Comparing GFF3824 PS417_19580 acetyl-CoA carboxylase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3u9sF Crystal structure of p. Aeruginosa 3-methylcrotonyl-coa carboxylase (mcc) 750 kd holoenzyme, coa complex (see paper)
48% identity, 95% coverage: 1:512/538 of query aligns to 3:514/537 of 3u9sF
8f3dA 3-methylcrotonyl-coa carboxylase in filament, beta-subunit centered (see paper)
45% identity, 86% coverage: 50:513/538 of query aligns to 85:555/566 of 8f3dA
1vrgA Crystal structure of propionyl-coa carboxylase, beta subunit (tm0716) from thermotoga maritima at 2.30 a resolution
31% identity, 89% coverage: 42:521/538 of query aligns to 24:499/515 of 1vrgA
Q168G2 Propionyl-CoA carboxylase beta chain; EC 6.4.1.3 from Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans) (see paper)
32% identity, 86% coverage: 50:510/538 of query aligns to 30:483/510 of Q168G2
3n6rB Crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) (see paper)
32% identity, 86% coverage: 50:510/538 of query aligns to 26:479/506 of 3n6rB
1on3E Transcarboxylase 12s crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound) (see paper)
30% identity, 87% coverage: 50:519/538 of query aligns to 38:502/520 of 1on3E
Sites not aligning to the query:
1on3C Transcarboxylase 12s crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound) (see paper)
30% identity, 87% coverage: 50:519/538 of query aligns to 34:492/510 of 1on3C
Sites not aligning to the query:
7ybuP Human propionyl-coenzyme a carboxylase
29% identity, 89% coverage: 49:527/538 of query aligns to 28:497/507 of 7ybuP
8pn7A Engineered glycolyl-coa carboxylase (g20r variant) with bound coa (see paper)
30% identity, 75% coverage: 49:454/538 of query aligns to 25:435/506 of 8pn7A
Sites not aligning to the query:
5iniF Structural basis for acyl-coa carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics (see paper)
30% identity, 80% coverage: 23:454/538 of query aligns to 6:434/511 of 5iniF
Sites not aligning to the query:
8sgxE Leishmania tarentolae propionyl-coa carboxylase (alpha-4-beta-6) (see paper)
28% identity, 86% coverage: 49:510/538 of query aligns to 10:462/489 of 8sgxE
3ib9A Propionyl-coa carboxylase beta subunit, d422l (see paper)
29% identity, 89% coverage: 31:510/538 of query aligns to 15:494/521 of 3ib9A
1xnyA Biotin and propionyl-coa bound to acyl-coa carboxylase beta subunit from s. Coelicolor (pccb) (see paper)
29% identity, 89% coverage: 31:510/538 of query aligns to 15:494/521 of 1xnyA
4g2rB Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor haloxyfop from mycobacterium tuberculosis (see paper)
31% identity, 73% coverage: 64:454/538 of query aligns to 1:376/441 of 4g2rB
6tzvA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor phenyl-cyclodiaone from mycobacterium tuberculosis
29% identity, 73% coverage: 63:454/538 of query aligns to 1:361/426 of 6tzvA
6prwA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
29% identity, 73% coverage: 63:454/538 of query aligns to 1:361/426 of 6prwA
6pk2A Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
29% identity, 73% coverage: 63:454/538 of query aligns to 1:361/426 of 6pk2A
6p7uA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p from mycobacterium tuberculosis
29% identity, 73% coverage: 63:454/538 of query aligns to 1:361/426 of 6p7uA
6tzvC Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor phenyl-cyclodiaone from mycobacterium tuberculosis
29% identity, 73% coverage: 63:454/538 of query aligns to 1:357/410 of 6tzvC
6prwC Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
29% identity, 73% coverage: 63:454/538 of query aligns to 1:357/410 of 6prwC
>GFF3824 PS417_19580 acetyl-CoA carboxylase
MPVIESLIDTHHAQFAQNREAMLAAIAHLHQLEHTLLAKAQEAKPKFDKRGQLLPRERLA
LLLDPGAPFLELASLAGYKLHDDKDGSAAGGGLIAGIGYVSGVRMLVVANNSAIKGGTIS
PTGLKKSLRLQHIAMENKLPVVTLAESGGANLNYAAEIFVEGARSFANQARMSAMGLPQI
TVVHGSATAGGAYQPGLSDYVVVVRGRAKLFLAGPPLLKAATGEVATDEELGGAEMHAHT
AGTAEYLAENDADGVRIARDIVGLLPWNDHLPMVPNRDYAEPLYPIEELLGLIPDDPKKP
YDVREILARLADGSRFLEFKGEFDAHTVCGHLHIQGHAVGVIGNNGPITPKGATKAAHFI
QLCDQSRTPLLFLHNTTGFMVGTESEQQGVIKHGAKMIQAVANARVPKLTIVVGGSYGAG
NYAMCGRGLDPRFIFAWPNSRTAVMGGAQAGKVLRIVTEAKQLKDGLVPDPKVLDMLEQV
TAQKLDSQSTALYGSANLWDDGLIDPRDTRTLLGFLLDICHEAQVRELQANTFGVARF
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory