SitesBLAST
Comparing GFF3096 HP15_3039 N-succinylglutamate 5-semialdehyde dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5u0mA Fatty aldehyde dehydrogenase from marinobacter aquaeolei vt8 and cofactor complex (see paper)
86% identity, 99% coverage: 3:490/491 of query aligns to 1:488/488 of 5u0mA
- active site: N148 (= N150), K171 (= K173), E246 (= E248), C280 (= C282), E377 (= E379), P455 (= P457)
- binding nicotinamide-adenine-dinucleotide: F144 (= F146), Y147 (= Y149), N148 (= N150), K171 (= K173), S173 (= S175), E174 (= E176), G207 (= G209), T222 (= T224), G223 (= G225), S224 (= S226), V227 (= V229), E246 (= E248), M247 (= M249), G248 (= G250), C280 (= C282), E377 (= E379), F379 (= F381)
5u0lA X-ray crystal structure of fatty aldehyde dehydrogenase enzymes from marinobacter aquaeolei vt8 complexed with a substrate (see paper)
86% identity, 99% coverage: 3:490/491 of query aligns to 1:488/488 of 5u0lA
- active site: N148 (= N150), K171 (= K173), E246 (= E248), C280 (= C282), E377 (= E379), P455 (= P457)
- binding decanal: K107 (= K109), H152 (= H154), L153 (= L155), G156 (= G158), H157 (= H159), S456 (= S458), A457 (= A459)
3ju8A Crystal structure of succinylglutamic semialdehyde dehydrogenase from pseudomonas aeruginosa.
61% identity, 98% coverage: 9:488/491 of query aligns to 6:486/486 of 3ju8A
- active site: N147 (= N150), K170 (= K173), E245 (= E248), C279 (= C282), E377 (= E379), P455 (= P457)
- binding nicotinamide-adenine-dinucleotide: G144 (= G147), Y146 (= Y149), N147 (= N150), L152 (= L155), K170 (= K173), S172 (= S175), F220 (= F223), T221 (= T224), G222 (= G225), S223 (= S226), T226 (≠ V229), E245 (= E248), M246 (= M249), G247 (= G250), C279 (= C282), E377 (= E379), F379 (= F381), F444 (= F446)
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
35% identity, 93% coverage: 7:465/491 of query aligns to 11:471/481 of 3jz4A
- active site: N156 (= N150), K179 (= K173), E254 (= E248), C288 (= C282), E385 (= E379), E462 (≠ P457)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (= P148), W155 (≠ Y149), K179 (= K173), A181 (≠ S175), S182 (≠ E176), A212 (= A205), G216 (= G209), G232 (= G225), S233 (= S226), I236 (≠ V229), C288 (= C282), K338 (= K334), E385 (= E379), F387 (= F381)
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
35% identity, 93% coverage: 7:465/491 of query aligns to 12:472/482 of P25526
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
35% identity, 93% coverage: 7:464/491 of query aligns to 12:476/494 of 4pz2B
- active site: N159 (= N150), K182 (= K173), E258 (= E248), C292 (= C282), E392 (= E379), D469 (≠ P457)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ F146), I156 (≠ G147), P157 (= P148), W158 (≠ Y149), N159 (= N150), M164 (≠ L155), K182 (= K173), A184 (≠ S175), E185 (= E176), G215 (≠ S206), G219 (= G209), F233 (= F223), T234 (= T224), G235 (= G225), S236 (= S226), V239 (= V229), E258 (= E248), L259 (≠ M249), C292 (= C282), E392 (= E379), F394 (= F381)
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
32% identity, 93% coverage: 7:464/491 of query aligns to 21:483/501 of Q56YU0
- G152 (= G130) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A396) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
33% identity, 92% coverage: 7:456/491 of query aligns to 13:467/492 of 6b5hA
- active site: N161 (= N150), E260 (= E248), C294 (= C282)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (≠ E102), G116 (≠ M106), F162 (= F151), W169 (≠ G158), Q284 (= Q272), F288 (≠ L276), T295 (= T283), N449 (≠ T438), L451 (≠ A440), N452 (≠ S441), F457 (= F446)
- binding nicotinamide-adenine-dinucleotide: I157 (≠ F146), I158 (≠ G147), W160 (≠ Y149), N161 (= N150), K184 (= K173), G217 (≠ S206), G221 (= G209), F235 (= F223), T236 (= T224), G237 (= G225), S238 (= S226), V241 (= V229), E260 (= E248), L261 (≠ M249), C294 (= C282), F393 (= F381)
Sites not aligning to the query:
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118) (see paper)
33% identity, 92% coverage: 7:456/491 of query aligns to 13:467/492 of 6b5gA
- active site: N161 (= N150), E260 (= E248), C294 (= C282)
- binding (3-ethoxythiophen-2-yl){4-[4-nitro-3-(pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone: F162 (= F151), L165 (≠ H154), W169 (≠ G158), F288 (≠ L276), C293 (≠ R281), C294 (= C282), T295 (= T283), N449 (≠ T438), L451 (≠ A440)
- binding nicotinamide-adenine-dinucleotide: I157 (≠ F146), I158 (≠ G147), P159 (= P148), W160 (≠ Y149), N161 (= N150), M166 (≠ L155), K184 (= K173), E187 (= E176), G217 (≠ S206), G221 (= G209), F235 (= F223), T236 (= T224), G237 (= G225), S238 (= S226), V241 (= V229), E260 (= E248), L261 (≠ M249), C294 (= C282), E391 (= E379), F393 (= F381)
Sites not aligning to the query:
6aljA Aldh1a2 liganded with NAD and compound win18,446 (see paper)
33% identity, 92% coverage: 7:456/491 of query aligns to 13:467/492 of 6aljA
- active site: N161 (= N150), E260 (= E248), C294 (= C282)
- binding N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide): G116 (≠ M106), F162 (= F151), L165 (≠ H154), M166 (≠ L155), W169 (≠ G158), E260 (= E248), C293 (≠ R281), C294 (= C282), L451 (≠ A440), N452 (≠ S441), A453 (≠ S442)
- binding nicotinamide-adenine-dinucleotide: I157 (≠ F146), I158 (≠ G147), P159 (= P148), W160 (≠ Y149), N161 (= N150), K184 (= K173), E187 (= E176), G217 (≠ S206), G221 (= G209), F235 (= F223), G237 (= G225), S238 (= S226), V241 (= V229), Q341 (≠ A331), K344 (= K334), E391 (= E379), F393 (= F381)
Sites not aligning to the query:
O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 6 papers)
33% identity, 92% coverage: 7:456/491 of query aligns to 39:493/518 of O94788
- E50 (≠ H18) to G: in dbSNP:rs34266719
- A110 (≠ G74) to V: in dbSNP:rs35365164
- Q182 (≠ V145) to K: in DIH4; decreased retinoic acid biosynthetic process
- IPW 184:186 (≠ GPY 147:149) binding
- KPAE 210:213 (≠ KPSE 173:176) binding
- STE 264:266 (≠ SST 226:228) binding
- C320 (= C282) active site, Nucleophile
- R347 (≠ I310) to H: in DIH4; decreased expression; dbSNP:rs141245344
- V348 (≠ K311) to I: in dbSNP:rs4646626
- KQYNK 366:370 (≠ EAAEK 330:334) binding
- A383 (≠ G347) to T: in DIH4; uncertain significance; dbSNP:rs749124508
- E417 (= E379) binding
- E436 (≠ A398) to K: in dbSNP:rs34744827
- S461 (≠ V423) to Y: in DIH4; decreased retinoic acid biosynthetic process
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
34% identity, 94% coverage: 4:466/491 of query aligns to 2:470/489 of 4o6rA
- active site: N150 (= N150), K173 (= K173), E248 (= E248), C282 (= C282), E383 (= E379), E460 (≠ P457)
- binding adenosine monophosphate: I146 (≠ F146), V147 (≠ G147), K173 (= K173), G206 (≠ S206), G210 (= G209), Q211 (≠ K210), F224 (= F223), G226 (= G225), S227 (= S226), T230 (≠ V229), R233 (≠ L232)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
31% identity, 93% coverage: 7:464/491 of query aligns to 18:478/491 of 5gtlA
- active site: N165 (= N150), K188 (= K173), E263 (= E248), C297 (= C282), E394 (= E379), E471 (≠ P457)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ F146), P163 (= P148), K188 (= K173), A190 (≠ S175), E191 (= E176), Q192 (≠ L177), G221 (≠ A205), G225 (= G209), G241 (= G225), S242 (= S226), T245 (≠ V229), L264 (≠ M249), C297 (= C282), E394 (= E379), F396 (= F381)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
31% identity, 93% coverage: 7:464/491 of query aligns to 18:478/491 of 5gtkA
- active site: N165 (= N150), K188 (= K173), E263 (= E248), C297 (= C282), E394 (= E379), E471 (≠ P457)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ F146), I162 (≠ G147), P163 (= P148), W164 (≠ Y149), K188 (= K173), E191 (= E176), G221 (≠ A205), G225 (= G209), A226 (≠ K210), F239 (= F223), G241 (= G225), S242 (= S226), T245 (≠ V229), Y248 (≠ L232), L264 (≠ M249), C297 (= C282), Q344 (≠ A331), R347 (≠ K334), E394 (= E379), F396 (= F381)
7radA Crystal structure analysis of aldh1b1
32% identity, 92% coverage: 7:456/491 of query aligns to 14:468/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ F146), I159 (≠ G147), P160 (= P148), W161 (≠ Y149), N162 (= N150), M167 (≠ L155), K185 (= K173), E188 (= E176), G218 (≠ S206), G222 (= G209), A223 (≠ K210), T237 (= T224), G238 (= G225), S239 (= S226), V242 (= V229), E261 (= E248), L262 (≠ M249), C295 (= C282), E392 (= E379), F394 (= F381)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ E102), E117 (≠ M106), F163 (= F151), E285 (≠ Q272), F289 (≠ L276), N450 (≠ T438), V452 (≠ A440)
7mjdA Crystal structure analysis of aldh1b1
32% identity, 92% coverage: 7:456/491 of query aligns to 14:468/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ F146), I159 (≠ G147), P160 (= P148), W161 (≠ Y149), N162 (= N150), M167 (≠ L155), K185 (= K173), E188 (= E176), G218 (≠ S206), G222 (= G209), F236 (= F223), T237 (= T224), G238 (= G225), S239 (= S226), V242 (= V229), E261 (= E248), L262 (≠ M249), C295 (= C282), E392 (= E379), F394 (= F381)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ M106), E285 (≠ Q272), F289 (≠ L276), N450 (≠ T438), V452 (≠ A440)
7mjcA Crystal structure analysis of aldh1b1
32% identity, 92% coverage: 7:456/491 of query aligns to 14:468/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ F146), I159 (≠ G147), P160 (= P148), W161 (≠ Y149), N162 (= N150), K185 (= K173), E188 (= E176), G218 (≠ S206), G222 (= G209), T237 (= T224), G238 (= G225), S239 (= S226), V242 (= V229), E261 (= E248), L262 (≠ M249), C295 (= C282), E392 (= E379), F394 (= F381)
5izdA Wild-type glyceraldehyde dehydrogenase from thermoplasma acidophilum in complex with NADP
31% identity, 88% coverage: 4:436/491 of query aligns to 1:438/494 of 5izdA
- active site: N149 (= N150), K172 (= K173), E247 (= E248), C281 (= C282), E381 (= E379)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: L145 (≠ F146), T146 (≠ G147), W148 (≠ Y149), K172 (= K173), P173 (= P174), S174 (= S175), S175 (≠ E176), R204 (vs. gap), G205 (≠ A205), G209 (= G209), D210 (≠ K210), G225 (= G225), S226 (= S226), T229 (≠ V229)
Sites not aligning to the query:
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
33% identity, 93% coverage: 9:465/491 of query aligns to 30:494/515 of 2d4eC
- active site: N173 (= N150), K196 (= K173), E271 (= E248), C305 (= C282), E409 (= E379), E486 (≠ P457)
- binding nicotinamide-adenine-dinucleotide: I169 (≠ F146), T170 (≠ G147), P171 (= P148), W172 (≠ Y149), K196 (= K173), A198 (≠ S175), G229 (≠ A205), G233 (= G209), A234 (≠ K210), T248 (= T224), G249 (= G225), E250 (≠ S226), T253 (≠ V229), E271 (= E248), L272 (≠ M249), C305 (= C282), E409 (= E379), F411 (= F381), F475 (= F446)
1t90A Crystal structure of methylmalonate semialdehyde dehydrogenase from bacillus subtilis
32% identity, 90% coverage: 9:452/491 of query aligns to 8:453/484 of 1t90A
- active site: N151 (= N150), K174 (= K173), L248 (≠ E248), C282 (= C282), E380 (= E379)
- binding nicotinamide-adenine-dinucleotide: I147 (≠ F146), A148 (≠ G147), P149 (= P148), F150 (≠ Y149), N151 (= N150), W159 (≠ G158), K174 (= K173), E177 (= E176), R178 (≠ L177), H207 (≠ S206), V225 (≠ T224), G226 (= G225), S227 (= S226), V230 (= V229), L248 (≠ E248), T249 (≠ M249), C282 (= C282), E380 (= E379), F382 (= F381)
Sites not aligning to the query:
Query Sequence
>GFF3096 HP15_3039 N-succinylglutamate 5-semialdehyde dehydrogenase
MAKLTGELFIDGLWLPGHGPVFESVQPVTGETLWDGESANLEDVDAAVREARNAFVKWQR
KSFAERQAVVEAFGELLEAHKEELAHQIGLETGKPLWESRTEVAAMIGKIGISVKAYNDR
TGTSESDVAGGHAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPG
VAELTVKLWGKAGIPDGVINLVQGASATGKSLAGHPLIDGLFFTGSSTVGHLLHKQFGGQ
PEKIVALEMGGNNPLIVQDVADVDGAVHHALQSAFLSAGQRCTCARRLLVPKGKKGDAFI
DRLVEVSARIKVGEFDADPQPFMGSVISSEAAEKLLAAQASLLEKGGKSLLEMKSLKSGT
GLLSPGIVDATGLDVTDEEFFGPLLKVYRYKSFDDALALANDTHYGLSAGILTDDRKLYE
RLVEEVRAGIVNWNRPLTGASSAAPFGGVGASGNHRPSAYYAADYCAWPMASLEAGKSEM
PESLAPGLNFD
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory