SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing GFF4212 FitnessBrowser__psRCH2:GFF4212 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5ti8B Crystal structure of an aspartate aminotransferase from pseu (see paper)
77% identity, 93% coverage: 33:451/452 of query aligns to 1:384/384 of 5ti8B

query
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5ti8B

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active site: E167 (= E225), D200 (= D258), I203 (= I261), K229 (= K287), T254 (= T320), I353 (= I420)
binding calcium ion: A71 (= A103), N79 (= N111)

6gwiB The crystal structure of halomonas elongata amino-transferase (see paper)
68% identity, 98% coverage: 5:448/452 of query aligns to 2:447/450 of 6gwiB

query
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6gwiB

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active site: F18 (= F21), Y149 (= Y152), D255 (= D258), K284 (= K287)
binding pyridoxal-5'-phosphate: S115 (= S118), G116 (= G119), S117 (= S120), N120 (= N123), Y149 (= Y152), H150 (= H153), G151 (= G154), E222 (= E225), D255 (= D258), V257 (= V260), I258 (= I261), K284 (= K287), F317 (= F319), T318 (= T320)

7qx0B Aminotransferase TR2 (see paper)
67% identity, 98% coverage: 5:448/452 of query aligns to 1:440/443 of 7qx0B

query
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7qx0B

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V

R

K

N

N

G

G

L

L

V

V

M

M

R

R

A

A

V

V

G

G

D

G

T

T

M

M

I

I

I

I

S

S

P

P

P

P

L

L

V

V

I

L

S

S

E

R

E

E

Q

Q

I

V

D

D

E

E

L

L

I

I

G

D

K

K

V

A

R

R

L

R

C

T

L

L

D

D

A

E

T

T

A

H

K

K

binding pyridoxal-5'-phosphate: S114 (= S118), G115 (= G119), S116 (= S120), Y148 (= Y152), H149 (= H153), G150 (= G154), E221 (= E225), D254 (= D258), V256 (= V260), I257 (= I261), K283 (= K287)

7qx3A Aminotransferase TR2 (see paper)
68% identity, 92% coverage: 32:448/452 of query aligns to 1:419/422 of 7qx3A

query
sites
7qx3A

T

S

R

R

I

I

I

I

T

T

K

R

A

A

S

E

G

G

V

C

Y

Y

L

L

W

W

D

D

S

S

E

D

G

G

H

N

K

Q

I

I

L

L

D

D

A

G

M

M

A

A

G

G

L
|
L

W
|
W

C

C

V

V

N

N

L

I

G

G

Y

Y

G

G

R

R

E

K

E

E

L

L

V

A

E

E

A

V

A

A

T

Y

R

R

Q

Q

M

M

R

Q

E

E

L

L

P

P

Y

Y

Y

Y

N

N

L

N

F

F

F

F

Q

Q

T

C

A

S

H

H

P

P

P

P

A

A

V

I

A

E

L

L

A

S

K

R

A

L

I

L

A

S

D

E

I

V

A

T

P

P

A

K

G

H

M

M

N

N

H

H

V

V

F

F

F

F

T

T

G

G

S

S

G

G

S

S

E

D

A

S

N

N

D

D

T

T

V

I

L

L

R

R

M

M

V

V

R

R

H

Y

Y

Y

W

W

A

K

I

L

K

L

G

G

Q

K

P

P

A

Y

K

K

K

K

V

V

V

V

I

I

G

S

R

R

W

E

N

N

G

A

Y
|
Y

H

H

G

G

S

S

T

T

I

V

A

A

G

G

A

A

S

S

L

L

G

S

G

G

M

M

K

K

A

A

M

M

H

H

E

S

Q

H

S

G

D

D

G

L

P

P

I

I

P

P

G

G

I

I

E

E

H

H

I

I

D

E

Q

Q

P

P

Y

Y

W

H

F

F

G

G

E

R

G

A

G

P

D

D

M

M

S

D

P

P

E

A

E

E

F

F

G

G

V

R

R

Q

I

A

A

A

D

Q

Q

A

L

L

E

E

Q

R

K

K

I

I

L

D

E

E

V

I

G

G

E

E

D

C

K

N

V

V

A

A

A

A

F

F

I

I

A

A

E

E

P

P

I

I

Q

Q

G

G

A
|
A

G

G

G

G

V

V

I

I

I

I

P

P

P

P

E

D

T

S

Y

Y

W

W

P

P

R

E

I

I

K

K

E

R

I

I

L

C

A

A

R

E

Y

R

D

D

I

I

L

L

F

L

I

I

A

V

D

D

E

E

V

V

I
|
I

C

T

G

G

F

F

G

G

R

R

T

L

G

G

E

T

W

W

F

F

G

G

S

S

D

Q

Y

Y

Y

Y

G

D

L

L

E

Q

P

P

D

D

L

L

M

M

P

P

I

I

A

A

K
|
K

G

G

L

L

T

S

S

S

G

G

Y

Y

I

M

P

P

M

I

G

G

G

G

V

V

I

M

V

V

R

S

D

D

E

R

V

V

V

A

Q

K

-

V

T

V

L

I

N

E

E

E

G

G

G

G

E

E

F

F

Y

F

H

H

G

G

F

Y

T

T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

A

A

A

A

A

V

V

A

A

L

A

E

E

N

N

I

I

R

R

I

I

L

M

R

R

E

D

E

E

K

G

I

I

V

I

E

E

R

R

V

A

K

G

T

A

K

E

T

I

A

A

P

P

Y

Y

L

L

Q

Q

S

A

R

R

W

W

Q

R

E

E

L

L

L

G

D

E

H

H

P

P

L

L

V

V

G

G

E

E

A

A

R

R

G

G

V

V

G

G

L

M

L

V

G

A

A

A

L

L

E

E

L

L

V

V

K

K

N

S

K

K

K

Q

T

P

R

L

E

E

R

R

F

F

A

E

D

E

P

P

G

G

-

K

V

V

G

G

M

S

L

L

C

C

R

R

E

D

H

L

C

S

F

V

R

K

N

N

G

G

L

L

V

V

M

M

R
|
R

A

A

V

V

G

G

D

G

T

T

M

M

I

I

I

I

S

S

P

P

P

P

L

L

V

V

I

L

S

S

E

R

E

E

Q

Q

I

V

D

D

E

E

L

L

I

I

G

D

K

K

V

A

R

R

L

R

C

T

L

L

D

D

A

E

T

T

A

H

K

K

binding 2-azanylethyl hydrogen sulfate: L27 (= L58), W28 (= W59), Y121 (= Y152), A199 (= A230), I230 (= I261), K256 (= K287), R384 (= R413)

6s4gA Crystal structure of the omega transaminase from chromobacterium violaceum in complex with pmp (see paper)
59% identity, 97% coverage: 6:444/452 of query aligns to 2:442/453 of 6s4gA

query
sites
6s4gA

T

T

L

S

H

Q

W

W

Q

R

A

E

L

L

S

D

R

A

D

A

H

H

H

H

L

L

P

H

P

P

F
|
F

T

T

D

D

Y

T

K

A

A

S

L

L

N

N

A

Q

K

A

G

G

T

A

R

R

I

V

I

M

T

T

K

R

A

G

S

E

G

G

V

V

Y

Y

L

L

W

W

D

D

S

S

E

E

G

G

H

N

K

K

I

I

L

I

D

D

A

G

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

E

K

E

D

L

F

V

A

E

E

A

A

A

A

T

R

R

R

Q

Q

M

M

R

E

E

E

L

L

P

P

Y

F

Y

Y

N

N

L

T

F

F

F

F

Q

K

T

T

A

T

H

H

P

P

P

A

A

V

V

V

A

E

L

L

A

S

K

S

A

L

I

L

A

A

D

E

I

V

A

T

P

P

A

A

G

G

M

F

N

D

H

R

V

V

F

F

F

Y

T

T

G

N

S
|
S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

V

M

L

I

R

R

M

M

V

V

R

R

H

R

Y

Y

W

W

A

D

I

V

K

Q

G

G

Q

K

P

P

A

E

K

K

K

K

V

T

V

L

I

I

G

G

R

R

W

W

N

N

G

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

I

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

K

K

A

Y

M

M

H

H

E

E

Q

Q

S

G

D

D

G

L

P

P

I

I

P

P

G

G

I

M

E

A

H

H

I

I

D

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

G

K

D

D

M

M

S

T

P

P

E

D

E

E

F

F

G

G

V

V

R

V

I

A

A

A

D

R

Q

W

L

L

E

E

Q

E

K

K

I

I

L

L

E

E

V

I

G

G

E

A

D

D

K

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

I

I

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

E

A

T

T

Y

Y

W

W

P

P

R

E

I

I

K

E

E

R

I

I

L

C

A

R

R

K

Y

Y

D

D

I

V

L

L

F

L

I

V

A

A

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

T

T

G

G

E

E

W

W

F

F

G

G

S

H

D

Q

Y

H

Y

F

G

G

L

F

E

Q

P

P

D

D

L

L

M

F

P

T

I

A

A

A

K
|
K

G

G

L

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

G

G

A

V

V

I

F

V

V

R

G

D

K

E

R

V

V

V

A

Q

E

T

G

L

L

N

I

E

A

G

G

G

G

E

D

F

F

Y

N

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

C

A

A

A

A

V

V

A

A

L

H

E

A

N

N

I

V

R

A

I

A

L

L

R

R

E

D

E

E

K

G

I

I

V

V

E

Q

R

R

V

V

K

K

T

D

K

D

T

I

A

G

P

P

Y

Y

L

M

Q

Q

S

K

R

R

W

W

Q

R

E

E

L

T

L

F

D

S

H

R

-

F

P

E

L

H

V

V

G

D

E

D

A

V

R

R

G

G

V

V

G

G

L

M

L

V

G

Q

A

A

L

F

E

T

L

L

V

V

K

K

N

N

K

K

K

A

T

K

R

R

E

E

R

L

F

F

A

P

D

D

P

F

G

G

-

E

V

I

G

G

M

T

L

L

C

C

R

R

E

D

H

I

C

F

F

F

R

R

N

N

G

N

L

L

V

I

M

M

R

R

A

A

V

C

G

G

D

D

T

H

M

I

I

V

I

S

S

A

P

P

P

P

L

L

V

V

I

M

S

T

E

R

E

A

Q

E

I

V

D

D

E

E

L

M

I

L

G

A

K

V

V

A

R

E

L

R

C

C

L

L

D

E

active site: F17 (= F21), Y148 (= Y152), D254 (= D258), K283 (= K287)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: S114 (= S118), G115 (= G119), S116 (= S120), Y148 (= Y152), H149 (= H153), G150 (= G154), E221 (= E225), D254 (= D258), V256 (= V260), I257 (= I261), K283 (= K287), F315 (= F319), T316 (= T320)

7q9xAAA Probable aminotransferase
59% identity, 97% coverage: 6:444/452 of query aligns to 3:443/455 of 7q9xAAA

query
sites
7q9xAAA

T

T

L

S

H

Q

W

W

Q

R

A

E

L

L

S

D

R

A

D

A

H

H

H

H

L

L

P

H

P

P

F

F

T

T

D

D

Y

T

K

A

A

S

L

L

N

N

A

Q

K

A

G

G

T

A

R

R

I

V

I

M

T

T

K

R

A

G

S

E

G

G

V

V

Y

Y

L

L

W

W

D

D

S

S

E

E

G

G

H

N

K

K

I

I

L

I

D

D

A

G

M

M

A

A

G

G

L
|
L

W
|
W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

E

K

E

D

L

F

V

A

E

E

A

A

A

A

T

R

R

R

Q

Q

M

M

R

E

E

E

L

L

P

P

Y

F

Y

Y

N

N

L

T

F
|
F

F

F

Q

K

T

T

A

T

H

H

P

P

P

A

A

V

V

V

A

E

L

L

A

S

K

S

A

L

I

L

A

A

D

E

I

V

A

T

P

P

A

A

G

G

M

F

N

D

H

R

V

V

F

F

F

Y

T

T

G

N

S
|
S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

V

M

L

I

R

R

M

M

V

V

R

R

H

R

Y

Y

W

W

A

D

I

V

K

Q

G

G

Q

K

P

P

A

E

K

K

K

K

V

T

V

L

I

I

G

G

R

R

W

W

N

N

G

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

I

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

K

K

A

Y

M

M

H

H

E

E

Q

Q

S

G

D

D

G

L

P

P

I

I

P

P

G

G

I

M

E

A

H

H

I

I

D

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

G

K

D

D

M

M

S

T

P

P

E

D

E

E

F

F

G

G

V

V

R

V

I

A

A

A

D

R

Q

W

L

L

E

E

Q

E

K

K

I

I

L

L

E

E

V

I

G

G

E

A

D

D

K

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

I

I

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

E

A

T

T

Y

Y

W

W

P

P

R

E

I

I

K

E

E

R

I

I

L

C

A

R

R

K

Y

Y

D

D

I

V

L

L

F

L

I

V

A

A

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

T

T

G

G

E

E

W

W

F

F

G

G

S

H

D

Q

Y

H

Y

F

G

G

L

F

E

Q

P

P

D

D

L

L

M

F

P

T

I

A

A

A

K
|
K

G

G

L

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

G

G

A

V

V

I

F

V

V

R

G

D

K

E

R

V

V

V

A

Q

E

T

G

L

L

N

I

E

A

G

G

G

G

E

D

F

F

Y

N

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

C

A

A

A

A

V

V

A

A

L

H

E

A

N

N

I

V

R

A

I

A

L

L

R

R

E

D

E

E

K

G

I

I

V

V

E

Q

R

R

V

V

K

K

T

D

K

D

T

I

A

G

P

P

Y

Y

L

M

Q

Q

S

K

R

R

W

W

Q

R

E

E

L

T

L

F

D

S

H

R

-

F

P

E

L

H

V

V

G

D

E

D

A

V

R

R

G

G

V

V

G

G

L

M

L

V

G

Q

A

A

L

F

E

T

L

L

V

V

K

K

N

N

K

K

K

A

T

K

R

R

E

E

R

L

F

F

A

P

D

D

P

F

G

G

-

E

V

I

G

G

M

T

L

L

C

C

R

R

E

D

H

I

C

F

F

F

R

R

N

N

G

N

L

L

V

I

M

M

R
|
R

A

A

V

C

G

G

D

D

T

H

M

I

I

V

I

S

S

A

P

P

P

P

L

L

V

V

I

M

S

T

E

R

E

A

Q

E

I

V

D

D

E

E

L

M

I

L

G

A

K

V

V

A

R

E

L

R

C

C

L

L

D

E

binding (3E)-4-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}-2-oxobut-3-enoic acid: L55 (= L58), W56 (= W59), F84 (= F87), S115 (= S118), G116 (= G119), S117 (= S120), Y149 (= Y152), H150 (= H153), G151 (= G154), E222 (= E225), D255 (= D258), V257 (= V260), I258 (= I261), K284 (= K287), F316 (= F319), T317 (= T320), R412 (= R413)
binding pyridoxal-5'-phosphate: F316 (= F319), T317 (= T320)

4a6tC Crystal structure of the omega transaminase from chromobacterium violaceum in complex with plp (see paper)
59% identity, 97% coverage: 6:444/452 of query aligns to 3:443/455 of 4a6tC

query
sites
4a6tC

T

T

L

S

H

Q

W

W

Q

R

A

E

L

L

S

D

R

A

D

A

H

H

H

H

L

L

P

H

P

P

F
|
F

T

T

D

D

Y

T

K

A

A

S

L

L

N

N

A

Q

K

A

G

G

T

A

R

R

I

V

I

M

T

T

K

R

A

G

S

E

G

G

V

V

Y

Y

L

L

W

W

D

D

S

S

E

E

G

G

H

N

K

K

I

I

L

I

D

D

A

G

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

E

K

E

D

L

F

V

A

E

E

A

A

A

A

T

R

R

R

Q

Q

M

M

R

E

E

E

L

L

P

P

Y

F

Y

Y

N

N

L

T

F

F

F

F

Q

K

T

T

A

T

H

H

P

P

P

A

A

V

V

V

A

E

L

L

A

S

K

S

A

L

I

L

A

A

D

E

I

V

A

T

P

P

A

A

G

G

M

F

N

D

H

R

V

V

F

F

F

Y

T

T

G

N

S
|
S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

V

M

L

I

R

R

M

M

V

V

R

R

H

R

Y

Y

W

W

A

D

I

V

K

Q

G

G

Q

K

P

P

A

E

K

K

K

K

V

T

V

L

I

I

G

G

R

R

W

W

N

N

G

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

I

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

K

K

A

Y

M

M

H

H

E

E

Q

Q

S

G

D

D

G

L

P

P

I

I

P

P

G

G

I

M

E

A

H

H

I

I

D

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

G

K

D

D

M

M

S

T

P

P

E

D

E

E

F

F

G

G

V

V

R

V

I

A

A

A

D

R

Q

W

L

L

E

E

Q

E

K

K

I

I

L

L

E

E

V

I

G

G

E

A

D

D

K

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

I

I

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

E

A

T

T

Y

Y

W

W

P

P

R

E

I

I

K

E

E

R

I

I

L

C

A

R

R

K

Y

Y

D

D

I

V

L

L

F

L

I

V

A

A

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

T

T

G

G

E

E

W

W

F

F

G

G

S

H

D

Q

Y

H

Y

F

G

G

L

F

E

Q

P

P

D

D

L

L

M

F

P

T

I

A

A

A

K
|
K

G

G

L

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

G

G

A

V

V

I

F

V

V

R

G

D

K

E

R

V

V

V

A

Q

E

T

G

L

L

N

I

E

A

G

G

G

G

E

D

F

F

Y

N

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

C

A

A

A

A

V

V

A

A

L

H

E

A

N

N

I

V

R

A

I

A

L

L

R

R

E

D

E

E

K

G

I

I

V

V

E

Q

R

R

V

V

K

K

T

D

K

D

T

I

A

G

P

P

Y

Y

L

M

Q

Q

S

K

R

R

W

W

Q

R

E

E

L

T

L

F

D

S

H

R

-

F

P

E

L

H

V

V

G

D

E

D

A

V

R

R

G

G

V

V

G

G

L

M

L

V

G

Q

A

A

L

F

E

T

L

L

V

V

K

K

N

N

K

K

K

A

T

K

R

R

E

E

R

L

F

F

A

P

D

D

P

F

G

G

-

E

V

I

G

G

M

T

L

L

C

C

R

R

E

D

H

I

C

F

F

F

R

R

N

N

G

N

L

L

V

I

M

M

R

R

A

A

V

C

G

G

D

D

T

H

M

I

I
x
V

I

S

S

A

P

P

P

P

L

L

V

V

I

M

S

T

E

R

E

A

Q

E

I

V

D

D

E

E

L

M

I

L

G

A

K

V

V

A

R

E

L

R

C

C

L

L

D

E

active site: F18 (= F21), Y149 (= Y152), E222 (= E225), D255 (= D258), I258 (= I261), K284 (= K287), V419 (≠ I420)
binding pyridoxal-5'-phosphate: S115 (= S118), G116 (= G119), S117 (= S120), Y149 (= Y152), H150 (= H153), G151 (= G154), E222 (= E225), D255 (= D258), V257 (= V260), I258 (= I261), K284 (= K287), F316 (= F319), T317 (= T320)

4ba5A Crystal structure of omega-transaminase from chromobacterium violaceum (see paper)
59% identity, 91% coverage: 33:444/452 of query aligns to 2:415/427 of 4ba5A

query
sites
4ba5A

R

R

I

V

I

M

T

T

K

R

A

G

S

E

G

G

V

V

Y

Y

L

L

W

W

D

D

S

S

E

E

G

G

H

N

K

K

I

I

L

I

D

D

A

G

M

M

A

A

G

G

L
|
L

W
|
W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

E

K

E

D

L

F

V

A

E

E

A

A

A

A

T

R

R

R

Q

Q

M

M

R

E

E

E

L

L

P

P

Y

F

Y

Y

N

N

L

T

F

F

F

F

Q

K

T

T

A

T

H

H

P

P

P

A

A

V

V

V

A

E

L

L

A

S

K

S

A

L

I

L

A

A

D

E

I

V

A

T

P

P

A

A

G

G

M

F

N

D

H

R

V

V

F

F

F

Y

T

T

G

N

S
|
S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

V

M

L

I

R

R

M

M

V

V

R

R

H

R

Y

Y

W

W

A

D

I

V

K

Q

G

G

Q

K

P

P

A

E

K

K

K

K

V

T

V

L

I

I

G

G

R

R

W

W

N

N

G

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

I

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

K

K

A

Y

M

M

H

H

E

E

Q

Q

S

G

D

D

G

L

P

P

I

I

P

P

G

G

I

M

E

A

H

H

I

I

D

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

G

K

D

D

M

M

S

T

P

P

E

D

E

E

F

F

G

G

V

V

R

V

I

A

A

A

D

R

Q

W

L

L

E

E

Q

E

K

K

I

I

L

L

E

E

V

I

G

G

E

A

D

D

K

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

I

I

Q

Q

G

G

A
|
A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

E

A

T

T

Y

Y

W

W

P

P

R

E

I

I

K

E

E

R

I

I

L

C

A

R

R

K

Y

Y

D

D

I

V

L

L

F

L

I

V

A

A

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

T

T

G

G

E

E

W

W

F

F

G

G

S

H

D

Q

Y

H

Y

F

G

G

L

F

E

Q

P

P

D

D

L

L

M

F

P

T

I

A

A

A

K
|
K

G

G

L

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

G

G

A

V

V

I

F

V

V

R

G

D

K

E

R

V

V

V

A

Q

E

T

G

L

L

N

I

E

A

G

G

G

G

E

D

F

F

Y

N

H

H

G

G

F

F

T

T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

C

A

A

A

A

V

V

A

A

L

H

E

A

N

N

I

V

R

A

I

A

L

L

R

R

E

D

E

E

K

G

I

I

V

V

E

Q

R

R

V

V

K

K

T

D

K

D

T

I

A

G

P

P

Y

Y

L

M

Q

Q

S

K

R

R

W

W

Q

R

E

E

L

T

L

F

D

S

H

R

-

F

P

E

L

H

V

V

G

D

E

D

A

V

R

R

G

G

V

V

G

G

L

M

L

V

G

Q

A

A

L

F

E

T

L

L

V

V

K

K

N

N

K

K

K

A

T

K

R

R

E

E

R

L

F

F

A

P

D

D

P

F

G

G

-

E

V

I

G

G

M

T

L

L

C

C

R

R

E

D

H

I

C

F

F

F

R

R

N

N

G

N

L

L

V

I

M

M

R
|
R

A

A

V

C

G

G

D

D

T

H

M

I

I
x
V

I

S

S

A

P

P

P

P

L

L

V

V

I

M

S

T

E

R

E

A

Q

E

I

V

D

D

E

E

L

M

I

L

G

A

K

V

V

A

R

E

L

R

C

C

L

L

D

E

active site: Y121 (= Y152), E194 (= E225), D227 (= D258), I230 (= I261), K256 (= K287), V391 (≠ I420)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: L27 (= L58), W28 (= W59), S87 (= S118), G88 (= G119), S89 (= S120), Y121 (= Y152), H122 (= H153), G123 (= G154), E194 (= E225), A199 (= A230), D227 (= D258), V229 (= V260), I230 (= I261), R384 (= R413)

7ypmA Crystal structure of transaminase cc1012 complexed with plp and l- alanine (see paper)
57% identity, 96% coverage: 12:444/452 of query aligns to 9:445/454 of 7ypmA

query
sites
7ypmA

L

L

S

D

R

L

D

A

H

H

H

H

L

L

P

P

P

A

F

Q

T

A

D

D

Y

H

K

K

A

V

L

I

N

A

A

E

K

Q

G

G

-

G

T

S

R

R

I

I

I

I

T

T

K

R

A

A

S

E

G

G

V

V

Y

Y

L

I

W

H

D

D

S

G

E

E

G

G

H

H

K

Q

I

I

L

L

D

D

A

G

M

M

A

A

G

G

L

L

W
|
W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

E

E

E

E

L

L

V

A

E

K

A

A

A

A

T

Y

R

D

Q

Q

M

M

R

L

E

E

L

L

P

P

Y

Y

Y

Y

N

N

L

T

F

F

F

F

Q

K

T

T

A

A

H

T

P

P

P

P

A

P

V

I

A

E

L

L

A

A

K

A

A

K

I

I

A

A

D

Q

I

K

A

M

P

G

A

G

G

H

M

L

N

S

H

H

V

V

F

F

F

Y

T

N

G

S

S
|
S

G
|
G

S
|
S

E

E

A

A

N
|
N

D

D

T

T

V

V

L

F

R

R

M

L

V

V

R

R

H

H

Y

F

W

W

A

K

I

L

K

K

G

G

Q

E

P

P

A

S

K

R

K

T

V

V

V

F

I

I

G

S

R

R

W

W

N

N

G

A

Y
|
Y

H
|
H

G
|
G

S

S

T

T

I

V

A

A

G

G

A

V

S

S

L

L

G

G

G

G

M

M

K

K

A

H

M

M

H

H

E

K

Q

Q

S

G

D

D

G

L

P

P

I

I

P

A

G

G

I

V

E

E

H

H

I

V

D

M

Q

Q

P

P

Y

Y

W

Q

F

F

G

G

E

D

G

G

G

F

D

G

M

E

S

D

P

P

E

A

E

A

F

F

G

R

V

D

R

R

I

A

A

V

D

Q

Q

A

L

I

E

E

Q

D

K

K

I

I

L

L

E

E

V

V

G

G

E

P

D

E

K

N

V

V

A

A

A

A

F

F

I

I

A

G

E
|
E

P

P

I

V

Q

Q

G

G

A
|
A

G

G

G

G

V

V

I

I

I

I

P

P

P

P

E

D

T

G

Y

Y

W

W

P

P

R

A

I

V

K

E

E

A

I

L

L

C

A

R

R

K

Y

Y

D

G

I

I

L

L

F

L

I

V

A

C

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

T

L

G

G

E

Q

W

W

F

F

G

G

S

H

D

Q

Y

H

Y

Y

G

G

L

I

E

K

P

P

D

D

L

L

M

I

P

A

I

M

A

A

K
|
K

G

G

L

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

S

G

A

V

V

I

G

V

V

R

A

D

D

E

H

V

I

V

V

Q

A

T

E

L

L

N

R

E

E

-

K

G

G

G

G

E

D

F

F

Y

I

H

H

G

G

F

F

T

T

Y

Y

S

S

G

G

H

H

P

P

V

T

A

A

A

A

A

A

V

V

A

A

L

L

E

K

N

N

I

I

R

E

I

I

L

M

R

E

E

R

E

E

K

G

I

L

V

V

E

E

R

R

V

T

K

R

T

D

K

E

T

T

A

G

P

P

Y

Y

L

L

Q

A

S

Q

R

A

W

L

Q

A

E

S

L

L

L

N

D

D

H

H

P

P

L

L

V

V

G

G

E

E

A

V

R

R

G

S

V

L

G

G

L

L

L

I

G

G

A

A

L

V

E

E

L

I

V

V

K

R

N

E

K

K

K

G

T

T

R

N

E

H

R

R

F

F

A

L

D

D

P

K

-

E

-

G

G

E

V

A

G

G

M

P

L

I

C

V

R

R

E

D

H

L

C

C

F

I

R

K

N

N

G

G

L

L

V

M

M

V

R

R

A

A

V

I

G

R

D

D

T

S

M

I

I

V

I

C

S

C

P

P

P

P

L

L

V

I

I

I

S

T

E

K

E

A

Q

Q

I

I

D

D

E

E

L

L

I

V

G

G

K

I

V

I

R

R

L

K

C

S

L

L

D

D

binding alanine: W57 (= W59), Y150 (= Y152), A228 (= A230), K285 (= K287)
binding pyridoxal-5'-phosphate: S116 (= S118), G117 (= G119), S118 (= S120), N121 (= N123), Y150 (= Y152), H151 (= H153), G152 (= G154), E223 (= E225), D256 (= D258), V258 (= V260), I259 (= I261), K285 (= K287)

7ypnD Crystal structure of transaminase cc1012 mutant m9 complexed with plp (see paper)
56% identity, 96% coverage: 12:444/452 of query aligns to 9:445/455 of 7ypnD

query
sites
7ypnD

L

L

S

D

R

L

D

A

H

H

H

H

L

L

P

P

P

A

F

F

T

A

D

D

Y

H

K

K

A

V

L

I

N

A

A

E

K

Q

G

G

-

G

T

S

R

R

I

I

I

I

T

T

K

R

A

A

S

E

G

G

V

V

Y

Y

L

I

W

H

D

D

S

G

E

E

G

G

H

H

K

Q

I

I

L

L

D

D

A

G

M

W

A

A

G

G

L

L

W

F

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

E

E

E

E

L

L

V

A

E

K

A

A

A

A

T

Y

R

D

Q

Q

M

M

R

L

E

E

L

L

P

P

Y

Y

Y

Y

N

N

L

T

F

F

F

F

Q

K

T

T

A

A

H

T

P

P

P

P

A

P

V

I

A

E

L

L

A

A

K

A

A

K

I

I

A

A

D

Q

I

K

A

M

P

G

A

G

G

H

M

L

N

S

H

H

V

V

F

F

F

Y

T

N

G

S

S
|
S

G
|
G

S
|
S

E

E

A

A

N
|
N

D

D

T

T

V

V

L

F

R

R

M

L

V

V

R

R

H

H

Y

F

W

W

A

K

I

L

K

K

G

G

Q

E

P

P

A

S

K

R

K

T

V

V

V

F

I

I

G

S

R

R

W

W

N

N

G

A

Y
|
Y

H
|
H

G
|
G

S

S

T

T

I

V

A

A

G

G

A

V

S

S

L

L

G

G

G

G

M

M

K

K

A

H

M

M

H

H

E

K

Q

Q

S

G

D

D

G

L

P

P

I

I

P

A

G

G

I

V

E

E

H

H

I

V

D

M

Q

Q

P

P

Y

Y

W

Q

F

F

G

G

E

D

G

G

G

F

D

G

M

E

S

D

P

P

E

A

E

A

F

F

G

R

V

D

R

R

I

A

A

V

D

Q

Q

A

L

I

E

E

Q

D

K

K

I

I

L

L

E

E

V

V

G

G

E

P

D

E

K

N

V

V

A

A

A

A

F

F

I

I

A

G

E
|
E

P

P

I

V

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

I

P

P

P

P

E

D

T

G

Y

Y

W

W

P

P

R

A

I

V

K

E

E

A

I

L

L

C

A

R

R

K

Y

Y

D

G

I

I

L

L

F

L

I

V

A

C

D
|
D

E

E

V
|
V

I
x
A

C

C

G

G

F

F

G

G

R

R

T

L

G

G

E

Q

W

W

F

F

G

G

S

H

D

Q

Y

H

Y

Y

G

G

L

I

E

K

P

P

D

D

L

L

M

I

P

A

I

M

A

A

K
|
K

G

G

L

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

S

G

A

V

V

I

G

V

V

R

A

D

D

E

H

V

I

V

V

Q

A

T

E

L

L

N

R

E

E

-

K

G

G

G

G

E

D

F

F

Y

I

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

T

A

A

A

A

A

A

V

V

A

A

L

L

E

K

N

N

I

I

R

E

I

I

L

M

R

E

E

R

E

E

K

G

I

L

V

V

E

E

R

R

V

T

K

R

T

D

K

E

T

T

A

G

P

P

Y

Y

L

L

Q

A

S

Q

R

A

W

L

Q

A

E

S

L

L

L

N

D

D

H

H

P

P

L

L

V

V

G

G

E

E

A

V

R

R

G

S

V

L

G

G

L

L

L

I

G

G

A

A

L

V

E

E

L

I

V

V

K

R

N

E

K

K

K

G

T

T

R

N

E

H

R

R

F

F

A

L

D

D

P

K

-

E

-

G

G

E

V

A

G

G

M

P

L

I

C

V

R

R

E

D

H

L

C

C

F

I

R

K

N

N

G

G

L

L

V

M

M

V

R

R

A

A

V

I

G

R

D

D

T

S

M

I

I

V

I

C

S

C

P

P

P

P

L

L

V

I

I

I

S

T

E

K

E

A

Q

Q

I

I

D

D

E

E

L

L

I

V

G

G

K

I

V

I

R

R

L

K

C

S

L

L

D

D

binding pyridoxal-5'-phosphate: S116 (= S118), G117 (= G119), S118 (= S120), N121 (= N123), Y150 (= Y152), H151 (= H153), G152 (= G154), E223 (= E225), D256 (= D258), V258 (= V260), A259 (≠ I261), K285 (= K287), F318 (= F319), T319 (= T320)

4a6rA Crystal structure of the omega transaminase from chromobacterium violaceum in the apo form, crystallised from polyacrylic acid (see paper)
59% identity, 91% coverage: 33:444/452 of query aligns to 1:411/423 of 4a6rA

query
sites
4a6rA

R

R

I

V

I

M

T

T

K

R

A

G

S

E

G

G

V

V

Y

Y

L

L

W

W

D

D

S

S

E

E

G

G

H

N

K

K

I

I

L

I

D

D

A

G

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

E

K

E

D

L

F

V

A

E

E

A

A

A

A

T

R

R

R

Q

Q

M

M

R

E

E

E

L

L

P

P

Y

F

Y

Y

N

N

L

T

F

F

F

F

Q

K

T

T

A

T

H

H

P

P

P

A

A

V

V

V

A

E

L

L

A

S

K

S

A

L

I

L

A

A

D

E

I

V

A

T

P

P

A

A

G

G

M

F

N

D

H

R

V

V

F

F

F

Y

T
|
T

G
x
N

S
|
S

G
|
G

S
|
S

E
|
E

A

S

N

V

D
|
D

T
|
T

V

M

L

I

R
|
R

M

M

V

V

R

R

H

R

Y

Y

W

W

A

D

I

V

K

Q

G

G

Q

K

P

P

A

E

K

K

K

K

V

T

V

L

I

I

G

G

R

R

W

W

N

N

G

G

Y
|
Y

H

H

G
|
G

S
|
S

T
|
T

I

I

A

G

G

G

A

A

S

S

L

L

G

G

G