Comparing GFF4003 FitnessBrowser__Marino:GFF4003 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P09110 3-ketoacyl-CoA thiolase, peroxisomal; Acetyl-CoA C-myristoyltransferase; Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase; EC 2.3.1.16; EC 2.3.1.155; EC 2.3.1.9 from Homo sapiens (Human) (see 3 papers)
42% identity, 98% coverage: 5:363/365 of query aligns to 68:420/424 of P09110
Sites not aligning to the query:
P42765 3-ketoacyl-CoA thiolase, mitochondrial; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1; EC 2.3.1.16; EC 2.3.1.9; EC 3.1.2.-; EC 3.1.2.1; EC 3.1.2.2 from Homo sapiens (Human) (see paper)
39% identity, 98% coverage: 7:363/365 of query aligns to 38:394/397 of P42765
4c2jD Crystal structure of human mitochondrial 3-ketoacyl-coa thiolase in complex with coa (see paper)
38% identity, 98% coverage: 7:363/365 of query aligns to 41:393/395 of 4c2jD
P07097 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Shinella zoogloeoides (Crabtreella saccharophila) (see 2 papers)
39% identity, 98% coverage: 5:363/365 of query aligns to 34:390/392 of P07097
2vu2A Biosynthetic thiolase from z. Ramigera. Complex with s-pantetheine-11- pivalate. (see paper)
38% identity, 98% coverage: 5:363/365 of query aligns to 31:387/389 of 2vu2A
2vu1A Biosynthetic thiolase from z. Ramigera. Complex of with o-pantheteine- 11-pivalate. (see paper)
38% identity, 98% coverage: 5:363/365 of query aligns to 33:389/391 of 2vu1A
1dm3A Acetylated biosynthetic thiolase from zoogloea ramigera in complex with acetyl-coa (see paper)
38% identity, 98% coverage: 5:363/365 of query aligns to 31:387/389 of 1dm3A
1dlvA Biosynthetic thiolase from zoogloea ramigera in complex with coa (see paper)
38% identity, 98% coverage: 5:363/365 of query aligns to 31:387/389 of 1dlvA
1ou6A Biosynthetic thiolase from zoogloea ramigera in complex with acetyl-o- pantetheine-11-pivalate
38% identity, 98% coverage: 5:363/365 of query aligns to 34:390/392 of 1ou6A
P45359 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; CaTHL; EC 2.3.1.9 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see paper)
38% identity, 98% coverage: 6:363/365 of query aligns to 34:390/392 of P45359
2wkuA Biosynthetic thiolase from z. Ramigera. The n316h mutant. (see paper)
38% identity, 98% coverage: 5:363/365 of query aligns to 31:387/389 of 2wkuA
Sites not aligning to the query:
P14611 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
40% identity, 97% coverage: 5:359/365 of query aligns to 33:387/393 of P14611
1m1oA Crystal structure of biosynthetic thiolase, c89a mutant, complexed with acetoacetyl-coa (see paper)
38% identity, 98% coverage: 5:363/365 of query aligns to 32:388/390 of 1m1oA
4xl4A Crystal structure of thiolase from clostridium acetobutylicum in complex with coa (see paper)
38% identity, 98% coverage: 6:363/365 of query aligns to 34:390/392 of 4xl4A
4o9cC Crystal structure of beta-ketothiolase (phaa) from ralstonia eutropha h16 (see paper)
39% identity, 97% coverage: 5:359/365 of query aligns to 33:387/393 of 4o9cC
2d3tC Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form v (see paper)
38% identity, 99% coverage: 1:363/365 of query aligns to 33:388/390 of 2d3tC
8oqlC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
38% identity, 96% coverage: 15:363/365 of query aligns to 45:395/397 of 8oqlC
Sites not aligning to the query:
8opxC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with trehalose (fragment-b-tre)
38% identity, 96% coverage: 15:363/365 of query aligns to 45:396/398 of 8opxC
8oqmD Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-10
38% identity, 96% coverage: 15:363/365 of query aligns to 46:397/399 of 8oqmD
Sites not aligning to the query:
8opuC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with sulfamethoxazole (fragment-b-e1)
38% identity, 96% coverage: 15:363/365 of query aligns to 45:397/399 of 8opuC
>GFF4003 FitnessBrowser__Marino:GFF4003
MAGHVIKHAVERAGIDPSIVEDVIMGAAYQEGAQGRNIARLAAIRAGLPVTTAGFSINRF
CSSGLQSIALAAQRVVSEKVPAMVAGGVESISLVQNEKINSFHATNEWLMKNKPELYLSM
IETADIVAKRYNVSREAQDEYSLISQQRTAAAQQAGKFDDEIVPFDATMLVKDKETGEVS
EKQVTLKGDECNRPNTTLEGLAGLEPVRGPEQFITAGNASQLSDGASVCTVMNSTYAEKH
NIEPMGIFRGFAVAGCEPDEMGIGPVYAIPRLLERNGLTMDDIDLWELNEAFASQVIYCR
DRLGIPMEKLNVNGGSISIGHPFGVTGARQTGHALIEGKRRGAKYVVITMCIGGGQGAAG
LFEVA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory