SitesBLAST
Comparing GFF3081 FitnessBrowser__Marino:GFF3081 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
29% identity, 93% coverage: 6:461/490 of query aligns to 5:462/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ A75), G75 (= G77), S76 (≠ A78), G77 (= G79), T78 (= T80), G79 (= G81), L80 (= L82), A83 (≠ G85), C84 (≠ A86), P137 (= P139), G138 (≠ S140), E139 (≠ S141), A142 (= A144), T143 (= T146), G146 (= G149), N147 (= N150), S149 (≠ A152), T150 (≠ E153), A152 (≠ S155), G153 (= G156), E203 (= E205), G204 (= G206), I209 (≠ V211), E422 (= E421), H423 (= H422)
- binding fe (iii) ion: H377 (= H377), H384 (= H384), E422 (= E421)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
31% identity, 92% coverage: 10:460/490 of query aligns to 2:453/459 of P9WIT1
- K354 (≠ Y356) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
27% identity, 92% coverage: 11:461/490 of query aligns to 4:454/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ G39), P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), W323 (≠ F332), E414 (= E421), H415 (= H422), N451 (= N458)
- binding manganese (ii) ion: H370 (= H377), H377 (= H384), E414 (= E421)
- binding pyruvic acid: R319 (= R328), H370 (= H377), H377 (= H384), H415 (= H422)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
27% identity, 92% coverage: 11:461/490 of query aligns to 4:453/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R328), W322 (≠ F332), H369 (= H377), H376 (= H384), H414 (= H422)
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), W322 (≠ F332), E413 (= E421), N450 (= N458)
- binding manganese (ii) ion: H369 (= H377), H376 (= H384), E413 (= E421)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
27% identity, 92% coverage: 11:461/490 of query aligns to 4:452/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ L82), R317 (= R328), W321 (≠ F332), H368 (= H377), H375 (= H384), H413 (= H422)
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), W321 (≠ F332), Y322 (≠ P333), E412 (= E421), H413 (= H422), N449 (= N458)
- binding manganese (ii) ion: H368 (= H377), H375 (= H384), E412 (= E421)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:453/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R328), H369 (= H377), H376 (= H384), H414 (= H422)
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), W322 (≠ F332), E413 (= E421), H414 (= H422), N450 (= N458)
- binding manganese (ii) ion: H369 (= H377), H376 (= H384), E413 (= E421)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
27% identity, 92% coverage: 11:461/490 of query aligns to 4:453/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), H369 (= H377), E413 (= E421), N450 (= N458)
- binding deaminohydroxyvaline: R319 (= R328), H414 (= H422)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:453/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), W322 (≠ F332), E413 (= E421), H414 (= H422), N450 (= N458)
- binding lactic acid: R318 (= R328), H369 (= H377), H376 (= H384), H414 (= H422)
- binding manganese (ii) ion: H369 (= H377), H376 (= H384), E413 (= E421)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:454/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), Y324 (≠ P333), H370 (= H377), E414 (= E421), N451 (= N458)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R328), W323 (≠ F332), H415 (= H422)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:454/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R328), W323 (≠ F332), H370 (= H377), H415 (= H422)
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), H370 (= H377), E414 (= E421), N451 (= N458)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:454/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R328), W323 (≠ F332), H415 (= H422)
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), Y324 (≠ P333), H370 (= H377), E414 (= E421), N451 (= N458)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:454/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), H370 (= H377), E414 (= E421), N451 (= N458)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R328), W323 (≠ F332), H415 (= H422)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:454/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), H370 (= H377), E414 (= E421), N451 (= N458)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R328), H415 (= H422)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:454/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), Y324 (≠ P333), H370 (= H377), E414 (= E421), N451 (= N458)
- binding (2R)-2-oxidanyloctanoic acid: V75 (≠ L82), R319 (= R328), W323 (≠ F332), H415 (= H422)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:453/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ G39), P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), W322 (≠ F332), E413 (= E421), H414 (= H422), N450 (= N458)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R328), H369 (= H377), H376 (= H384), H414 (= H422)
- binding manganese (ii) ion: H369 (= H377), H376 (= H384), E413 (= E421)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:452/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R328), W322 (≠ F332), H369 (= H377), H376 (= H384), H413 (= H422)
- binding flavin-adenine dinucleotide: E32 (≠ G39), P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), W322 (≠ F332), E412 (= E421), H413 (= H422), N449 (= N458)
- binding manganese (ii) ion: H369 (= H377), H376 (= H384), E412 (= E421)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
26% identity, 92% coverage: 11:461/490 of query aligns to 4:452/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R328), W322 (≠ F332), S336 (≠ C344), H369 (= H377), H376 (= H384), H413 (= H422)
- binding flavin-adenine dinucleotide: P68 (≠ A75), G70 (= G77), T71 (≠ A78), G72 (= G79), T73 (= T80), G74 (= G81), G78 (= G85), V79 (≠ A86), L90 (= L97), P132 (= P139), G133 (≠ S140), A134 (≠ S141), G140 (= G149), M141 (≠ N150), A143 (= A152), T144 (≠ E153), A146 (≠ S155), S147 (≠ G156), E200 (= E205), G201 (= G206), I206 (≠ V211), E412 (= E421), N449 (= N458)
- binding manganese (ii) ion: H369 (= H377), H376 (= H384), E412 (= E421)
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
29% identity, 92% coverage: 11:463/490 of query aligns to 5:465/465 of 3pm9A
- active site: A149 (≠ S155), L159 (= L165)
- binding flavin-adenine dinucleotide: P69 (≠ A75), Q70 (≠ R76), G71 (= G77), G72 (≠ A78), N73 (≠ G79), T74 (= T80), G75 (= G81), L76 (= L82), G79 (= G85), Q80 (≠ A86), L91 (= L97), L133 (≠ P139), G134 (≠ S140), A135 (≠ S141), C139 (= C145), T140 (= T146), G142 (= G148), G143 (= G149), S146 (≠ A152), T147 (≠ E153), A149 (≠ S155), G150 (= G156), E200 (= E205), G201 (= G206), I205 (≠ V210), I206 (≠ V211), E423 (= E421)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
28% identity, 94% coverage: 7:465/490 of query aligns to 9:466/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R328), T337 (≠ F332), K348 (≠ C344), Y379 (≠ V375), H381 (= H377), H388 (= H384), H423 (= H422)
- binding flavin-adenine dinucleotide: W39 (≠ G39), P75 (≠ A75), Q76 (≠ R76), G77 (= G77), G78 (≠ A78), N79 (≠ G79), T80 (= T80), G81 (= G81), M82 (≠ L82), G85 (= G85), S86 (≠ A86), L139 (≠ P139), G140 (≠ S140), A141 (≠ S141), C145 (= C145), G149 (= G149), N150 (= N150), A152 (= A152), T153 (≠ E153), G157 (= G157), G207 (= G206), I212 (≠ V211), E422 (= E421), N459 (= N458)
- binding zinc ion: H381 (= H377), H388 (= H384), E422 (= E421)
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
28% identity, 94% coverage: 7:465/490 of query aligns to 9:466/466 of 6lpuA
- binding flavin-adenine dinucleotide: W39 (≠ G39), P75 (≠ A75), G77 (= G77), G78 (≠ A78), N79 (≠ G79), T80 (= T80), G81 (= G81), G85 (= G85), S86 (≠ A86), L139 (≠ P139), G140 (≠ S140), A141 (≠ S141), C145 (= C145), H146 (≠ T146), G148 (= G148), G149 (= G149), N150 (= N150), A152 (= A152), T153 (≠ E153), A155 (≠ S155), E206 (= E205), G207 (= G206), I211 (≠ V210), I212 (≠ V211), E422 (= E421), N459 (= N458)
- binding (2s)-2-hydroxypentanedioic acid: R333 (= R328), T337 (≠ F332), K348 (≠ C344), Y379 (≠ V375), H381 (= H377), H388 (= H384), H423 (= H422)
- binding zinc ion: H381 (= H377), H388 (= H384), E422 (= E421)
Query Sequence
>GFF3081 FitnessBrowser__Marino:GFF3081
MTTKPKVSKAELAEQFRAFIDPDYVITDDETMKPYECDGMSMYCEMPLLVVLPETVEQVQ
RVMRICNENAVPVVARGAGTGLSAGAMPNKEGVVLSLAKFNRIVEIDPLARTARLQPGVR
NLAISEEAAQYGLYYGPDPSSQIACTIGGNVAENSGGVHCLKYGLTVHNILSVEMVTAEG
DVVTVGSDGLDGCGMDLLALMTGSEGLLGVVTEVKVKLLPKPEVAQVVMAGFDDVQKGGD
AVGGIISHGIIPGGLEMMDGHAIIAADDFAQAGYPRDAKALLLCEVDGTEEEVHEHIAQA
EEVFRKLGATSVRTSQSEEERALLWKGRKSAFPAVGRISPDYYCMDGTIPRREIAYVLTE
MEKMSEEFGLRVANVFHAGDGNLHPLILFDANVPGEFERTEAFGSRILEMCVEVGGCITG
EHGVGVEKIRQMAVQFNDEELQQFHDVKAAFDPAGILNPGKGVPALRFCQEYRSLEHKQH
THEHTEAAHG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory