59:269/466 of 6lppA
- binding flavin-adenine dinucleotide: P75 (≠ D17), G77 (= G19), G78 (≠ H20), N79 (≠ K21), T80 (≠ L22), G81 (≠ N23), M82 (≠ I24), G85 (= G27), S86 (≠ G28), L139 (≠ F91), G140 (= G92), A141 (= A93), C145 (vs. gap), G149 (= G99), N150 (≠ T100), A152 (= A102), T153 (≠ C103), A155 (≠ L105), G157 (= G107), G207 (= G157), I212 (= I162)
Sites not aligning to the query:
- binding (2R)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 390, 423
- binding flavin-adenine dinucleotide: 39, 422, 423
- binding zinc ion: 381, 388, 422
Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
27% identity, 61% coverage: 1:218/355 of query aligns to 112:322/521 of Q8N465
- N127 (≠ R16) to K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
- G131 (≠ H20) to V: in D2HGA1; uncertain significance; complete loss of catalytic activity
- I147 (≠ T43) to S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
- M153 (≠ H49) to T: in D2HGA1; uncertain significance; significant loss of catalytic activity; to V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
- C172 (≠ T68) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
- P189 (= P88) to L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
- A205 (= A102) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
- A231 (≠ G128) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
- G233 (= G130) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734
Sites not aligning to the query:
- 15 R → G: in dbSNP:rs4675887
- 109 S → W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
- 169:521 natural variant: Missing (in D2HGA1; uncertain significance)
- 375 D → Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
- 386 binding ; binding ; binding ; R→A: Loss of catalytic activity.
- 390 binding ; binding ; T→A: Significantly reduced catalytic activity.
- 399 V → M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
- 400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
- 401 binding ; binding ; K→A: Loss of catalytic activity.
- 419 R → H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
- 426 A → T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
- 434 binding ; H→A: Loss of catalytic activity.
- 436 G → V: slight reduction in catalytic activity
- 439 N → D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
- 441 binding ; H→A: Loss of catalytic activity.
- 443 binding ; N→A: Significantly reduced catalytic activity.
- 444 V → A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
- 446 A → V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
- 475 binding ; E→A: Loss of catalytic activity.
- 476 binding ; binding ; binding ; H→A: Loss of catalytic activity.
- 477 G → R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640
6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
27% identity, 61% coverage: 1:218/355 of query aligns to 60:270/467 of 6lpnB
- binding flavin-adenine dinucleotide: P76 (≠ D17), G78 (= G19), G79 (≠ H20), N80 (≠ K21), T81 (≠ L22), G82 (≠ N23), M83 (≠ I24), G86 (= G27), S87 (≠ G28), L140 (≠ F91), A142 (= A93), C146 (vs. gap), H147 (vs. gap), G150 (= G99), N151 (≠ T100), A153 (= A102), T154 (≠ C103), G208 (= G157), I212 (≠ V161), I213 (= I162)
Sites not aligning to the query:
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
32% identity, 32% coverage: 61:172/355 of query aligns to 105:214/459 of P9WIT1
Sites not aligning to the query:
- 354 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
O00116 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Aging-associated gene 5 protein; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Homo sapiens (Human) (see 2 papers)
30% identity, 42% coverage: 25:173/355 of query aligns to 235:385/658 of O00116
Sites not aligning to the query:
- 182 R → Q: in RCDP3; severely reduced protein levels
- 419 Important for enzyme activity; R → H: in RCDP3; loss of enzyme activity; dbSNP:rs121434411
- 471 E → K: in RCDP3; severely reduced protein levels
- 568 T → M: in RCDP3; does not affect protein levels; dbSNP:rs387907214
5ae3A Ether lipid-generating enzyme agps in complex with antimycin a (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 141:291/539 of 5ae3A
- binding flavin-adenine dinucleotide: I141 (≠ V25), G142 (= G26), G143 (= G27), G144 (= G28), T145 (= T29), S146 (≠ K30), V147 (≠ A31), L151 (≠ R35), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (= S95), T215 (= T96), G218 (= G99), W219 (≠ T100), S221 (≠ A102), T222 (≠ C103), A224 (≠ L105), S225 (= S106), E274 (≠ L156), V279 (= V161), I280 (= I162)
Sites not aligning to the query:
- binding [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 3-methylbutanoate: 45, 49, 53, 325, 327, 331, 334, 349, 386, 393, 396, 400, 447, 461
- binding flavin-adenine dinucleotide: 140, 497
5adzC Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 155:305/557 of 5adzC
- binding flavin-adenine dinucleotide: I155 (≠ V25), G156 (= G26), G157 (= G27), G158 (= G28), T159 (= T29), S160 (≠ K30), P222 (= P88), D223 (≠ P89), S224 (≠ H90), S228 (= S95), T229 (= T96), G232 (= G99), W233 (≠ T100), S235 (≠ A102), T236 (≠ C103), A238 (≠ L105), S239 (= S106), E288 (≠ L156), G289 (= G157), I294 (= I162)
- binding (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide): D223 (≠ P89)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 16, 154, 515
- binding (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide): 410, 414, 424, 425, 426, 477, 515, 516
4bc9A Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 146:296/555 of 4bc9A
- binding propanenitrile: D214 (≠ P89)
- binding flavin-adenine dinucleotide: I146 (≠ V25), G147 (= G26), G148 (= G27), G149 (= G28), T150 (= T29), S151 (≠ K30), V152 (≠ A31), G155 (= G34), L156 (≠ R35), P213 (= P88), D214 (≠ P89), S215 (≠ H90), S219 (= S95), T220 (= T96), G223 (= G99), W224 (≠ T100), S226 (≠ A102), T227 (≠ C103), A229 (≠ L105), S230 (= S106), E279 (≠ L156), V284 (= V161), I285 (= I162)
Sites not aligning to the query:
6gouA Development of alkyl glycerone phosphate synthase inhibitors: complex with inhibitor 2i (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 155:305/554 of 6gouA
- binding (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide: D223 (≠ P89)
- binding flavin-adenine dinucleotide: I155 (≠ V25), G156 (= G26), G157 (= G27), G158 (= G28), T159 (= T29), S160 (≠ K30), V161 (≠ A31), G164 (= G34), P222 (= P88), D223 (≠ P89), S224 (≠ H90), S228 (= S95), T229 (= T96), G232 (= G99), W233 (≠ T100), S235 (≠ A102), T236 (≠ C103), A238 (≠ L105), S239 (= S106), E288 (≠ L156), V293 (= V161), I294 (= I162)
Sites not aligning to the query:
- binding (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide: 411, 421, 422, 423, 474, 476, 478
- binding flavin-adenine dinucleotide: 16, 154, 512
5ae1A Ether lipid-generating enzyme agps in complex with inhibitor zinc69435460 (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 140:290/560 of 5ae1A
- binding flavin-adenine dinucleotide: I140 (≠ V25), G141 (= G26), G142 (= G27), G143 (= G28), T144 (= T29), S145 (≠ K30), V146 (≠ A31), G149 (= G34), L150 (≠ R35), P207 (= P88), D208 (≠ P89), S209 (≠ H90), S213 (= S95), T214 (= T96), G216 (= G98), G217 (= G99), W218 (≠ T100), S220 (≠ A102), T221 (≠ C103), A223 (≠ L105), S224 (= S106), E273 (≠ L156), G274 (= G157), V278 (= V161), I279 (= I162)
Sites not aligning to the query:
5ae1B Ether lipid-generating enzyme agps in complex with inhibitor zinc69435460 (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 141:291/539 of 5ae1B
- binding flavin-adenine dinucleotide: I141 (≠ V25), G142 (= G26), G143 (= G27), G144 (= G28), T145 (= T29), S146 (≠ K30), G150 (= G34), L151 (≠ R35), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (= S95), T215 (= T96), G218 (= G99), W219 (≠ T100), S221 (≠ A102), T222 (≠ C103), A224 (≠ L105), S225 (= S106), E274 (≠ L156), V279 (= V161), I280 (= I162)
Sites not aligning to the query:
- binding (3-(2-fluorophenyl)-n-(1-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-5-yl)ethyl)butanamide): 392, 396, 406, 407, 408, 459, 497
- binding flavin-adenine dinucleotide: 16, 140, 497, 535
P97275 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Cavia porcellus (Guinea pig) (see 4 papers)
29% identity, 42% coverage: 25:173/355 of query aligns to 235:385/658 of P97275
- H300 (≠ F86) mutation to A: Loss of activity.
- 303:309 (vs. 89:96, 25% identical) binding
- T309 (= T96) mutation to I: Impaired FAD binding and protein stability. Loss of activity.
- TRAS 316:319 (≠ CNLS 103:106) binding
- S367 (≠ A155) mutation to A: Strongly reduced activity.
- 368:374 (vs. 156:162, 86% identical) binding
Sites not aligning to the query:
- 1:58 modified: transit peptide, Peroxisome
- 234:240 binding
- 419 Important for enzyme activity; R→H: Loss of activity.; R→K: Strongly reduced activity.
- 469 L→P: Impaired FAD binding and protein stability. Loss of activity.
- 515 binding ; R→L: Impaired FAD binding and protein stability. Loss of activity.
- 576 C→A: No effect on activity.
- 578 active site, Proton donor/acceptor; Y→F: Loss of activity.
- 615 H→A: Loss of activity.
- 615:617 Important for enzyme activity
- 616 H→A: Loss of activity.
- 617 H→A: Loss of activity.
- 654:658 Important for enzyme activity
4bc9B Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 141:291/542 of 4bc9B
- binding propanenitrile: D209 (≠ P89)
- binding flavin-adenine dinucleotide: G142 (= G26), G143 (= G27), G144 (= G28), T145 (= T29), S146 (≠ K30), V147 (≠ A31), G150 (= G34), L151 (≠ R35), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (= S95), T215 (= T96), G218 (= G99), W219 (≠ T100), S221 (≠ A102), T222 (≠ C103), A224 (≠ L105), S225 (= S106), E274 (≠ L156), G275 (= G157), I280 (= I162)
Sites not aligning to the query:
4bc7B Mammalian alkyldihydroxyacetonephosphate synthase: arg419his mutant (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 141:291/543 of 4bc7B
- binding flavin-adenine dinucleotide: G142 (= G26), G143 (= G27), G144 (= G28), T145 (= T29), S146 (≠ K30), V147 (≠ A31), G150 (= G34), L151 (≠ R35), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (= S95), T215 (= T96), G218 (= G99), S221 (≠ A102), T222 (≠ C103), A224 (≠ L105), S225 (= S106), E274 (≠ L156), G275 (= G157), I280 (= I162)
Sites not aligning to the query:
5ae2A Ether lipid-generating enzyme agps in complex with inhibitor 1e (see paper)
29% identity, 42% coverage: 25:173/355 of query aligns to 146:296/561 of 5ae2A
- binding flavin-adenine dinucleotide: I146 (≠ V25), G147 (= G26), G148 (= G27), G149 (= G28), T150 (= T29), S151 (≠ K30), G155 (= G34), L156 (≠ R35), P213 (= P88), D214 (≠ P89), S215 (≠ H90), S219 (= S95), T220 (= T96), G223 (= G99), W224 (≠ T100), S226 (≠ A102), T227 (≠ C103), A229 (≠ L105), S230 (= S106), E279 (≠ L156), V284 (= V161), I285 (= I162)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 16, 145, 519
- binding 3-(2-fluorophenyl)-2-methyl-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)acrylamide: 415, 418, 428, 429, 430, 481, 483, 519
Query Sequence
>GFF3080 FitnessBrowser__Marino:GFF3080
MADISQQLKEQVLQARDSGHKLNIVGGGTKAFMGREADTDAGTLNVGEHTGIVDYHPVEL
VLTVRAGTPLSEIEATLAEEGQCLHFEPPHFGAASTIGGTLACNLSGPGRPWAGSVRDQV
LGIRLLNGKGEHLRFGGQVMKNVAGYDVSRLQAGALGTLGVITEISMKVMPKPAASLTLV
QEMGMDEVVHYMNSRAAEPKPITAACWVDGKVYLRLAGAKSGVEATAEKWSGEVMEEGDH
FWRQVQDMHHEFFAGNDVPLWRFSVGSTAATPKLEGNWFIDWAGSQRWFRGAGELKDLEP
AARAAGGQVSLFRGGDRTGEVMHHQPEALKGIQRRIKNAFDPDNIFNPGRLYSWL
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory