SitesBLAST

A9 (= A6) binding
NPFC 39:42 (= NPFC 36:39) binding
C66 (≠ I63) binding
123:134 (vs. 116:127, 83% identical) binding
D128 (= D121) to N: in GA2B; decreased protein stability; dbSNP:rs104894678
T154 (≠ E147) to M: in dbSNP:rs1130426
R164 (= R157) to Q: in GA2B; reduced electron transfer activity; dbSNP:rs104894677
E165 (= E158) mutation E->A,Q: Drastically increases interprotein electron transfer rates.
183:205 (vs. 176:198, 87% identical) Recognition loop
L195 (= L188) mutation to A: Severely impaired in complex formation with ACADM.
K200 (= K193) modified: N6,N6,N6-trimethyllysine; by ETFBKMT; alternate; mutation to R: Does not abolish electron transfer activity. Decreases sensitivity to inhibition by lysine methyltransferase ETFBKMT.
KAK 200:202 (= KAK 193:195) mutation to RAR: Does not abolish methylation by ETFBKMT.
KAKK 200:203 (= KAKK 193:196) mutation to RAKR: Does not abolish electron transfer activity. Abolishes sensitivity to inhibition by lysine methyltransferase ETFBKMT.
K203 (= K196) modified: N6,N6,N6-trimethyllysine; by ETFBKMT; mutation to R: Does not abolish electron transfer activity. Decreases sensitivity to inhibition by lysine methyltransferase ETFBKMT.

Q9DCW4 Electron transfer flavoprotein subunit beta; Beta-ETF from Mus musculus (Mouse) (see paper)
59% identity, 100% coverage: 1:248/249 of query aligns to 4:255/255 of Q9DCW4

query
sites
Q9DCW4

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K200 (= K193) modified: N6,N6,N6-trimethyllysine; by ETFBKMT; alternate
K203 (= K196) modified: N6,N6,N6-trimethyllysine; by ETFBKMT

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylalanine

2a1uB Crystal structure of the human etf e165betaa mutant (see paper)
58% identity, 100% coverage: 1:248/249 of query aligns to 1:252/252 of 2a1uB

query
sites
2a1uB

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binding adenosine monophosphate: A6 (= A6), V7 (= V7), K8 (= K8), N36 (= N36), C39 (= C39), S62 (= S62), C63 (≠ I63), P98 (≠ S94), V101 (= V97), L119 (= L115), G120 (= G116), K121 (= K117), Q122 (= Q118), A123 (= A119), D126 (≠ S122), C128 (≠ N124), N129 (= N125), Q130 (= Q126), T131 (= T127)
binding flavin-adenine dinucleotide: P37 (= P37), F38 (= F38), L182 (= L178)

Q2TBV3 Electron transfer flavoprotein subunit beta; Beta-ETF from Bos taurus (Bovine) (see paper)
57% identity, 100% coverage: 1:248/249 of query aligns to 4:255/255 of Q2TBV3

query
sites
Q2TBV3

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K200 (= K193) modified: N6,N6,N6-trimethyllysine; by ETFBKMT; alternate
K203 (= K196) modified: N6,N6,N6-trimethyllysine; by ETFBKMT

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylalanine

P53570 Electron transfer flavoprotein subunit beta; Beta-ETF; Electron transfer flavoprotein small subunit; ETFSS from Methylophilus methylotrophus (Bacterium W3A1) (see paper)
36% identity, 84% coverage: 1:210/249 of query aligns to 1:216/264 of P53570

query
sites
P53570

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A6 (= A6) binding
NEWD 36:39 (≠ NPFC 36:39) binding
GVQS 119:122 (≠ GKQA 116:119) binding
YAST 127:130 (≠ NNQT 124:127) binding

6fahB Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
31% identity, 98% coverage: 1:243/249 of query aligns to 1:257/262 of 6fahB

query
sites
6fahB

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L

L

N

N

E

D

P

P

R

R

Y

Y

A

M

S

S

L

V

P

G

N

G

I

I

M

M

K

D

A

A

K

Y

K

E

K

Q

P

P

L

I

E

T

-

I

-

W

-

N

-

H

-

E

-

D

-

I

S

G

L

L

T

S

P

P

D

E

A

A

L

C

G

G

V

L

S

N

T

-

A

A

S

S

T

P

N
x
T

K

Q

T
x
V

V

F

K

R

V

S

E

F

A

S

P

P

A

P

A

A

R

K

S

G

A

G

-

G

-

E

-

M

-

I

-

T

G

G

I

T

K

T

V

V

K

N

S

E

V

V

A

A

-

G

E

S

L

L

V

V

E

S

K

K

L

L

K

K

binding flavin-adenine dinucleotide: C6 (≠ A6), A7 (≠ V7), K8 (= K8), D38 (≠ C39), T61 (≠ S62), M62 (≠ I63), A93 (≠ L92), D94 (≠ T93), T95 (≠ S94), T98 (≠ V97), L102 (= L101), A117 (≠ L115), G118 (= G116), Q120 (= Q118), A121 (= A119), G124 (≠ S122), T126 (≠ N124), A127 (≠ N125), Q128 (= Q126), V129 (≠ T127), T223 (≠ N215), V225 (≠ T217)

7koeA Electron bifurcating flavoprotein fix/etfabcx (see paper)
32% identity, 91% coverage: 3:229/249 of query aligns to 4:244/282 of 7koeA

query
sites
7koeA

V

V

L

V

V

V

A
x
C

V
x
I

K
|
K

R

Q

V

V

V

P

D

D

Y

-

N

T

V

T

K

N

V

V

R

R

V

I

K

D

A

R

D

K

N

T

S

N

G

N

V

L

D

V

L

R

A

E

N

G

V

V

K

P

M

S

S

I

M

I

N
|
N

P

P

F

D

C
x
D

E

E

I

R

A

A

V

L

E

E

E

L

A

A

V

S

R

Q

L

L

K

K

E

E

K

K

G

F

V

G

A

A

T

T

E

-

I

V

V

Y

V

V

V

I

S
x
T

I
x
M

G

G

P

P

T

P

T

Q

A

A

Q

K

E

E

Q

A

L

L

R

K

T

D

A

A

L

I

A

A

L

F

G

G

A

L

D

D

R

E

A

A

I

V

L

H

V

L

-

S

-

D

E

R

S

T

A

F

E

A

E

G

L
x
A

T
x
D

S
x
T

L

L

A

A

V
x
T

A

T

K

Y

L

T

L
|
L

K

Y

A

W

V

G

V

I

D

K

K

K

E

I

Q

E

P

E

Q

R

-

I

-

G

-

K

-

I

-

D

L

L

V

I

I

L

L
x
T

G
|
G

K

K

Q
|
Q

A
|
A

I

V

D
|
D

S
x
G

D

D

N
x
T

N
x
G

Q
|
Q

T
x
V

G

G

Q

P

M

G

L

L

A

A

A

T

L

R

T

F

G

G

Y

Y

G

A

Q

L

G

G

T

A

F

Y

A

V

S

V

K

R

V

I

E

E

-

E

-

I

-

D

V

P

N

E

G

K

D

K

S

E

V

M

A

V

V

I

T

V

R

R

E

R

I

L

D

D

G

Q

G

G

A

F

Q

E

T

K

V

I

S

R

L

L

K

K

L

L

P

P

A

A

I

V

V

L

T

T

T

I

D

T

L

D

R

E

L

L

N

N

E

K

P

P

R

R

Y

Y

A

A

S

D

L

L

P

P

N

N

I

L

M

I

K

R

A

A

-

I

K

R

K

Y

K

E

P

P

L

I

-

V

-

W

-

T

-

H

-

K

-

D

E

L

S

G

L

L

T

D

P

P

D

K

A

K

L

C

G

G

V

F

S

F

T

G

A

S

S

P

T

T

N

-

K

R

T
x
V

V

V

K

S

V

T

E

N

A

I

P

P

A

P

A

A

R

R

S

K

A

G

G

G

binding flavin-adenine dinucleotide: C7 (≠ A6), I8 (≠ V7), K9 (= K8), N36 (= N36), D39 (≠ C39), T61 (≠ S62), M62 (≠ I63), A93 (≠ L92), D94 (≠ T93), T95 (≠ S94), T98 (≠ V97), L102 (= L101), T121 (≠ L115), G122 (= G116), Q124 (= Q118), A125 (= A119), D127 (= D121), G128 (≠ S122), T130 (≠ N124), G131 (≠ N125), Q132 (= Q126), V133 (≠ T127), V232 (≠ T217)

1o96A Structure of electron transferring flavoprotein for methylophilus methylotrophus. (see paper)
35% identity, 84% coverage: 1:210/249 of query aligns to 1:215/261 of 1o96A

query
sites
1o96A

M

M

K

K

V

I

L

L

V

V

A
|
A

V
|
V

K
|
K

R

Q

V

T

V

A

-

A

-

L

-

E

D

D

Y

F

N

E

V

I

K

R

V

-

R

-

V

-

K

-

A

-

D

D

N

G

S

M

G

D

V

V

D

D

L

E

A

D

N

F

V

M

K

M

M

Y

S

D

M

L

N
|
N

P

E

F
x
W

C
x
D

E

D

I

F

A

S

V

L

E

E

A

A

V

M

R

K

L

I

K

K

E

E

K

S

G

S

-

D

V

T

A

D

T

V

E

E

I

V

V

V

S
|
S

I
x
V

G

G

P

P

T

D

T

R

A

V

Q

D

E

E

Q

S

L

L

R

R

T

K

A

C

L

L

A

A

L

K

G

G

A

A

D

D

R

R

A

A

I

V

L

R

V

V

-

W

-

D

E

D

S

A

A

A

E

E

E

G

L

S

T

D

S

A

L

I

A

V

V
|
V

A

G

K

R

L

I

L
|
L

K

T

A

E

V

V

V

I

D

K

K

K

E

E

Q

A

P

P

Q

D

L

M

V

V

I

F

L
x
A

G
|
G

K
x
V

Q
|
Q

A
x
S

I

S

D

D

S

Q

D
x
A

N
x
Y

N
x
A

Q
x
S

T
|
T

G

G

Q

I

M

S

L

V

A

A

A

S

L

Y

T

L

G

N

Y

W

G

P

Q

H

G

A

T

A

F

V

A

V

S

A

K

D

V

L

E

Q

V

Y

N

K

-

P

G

G

D

D

S

N

V

K

A

A

V

V

T

I

R

R

-

R

E

E

I

L

D

E

G

G

A

M

-

L

Q

Q

T

E

V

V

S

E

L

I

K

N

L

C

P

P

A

A

I

V

V

L

T

T

T

I

D
x
Q

L

L

R

G

L

I

N

N

E

K

P

P

R

R

Y

Y

A

A

S

S

L

L

P

R

N

G

I

I

M

K

K

Q

A

A

K

A

K

T

K

K

P

P

L

I

E

E

S

E

L

V

T

S

P

L

D

A

A

D

L

I

G

G

V

L

S

S

binding adenosine monophosphate: A6 (= A6), V7 (= V7), K8 (= K8), N35 (= N36), D38 (≠ C39), S62 (= S62), V63 (≠ I63), V99 (= V97), L103 (= L101), A117 (≠ L115), G118 (= G116), V119 (≠ K117), Q120 (= Q118), S121 (≠ A119), A125 (≠ D123), Y126 (≠ N124), A127 (≠ N125), S128 (≠ Q126), T129 (= T127)
binding flavin-adenine dinucleotide: W37 (≠ F38), Q120 (= Q118), Q182 (≠ D177)

4l2iB Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
34% identity, 84% coverage: 1:209/249 of query aligns to 1:209/263 of 4l2iB

query
sites
4l2iB

M

M

K

N

V

I

L

V

V

V

A
x
C

V
|
V

K
|
K

R

Q

V

V

V

P

D

D

Y

-

N

T

V

A

K

E

V

M

R

K

V

I

K

D

A

P

D

V

N

T

S

N

G

N

V

L

D

V

L

R

A

D

N

G

V

V

K

T

M

N

S

I

M

M

N

N

P
|
P

F
x
Y

C
x
D

E

Q

I
x
Y

A

A

V

L

E

E

E

T

A

A

V

L

R

Q

L

L

K

K

E

D

K

E

G

-

V

L

A

G

T

A

E

H

I

V

V

T

V

V

V

I

S
x
T

I
x
M

G
|
G

P
|
P

T

P

T

H

A

A

Q

E

E

S

Q

V

L

L

R

R

T

D

A

C

L

L

A

A

L

V

G

G

A

A

D

D

R

E

A

A

I

K

L

L

V
|
V

E
x
S

S
x
D

-
x
R

-

A

-
x
F

-
x
G

A
|
A

E
x
D

E
x
T

L

L

-

A

T
|
T

S

S

L

A

A

A

V
x
M

A

A

K

N

L

T

L

I

K

K

A

H

V

F

V

-

D

-

K

-

E

G

Q

V

P

P

Q

D

L

L

V

I

I

L

L
x
C

G
|
G

K

R

Q
|
Q

A
|
A

I

I

D

D

S
x
G

D
|
D

N
x
T

N
x
A

Q
|
Q

T
x
V

G

G

Q

P

M

E

L

I

A

A

A

E

L

H

T

L

G

G

Y

L

G

P

Q

Q

G

V

T

T

F

A

A

A

S

L

K

K

V

V

E

Q

V

V

N

K

G

D

D

D

S

T

V

V

A

V

V

V

T

D

R

R

E

D

I

N

D

E

G

Q

G

M

A

S

Q

M

T

T

V

F

S

T

L

M

K

K

L

M

P

P

A

C

I

V

V

V

T

T

T

V

D

-

L

M

R

R

L

S

N

K

E

D

P

L

R

R

Y

F

A

A

S

S

L

I

P

R

N

G

I

K

M

M

K

K

A

A

K

R

K

K

K

A

P

E

L

I

E

P

S

V

L

Y

T

T

P

A

D

A

A

A

L

L

G

E

V

I

binding flavin-adenine dinucleotide: C6 (≠ A6), V7 (= V7), K8 (= K8), P36 (= P37), Y37 (≠ F38), D38 (≠ C39), Y40 (≠ I41), T60 (≠ S62), M61 (≠ I63), A92 (= A89), D93 (≠ E90), T94 (≠ E91), T97 (= T93), M101 (≠ V97), C116 (≠ L115), G117 (= G116), Q119 (= Q118), A120 (= A119), G123 (≠ S122), D124 (= D123), T125 (≠ N124), A126 (≠ N125), Q127 (= Q126), V128 (≠ T127)
binding nicotinamide-adenine-dinucleotide: M61 (≠ I63), G62 (= G64), P63 (= P65), V84 (= V86), S85 (≠ E87), D86 (≠ S88), R87 (vs. gap), F89 (vs. gap), G90 (vs. gap), G91 (vs. gap), A92 (= A89)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 221, 223

4kpuB Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
34% identity, 84% coverage: 1:209/249 of query aligns to 1:209/263 of 4kpuB

query
sites
4kpuB

M

M

K

N

V

I

L

V

V

V

A
x
C

V
|
V

K
|
K

R

Q

V

V

V

P

D

D

Y

-

N

T

V

A

K

E

V

M

R

K

V

I

K

D

A

P

D

V

N

T

S

N

G

N

V

L

D

V

L

R

A

D

N

G

V

V

K

T

M

N

S

I

M

M

N

N

P

P

F
x
Y

C
x
D

E

Q

I
x
Y

A

A

V

L

E

E

E

T

A

A

V

L

R

Q

L

L

K

K

E

D

K

E

G

-

V

L

A

G

T

A

E

H

I

V

V

T

V

V

V

I

S
x
T

I
x
M

G

G

P

P

T

P

T

H

A

A

Q

E

E

S

Q

V

L

L

R

R

T

D

A

C

L

L

A

A

L

V

G

G

A

A

D

D

R

E

A

A

I

K

L

L

V

V

E

S

S

D

-

R

-

A

-

F

-

G

A
|
A

E
x
D

E
x
T

L

L

-

A

T
|
T

S

S

L

A

A

A

V
x
M

A

A

K

N

L

T

L

I

K

K

A

H

V

F

V

-

D

-

K

-

E

G

Q

V

P

P

Q

D

L

L

V

I

I

L

L
x
C

G
|
G

K

R

Q
|
Q

A
|
A

I

I

D

D

S
x
G

D
|
D

N
x
T

N
x
A

Q
|
Q

T
x
V

G

G

Q

P

M

E

L

I

A

A

A

E

L

H

T

L

G

G

Y

L

G

P

Q

Q

G

V

T

T

F

A

A

A

S

L

K

K

V

V

E

Q

V

V

N

K

G

D

D

D

S

T

V

V

A

V

V

V

T

D

R

R

E

D

I

N

D

E

G

Q

G

M

A

S

Q

M

T

T

V

F

S

T

L

M

K

K

L

M

P

P

A

C

I

V

V

V

T

T

T

V

D

-

L

M

R

R

L

S

N

K

E

D

P

L

R

R

Y

F

A

A

S

S

L

I

P

R

N

G

I

K

M

M

K

K

A

A

K

R

K

K

K

A

P

E

L

I

E

P

S

V

L

Y

T

T

P

A

D

A

A

A

L

L

G

E

V

I

binding flavin-adenine dinucleotide: C6 (≠ A6), V7 (= V7), K8 (= K8), Y37 (≠ F38), D38 (≠ C39), Y40 (≠ I41), T60 (≠ S62), M61 (≠ I63), A92 (= A89), D93 (≠ E90), T94 (≠ E91), T97 (= T93), M101 (≠ V97), C116 (≠ L115), G117 (= G116), Q119 (= Q118), A120 (= A119), G123 (≠ S122), D124 (= D123), T125 (≠ N124), A126 (≠ N125), Q127 (= Q126), V128 (≠ T127)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 221, 223

5ol2B The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
32% identity, 78% coverage: 1:194/249 of query aligns to 1:194/260 of 5ol2B

query
sites
5ol2B

M

M

K

N

V

I

L

V

V

V

A
x
C

V
x
I

K
|
K

R

Q

V

V

V

P

D

D

Y

-

N

-

V

-

K

T

V

T

R

E

V

V

K

K

A

L

D

D

-

P

N

N

S

T

G

G

V

T

D

L

L

I

A

R

N

D

-

G

V

V

K

P

M

S

S

I

M

I

N

N

P

P

F

D

C
x
D

E

K

I

A

A

G

V

L

E

E

A

A

V

I

R

K

L

L

K

K

E

E

K

E

G

-

V

M

A

G

T

A

E

H

I

V

V

T

V

V

V

I

S
x
T

I
x
M

G

G

P

P

T

P

T

Q

A

A

Q

D

E

M

Q

A

L

L

R

K

T

E

A

A

L

L

A

A

L

M

G

G

A

A

D

D

R

R

A

G

I

I

L

L

V

L

E

T

-

D

-

R

-

A

-

F

-

A

-

G

S
x
A

A
x
D

E
x
T

E

W

L

A

T
|
T

S

S

L

S

A

A

V
x
L

A

A

K

G

L

A

L

L

K

K

A

N

V

I

V

-

D

-

K

-

E

-

Q

D

P

F

Q

D

L

I

V

I

I

I

L
x
A

G
|
G

K
x
R

Q
|
Q

A
|
A

I

I

D

D

S
x
G

D
|
D

N
x
T

N
x
A

Q
|
Q

T
x
V

G
|
G

Q

P

M

Q

L

I

A

A

A

E

L

H

T

L

G

N

Y

L

G

P

Q

S

G

I

T

T

F

Y

A

A

S

E

K

E

V

I

E

K

V

T

N

E

G

G

D

E

S

Y

V

V

A

L

V

V

T

K

R

R

E

Q

I

F

D

E

G

D

G

C

A

C

Q

H

T

D

V

L

S

K

L

V

K

K

L

M

P

P

A

C

I

L

V

I

T

T

D

L

L

K

R

D

L

M

N

N

E

T

P

P

R

R

Y

Y

A

M

S

K

L

V

P

G

N

R

I

I

M

Y

K

D

A

A

binding flavin-adenine dinucleotide: C6 (≠ A6), I7 (≠ V7), K8 (= K8), D38 (≠ C39), T60 (≠ S62), M61 (≠ I63), A92 (≠ S88), D93 (≠ A89), T94 (≠ E90), T97 (= T93), L101 (≠ V97), A115 (≠ L115), G116 (= G116), R117 (≠ K117), Q118 (= Q118), A119 (= A119), G122 (≠ S122), D123 (= D123), T124 (≠ N124), A125 (≠ N125), Q126 (= Q126), V127 (≠ T127), G128 (= G128)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 222

5ow0B Crystal structure of an electron transfer flavoprotein from geobacter metallireducens (see paper)
29% identity, 81% coverage: 1:202/249 of query aligns to 1:202/251 of 5ow0B

query
sites
5ow0B

M

M

K

Q

V

I

L

V

V

V

A
x
L

V
x
A

K
|
K

R

V

V

V

V

P

D

D

Y
|
Y

N

E

V

V

K

-

V

-

R

-

V

-

K

-

A

-

D

-

N

-

S

P

G

S

V

A

D

D

L

F

A

E

N

L

V

V

K

G

M

N

S

R

M

A

N

H

P

P

-

R

-

Y

-

T

-

R

-

M

-

I

-

G

-
x
L

F
x
Y

C
x
D

E

E

I

N

A

A

V

V

E

E

E

L

A

G

V

V

R

Q

L

L

K

K

E

E

K

K

G

-

V

L

A

G

T

A

E

D

I

L

V

T

V

V

S
|
S

I
x
Y

G

G

P

R

T

N

T

D

A

D

Q

V

E

Q

Q

F

L

L

R

R

T

K

A

A

L

L

A

A

L

M

G

G

A

A

D

D

R

K

A

V

I

V

L

L

V

V

E

E

S

G

A

D

E

S

E

D

L

D

T

P

S

Y

L

V

A
x
I

V

A

A

A

K

N

L
|
L

L

K

K

D

A

A

V

I

V

D

D

R

K

Q

E

G

Q

T

P

V

Q

D

L

L

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I

I

L

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x
A

G
|
G

K

R

Q
|
Q

A
x
S

I
x
S

D

D

S

M

D

D

N
x
R

N
x
G

Q
x
V

T
x
V

G
x
P

Q

G

M

V

L

L

A

A

A

G

L

M

T

L

G

D

Y

L

G

P

Q

F

G

V

T

P

F

Q

A

A

S

C

K

S

V

V

E

E

V

S

N

V

G

D

D

G

S

G

V

W

A

K

V

I

T

S

R

Q

E

I

I

T

D

E

G

T

G

G

A

K

Q

R

T

L

V

L

S

K

L

L

K

S

L

G

P

K

A

G

I

V

V

L

T

S

-

I

T

T

D

S

L

V

R

P

L

E

N

N

E

V

P

P

R

R

Y

I

A

P

S

A

L

V

P

K

N

A

I

I

M

F

K

A

A

A

K

K

P

P

L

V

E

E

S

K

L

L

binding adenosine monophosphate: L6 (≠ A6), A7 (≠ V7), K8 (= K8), D39 (≠ C39), S61 (= S62), Y62 (≠ I63), I95 (≠ A96), L99 (= L100), A114 (≠ L115), G115 (= G116), Q117 (= Q118), S118 (≠ A119), R123 (≠ N124), G124 (≠ N125), V125 (≠ Q126), V126 (≠ T127), P127 (≠ G128)
binding flavin-adenine dinucleotide: Y13 (= Y13), L37 (vs. gap), Y38 (≠ F38), Q117 (= Q118), S119 (≠ I120)

7qh2B Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
26% identity, 79% coverage: 2:198/249 of query aligns to 3:201/265 of 7qh2B

query
sites
7qh2B

K

K

V

I

L

L

V

V

A
x
C

V
x
I

K
|
K

R

Q

V

V

V

P

D

G

Y

T

N

S

V

-

K

N

V

V

R

E

V

V

K

D

A

P

D

E

N

T

S

G

G

V

V

L

D

I

L

R

A

D

N

G

V

V

K

E

M

S

S

K

M

L

N

N

P

P

F

Y

C
x
D

E

L

I

F

A

G

V

L

E

E

E

T

A

A

V

F

R

R

L

L

K

K

E

E

K

Q

G

-

V

L

A

G

T

G

E

T

I

I

V

T

V

L

S
|
S

I
x
M

G

G

P

P

T

M

T

Q

A

S

Q

K

E

E

Q

V

L

L

R

M

T

E

A

S

L

F

A

Y

L

M

G

G

A

A

D

D

R

E

A

G

I

C

L

L

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L

E

S

S

D

A

R

E

K

E

F

-

G

-
x
A

-
x
D

-
x
V

-

V

L

A

T
|
T

S

S

L

Y

A

T

V
x
L

A

A

K

Q

L

G

L

T

K

K

A

R

V

L

V

G

D

D

K

F

E

D

Q

-

P

-

Q

-

L

L

V

I

I

I

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x
C

G
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G

K
|
K

Q
|
Q

A
x
T

I

T

D

D

S
x
G

D
|
D

N
x
T

N
x
A

Q
|
Q

T
x
V

G

G

Q

P

M

E

L

M

A

A

A

E

L

F

T

L

G

G

Y

I

G

P

Q

H

G

V

T

T

F

N

A

V

S

I

K

K

V

I

E

-

V

L

N

A

G

A

D

D

S

E

V

K

A

G

V

L

T

T

R

L

E

Q

-

M

-

N

I

M

D

E

G

E

G

S

A

L

Q

E

T

I

V

Q

S

R

L

V

K

P

L

Y

P

P

A

C

I

L

V

I

T

T

T

V

D

D

L

K

R

D

L

I

N

Y

E

T

P

P

R

R

Y

L

A

P

S

S

L

Y

P

K

N

R

I

K

M

L

K

D

A

I

K

S

K

K

K

N

P

P

binding flavin-adenine dinucleotide: C7 (≠ A6), I8 (≠ V7), K9 (= K8), D39 (≠ C39), S61 (= S62), M62 (≠ I63), A93 (vs. gap), D94 (vs. gap), V95 (vs. gap), T98 (= T93), L102 (≠ V97), C117 (≠ L115), G118 (= G116), K119 (= K117), Q120 (= Q118), T121 (≠ A119), G124 (≠ S122), D125 (= D123), T126 (≠ N124), A127 (≠ N125), Q128 (= Q126), V129 (≠ T127)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 226

Query Sequence

>GFF4158 FitnessBrowser__WCS417:GFF4158
MKVLVAVKRVVDYNVKVRVKADNSGVDLANVKMSMNPFCEIAVEEAVRLKEKGVATEIVV
VSIGPTTAQEQLRTALALGADRAILVESAEELTSLAVAKLLKAVVDKEQPQLVILGKQAI
DSDNNQTGQMLAALTGYGQGTFASKVEVNGDSVAVTREIDGGAQTVSLKLPAIVTTDLRL
NEPRYASLPNIMKAKKKPLESLTPDALGVSTASTNKTVKVEAPAARSAGIKVKSVAELVE
KLKNEAKVI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory