SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing GFF3454 FitnessBrowser__WCS417:GFF3454 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
46% identity, 100% coverage: 1:230/231 of query aligns to 6:240/240 of 1ji0A

query
sites
1ji0A

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binding adenosine-5'-triphosphate: Y16 (= Y11), G42 (= G37), G44 (= G39), K45 (= K40), T46 (= T41), T47 (= T42), E88 (= E83), E165 (= E155)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
33% identity, 99% coverage: 1:228/231 of query aligns to 2:235/240 of 6mjpA

query
sites
6mjpA

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binding calcium ion: E111 (≠ K103), D115 (≠ W107)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
35% identity, 98% coverage: 2:227/231 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

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binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ S14), V17 (= V16), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding magnesium ion: T42 (= T41), Q84 (≠ E83)
binding novobiocin: L71 (≠ I70), H72 (≠ F71), P83 (= P82), A86 (≠ R85), S87 (≠ G86), F89 (= F88), R90 (= R89), R91 (≠ L90), L92 (= L91), V101 (≠ A100), Q135 (≠ H128), R149 (= R142)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
35% identity, 98% coverage: 2:227/231 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

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binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ S14), V17 (= V16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding magnesium ion: T42 (= T41), Q84 (≠ E83)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
35% identity, 98% coverage: 2:228/231 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

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binding adp orthovanadate: Y12 (= Y11), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42), Q84 (≠ E83), S136 (≠ A129), S138 (= S131), G139 (= G132), G140 (= G133), E162 (= E155), G166 (= G159), H194 (≠ Q187)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
35% identity, 98% coverage: 2:228/231 of query aligns to 3:235/238 of 6s8nB

query
sites
6s8nB

L

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K

Y

A

Y

Y

D

K

K

G

S

R

H

R

V

V

L

V

E

E

G

D

V

V

S

S

L

L

T

T

V

V

N

N

P

S

G

G

E

E

L

I

V

V

T

G

L

L

L

L

G

G

R

P

N

N

G

G

A

A

G

G

K

K

T

T

T

T

T

T

L

F

R

Y

S

M

I

V

L

V

G

G

I

I

I

V

C

P

P

R

R

D

K

A

G

G

Q

N

I

I

H

I

F

I

N

D

G

D

Q

D

A

D

L

I

V

S

G

L

Q

L

K

P

I

L

F

H

E

A

I

R

A

A

R

R

Q

R

G

G

L

I

A

G

L

Y

V

L

P

P

E

Q

N

E

R

A

G

S

I

I

F

F

R
|
R

L

R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

R

M

I

A

A

V

T

L

R

Q

-

I

-

R

-

D

K

D

T

L

S

S

R

A

W

E

Q

Q

L

R

E

E

D

D

V

R

Y

A

G

N

M

E

F

L

P

M

-

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

K

D

N

S

A
x
M

G
|
G

H
x
Q

A

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

L

A

N

A

D

N

P

P

K

K

L

F

L

I

I

L

L

L

D

D

E

E

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

D

I

E

D

L

I

V

K

K

R

I

I

L

I

R

E

K

H

V

L

K

R

D

D

D

S

G

G

L

L

P

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

L

V

M

R

V

E

C

T

D

L

K

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

L

V

E

S

Q

Q

G

G

R

H

V

L

V

I

Y

A

E

H

G

G

S

T

A

P

E

T

A

E

F

I

R

L

A

Q

D

D

P

E

T

H

I

V

K

K

N

R

R

V

Y

Y

L

L

A

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (= R89), M133 (≠ A126), G134 (= G127), Q135 (≠ H128)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
35% identity, 98% coverage: 2:228/231 of query aligns to 3:235/238 of 6s8gA

query
sites
6s8gA

L

L

I

T

V

A

E

K

N

N

I

L

H

A

S

K

Y

A

Y
|
Y

D

K

K

G

S
x
R

H

R

V

V

L

V

E

E

G

D

V

V

S

S

L

L

T

T

V

V

N

N

P

S

G

G

E

E

L

I

V

V

T

G

L

L

L

L

G

G

R

P

N
|
N

G

G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

S

M

I

V

L

V

G

G

I

I

I

V

C

P

P

R

R

D

K

A

G

G

Q

N

I

I

H

I

F

I

N

D

G

D

Q

D

A

D

L

I

V

S

G

L

Q

L

K

P

I

L

F

H

E

A

I

R

A

A

R

R

Q

R

G

G

L

I

A

G

L

Y

V

L

P

P

E
x
Q

N

E

R

A

G

S

I

I

F

F

R

R

L

R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

R

M

I

A

A

V

T

L

R

Q

-

I

-

R

-

D

K

D

T

L

S

S

R

A

W

E

Q

Q

L

R

E

E

D

D

V

R

Y

A

G

N

M

E

F

L

P

M

-

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

K

D

N

S

A

M

G

G

H

Q

A
x
S

L

L

S
|
S

G

G

G

G

E
|
E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

L

A

N

A

D

N

P

P

K

K

L

F

L

I

I

L

L

L

D

D

E

E

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

D

I

E

D

L

I

V

K

K

R

I

I

L

I

R

E

K

H

V

L

K

R

D

D

D

S

G

G

L

L

P

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

L

V

M

R

V

E

C

T

D

L

K

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

L

V

E

S

Q

Q

G

G

R

H

V

L

V

I

Y

A

E

H

G

G

S

T

A

P

E

T

A

E

F

I

R

L

A

Q

D

D

P

E

T

H

I

V

K

K

N

R

R

V

Y

Y

L

L

A

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y11), R15 (≠ S14), N37 (= N36), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42), Q84 (≠ E83), S136 (≠ A129), S138 (= S131), E141 (= E134)

6mbnA Lptb e163q in complex with atp (see paper)
34% identity, 98% coverage: 2:228/231 of query aligns to 4:236/241 of 6mbnA

query
sites
6mbnA

L

L

I

T

V

A

E

K

N

N

I

L

H

A

S

K

Y

A

Y
|
Y

D

K

K

G

S
x
R

H

R

V
|
V

L

V

E

E

G

D

V

V

S

S

L

L

T

T

V

V

N

N

P

S

G

G

E

E

L

I

V

V

T

G

L

L

L

L

G

G

R

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

S

M

I

V

L

V

G

G

I

I

I

V

C

P

P

R

R

D

K

A

G

G

Q

N

I

I

H

I

F

I

N

D

G

D

Q

D

A

D

L

I

V

S

G

L

Q

L

K

P

I

L

F

H

E

A

I

R

A

A

R

R

Q

R

G

G

L

I

A

G

L

Y

V

L

P

P

E

Q

N

E

R

A

G

S

I

I

F

F

R

R

L

R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

R

M

I

A

A

V

T

L

R

Q

-

I

-

R

-

D

K

D

T

L

S

S

R

A

W

E

Q

Q

L

R

E

E

D

D

V

R

Y

A

G

N

M

E

F

L

P

M

-

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

K

D

N

S

A

M

G

G

H

Q

A

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

L

A

N

A

D

N

P

P

K

K

L

F

L

I

I

L

L

L

D

D

E

Q

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

D

I

E

D

L

I

V

K

K

R

I

I

L

I

R

E

K

H

V

L

K

R

D

D

D

S

G

G

L

L

P

G

V

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

L

V

M

R

V

E

C

T

D

L

K

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

L

V

E

S

Q

Q

G

G

R

H

V

L

V

I

Y

A

E

H

G

G

S

T

A

P

E

T

A

E

F

I

R

L

A

Q

D

D

P

E

T

H

I

V

K

K

N

R

R

V

Y

Y

L

L

A

G

binding adenosine-5'-triphosphate: Y13 (= Y11), R16 (≠ S14), V18 (= V16), N38 (= N36), G39 (= G37), G41 (= G39), K42 (= K40), T43 (= T41), T44 (= T42), H195 (≠ Q187)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
35% identity, 97% coverage: 2:226/231 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

I

T

V

A

E

K

N

N

I

L

H

A

S

K

Y

A

Y
|
Y

D

K

K

G

S
x
R

H

R

V
|
V

L

V

E

E

G

D

V

V

S

S

L

L

T

T

V

V

N

N

P

S

G

G

E

E

L

I

V

V

T

G

L

L

L

L

G

G

R

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

S

M

I

V

L

V

G

G

I

I

I

V

C

P

P

R

R

D

K

A

G

G

Q

N

I

I

H

I

F

I

N

D

G

D

Q

D

A

D

L

I

V

S

G

L

Q

L

K

P

I

L

F

H

E

A

I

R

A

A

R

R

Q

R

G

G

L

I

A

G

L

Y

V

L

P

P

E

Q

N

E

R

A

G

S

I

I

F
|
F

R
|
R

L
x
R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

R

M

I

A

A

V

T

L

R

Q

-

I

-

R

-

D

K

D

T

L

S

S

R

A

W

E

Q

Q

L

R

E

E

D

D

V

R

Y

A

G

N

M

E

F

L

P

M

-

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

K

D

N

S

A

M

G

G

H

Q

A

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

L

A

N

A

D

N

P

P

K

K

L

F

L

I

I

L

L

L

D

D

E

E

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

D

I

E

D

L

I

V

K

K

R

I

I

L

I

R

E

K

H

V

L

K

R

D

D

D

S

G

G

L

L

P

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

L

V

M

R

V

E

C

T

D

L

K

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

L

V

E

S

Q

Q

G

G

R

H

V

L

V

I

Y

A

E

H

G

G

S

T

A

P

E

T

A

E

F

I

R

L

A

Q

D

D

P

E

T

H

I

V

K

K

N

R

R

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ S14), V17 (= V16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F88), R90 (= R89), R91 (≠ L90)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
31% identity, 94% coverage: 4:220/231 of query aligns to 5:227/241 of 4u00A

query
sites
4u00A

V

I

E

R

N

N

I

L

H

H

S

K

Y

W

Y
x
F

D

G

K

P

S

L

H

H

V
|
V

L

L

E

K

G

G

V

I

S

H

L

L

T

E

V

V

N

A

P

P

G

G

E

E

L

K

V

L

T

V

L

I

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

I

R

R

S

T

I

I

L

N

G

R

I

L

I

E

C

D

P

F

R

Q

K

E

G

G

Q

E

I

V

H

V

F

V

N

D

G

G

Q

L

A

S

L

V

V

K

G

D

Q

D

K

R

I

A

F

L

E

R

I

E

A

I

R

R

Q

R

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

N

Q

R

F

G

N

I

L

F

F

R

P

L

H

L

M

T

T

V

V

E

L

E

E

N

N

L

V

R

T

I

L

A

A

T

P

R

M

K

R

T

V

S

R

R

R

W

W

Q

P

L

R

E

E

D

K

V

A

Y

E

G

K

M

K

F

A

P

L

R

E

L

L

K

L

E

E

R

R

-

V

-

G

-

I

-

L

-

D

-

Q

-

A

R

R

K

K

N

Y

A

P

G

A

H

Q

A

-

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

L

A

N

M

D

E

P

P

K

K

L

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

D

G

E

E

L

V

V

L

K

D

I

V

L

M

R

R

K

D

V

L

K

A

D

Q

D

G

G

G

L

M

P

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

L

M

M

G

V

F

C

A

D

R

K

E

L

V

A

A

D

D

R

R

H

V

Y

V

V

F

L

M

E

D

Q

G

G

G

R

Q

V

I

V

V

Y

E

E

E

G

G

S

R

A

P

E

E

A

E

F

I

R

F

A

T

D

R

P

P

binding adenosine-5'-diphosphate: F12 (≠ Y11), V17 (= V16), S37 (≠ N36), G38 (= G37), S39 (≠ A38), G40 (= G39), K41 (= K40), S42 (≠ T41), T43 (= T42)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
30% identity, 93% coverage: 1:214/231 of query aligns to 1:221/240 of 4ymuJ

query
sites
4ymuJ

M

M

L

I

I

F

V

V

E

N

N

D

I

V

H

Y

S

K

Y

N

Y
x
F

D

G

K

S

S

L

H

E

V
|
V

L

L

E

K

G

G

V

V

S

T

L

L

T

K

V

V

N

N

P

K

G

G

E

E

L

V

V

V

T

V

L

I

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

L

R

R

S

C

I

I

L

N

G

L

I

L

I

E

C

E

P

P

R

T

K

K

G

G

Q

E

I

V

H

F

F

I

N

D

G

G

Q

V

A

K

L

I

V

N

G

N

Q

G

K

K

I

V

-

N

F

I

E

N

I

K

A

V

R

R

Q

Q

G

K

L

V

A

G

L

M

V

V

P

F

E

Q

N

H

R

F

G

N

I

L

F

F

R

P

L

H

L

L

T

T

V

A

E

I

E

E

N

N

L

I

R

T

I

L

A

A

-

P

-

V

-

K

T

V

R

K

K

K

T

M

S

N

R

K

W

K

Q

E

L

A

E

E

D

E

V

L

-

A

Y

V

G

D

M

L

F

L

P

A

R

K

-

V

-

G

L

L

K

L

E

D

R

K

R

K

K

D

N

Q

A

Y

G

P

H

I

A

K

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

M

R

L

L

A

A

I

I

A

A

R

R

A

A

L

L

L

A

N

M

D

Q

P

P

K

E

L

V

L

M

I

L

L

F

D

D

E
|
E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

D

K

E

E

L

V

V

L

K

N

I

V

L

M

R

K

K

Q

V

L

K

A

D

N

D

E

G

G

L

M

P

T

V

M

L

V

L

V

V

V

E

T

Q
x
H

N

E

L

M

M

G

V

F

C

A

D

R

K

E

L

V

A

G

D

D

R

R

H

V

Y

I

V

F

L

M

E

D

Q

D

G

G

R

V

V

I

V

V

Y

E

E

E

G

G

S

T

A

P

E

E

binding adenosine-5'-triphosphate: F11 (≠ Y11), V16 (= V16), S36 (≠ N36), G37 (= G37), S38 (≠ A38), G39 (= G39), K40 (= K40), S41 (≠ T41), T42 (= T42), E162 (= E155), H194 (≠ Q187)
binding magnesium ion: S41 (≠ T41), E162 (= E155)

P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
30% identity, 100% coverage: 1:230/231 of query aligns to 3:240/247 of P55339

query
sites
P55339

M

L

L

L

I

S

V

V

E

K

N

D

I

L

H

T

S

G

Y

G

Y

Y

D

T

K

R

S

N

H

P

V

V

L

L

E

K

G

N

V

V

S

S

L

F

T

T

V

L

N

E

P

P

G

N

E

Q

L

I

V

V

T

G

L

L

L

I

G

G

R

L

N

N

G

G

A

A

G

G

K

K

T

S

T

T

T

T

L

I

R

R

S

H

I

I

L

I

G

G

I

L

I

M

C

D

P

P

R

H

K

K

G

G

Q

S

I

I

H

E

F

L

N

N

G

G

Q

K

A

T

L

F

V

A

G

E

Q

D

K

P

I

-

F

-

E

E

I

G

A

Y

R

R

Q

S

G

Q

L

F

A

T

L

Y

V

I

P

P

E

E

N

T

R

P

G

V

I

L

F

Y

R

E

L

E

L

L

T

T

V

L

E

M

E

E

N

H

L

L

R

E

I

L

A

T

-

A

-

M

-

A

-

Y

-

G

-

L

T

S

R

K

K

E

T

T

S

M

R

E

W

K

Q

R

L

L

E

P

D

P

V

L

Y

L

G

K

M

E

F

F

P

-

R

R

L

M

K

E

E

K

R

R

R

L

K

K

N

W

A

F

G

P

H

A

A

H

L

F

S

S

G

K

G

G

E

M

Q

K

Q

Q

M

K

L

V

A

M

I

I

A

M

R

C

A

A

L

F

L

L

N

A

D

E

P

P

K

A

L

L

L

Y

I

I

L

I

D

D

E

E

P

P

T

F

E

L

G
|
G

L

L

A

D

P

P

V

L

I

A

V

I

D

N

E

A

L

L

V

L

K

E

I

R

L

M

R

N

K

E

V

A

K

K

D

K

D

G

G

G

L

A

P

S

V

V

L

L

L

M

V

S

E

T

Q

H

N

I

L

L

M

A

V

T

C

A

D

E

K

R

L

Y

A

C

D

D

R

S

H

F

Y

I

V

I

L

L

E

H

Q

N

G

G

R

E

V

V

V

R

Y

A

E

R

G

G

S

T

A

L

E

S

A

E

F

L

R

R

-

E

-

Q

-

F

-

G

-

M

A

K

D

D

P

A

T

A

I

L

K

D

N

D

R

L

Y

Y

L

L

A

E

L

L

S

T

G164 (= G159) mutation to E: In ecsA-26; exoamylase and other exoenzymes decrease, competence- and sporulation-deficient phenotype.

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
26% identity, 99% coverage: 1:228/231 of query aligns to 4:253/254 of 1g6hA

query
sites
1g6hA

M

I

L

L

I

R

V

T

E

E

N

N

I

I

H

V

S

K

Y

Y

Y
x
F

D

G

K

E

S
x
F

H

K

V

A

L

L

E

D

G

G

V

V

S

S

L

I

T

S

V

V

N

N

P

K

G

G

E

D

L

V

V

T

T

L

L

I

L

I

G

G

R

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

I

R

N

S

V

I

I

L

T

G

G

I

F

I

L

C

K

P

A

R

D

K

E

G

G

Q

R

I

V

H

Y

F

F

N

E

G

N

Q

K

A

D

L

I

V

T

G

N

Q

K

K

E

I

P

F

A

E

E

I

L

A

Y

R

H

Q

Y

G

G

L

I

A

V

L

R

V

T

P

F

E

Q

N

T

R

P

G

Q

I

P

F

L

R

K

L

E

L

M

T

T

V

V

E

L

E

E

N

N

L

L

R

L

I

I

A

G

-

E

-

I

-

C

-

P

-

G

-

E

-

S

-

P

-

L

-

N

T

S

R

L

K

F

T

Y

S

K

R

K

W

W

-

I

-

P

-

K

-

E

-

E

-

E

Q

M

L

V

E

E

D

K

V

A

Y

F

G

K

M

I

-

L

-

E

F

F

P

L

R

K

L

L

K

S

E

H

R

L

R

Y

K

D

N

R

A

K

G

A

H

G

A

E

L

L

S

S

G

G

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

I

I

A

G

R

R

A

A

L

L

L

M

N

T

D

N

P

P

K

K

L

M

L

I

I

V

L

M

D

D

E

E

P

P

T

I

E

A

G

G

L

V

A

A

P

P

V

G

I

L

V

A

D

H

E

D

L

I

V

F

K

N

I

H

L

V

R

L

K

E

V

L

K

K

D

A

D

K

G

G

L

I

P

T

V

F

L

L

L

I

V

I

E

E

Q

H

N

R

L

L

M

D

V

I

C

V

D

L

K

N

L

Y

A

I

D

D

R

H

H

L

Y

Y

V

V

L

M

E

F

Q

N

G

G

R

Q

V

I

V

I

Y

A

E

E

G

G

S

R

A

G

E

E

A

E

-

E

-

I

-

K

-

N

F

V

R

L

A

S

D

D

P

P

T

K

I

V

K

V

N

E

R

I

Y

Y

L

I

A

G

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ S14), N39 (= N36), G40 (= G37), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (= T42)

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
32% identity, 92% coverage: 7:219/231 of query aligns to 10:229/229 of 6z67B

query
sites
6z67B

I

V

H

K

S

K

Y
|
Y

Y

D

D

N

K
x
G

S

T

H

T

V
x
A

L

L

E

R

G

G

V

V

S

S

L

V

T

S

V

V

N

Q

P

P

G

G

E

E

L

F

V

A

T

Y

L

I

L

V

G

G

R

P

N
x
S

G
|
G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

T

F

L

I

R

R

S

S

I

L

L

Y

G

R

I

E

I

V

C

K

P

I

R

D

K

K

G

G

Q

S

I

L

H

S

F

V

N

A

G

G

Q

F

A

N

L

L

V

V

G

K

-

I

-

K

Q

K

K

K

I

D

F

V

E

P

I

L

A

L

R

R

Q

R

G

S

L

V

A

G

L

V

V

V

P

F

E

Q

N

D

R

Y

G

K

I

L

F

L

R

P

L

K

L

K

T

T

V

V

E

Y

E

E

N

N

L

I

R

A

I

Y

A

A

-

M

-

E

-

V

-

I

-

G

-

E

T

N

R

R

K

R

T

N

S

I

R

K

W

R

Q

R

L

V

E

M

D

E

V

V

Y

L

G

D

M

L

F

V

P

G

R

-

L

L

K

K

E

H

R

K

R

V

K

R

N

S

A

F

G

P

H

N

A

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

M

R

L

I

A

A

I

I

A

A

R

R

A

A

L

I

L

V

N

N

D

N

P

P

K

K

L

V

L

L

I

I

L

A

D

D

E

E

P

P

T

T

E

G

G

N

L

L

A

D

P

P

V

D

I

N

V

S

D

W

E

E

L

I

V

M

K

N

I

L

L

L

R

E

K

R

V

I

K

N

D

L

D

Q

G

G

L

T

P

T

V

I

L

L

L

M

V

A

E

T

Q

H

N

N

L

S

M

Q

V

I

C

V

D

N

K

T

L

L

A

R

D

H

R

R

H

V

Y

I

V

A

L

I

E

E

Q

N

G

G

R

R

V

V

V

V

Y

R

E

D

G

E

S

S

A

K

E

G

A

E

F

Y

R

G

A

Y

D

D

binding phosphoaminophosphonic acid-adenylate ester: Y13 (= Y10), G16 (≠ K13), A19 (≠ V16), S39 (≠ N36), G40 (= G37), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (= T42)

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
32% identity, 92% coverage: 7:219/231 of query aligns to 10:229/230 of 6z4wA

query
sites
6z4wA

I

V

H

K

S

K

Y
|
Y

Y

D

D

N

K

G

S
x
T

H

T

V
x
A

L

L

E

R

G

G

V

V

S

S

L

V

T

S

V

V

N

Q

P

P

G

G

E

E

L

F

V

A

T

Y

L

I

L

V

G

G

R

P

N

S

G
|
G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

T

F

L

I

R

R

S

S

I

L

L

Y

G

R

I

E

I

V

C

K

P

I

R

D

K

K

G

G

Q

S

I

L

H

S

F

V

N

A

G

G

Q

F

A

N

L

L

V

V

G

K

-

I

-

K

Q

K

K

K

I

D

F

V

E

P

I

L

A

L

R

R

Q

R

G

S

L

V

A

G

L

V

V

V

P

F

E

Q

N

D

R

Y

G

K

I

L

F

L

R

P

L

K

L

K

T

T

V

V

E

Y

E

E

N

N

L

I

R

A

I

Y

A

A

-

M

-

E

-

V

-

I

-

G

-

E

T

N

R

R

K

R

T

N

S

I

R

K

W

R

Q

R

L

V

E

M

D

E

V

V

Y

L

G

D

M

L

F

V

P

G

R

-

L

L

K

K

E

H

R

K

R

V

K

R

N

S

A

F

G

P

H

N

A

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

M

R

L

I

A

A

I

I

A

A

R

R

A

A

L

I

L

V

N

N

D

N

P

P

K

K

L

V

L

L

I

I

L

A

D

D

E

E

P

P

T

T

E

G

G

N

L

L

A

D

P

P

V

D

I

N

V

S

D

W

E

E

L

I

V

M

K

N

I

L

L

L

R

E

K

R

V

I

K

N

D

L

D

Q

G

G

L

T

P

T

V

I

L

L

L

M

V

A

E

T

Q

H

N

N

L

S

M

Q

V

I

C

V

D

N

K

T

L

L

A

R

D

H

R

R

H

V

Y

I

V

A

L

I

E

E

Q

N

G

G

R

R

V

V

V

V

Y

R

E

D

G

E

S

S

A

K

E

G

A

E

F

Y

R

G

A

Y

D

D

binding adenosine-5'-diphosphate: Y13 (= Y10), T17 (≠ S14), A19 (≠ V16), G40 (= G37), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (= T42)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
26% identity, 99% coverage: 1:228/231 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

M

I

L

L

I

R

V

T

E

E

N

N

I

I

H

V

S

K

Y

Y

Y
x
F

D

G

K

E

S
x
F

H

K

V

A

L

L

E

D

G

G

V

V

S

S

L

I

T

S

V

V

N

C

P

K

G

G

E

D

L

V

V

T

T

L

L

I

L

I

G

G

R

P

N

N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

I

R

N

S

V

I

I

L

T

G

G

I

F

I

L

C

K

P

A

R

D

K

E

G

G

Q

R

I

V

H

Y

F

F

N

E

G

N

Q

K

A

D

L

I

V

T

G

N

Q

K

K

E

I

P

F

A

E

E

I

L

A

Y

R

H

Q

Y

G

G

L

I

A

V

L

R

V

T

P

F

E

Q

N

T

R

P

G

Q

I

P

F

L

R

K

L

E

L

M

T

T

V

V

E

L

E

E

N

N

L

L

R

L

I

I

A

G

-

E

-

I

-

N

-

P

-

G

-

E

-

S

-

P

-

L

-

N

T

S

R

L

K

F

T

Y

S

K

R

K

W

W

-

I

-

P

-

K

-

E

-

E

-

E

Q

M

L

V

E

E

D

K

V

A

Y

F

G

K

M

I

-

L

-

E

F

F

P

L

R

K

L

L

K

S

E

H

R

L

R

Y

K

D

N

R

A

K

G

A

H

G

A

E

L

L

S

S

G

G

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

I

I

A

G

R

R

A

A

L

L

L

M

N

T

D

N

P

P

K

K

L

M

L

I

I

V

L

M

D

D

E
|
E

P

P

T

I

E

A

G

G

L

V

A

A

P

P

V

G

I

L

V

A

D

H

E

D

L

I

V

F

K

N

I

H

L

V

R

L

K

E

V

L

K

K

D

A

D

K

G

G

L

I

P

T

V

F

L

L

L

I

V

I

E

E

Q

H

N

R

L

L

M

D

V

I

C

V

D

L

K

N

L

Y

A

I

D

D

R

H

H

L

Y

Y

V

V

L

M

E

F

Q

N

G

G

R

Q

V

I

V

I

Y

A

E

E

G

G

S

R

A

G

E

E

A

E

-

E

-

I

-

K

-

N

F

V

R

L

A

S

D

D

P

P

T

K

I

V

K

V

N

E

R

I

Y

Y

L

I

A

G

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ S14), G40 (= G37), S41 (≠ A38), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (= T42)
binding magnesium ion: S44 (≠ T41), E176 (= E155)

3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 95% coverage: 1:220/231 of query aligns to 3:229/242 of 3c4jA

query
sites
3c4jA

M

M

L

I

I

D

V

V

E

H

N

Q

I

L

H

K

S

K

Y

S

Y
x
F

D

G

K

S

S

L

H

E

V
|
V

L

L

E

K

G

G

V

I

S

N

L

V

T

H

V

I

N

R

P

E

G

G

E

E

L

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

L

L

R

R

S

C

I

L

L

N

G

L

I

L

I

E

C

D

P

F

R

D

K

E

G

G

Q

E

I

I

H

I

F

I

N

D

G

G

Q

I

A

N

L

L

V

K

G

A

Q

K

K

D

I

T

-

N

F

L

E

N

I

K

A

V

R

R

Q

E

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

N

R

R

F

G

N

I

L

F

F

R

P

L

H

L

M

T

T

V

V

E

L

E

N

N

N

L

I

R

T

I

L

A

A

T

P

R

M

K

K

T

V

S

R

R

K

W

W

Q

P

L

R

E

E

D

K

V

A

Y

E

G

A

M

K

F

A

P

M

R

E

L

L

K

L

E

D

R

K

-

V

-

G

R

L

K

K

N

D

A

K

G

A

H

H

A

A

-

Y

-

P

-

D

-

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

L

A

N

M

D

E

P

P

K

K

L

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

D

G

E

E

L

V

V

L

K

S

I

V

L

M

R

K

K

Q

V

L

K

A

D

N

D

E

G

G

L

M

P

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

L

M

M

G

V

F

C

A

D

R

K

E

L

V

A

G

D

D

R

R

H

V

Y

L

V

F

L

M

E

D

Q

G

G

G

R

Y

V

I

V

I

Y

E

E

E

G

G

S

K

A

P

E

E

A

D

F

L

R

F

A

D

D

R

P

P

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y11), V18 (= V16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)

3c41J Abc protein artp in complex with amp-pnp/mg2+
28% identity, 95% coverage: 1:220/231 of query aligns to 3:229/242 of 3c41J

query
sites
3c41J

M

M

L

I

I

D

V

V

E

H

N

Q

I

L

H

K

S

K

Y

S

Y
x
F

D

G

K

S

S

L

H

E

V
|
V

L

L

E

K

G

G

V

I

S

N

L

V

T

H

V

I

N

R

P

E

G

G

E

E

L

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

L

L

R

R

S

C

I

L

L

N

G

L

I

L

I

E

C

D

P

F

R

D

K

E

G

G

Q

E

I

I

H

I

F

I

N

D

G

G

Q

I

A

N

L

L

V

K

G

A

Q

K

K

D

I

T

-

N

F

L

E

N

I

K

A

V

R

R

Q

E

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

N

R

R

F

G

N

I

L

F

F

R

P

L

H

L

M

T

T

V

V

E

L

E

N

N

N

L

I

R

T

I

L

A

A

T

P

R

M

K

K

T

V

S

R

R

K

W

W

Q

P

L

R

E

E

D

K

V

A

Y

E

G

A

M

K

F

A

P

M

R

E

L

L

K

L

E

D

R

K

-

V

-

G

R

L

K

K

N

D

A

K

G

A

H

H

A

A

-

Y

-

P

-

D

-

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

L

A

N

M

D

E

P

P

K

K

L

I

L

M

I

L

L

F

D
|
D

E

E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

D

G

E

E

L

V

V

L

K

S

I

V

L

M

R

K

K

Q

V

L

K

A

D

N

D

E

G

G

L

M

P

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

L

M

M

G

V

F

C

A

D

R

K

E

L

V

A

G

D

D

R

R

H

V

Y

L

V

F

L

M

E

D

Q

G

G

G

R

Y

V

I

V

I

Y

E

E

E

G

G

S

K

A

P

E

E

A

D

F

L

R

F

A

D

D

R

P

P

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y11), V18 (= V16), S38 (≠ N36), G39 (= G37), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)
binding magnesium ion: S43 (≠ T41), D163 (= D154)

2olkA Abc protein artp in complex with adp-beta-s
28% identity, 95% coverage: 1:220/231 of query aligns to 3:229/242 of 2olkA

query
sites
2olkA

M

M

L

I

I

D

V

V

E

H

N

Q

I

L

H

K

S

K

Y

S

Y
x
F

D

G

K

S

S

L

H

E

V
|
V

L

L

E

K

G

G

V

I

S

N

L

V

T

H

V

I

N

R

P

E

G

G

E

E

L

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

L

L

R

R

S

C

I

L

L

N

G

L

I

L

I

E

C

D

P

F

R

D

K

E

G

G

Q

E

I

I

H

I

F

I

N

D

G

G

Q

I

A

N

L

L

V

K

G

A

Q

K

K

D

I

T

-

N

F

L

E

N

I

K

A

V

R

R

Q

E

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

N

R

R

F

G

N

I

L

F

F

R

P

L

H

L

M

T

T

V

V

E

L

E

N

N

N

L

I

R

T

I

L

A

A

T

P

R

M

K

K

T

V

S

R

R

K

W

W

Q

P

L

R

E

E

D

K

V

A

Y

E

G

A

M

K

F

A

P

M

R

E

L

L

K

L

E

D

R

K

-

V

-

G

R

L

K

K

N

D

A

K

G

A

H

H

A

A

-

Y

-

P

-

D

-

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

L

A

N

M

D

E

P

P

K

K

L

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

D

G

E

E

L

V

V

L

K

S

I

V

L

M

R

K

K

Q

V

L

K

A

D

N

D

E

G

G

L

M

P

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

L

M

M

G

V

F

C

A

D

R

K

E

L

V

A

G

D

D

R

R

H

V

Y

L

V

F

L

M

E

D

Q

G

G

G

R

Y

V

I

V

I

Y

E

E

E

G

G

S

K

A

P

E

E

A

D

F

L

R

F

A

D

D

R

P

P

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y11), V18 (= V16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)

2oljA Abc protein artp in complex with adp/mg2+
28% identity, 95% coverage: 1:220/231 of query aligns to 3:229/242 of 2oljA

query
sites
2oljA

M

M

L

I

I

D

V

V

E

H

N

Q

I

L

H

K

S

K

Y

S

Y
x
F

D

G

K

S

S

L

H

E

V
|
V

L

L

E

K

G

G

V

I

S

N

L

V

T

H

V

I

N

R

P

E

G

G

E

E

L

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

L

L

R

R

S

C

I

L

L

N

G

L

I

L

I

E

C

D

P

F

R

D

K

E

G

G

Q

E

I

I

H

I

F

I

N

D

G

G

Q

I

A

N

L

L

V

K

G

A

Q

K

K

D

I

T

-

N

F

L

E

N

I

K

A

V

R

R

Q

E

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

N

R

R

F

G

N

I

L

F

F

R

P

L

H

L

M

T

T

V

V

E

L

E

N

N

N

L

I

R

T

I

L

A

A

T

P

R

M

K

K

T

V

S

R

R

K

W

W

Q

P

L

R

E

E

D

K

V

A

Y

E

G

A

M

K

F

A

P

M

R

E

L

L

K

L

E

D

R

K

-

V

-

G

R

L

K

K

N

D

A

K

G

A

H

H

A

A

-

Y

-

P

-

D

-

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

L

A

N

M

D

E

P

P

K

K

L

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

D

G

E

E

L

V

V

L

K

S

I

V

L

M

R

K

K

Q

V

L

K

A

D

N

D

E

G

G

L

M

P

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

L

M

M

G

V

F

C

A

D

R

K

E

L

V

A

G

D

D

R

R

H

V

Y

L

V

F

L

M

E

D

Q

G

G

G

R

Y

V

I

V

I

Y

E

E

E

G

G

S

K

A

P

E

E

A

D

F

L

R

F

A

D

D

R

P

P

binding adenosine-5'-diphosphate: F13 (≠ Y11), V18 (= V16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)

Query Sequence

>GFF3454 FitnessBrowser__WCS417:GFF3454
MLIVENIHSYYDKSHVLEGVSLTVNPGELVTLLGRNGAGKTTTLRSILGIICPRKGQIHF
NGQALVGQKIFEIARQGLALVPENRGIFRLLTVEENLRIATRKTSRWQLEDVYGMFPRLK
ERRKNAGHALSGGEQQMLAIARALLNDPKLLILDEPTEGLAPVIVDELVKILRKVKDDGL
PVLLVEQNLMVCDKLADRHYVLEQGRVVYEGSAEAFRADPTIKNRYLALSA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory