SitesBLAST – Find functional sites

 

SitesBLAST

Comparing GFF364 FitnessBrowser__WCS417:GFF364 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
44% identity, 77% coverage: 5:104/130 of query aligns to 6:104/204 of 7bgnA

query
sites
7bgnA
L
 
L
D
 
D
E
 
S
I
 
V
K
 
K
W
 
W
D
 
D
S
 
N
D
 
K
G
 
G
L
 
L
V
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
D
 
N
Y
 
V
K
 
D
T
 
T
G
 
G
R
 
A
V
 
I
L
 
L
M
 
M
M
 
Q
A
 
G
W
 
F
M
 
A
N
 
N
R
 
R
E
 
E
A
 
A
L
 
V
S
 
A
L
 
T
T
 
T
A
 
I
A
 
S
E
 
S
Q
 
R
R
 
K
A
 
A
I
 
T
Y
 
F
W
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
G
 
S
K
 
S
L
 
L
W
|
W
R
 
T
K
|
K
G
|
G
E
 
E
E
x
T
S
|
S
G
 
N
H
 
N
V
 
F
Q
 
I
T
 
N
L
 
V
H
 
H
E
 
D
M
 
V
R
 
F
I
 
L
D
|
D
C
 
C
D
|
D
A
 
R
D
|
D
V
 
S
V
 
I
I
 
I
L
 
Y
M
 
L
V
 
G
E
 
K
Q
 
P
I
 
D
G
 
G
D
 
P
I
 
-
A
x
T
C
|
C
H
|
H
T
 
T
G
 
G
R
 
A
H
 
E
S
 
T
C
|
C
F
 
Y
Y
 
Y

Sites not aligning to the query:

7bgmA Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
44% identity, 77% coverage: 5:104/130 of query aligns to 8:106/213 of 7bgmA

query
sites
7bgmA
L
 
L
D
 
D
E
 
S
I
 
V
K
 
K
W
 
W
D
 
D
S
 
N
D
 
K
G
 
G
L
 
L
V
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
D
 
N
Y
 
V
K
 
D
T
 
T
G
 
G
R
 
A
V
 
I
L
 
L
M
 
M
M
 
Q
A
 
G
W
 
F
M
 
A
N
 
N
R
 
R
E
 
E
A
 
A
L
 
V
S
 
A
L
 
T
T
 
T
A
 
I
A
 
S
E
 
S
Q
 
R
R
 
K
A
 
A
I
 
T
Y
 
F
W
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
G
 
S
K
 
S
L
 
L
W
 
W
R
 
T
K
 
K
G
 
G
E
 
E
E
 
T
S
 
S
G
 
N
H
 
N
V
 
F
Q
 
I
T
 
N
L
 
V
H
 
H
E
 
D
M
 
V
R
 
F
I
 
L
D
|
D
C
 
C
D
|
D
A
 
R
D
|
D
V
 
S
V
 
I
I
 
I
L
 
Y
M
 
L
V
 
G
E
 
K
Q
 
P
I
 
D
G
 
G
D
 
P
I
 
-
A
 
T
C
|
C
H
 
H
T
 
T
G
 
G
R
 
A
H
 
E
S
 
T
C
|
C
F
 
Y
Y
 
Y

Sites not aligning to the query:

6j2lA Crystal structure of bi-functional enzyme (see paper)
40% identity, 75% coverage: 7:103/130 of query aligns to 8:104/200 of 6j2lA

query
sites
6j2lA
E
 
E
I
 
L
K
 
D
W
 
W
D
 
E
-
 
K
S
 
T
D
 
D
G
 
G
L
 
L
V
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
D
 
H
Y
 
A
K
 
V
T
 
S
G
 
G
R
 
E
V
 
V
L
 
L
M
 
M
M
 
L
A
 
G
W
 
Y
M
 
M
N
 
N
R
 
P
E
 
E
A
 
A
L
 
L
S
 
D
L
 
K
T
 
T
A
 
I
A
 
E
E
 
S
Q
 
G
R
 
K
A
 
V
I
 
T
Y
 
F
W
 
F
S
 
S
R
 
R
S
 
T
R
 
K
G
 
Q
K
 
R
L
 
L
W
 
W
R
 
I
K
 
K
G
 
G
E
 
E
E
 
T
S
 
S
G
 
G
H
 
N
V
 
F
Q
 
L
T
 
N
L
 
V
H
 
V
E
 
S
M
 
I
R
 
A
I
 
P
D
|
D
C
 
C
D
|
D
A
 
N
D
|
D
V
 
T
V
 
L
I
 
L
L
 
V
M
 
L
V
 
A
E
 
N
Q
 
P
I
 
I
G
 
G
D
 
P
I
 
-
A
 
T
C
|
C
H
 
H
T
 
K
G
 
G
R
 
T
H
 
S
S
 
S
C
|
C
F
 
F

Sites not aligning to the query:

6j2lB Crystal structure of bi-functional enzyme (see paper)
38% identity, 68% coverage: 7:95/130 of query aligns to 7:96/185 of 6j2lB

query
sites
6j2lB
E
 
E
I
 
L
K
 
D
W
 
W
D
 
E
-
 
K
S
 
T
D
 
D
G
 
G
L
 
L
V
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
D
 
H
Y
 
A
K
 
V
T
 
S
G
 
G
R
 
E
V
 
V
L
 
L
M
 
M
M
 
L
A
 
G
W
 
Y
M
 
M
N
 
N
R
 
P
E
 
E
A
 
A
L
 
L
S
 
D
L
 
K
T
 
T
A
 
I
A
 
E
E
 
S
Q
 
G
R
 
K
A
 
V
I
 
T
Y
 
F
W
 
F
S
 
S
R
 
R
S
 
T
R
 
K
G
 
Q
K
 
R
L
 
L
W
 
W
R
 
I
K
 
K
G
 
G
E
 
E
E
 
T
S
 
S
G
 
G
H
 
N
V
 
F
Q
 
L
T
 
N
L
 
V
H
 
V
E
 
S
M
 
I
R
 
A
I
 
P
D
|
D
C
 
C
D
|
D
A
 
N
D
|
D
V
 
T
V
 
L
I
 
L
L
 
V
M
 
L
V
 
A
E
 
N
Q
 
P
I
 
I
G
 
G
D
 
P
I
 
S
A
 
S
C
 
C

Sites not aligning to the query:

Query Sequence

>GFF364 FitnessBrowser__WCS417:GFF364
MKDWLDEIKWDSDGLVPAIAQDYKTGRVLMMAWMNREALSLTAAEQRAIYWSRSRGKLWR
KGEESGHVQTLHEMRIDCDADVVILMVEQIGDIACHTGRHSCFYRVFENGEWKTVEPVLK
DPDAIYSAGH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory