SitesBLAST
Comparing GFF374 FitnessBrowser__psRCH2:GFF374 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4neaA 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
36% identity, 97% coverage: 10:475/480 of query aligns to 21:489/505 of 4neaA
- active site: N166 (= N152), K189 (= K175), E264 (= E250), C298 (= C284), E399 (= E383), E476 (= E462)
- binding nicotinamide-adenine-dinucleotide: P164 (= P150), K189 (= K175), E192 (≠ D178), G222 (= G208), G226 (= G212), G242 (= G228), G243 (≠ S229), T246 (≠ V232), H249 (≠ G235), I250 (= I236), C298 (= C284), E399 (= E383), F401 (= F385)
7radA Crystal structure analysis of aldh1b1
41% identity, 99% coverage: 3:479/480 of query aligns to 9:486/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I148), I159 (≠ T149), P160 (= P150), W161 (= W151), N162 (= N152), M167 (≠ I157), K185 (= K175), E188 (≠ D178), G218 (= G208), G222 (= G212), A223 (≠ E213), T237 (= T227), G238 (= G228), S239 (= S229), V242 (= V232), E261 (= E250), L262 (≠ M251), C295 (= C284), E392 (= E383), F394 (= F385)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (vs. gap), E117 (≠ R106), F163 (= F153), E285 (≠ Q274), F289 (≠ Y278), N450 (≠ T441), V452 (= V444)
7mjdA Crystal structure analysis of aldh1b1
41% identity, 99% coverage: 3:479/480 of query aligns to 9:486/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I148), I159 (≠ T149), P160 (= P150), W161 (= W151), N162 (= N152), M167 (≠ I157), K185 (= K175), E188 (≠ D178), G218 (= G208), G222 (= G212), F236 (= F226), T237 (= T227), G238 (= G228), S239 (= S229), V242 (= V232), E261 (= E250), L262 (≠ M251), C295 (= C284), E392 (= E383), F394 (= F385)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ R106), E285 (≠ Q274), F289 (≠ Y278), N450 (≠ T441), V452 (= V444)
7mjcA Crystal structure analysis of aldh1b1
41% identity, 99% coverage: 3:479/480 of query aligns to 9:486/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I148), I159 (≠ T149), P160 (= P150), W161 (= W151), N162 (= N152), K185 (= K175), E188 (≠ D178), G218 (= G208), G222 (= G212), T237 (= T227), G238 (= G228), S239 (= S229), V242 (= V232), E261 (= E250), L262 (≠ M251), C295 (= C284), E392 (= E383), F394 (= F385)
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
38% identity, 100% coverage: 2:480/480 of query aligns to 6:481/482 of P25526
5ac0A Ovis aries aldehyde dehydrogenase 1a1 in complex with a duocarmycin analog (see paper)
42% identity, 98% coverage: 10:479/480 of query aligns to 17:487/494 of 5ac0A
- active site: N163 (= N152), K186 (= K175), E262 (= E250), C296 (= C284), E393 (= E383), E470 (= E462)
- binding 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one: M114 (≠ G102), F164 (= F153), W171 (= W160), Y290 (= Y278), C295 (≠ R283), C296 (= C284)
- binding nicotinamide-adenine-dinucleotide: I159 (= I148), I160 (≠ T149), P161 (= P150), W162 (= W151), K186 (= K175), E189 (≠ D178), G219 (= G208), G223 (= G212), A224 (≠ E213), F237 (= F226), G239 (= G228), S240 (= S229), V243 (= V232), G264 (= G252), C296 (= C284), Q343 (= Q331), K346 (≠ Q334), E393 (= E383)
5abmA Sheep aldehyde dehydrogenase 1a1 (see paper)
42% identity, 98% coverage: 10:479/480 of query aligns to 17:487/494 of 5abmA
- active site: N163 (= N152), K186 (= K175), E262 (= E250), C296 (= C284), E393 (= E383), E470 (= E462)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I159 (= I148), I160 (≠ T149), P161 (= P150), W162 (= W151), K186 (= K175), E189 (≠ D178), G219 (= G208), G223 (= G212), F237 (= F226), G239 (= G228), S240 (= S229), V243 (= V232), G264 (= G252), Q343 (= Q331), K346 (≠ Q334), E393 (= E383), F395 (= F385)
1bxsA Sheep liver class 1 aldehyde dehydrogenase with NAD bound (see paper)
42% identity, 98% coverage: 10:479/480 of query aligns to 17:487/494 of 1bxsA
- active site: N163 (= N152), K186 (= K175), E262 (= E250), C296 (= C284), E393 (= E383), E470 (= E462)
- binding nicotinamide-adenine-dinucleotide: I159 (= I148), I160 (≠ T149), P161 (= P150), W162 (= W151), K186 (= K175), E189 (≠ D178), G219 (= G208), G223 (= G212), F237 (= F226), G239 (= G228), S240 (= S229), V243 (= V232), L263 (≠ M251), C296 (= C284), Q343 (= Q331), K346 (≠ Q334), E393 (= E383), F395 (= F385)
P51977 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Ovis aries (Sheep) (see 2 papers)
42% identity, 98% coverage: 10:479/480 of query aligns to 24:494/501 of P51977
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
38% identity, 100% coverage: 2:480/480 of query aligns to 5:480/481 of 3jz4A