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Comparing GFF3202 HP15_3144 NAD-dependent aldehyde dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P37685 Aldehyde dehydrogenase B; Acetaldehyde dehydrogenase; EC 1.2.1.4 from Escherichia coli (strain K12) (see paper)
67% identity, 94% coverage: 32:533/533 of query aligns to 11:512/512 of P37685
- R197 (≠ E218) mutation to E: Less than 10% of wild-type acetaldehyde dehydrogenase activity.
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
42% identity, 90% coverage: 49:528/533 of query aligns to 7:482/489 of 4o6rA
- active site: N150 (= N192), K173 (= K215), E248 (= E289), C282 (= C328), E383 (= E429), E460 (= E506)
- binding adenosine monophosphate: I146 (= I188), V147 (≠ I189), K173 (= K215), G206 (= G247), G210 (= G251), Q211 (= Q252), F224 (= F265), G226 (= G267), S227 (= S268), T230 (≠ V271), R233 (≠ H274)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
43% identity, 89% coverage: 49:521/533 of query aligns to 43:511/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
5l13A Structure of aldh2 in complex with 2p3 (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 5l13A
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F193), M168 (= M197), W171 (= W200), F290 (= F322), C295 (≠ V327), C296 (= C328), C297 (≠ T329), D451 (≠ H487), F453 (≠ Y489)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 4kwgA
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F193), M168 (= M197), C295 (≠ V327), C296 (= C328), C297 (≠ T329), D451 (≠ H487), F453 (≠ Y489)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 4kwfA
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F193), M168 (= M197), W171 (= W200), E262 (= E289), C295 (≠ V327), C296 (= C328), C297 (≠ T329), D451 (≠ H487), F453 (≠ Y489), F459 (= F495)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 3sz9A
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F193), C295 (≠ V327), C296 (= C328), D451 (≠ H487), F453 (≠ Y489), F459 (= F495)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 3injA
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ L147), F164 (= F193), L167 (= L196), F286 (≠ L319), F290 (= F322), D451 (≠ H487), F453 (≠ Y489)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 2vleA
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding daidzin: M118 (≠ L147), F164 (= F193), M168 (= M197), W171 (= W200), F286 (≠ L319), F290 (= F322), C295 (≠ V327), C296 (= C328), D451 (≠ H487), V452 (≠ A488), F453 (≠ Y489)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 1o01B
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding (2e)-but-2-enal: C296 (= C328), C297 (≠ T329), F453 (≠ Y489)
- binding nicotinamide-adenine-dinucleotide: I159 (= I188), I160 (= I189), P161 (= P190), W162 (= W191), K186 (= K215), E189 (= E218), G219 (= G247), G223 (= G251), A224 (≠ Q252), F237 (= F265), G239 (= G267), S240 (= S268), I243 (≠ V271), L263 (= L290), G264 (= G291), C296 (= C328), Q343 (= Q375), E393 (= E429), F395 (= F431)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 1cw3A
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding magnesium ion: V34 (≠ I66), D103 (= D132), Q190 (= Q219)
- binding nicotinamide-adenine-dinucleotide: I159 (= I188), I160 (= I189), P161 (= P190), W162 (= W191), K186 (= K215), G219 (= G247), G223 (= G251), A224 (≠ Q252), F237 (= F265), G239 (= G267), S240 (= S268), I243 (≠ V271), L263 (= L290), G264 (= G291), C296 (= C328), Q343 (= Q375), K346 (= K378), E393 (= E429), F395 (= F431)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
42% identity, 89% coverage: 49:521/533 of query aligns to 16:484/493 of 4fr8A
- active site: N162 (= N192), K185 (= K215), Q261 (≠ E289), C295 (= C328), E392 (= E429), E469 (= E506)
- binding nicotinamide-adenine-dinucleotide: I158 (= I188), I159 (= I189), W161 (= W191), K185 (= K215), G218 (= G247), G222 (= G251), A223 (≠ Q252), F236 (= F265), G238 (= G267), S239 (= S268), I242 (≠ V271), Q342 (= Q375), K345 (= K378), E392 (= E429), F394 (= F431)
- binding propane-1,2,3-triyl trinitrate: F163 (= F193), L166 (= L196), W170 (= W200), F289 (= F322), S294 (≠ V327), C295 (= C328), D450 (≠ H487), F452 (≠ Y489)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
42% identity, 89% coverage: 49:521/533 of query aligns to 19:487/496 of 4fr8C
- active site: N165 (= N192), K188 (= K215), Q264 (≠ E289), C298 (= C328), E395 (= E429), E472 (= E506)
- binding nicotinamide-adenine-dinucleotide: I161 (= I188), I162 (= I189), W164 (= W191), K188 (= K215), G221 (= G247), G225 (= G251), A226 (≠ Q252), F239 (= F265), G241 (= G267), S242 (= S268), I245 (≠ V271), Q345 (= Q375), E395 (= E429), F397 (= F431)
2onmA Human mitochondrial aldehyde dehydrogenase asian variant, aldh2 2, Complexed with NAD+ (see paper)
43% identity, 88% coverage: 49:515/533 of query aligns to 17:479/494 of 2onmA
- active site: N163 (= N192), K186 (= K215), E262 (= E289), C296 (= C328), E393 (= E429), E470 (= E506)
- binding adenosine-5'-diphosphate: E189 (= E218), G219 (= G247), G223 (= G251), A224 (≠ Q252), F237 (= F265), G239 (= G267), S240 (= S268), I243 (≠ V271)
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
43% identity, 89% coverage: 49:521/533 of query aligns to 17:485/494 of 1nzwA
- active site: N163 (= N192), K186 (= K215), E262 (= E289), S296 (≠ T329), E393 (= E429), E470 (= E506)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (= I188), I160 (= I189), P161 (= P190), K186 (= K215), E189 (= E218), G219 (= G247), P220 (≠ I248), G223 (= G251), A224 (≠ Q252), F237 (= F265), G239 (= G267), S240 (= S268), I243 (≠ V271), E262 (= E289), G264 (= G291), S296 (≠ T329), Q343 (= Q375), E393 (= E429), F395 (= F431)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
41% identity, 90% coverage: 49:526/533 of query aligns to 6:478/487 of 4go4A
- active site: N149 (= N192), K172 (= K215), E247 (= E289), C281 (= C328), E381 (= E429), E458 (= E506)
- binding nicotinamide-adenine-dinucleotide: I145 (= I188), V146 (≠ I189), W148 (= W191), N149 (= N192), F154 (≠ M197), K172 (= K215), G205 (= G247), G209 (= G251), Q210 (= Q252), F223 (= F265), T224 (= T266), G225 (= G267), S226 (= S268), T229 (≠ V271), E247 (= E289), G249 (= G291), C281 (= C328), E381 (= E429), F383 (= F431)
7radA Crystal structure analysis of aldh1b1
42% identity, 89% coverage: 49:521/533 of query aligns to 16:484/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I188), I159 (= I189), P160 (= P190), W161 (= W191), N162 (= N192), M167 (= M197), K185 (= K215), E188 (= E218), G218 (= G247), G222 (= G251), A223 (≠ Q252), T237 (= T266), G238 (= G267), S239 (= S268), V242 (= V271), E261 (= E289), L262 (= L290), C295 (= C328), E392 (= E429), F394 (= F431)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ A143), E117 (≠ L147), F163 (= F193), E285 (= E315), F289 (= F322), N450 (≠ H487), V452 (≠ Y489)
7mjdA Crystal structure analysis of aldh1b1
42% identity, 89% coverage: 49:521/533 of query aligns to 16:484/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I188), I159 (= I189), P160 (= P190), W161 (= W191), N162 (= N192), M167 (= M197), K185 (= K215), E188 (= E218), G218 (= G247), G222 (= G251), F236 (= F265), T237 (= T266), G238 (= G267), S239 (= S268), V242 (= V271), E261 (= E289), L262 (= L290), C295 (= C328), E392 (= E429), F394 (= F431)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ L147), E285 (= E315), F289 (= F322), N450 (≠ H487), V452 (≠ Y489)
7mjcA Crystal structure analysis of aldh1b1
42% identity, 89% coverage: 49:521/533 of query aligns to 16:484/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I188), I159 (= I189), P160 (= P190), W161 (= W191), N162 (= N192), K185 (= K215), E188 (= E218), G218 (= G247), G222 (= G251), T237 (= T266), G238 (= G267), S239 (= S268), V242 (= V271), E261 (= E289), L262 (= L290), C295 (= C328), E392 (= E429), F394 (= F431)
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
41% identity, 90% coverage: 49:529/533 of query aligns to 23:499/501 of Q56YU0
- G152 (≠ A175) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A446) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
Query Sequence
>GFF3202 HP15_3144 NAD-dependent aldehyde dehydrogenase
MGIGVYIEWVNAKGRVALRQTQQEVEIMIYAQPGKDGSVVSFKSRYENYIGGEWVAPVKG
QYFENITPVTGNVICEIPRSSAEDIDLALDAAHKAAPAWGKTSPTERSNILLKIADRIEA
NLEKLAVAETWDNGKAVRETLNADIPLAADHFRYFAGCLRAQEGHMGEIDHNTVAYHFHE
PLGVVGQIIPWNFPILMAAWKLGPCLAAGNCTVLKPAEQTPASILVLMEIIGDLLPPGVL
NIVNGYGIEAGQALATSKRIAKIAFTGSTPVGSHILKCAAENIIPSTVELGGKSPNIYFS
DVMKAEPEFIDKCVEGLVLAFFNQGEVCTCPSRALVQEDMFEEFMQKVVQRTKSIKRGNP
LDTDVQVGAQASKEQFDKIMSYLAIGKEEGAVVLTGGDREHLDEEFNNGFYIQPTLFKGD
NKMRVFQEEIFGPVVGVTTFKTEEEALAIANDTEFGLGAGVWTRDTNLAYRMGRNIQAGR
VWMNCYHAYPAHAAFGGYKKSGVGRETHKMALEHYQQTKCMLTSYDTNPLGFF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory