SitesBLAST
Comparing GFF3171 FitnessBrowser__Phaeo:GFF3171 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
49% identity, 98% coverage: 11:501/503 of query aligns to 15:514/515 of 2d4eC
- active site: N173 (= N167), K196 (= K190), E271 (= E265), C305 (= C299), E409 (= E396), E486 (≠ D473)
- binding nicotinamide-adenine-dinucleotide: I169 (= I163), T170 (= T164), P171 (= P165), W172 (= W166), K196 (= K190), A198 (= A192), G229 (= G223), G233 (= G227), A234 (≠ K228), T248 (≠ V242), G249 (= G243), E250 (= E244), T253 (= T247), E271 (= E265), L272 (= L266), C305 (= C299), E409 (= E396), F411 (= F398), F475 (= F462)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
42% identity, 90% coverage: 37:488/503 of query aligns to 19:475/489 of 4o6rA
- active site: N150 (= N167), K173 (= K190), E248 (= E265), C282 (= C299), E383 (= E396), E460 (≠ D473)
- binding adenosine monophosphate: I146 (= I163), V147 (≠ T164), K173 (= K190), G206 (= G223), G210 (= G227), Q211 (≠ K228), F224 (= F241), G226 (= G243), S227 (≠ E244), T230 (= T247), R233 (≠ L250)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
39% identity, 95% coverage: 10:488/503 of query aligns to 4:486/491 of 5gtlA
- active site: N165 (= N167), K188 (= K190), E263 (= E265), C297 (= C299), E394 (= E396), E471 (≠ D473)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I163), P163 (= P165), K188 (= K190), A190 (= A192), E191 (= E193), Q192 (≠ A194), G221 (= G223), G225 (= G227), G241 (= G243), S242 (≠ E244), T245 (= T247), L264 (= L266), C297 (= C299), E394 (= E396), F396 (= F398)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
39% identity, 95% coverage: 10:488/503 of query aligns to 4:486/491 of 5gtkA
- active site: N165 (= N167), K188 (= K190), E263 (= E265), C297 (= C299), E394 (= E396), E471 (≠ D473)
- binding nicotinamide-adenine-dinucleotide: I161 (= I163), I162 (≠ T164), P163 (= P165), W164 (= W166), K188 (= K190), E191 (= E193), G221 (= G223), G225 (= G227), A226 (≠ K228), F239 (= F241), G241 (= G243), S242 (≠ E244), T245 (= T247), Y248 (≠ L250), L264 (= L266), C297 (= C299), Q344 (≠ H346), R347 (≠ K349), E394 (= E396), F396 (= F398)
4u3wA X-ray crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase from burkholderia cenocepacia
44% identity, 93% coverage: 23:488/503 of query aligns to 4:480/485 of 4u3wA
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
41% identity, 90% coverage: 36:488/503 of query aligns to 15:479/483 of 4npiA
- active site: N152 (= N167), K175 (= K190), E251 (= E265), C285 (= C299), E387 (= E396), E464 (≠ D473)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R122), L157 (= L172), W160 (= W175), E251 (= E265), C285 (= C299), Y445 (≠ N454), R447 (= R456), F453 (= F462)
- binding nicotinamide-adenine-dinucleotide: I148 (= I163), S149 (≠ T164), P150 (= P165), W151 (= W166), K175 (= K190), E178 (= E193), G208 (= G223), G213 (= G227), E214 (≠ K228), F227 (= F241), G229 (= G243), E230 (= E244), T233 (= T247), G253 (= G267), C285 (= C299), K335 (= K349), E387 (= E396), F389 (= F398)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
41% identity, 90% coverage: 36:488/503 of query aligns to 15:479/483 of 4i2rA
- active site: N152 (= N167), K175 (= K190), E251 (= E265), C285 (= C299), E387 (= E396), E464 (≠ D473)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R122), L157 (= L172), C285 (= C299), Y445 (≠ N454), R447 (= R456), F453 (= F462)
- binding nicotinamide-adenine-dinucleotide: I148 (= I163), S149 (≠ T164), W151 (= W166), N152 (= N167), K175 (= K190), E178 (= E193), G208 (= G223), F227 (= F241), T228 (≠ V242), G229 (= G243), E230 (= E244), T233 (= T247), E251 (= E265), L252 (= L266), G253 (= G267), C285 (= C299), E387 (= E396), F389 (= F398)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
41% identity, 90% coverage: 36:488/503 of query aligns to 15:479/483 of 4i25A
- active site: N152 (= N167), K175 (= K190), E251 (= E265), C285 (= C299), E387 (= E396), E464 (≠ D473)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (= R122), L157 (= L172), C285 (= C299), Y445 (≠ N454), R447 (= R456), F453 (= F462)
- binding nicotinamide-adenine-dinucleotide: I148 (= I163), S149 (≠ T164), P150 (= P165), W151 (= W166), N152 (= N167), K175 (= K190), E178 (= E193), G208 (= G223), G213 (= G227), F227 (= F241), T228 (≠ V242), G229 (= G243), E230 (= E244), T233 (= T247), E251 (= E265), L252 (= L266), C285 (= C299), E387 (= E396), F389 (= F398)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d (see paper)
41% identity, 90% coverage: 36:488/503 of query aligns to 15:479/483 of 5kllA
- active site: D152 (≠ N167), K175 (= K190), E251 (= E265), C285 (= C299), E387 (= E396), E464 (≠ D473)
- binding (3~{E},5~{E})-6-oxidanyl-2-oxidanylidene-hexa-3,5-dienoic acid: R103 (= R122), D152 (≠ N167), L157 (= L172), W160 (= W175), C285 (= C299), Y445 (≠ N454), R447 (= R456), F453 (= F462)
5kj5B Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
41% identity, 90% coverage: 36:488/503 of query aligns to 16:480/484 of 5kj5B
- active site: D153 (≠ N167), K176 (= K190), E252 (= E265), C286 (= C299), E388 (= E396), E465 (≠ D473)
- binding nicotinamide-adenine-dinucleotide: I149 (= I163), S150 (≠ T164), P151 (= P165), W152 (= W166), D153 (≠ N167), L158 (= L172), K176 (= K190), G209 (= G223), K210 (vs. gap), G214 (= G227), F228 (= F241), T229 (≠ V242), G230 (= G243), E231 (= E244), T234 (= T247), E252 (= E265), L253 (= L266), C286 (= C299), E388 (= E396), F390 (= F398), F454 (= F462)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens (see paper)
41% identity, 90% coverage: 36:488/503 of query aligns to 15:479/483 of 4ou2A
- active site: N152 (= N167), K175 (= K190), A251 (≠ E265), C285 (= C299), E387 (= E396), E464 (≠ D473)
- binding (2Z,4E)-2,6-dihydroxyhexa-2,4-dienoic acid: R103 (= R122), L157 (= L172), C285 (= C299), Y445 (≠ N454), R447 (= R456), F453 (= F462)
- binding nicotinamide-adenine-dinucleotide: I148 (= I163), S149 (≠ T164), P150 (= P165), W151 (= W166), N152 (= N167), K175 (= K190), G208 (= G223), G213 (= G227), E214 (≠ K228), F227 (= F241), T228 (≠ V242), G229 (= G243), E230 (= E244), T233 (= T247), A251 (≠ E265), L252 (= L266), G253 (= G267), C285 (= C299), E387 (= E396), F389 (= F398)
4neaA 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
42% identity, 89% coverage: 42:488/503 of query aligns to 38:491/505 of 4neaA
- active site: N166 (= N167), K189 (= K190), E264 (= E265), C298 (= C299), E399 (= E396), E476 (≠ D473)
- binding nicotinamide-adenine-dinucleotide: P164 (= P165), K189 (= K190), E192 (= E193), G222 (= G223), G226 (= G227), G242 (= G243), G243 (≠ E244), T246 (= T247), H249 (≠ L250), I250 (= I251), C298 (= C299), E399 (= E396), F401 (= F398)
P17202 Aminoaldehyde dehydrogenase BADH; 4-trimethylammoniobutyraldehyde dehydrogenase BADH; Aminobutyraldehyde dehydrogenase BADH; Betaine aldehyde dehydrogenase; SoBADH; EC 1.2.1.-; EC 1.2.1.47; EC 1.2.1.19; EC 1.2.1.8 from Spinacia oleracea (Spinach) (see 3 papers)
40% identity, 89% coverage: 41:488/503 of query aligns to 27:482/497 of P17202
- I28 (= I42) binding
- D96 (= D108) binding
- SPW 156:158 (≠ TPW 164:166) binding
- Y160 (≠ T168) mutation to A: Decreases binding affinity for betaine aldehyde; increases binding affinity for 4-(trimethylamino)butanal.
- W167 (= W175) mutation to A: Decreases binding affinity for betaine aldehyde; increases binding affinity for 4-aminobutanal.
- KPSE 182:185 (≠ KPAE 190:193) binding
- L186 (≠ A194) binding
- SSAT 236:239 (≠ ESRT 244:247) binding
- V251 (≠ L259) binding in other chain
- L258 (= L266) binding
- W285 (≠ S293) mutation to A: Decreases binding affinity for betaine aldehyde.
- E390 (= E396) binding
- A441 (≠ M447) mutation to I: Decreases binding affinity for betaine aldehyde; increases binding affinity for 4-aminobutanal.
- C450 (≠ R456) mutation to S: Loss of partial inactivation by betaine aldehyde in the absence of NAD(+).
- W456 (≠ F462) binding ; mutation to A: Decreases binding affinity for betaine aldehyde.
- K460 (= K466) binding
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
39% identity, 88% coverage: 44:488/503 of query aligns to 30:483/487 of Q9H2A2
- R109 (= R122) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N167) mutation to A: Complete loss of activity.
- R451 (= R456) mutation to A: Complete loss of activity.
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
39% identity, 89% coverage: 39:488/503 of query aligns to 23:476/486 of 4pxlA
- active site: N154 (= N167), K177 (= K190), E253 (= E265), C287 (= C299), E384 (= E396), D461 (= D473)
- binding nicotinamide-adenine-dinucleotide: I150 (= I163), V151 (≠ T164), P152 (= P165), W153 (= W166), K177 (= K190), E180 (= E193), G210 (= G223), G214 (= G227), A215 (≠ K228), F228 (= F241), G230 (= G243), S231 (≠ E244), V234 (≠ T247), E253 (= E265), G255 (= G267), C287 (= C299), Q334 (≠ H346), K337 (= K349), E384 (= E396), F386 (= F398)
4v37A Crystal structure of betaine aldehyde dehydrogenase from spinach showing a thiohemiacetal with 3-aminopropionaldehyde
40% identity, 89% coverage: 41:488/503 of query aligns to 25:480/495 of 4v37A
- active site: N157 (= N167), K180 (= K190), E255 (= E265), A289 (≠ C299), E388 (= E396), E465 (≠ D473)
- binding 3-aminopropan-1-ol: C448 (≠ R456), W454 (≠ F462)
- binding nicotinamide-adenine-dinucleotide: I153 (= I163), S154 (≠ T164), P155 (= P165), W156 (= W166), N157 (= N167), M162 (≠ L172), K180 (= K190), S182 (≠ A192), E183 (= E193), G213 (= G223), G217 (= G227), A218 (≠ K228), T232 (≠ V242), G233 (= G243), S234 (≠ E244), T237 (= T247), E255 (= E265), L256 (= L266), A289 (≠ C299), E388 (= E396), F390 (= F398)
7radA Crystal structure analysis of aldh1b1
41% identity, 89% coverage: 39:488/503 of query aligns to 30:484/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I163), I159 (≠ T164), P160 (= P165), W161 (= W166), N162 (= N167), M167 (≠ L172), K185 (= K190), E188 (= E193), G218 (= G223), G222 (= G227), A223 (≠ K228), T237 (≠ V242), G238 (= G243), S239 (≠ E244), V242 (≠ T247), E261 (= E265), L262 (= L266), C295 (= C299), E392 (= E396), F394 (= F398)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (= L121), E117 (= E125), F163 (≠ T168), E285 (≠ F289), F289 (≠ S293), N450 (= N454), V452 (≠ R456)
7mjdA Crystal structure analysis of aldh1b1
41% identity, 89% coverage: 39:488/503 of query aligns to 30:484/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I163), I159 (≠ T164), P160 (= P165), W161 (= W166), N162 (= N167), M167 (≠ L172), K185 (= K190), E188 (= E193), G218 (= G223), G222 (= G227), F236 (= F241), T237 (≠ V242), G238 (= G243), S239 (≠ E244), V242 (≠ T247), E261 (= E265), L262 (= L266), C295 (= C299), E392 (= E396), F394 (= F398)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (= E125), E285 (≠ F289), F289 (≠ S293), N450 (= N454), V452 (≠ R456)
7mjcA Crystal structure analysis of aldh1b1
41% identity, 89% coverage: 39:488/503 of query aligns to 30:484/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I163), I159 (≠ T164), P160 (= P165), W161 (= W166), N162 (= N167), K185 (= K190), E188 (= E193), G218 (= G223), G222 (= G227), T237 (≠ V242), G238 (= G243), S239 (≠ E244), V242 (≠ T247), E261 (= E265), L262 (= L266), C295 (= C299), E392 (= E396), F394 (= F398)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
42% identity, 89% coverage: 39:488/503 of query aligns to 28:484/494 of 4pz2B
- active site: N159 (= N167), K182 (= K190), E258 (= E265), C292 (= C299), E392 (= E396), D469 (= D473)
- binding nicotinamide-adenine-dinucleotide: I155 (= I163), I156 (≠ T164), P157 (= P165), W158 (= W166), N159 (= N167), M164 (≠ L172), K182 (= K190), A184 (= A192), E185 (= E193), G215 (= G223), G219 (= G227), F233 (= F241), T234 (≠ V242), G235 (= G243), S236 (≠ E244), V239 (≠ T247), E258 (= E265), L259 (= L266), C292 (= C299), E392 (= E396), F394 (= F398)
Query Sequence
>GFF3171 FitnessBrowser__Phaeo:GFF3171
MSQLDSNIGKLESYLARFRDTGIRNRIAGADVAGGAGVFQTISPVDKSVICDVAHGTAAD
IDAAAQAARQAFAEWRDLPAVQRKKILIRIAEGIEARAEEIALCECWDTGQAYKFMSKAA
LRGAENFRYFADQVVQARDGQHLQSPTLMNVTTRVPIGPVGVITPWNTPFMLSTWKIAPA
LAAGCTVVHKPAEASPLTARLLVEIAEEAGLPPGVLNTVNGFGDEAGKALCEHPAIRAIA
FVGESRTGSLITKQGADTLKRNHLELGGKNPVIVFEDADLERALDAVIFMIYSINGERCT
SSSRLLIQDSIRDDFEARLIERINNIKVGHPLDPTTEIGPLVSEEHFNKVTSYFDIATKE
GATIAAGGEPVGEEGYFIRPTLFTDARNDMRIAQEEIFGPVLTSIPFTTEAEALALANDT
AYGLTGYLWTNDLTRALRFTDRLEAGMIWVNSENVRHLPTPFGGVKASGIGRDGGDWSFE
FYMEQKHIGFATGSHKITKLGAL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory