SitesBLAST

Q4WF54 Mevalonyl-coenzyme A hydratase sidH; Siderophore biosynthesis protein H; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
29% identity, 99% coverage: 3:234/235 of query aligns to 43:269/270 of Q4WF54

query
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Q4WF54

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Sites not aligning to the query:

268:270 PTS1-type peroxisomal targeting signal

2hw5C The crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1
29% identity, 97% coverage: 2:230/235 of query aligns to 35:257/260 of 2hw5C

query
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2hw5C

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active site: A68 (= A35), M73 (= M40), S83 (= S55), L87 (≠ A59), G111 (= G83), E114 (≠ G86), P133 (≠ S105), E134 (= E106), T139 (≠ L111), P141 (= P113), G142 (vs. gap), K227 (≠ I199), F237 (≠ I209)
binding crotonyl coenzyme a: K62 (= K29), I70 (≠ L37), F109 (= F81)

Sites not aligning to the query:

binding crotonyl coenzyme a: 26, 27, 28, 30

6l3pA Crystal strcuture of feruloyl-coa hydratase lyase(fchl) complexed with coa
30% identity, 77% coverage: 4:184/235 of query aligns to 38:215/244 of 6l3pA

query
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6l3pA

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active site: M69 (≠ A35), Y74 (≠ N46), R86 (= R56), Q90 (≠ R60), G114 (= G83), S117 (≠ G86), S136 (= S105), E137 (= E106), I142 (≠ L111), P144 (= P113), G145 (≠ A114)
binding coenzyme a: A67 (= A33), M69 (≠ A35), D70 (= D36), L71 (= L37), G113 (= G82)

Sites not aligning to the query:

active site: 233, 243
binding coenzyme a: 28, 29, 31

6n97A Methylmalonyl-coa decarboxylase in complex with 2-sulfonate-propionyl- amino(dethia)-coa (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 30:258/260 of 6n97A

query
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6n97A

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active site: H65 (≠ A35), L70 (≠ M40), G109 (= G83), E112 (≠ G86), P132 (≠ E106), V137 (≠ L111), Y139 (≠ P113), E227 (≠ D200), Y237 (≠ R210)
binding (2R)-sulfonatepropionyl-amino(dethia)-CoA: K59 (= K29), A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), W107 (≠ F81), G108 (= G82), G109 (= G83), T131 (≠ S105), P132 (≠ E106), L135 (= L109), Y139 (≠ P113), F249 (= F222), K252 (= K225)
binding (2S)-sulfonatepropionyl-amino(dethia)-CoA: K59 (= K29), A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), W107 (≠ F81), G108 (= G82), G109 (= G83), T131 (≠ S105), P132 (≠ E106), L135 (= L109), Y139 (≠ P113), F249 (= F222), K252 (= K225)

Sites not aligning to the query:

6n96A Methylmalonyl-coa decarboxylase in complex with 2-sulfonate-propionyl- oxa(dethia)-coa (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 30:258/260 of 6n96A

query
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active site: H65 (≠ A35), L70 (≠ M40), G109 (= G83), E112 (≠ G86), P132 (≠ E106), V137 (≠ L111), Y139 (≠ P113), E227 (≠ D200), Y237 (≠ R210)
binding (2~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid: K59 (= K29), A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), H68 (≠ G38), W107 (≠ F81), G108 (= G82), G109 (= G83), T131 (≠ S105), P132 (≠ E106), L135 (= L109), V137 (≠ L111), Y139 (≠ P113), F249 (= F222), K252 (= K225)
binding (2~{R})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid: K59 (= K29), A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), H68 (≠ G38), W107 (≠ F81), G108 (= G82), G109 (= G83), T131 (≠ S105), P132 (≠ E106), L135 (= L109), V137 (≠ L111), Y139 (≠ P113), F249 (= F222), K252 (= K225)

6n95A Methylmalonyl-coa decarboxylase in complex with 2-sulfonate-propionyl- coa (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 30:258/260 of 6n95A

query
sites
6n95A

M

V

I

F

I

I

Q

D

L

L

I

M

S

Q

T

A

L

L

T

S

E

D

V

L

N

N

A

R

D

P

N

-

S

E

V

I

K

R

V

C

V

I

I

I

L

L

R

R

-

A

-

P

S

S

E

G

G

S

K
|
K

H

V

F

F

S

S

A
|
A

G

G

A
x
H

D
|
D

L
x
I

G
x
H

W

E

M
x
L

R

P

R

S

M

G

A

G

E

R

N

D

S

P

R

L

Q

S

E

Y

N

D

L

-

D

D

D

P

S

L

R

R

E

Q

L

I

A

T

R

R

L

M

M

-

N

-

V

-

L

I

N

Q

H

K

L

F

S

P

K

K

P

P

V

I

I

I

G

S

L

M

V

V

Q

E

G

G

A

S

A

V

F
x
W

G
|
G

A

A

V

F

G
x
E

L

M

A

I

A

M

C

S

D

D

I

L

V

I

I

I

A

A

T

A

E

S

K

T

S

S

S

T

F

F

C

S

L

M

S
x
T

E
x
P

V

V

K

N

L
|
L

G

G

L
x
V

I

P

P
x
Y

A

N

V

L

I

V

S

G

P

I

Y

H

-

N

V

L

V

T

R

R

A

D

I

A

G

G

E

F

R

H

Q

I

A

V

R

K

R

E

Y

L

F

I

I

F

S

T

A

A

E

S

V

P

F

I

T

T

A

A

R

Q

Q

R

A

A

Q

L

E

A

Y

V

G

G

L

I

V

L

-

N

H

H

I

V

V

V

C

-

D

-

D

E

V

V

D

E

A

E

M

L

E

E

A

D

R

F

C

T

N

L

E

Q

M

M

L

A

Q

H

L

I

A

S

M

E

N

K

G

A

P

P

E

L

A

A

M

I

K

A

A

V

A

I

K

K

D

E

-

E

-

L

L

R

V

V

F

L

A

G

V

E

S

A

H

H

K

T

P

-

I

M

N

N

D

S

D

D

V

E

I

F

D
x
E

D

R

T

I

A

Q

H

G

R

M

I

R

A

R

D

A

I

V

R
x
Y

V

D

G

S

E

E

E

D

G

Y

Q

Q

E

E

G

G

L

M

S

N

A

A

F
|
F

L

L

N

E

K
|
K

R

R

K

K

A

P

N

N

W

F

V

V

active site: H65 (≠ A35), L70 (≠ M40), G109 (= G83), E112 (≠ G86), P132 (≠ E106), V137 (≠ L111), Y139 (≠ P113), E227 (≠ D200), Y237 (≠ R210)
binding (2R)-sulfonatepropionyl-CoA: K59 (= K29), A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), H68 (≠ G38), W107 (≠ F81), G108 (= G82), G109 (= G83), T131 (≠ S105), P132 (≠ E106), L135 (= L109), Y139 (≠ P113), F249 (= F222), K252 (= K225)
binding (2S)-sulfonatepropionyl-CoA: K59 (= K29), A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), H68 (≠ G38), W107 (≠ F81), G108 (= G82), G109 (= G83), T131 (≠ S105), P132 (≠ E106), L135 (= L109), V137 (≠ L111), Y139 (≠ P113), F249 (= F222), K252 (= K225)

Sites not aligning to the query:

6n94A Methylmalonyl-coa decarboxylase in complex with 2-nitronate-propionyl- amino(dethia)-coa (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 30:258/260 of 6n94A

query
sites
6n94A

M

V

I

F

I

I

Q

D

L

L

I

M

S

Q

T

A

L

L

T

S

E

D

V

L

N

N

A

R

D

P

N

-

S

E

V

I

K

R

V

C

V

I

I

I

L

L

R

R

-

A

-

P

S

S

E

G

G

S

K

K

H

V

F

F

S

S

A
|
A

G

G

A
x
H

D
|
D

L
x
I

G
x
H

W

E

M
x
L

R

P

R

S

M

G

A

G

E

R

N

D

S

P

R

L

Q

S

E

Y

N

D

L

-

D

D

D

P

S

L

R

R

E

Q

L

I

A

T

R

R

L

M

M

-

N

-

V

-

L

I

N

Q

H

K

L

F

S

P

K

K

P

P

V

I

I

I

G

S

L

M

V

V

Q

E

G

G

A

S

A

V

F
x
W

G
|
G

A

A

V

F

G
x
E

L

M

A

I

A

M

C

S

D

D

I

L

V

I

I

I

A

A

T

A

E

S

K

T

S

S

S

T

F

F

C

S

L

M

S
x
T

E
x
P

V

V

K

N

L

L

G

G

L
x
V

I

P

P
x
Y

A

N

V

L

I

V

S

G

P

I

Y

H

-

N

V

L

V

T

R

R

A

D

I

A

G

G

E

F

R

H

Q

I

A

V

R

K

R

E

Y

L

F

I

I

F

S

T

A

A

E

S

V

P

F

I

T

T

A

A

R

Q

Q

R

A

A

Q

L

E

A

Y

V

G

G

L

I

V

L

-

N

H

H

I

V

V

V

C

-

D

-

D

E

V

V

D

E

A

E

M

L

E

E

A

D

R

F

C

T

N

L

E

Q

M

M

L

A

Q

H

L

I

A

S

M

E

N

K

G

A

P

P

E

L

A

A

M

I

K

A

A

V

A

I

K

K

D

E

-

E

-

L

L

R

V

V

F

L

A

G

V

E

S

A

H

H

K

T

P

-

I

M

N

N

D

S

D

D

V

E

I

F

D
x
E

D

R

T

I

A

Q

H

G

R

M

I

R

A

R

D

A

I

V

R
x
Y

V

D

G

S

E

E

E

D

G

Y

Q

Q

E

E

G

G

L

M

S

N

A

A

F

F

L

L

N

E

K

K

R

R

K

K

A

P

N

N

W

F

V

V

active site: H65 (≠ A35), L70 (≠ M40), G109 (= G83), E112 (≠ G86), P132 (≠ E106), V137 (≠ L111), Y139 (≠ P113), E227 (≠ D200), Y237 (≠ R210)
binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylamino]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), H68 (≠ G38), W107 (≠ F81), G108 (= G82), G109 (= G83), T131 (≠ S105), P132 (≠ E106), Y139 (≠ P113)

Sites not aligning to the query:

binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylamino]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: 23, 24

6n93A Methylmalonyl-coa decarboxylase in complex with 2-nitronate-propionyl- oxa(dethia)-coa (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 30:258/260 of 6n93A

query
sites
6n93A

M

V

I

F

I

I

Q

D

L

L

I

M

S

Q

T

A

L

L

T

S

E

D

V

L

N

N

A

R

D

P

N

-

S

E

V

I

K

R

V

C

V

I

I

I

L

L

R

R

-

A

-

P

S

S

E

G

G

S

K

K

H

V

F

F

S

S

A
|
A

G

G

A
x
H

D
|
D

L
x
I

G
x
H

W

E

M
x
L

R

P

R

S

M

G

A

G

E

R

N

D

S

P

R

L

Q

S

E

Y

N

D

L

-

D

D

D

P

S

L

R

R

E

Q

L

I

A

T

R

R

L

M

M

-

N

-

V

-

L

I

N

Q

H

K

L

F

S

P

K

K

P

P

V

I

I

I

G

S

L

M

V

V

Q

E

G

G

A

S

A

V

F
x
W

G

G

G
|
G

A

A

V

F

G
x
E

L

M

A

I

A

M

C

S

D

D

I

L

V

I

I

I

A

A

T

A

E

S

K

T

S

S

S

T

F

F

C

S

L

M

S
x
T

E
x
P

V

V

K

N

L
|
L

G

G

L
x
V

I

P

P
x
Y

A

N

V

L

I

V

S

G

P

I

Y

H

-

N

V

L

V

T

R

R

A

D

I

A

G

G

E

F

R

H

Q

I

A

V

R

K

R

E

Y

L

F

I

I

F

S

T

A

A

E

S

V

P

F

I

T

T

A

A

R

Q

Q

R

A

A

Q

L

E

A

Y

V

G

G

L

I

V

L

-

N

H

H

I

V

V

V

C

-

D

-

D

E

V

V

D

E

A

E

M

L

E

E

A

D

R

F

C

T

N

L

E

Q

M

M

L

A

Q

H

L

I

A

S

M

E

N

K

G

A

P

P

E

L

A

A

M

I

K

A

A

V

A

I

K

K

D

E

-

E

-

L

L

R

V

V

F

L

A

G

V

E

S

A

H

H

K

T

P

-

I

M

N

N

D

S

D

D

V

E

I

F

D
x
E

D

R

T

I

A

Q

H

G

R

M

I

R

A

R

D

A

I

V

R
x
Y

V

D

G

S

E

E

E

D

G

Y

Q

Q

E

E

G

G

L

M

S

N

A

A

F
|
F

L

L

N

E

K
|
K

R

R

K

K

A

P

N

N

W

F

V

V

active site: H65 (≠ A35), L70 (≠ M40), G109 (= G83), E112 (≠ G86), P132 (≠ E106), V137 (≠ L111), Y139 (≠ P113), E227 (≠ D200), Y237 (≠ R210)
binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), H68 (≠ G38), W107 (≠ F81), T131 (≠ S105), L135 (= L109), F249 (= F222), K252 (= K225)

Sites not aligning to the query:

binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: 24

6n92F Methylmalonyl-coa decarboxylase in complex with 2-nitronate-propionyl- coa (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 30:258/260 of 6n92F

query
sites
6n92F

M

V

I

F

I

I

Q

D

L

L

I

M

S

Q

T

A

L

L

T

S

E

D

V

L

N

N

A

R

D

P

N

-

S

E

V

I

K

R

V

C

V

I

I

I

L

L

R

R

-

A

-

P

S

S

E

G

G

S

K

K

H

V

F

F

S

S

A
|
A

G

G

A
x
H

D
|
D

L

I

G

H

W

E

M
x
L

R

P

R

S

M

G

A

G

E

R

N

D

S

P

R

L

Q

S

E

Y

N

D

L

-

D

D

D

P

S

L

R

R

E

Q

L

I

A

T

R

R

L

M

M

-

N

-

V

-

L

I

N

Q

H

K

L

F

S

P

K

K

P

P

V

I

I

I

G

S

L

M

V

V

Q

E

G

G

A
x
S

A

V

F
x
W

G
|
G

A

A

V

F

G
x
E

L

M

A

I

A

M

C

S

D

D

I

L

V

I

I

I

A

A

T

A

E

S

K

T

S

S

S
x
T

F
|
F

C
x
S

L

M

S
x
T

E
x
P

V

V

K

N

L

L

G

G

L
x
V

I

P

P
x
Y

A

N

V

L

I

V

S

G

P

I

Y

H

-

N

V

L

V

T

R

R

A

D

I

A

G

G

E

F

R

H

Q

I

A

V

R

K

R

E

Y

L

F

I

I

F

S

T

A

A

E
x
S

V
x
P

F

I

T

T

A

A

R

Q

Q

R

A

A

Q

L

E

A

Y

V

G

G

L

I

V

L

-

N

H

H

I

V

V

V

C

-

D

-

D

E

V

V

D

E

A

E

M

L

E

E

A

D

R

F

C

T

N

L

E

Q

M

M

L

A

Q

H

L

I

A

S

M

E

N

K

G

A

P

P

E

L

A

A

M

I

K

A

A

V

A

I

K

K

D

E

-

E

-

L

L

R

V

V

F

L

A

G

V

E

S

A

H

H

K

T

P

-

I

M

N

N

D

S

D

D

V

E

I

F

D
x
E

D

R

T

I

A

Q

H

G

R

M

I

R

A

R

D

A

I

V

R
x
Y

V

D

G

S

E
|
E

E

D

G

Y

Q

Q

E

E

G

G

L

M

S

N

A

A

F
|
F

L

L

N

E

K

K

R

R

K

K

A

P

N

N

W

F

V

V

active site: H65 (≠ A35), L70 (≠ M40), G109 (= G83), E112 (≠ G86), P132 (≠ E106), V137 (≠ L111), Y139 (≠ P113), E227 (≠ D200), Y237 (≠ R210)
binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: A63 (= A33), H65 (≠ A35), D66 (= D36), S105 (≠ A79), W107 (≠ F81), W107 (≠ F81), G108 (= G82), G109 (= G83), T127 (≠ S101), F128 (= F102), S129 (≠ C103), T131 (≠ S105), P132 (≠ E106), Y139 (≠ P113), S164 (≠ E137), P165 (≠ V138), F249 (= F222)
binding (2E)-2-(hydroxyimino)propanoic acid: E240 (= E213)

Sites not aligning to the query:

6n92A Methylmalonyl-coa decarboxylase in complex with 2-nitronate-propionyl- coa (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 30:258/260 of 6n92A

query
sites
6n92A

M

V

I

F

I

I

Q

D

L

L

I

M

S

Q

T

A

L

L

T

S

E

D

V

L

N

N

A

R

D

P

N

-

S

E

V

I

K

R

V

C

V

I

I

I

L

L

R

R

-

A

-

P

S

S

E

G

G

S

K

K

H

V

F

F

S

S

A
|
A

G

G

A
x
H

D
|
D

L
x
I

G
x
H

W

E

M
x
L

R

P

R

S

M

G

A

G

E

R

N

D

S

P

R

L

Q

S

E

Y

N

D

L

-

D

D

D

P

S

L

R

R

E

Q

L

I

A

T

R

R

L

M

M

-

N

-

V

-

L

I

N

Q

H

K

L

F

S

P

K

K

P

P

V

I

I

I

G

S

L

M

V

V

Q

E

G

G

A

S

A

V

F
x
W

G
|
G

A

A

V

F

G
x
E

L

M

A

I

A

M

C

S

D

D

I

L

V

I

I

I

A

A

T

A

E

S

K

T

S

S

S

T

F

F

C

S

L

M

S
x
T

E
x
P

V

V

K

N

L

L

G

G

L
x
V

I

P

P
x
Y

A

N

V

L

I

V

S

G

P

I

Y

H

-

N

V

L

V

T

R

R

A

D

I

A

G

G

E

F

R

H

Q

I

A

V

R

K

R

E

Y

L

F

I

I

F

S

T

A

A

E

S

V

P

F

I

T

T

A

A

R

Q

Q

R

A

A

Q

L

E

A

Y

V

G

G

L

I

V

L

-

N

H

H

I

V

V

V

C

-

D

-

D

E

V

V

D

E

A

E

M

L

E

E

A

D

R

F

C

T

N

L

E

Q

M

M

L

A

Q

H

L

I

A

S

M

E

N

K

G

A

P

P

E

L

A

A

M

I

K

A

A

V

A

I

K

K

D

E

-

E

-

L

L

R

V

V

F

L

A

G

V

E

S

A

H

H

K

T

P

-

I

M

N

N

D

S

D

D

V

E

I

F

D
x
E

D

R

T

I

A

Q

H

G

R

M

I

R

A

R

D

A

I

V

R
x
Y

V

D

G

S

E

E

E

D

G

Y

Q

Q

E

E

G

G

L

M

S

N

A

A

F
|
F

L

L

N

E

K
|
K

R

R

K

K

A

P

N

N

W

F

V

V

active site: H65 (≠ A35), L70 (≠ M40), G109 (= G83), E112 (≠ G86), P132 (≠ E106), V137 (≠ L111), Y139 (≠ P113), E227 (≠ D200), Y237 (≠ R210)
binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: A63 (= A33), H65 (≠ A35), D66 (= D36), I67 (≠ L37), H68 (≠ G38), W107 (≠ F81), G108 (= G82), G109 (= G83), T131 (≠ S105), P132 (≠ E106), Y139 (≠ P113), F249 (= F222), K252 (= K225)

Sites not aligning to the query:

binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: 24

Q7CQ56 1,4-dihydroxy-2-naphthoyl-CoA synthase; DHNA-CoA synthase; EC 4.1.3.36 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
29% identity, 98% coverage: 1:230/235 of query aligns to 51:278/285 of Q7CQ56

query
sites
Q7CQ56

M

L

I

T

I

V

Q

K

Q

E

L

M

I

I

S

Q

T

A

L

L

T

A

E

D

V

A

N

R

A

Y

D

D

N

D

S

N

V

V

K

G

V

V

V

I

I

I

L

L

R

T

S

G

E

E

G

G

-

D

K

K

H

A

F

F

S

C

A

A

G

G

A

G

D

D

L

-

G

-

W

-

M

-

R

-

R

Q

M

K

A

V

E

R

N

G

S

D

R

Y

Q

G

E

G

N

Y

L

Q

D

D

S

S

R

G

E

-

L

-

A

V

R

H

L

H

M

L

N

N

V

V

L

L

N

D

H

F

-

Q

-

R

-

Q

-

I

-

R

-

T

L

C

S

P

K

K

P

P

V

V

I

V

G

A

L

M

V

V

Q

A

G

G

A

Y

A

S

F

I

G

G

A

G

V

H

G

V

L

L

A

H

A

M

C

M

C

C

D

D

I

L

V

T

I

I

A

A

T

A

E

E

K

N

S

A

S

I

F

F

C

G

L
x
Q

S
x
T

E
x
G

V

P

K

K

L

V

G

G

L

S

I

F

P

D

A

G

V

G

I

W

-

G

S

A

P

S

Y

Y

V

M

V

A

R

R

A

I

I

V

G

G

E

Q

R

K

Q

K

A

A

R

R

R

E

Y

I

F

W

I

F

S

L

A

C

E

R

V

Q

F

Y

T

D

A

A

R

Q

Q

Q

A

A

Q

L

E

D

Y

M

G

G

L

L

V

V

H

N

I

T

V

V

C

V

D

P

-

L

-

A

D

D

V

L

D

E

A

K

M

E

E

T

A

V

R

R

-

W

C

C

N

R

E

E

M

M

L

L

Q

Q

Q

-

L

-

A

-

M

-

N

N

G

S

P

P

E

M

A

A

M

L

K

R

A

C

A

L

K

K

D

A

L

A

V

L

F

N

A

A

V

D

S

C

H

D

K

G

P

Q

I

A

N

G

D

L

D

Q

V

E

I

L

D

A

D

G

T

N

A

A

H

T

R

M

I

L

A

-

D

-

I

F

R

Y

V

M

G

T

E

E

G

G

Q

Q

E

E

G

G

L

R

S

N

A

A

F

F

L

N

N

Q

K

K

R

R

K

Q

A

P

N

D

W

F

QTG 154:156 (≠ LSE 104:106) binding

1ey3A Structure of enoyl-coa hydratase complexed with the substrate dac-coa (see paper)
28% identity, 97% coverage: 2:230/235 of query aligns to 33:255/258 of 1ey3A

query
sites
1ey3A

I

L

I

I

Q

E

L

L

I

N

S

Q

T

A

L

L

T

E

E

T

V

F

N

E

A

E

D

D

N

P

S

A

V

V

K

G

V

A

V

I

I

V

L

L

R

T

S

G

E

G

G

E

K

K

H

A

F

F

S

A

A
|
A

G
|
G

A
|
A

D
|
D

L
x
I

G

K

W

E

M
|
M

R

-

M

-

A

-

E

Q

N

N

S

R

R

T

Q

F

E

Q

N

D

L

C

D

Y

D
x
S

S

G

R

K

E

F

L
|
L

A

S

R

H

L
x
W

M

D

N

H

V

I

L

-

N

T

H

R

L

I

S

K

K

K

P

P

V

V

I

I

G

A

L

A

V

V

Q

N

G

G

A

Y

A

A

F

L

G

G

G
|
G

A

G

V

C

G
x
E

L

L

A

A

A

M

C

M

C

C

D

D

I

I

V

I

I

Y

A

A

T

G

E

E

K

K

S

A

S

Q

F

F

C

G

L

Q

S
x
P

E
|
E

V

I

K

L

L
|
L

G

G

L
x
T

I

I

P
|
P

-
x
G

A

A

V

G

I

G

S

T

P

Q

Y

R

V

L

V

T

R

R

A

A

I

V

G

G

E

K

R

S

Q

L

A

A

R

M

R

E

Y

M

F

V

I

L

S

T

A

G

E

D

V

R

F

I

T

S

A

A

R

Q

Q

D

A

A

Q

K

E

Q

Y

A

G

G

L

L

V

V

H

S

I

K

V

I

C

F

D

-

D

P

V

V

D

E

A

T

M

L

E

V

A

E

R

E

C

A

N

I

E

Q

M

C

L

A

Q

E

Q

K

L

I

A

A

M

N

N

N

G

S

P

K

E

I

A

I

M

V

K

A

A

M

A

A

K

K

D

E

L

S

V

V

F

N

A

A

V

A

S

F

H

E

K

M

P

T

I

L

N

T

D

E

D

G

V

N

I
x
K

D

L

D

E

T

K

A

K

H

L

R

F

I

Y

A

S

D

T

I
x
F

R

A

V

T

G

-

E

D

G

R

Q

R

E

E

G

G

L

M

S

S

A

A

F

F

L

V

N

E

K

K

R

R

K

K

A

A

N

N

W

F

active site: A66 (= A35), M71 (= M40), S81 (≠ D54), L85 (= L58), G109 (= G83), E112 (≠ G86), P131 (≠ S105), E132 (= E106), T137 (≠ L111), P139 (= P113), G140 (vs. gap), K225 (≠ I199), F235 (≠ I209)
binding 4-(n,n-dimethylamino)cinnamoyl-coa: A64 (= A33), G65 (= G34), A66 (= A35), D67 (= D36), I68 (≠ L37), L85 (= L58), W88 (≠ L61), G109 (= G83), P131 (≠ S105), L135 (= L109), G140 (vs. gap)

Sites not aligning to the query:

binding 4-(n,n-dimethylamino)cinnamoyl-coa: 24, 26, 28

1ef9A The crystal structure of methylmalonyl coa decarboxylase complexed with 2s-carboxypropyl coa (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 31:259/261 of 1ef9A

query
sites
1ef9A

M

V

I

F

I

I

Q

D

L

L

I

M

S

Q

T

A

L

L

T

S

E

D

V

L

N

N

A

R

D

P

N

-

S

E

V

I

K

R

V

C

V

I

I

I

L

L

R

R

-

A

-

P

S

S

E

G

G

S

K

K

H

V

F

F

S

S

A
|
A

G

G

A
x
H

D
|
D

L
x
I

G
x
H

W

E

M
x
L

R

P

R

S

M

G

A

G

E

R

N

D

S

P

R

L

Q

S

E

Y

N
x
D

L

-

D

D

D

P

S

L

R
|
R

E

Q

L

I

A

T

R

R

L

M

M

-

N

-

V

-

L

I

N

Q

H

K

L

F

S

P

K

K

P

P

V

I

I

I

G

S

L

M

V

V

Q

E

G

G

A

S

A

V

F
x
W

G

G

G
|
G

A

A

V

F

G
x
E

L

M

A

I

A

M

C

S

D

D

I

L

V

I

I

I

A

A

T

A

E

S

K

T

S

S

S

T

F

F

C

S

L

M

S
x
T

E
x
P

V

V

K

N

L

L

G

G

L
x
V

I

P

P
x
Y

A
x
N

V

L

I

V

S

G

P

I

Y

H

-

N

V

L

V

T

R

R

A

D

I

A

G

G

E

F

R

H

Q

I

A

V

R

K

R

E

Y

L

F

I

I

F

S

T

A

A

E

S

V

P

F

I

T

T

A

A

R

Q

Q

R

A

A

Q

L

E

A

Y

V

G

G

L

I

V

L

-

N

H

H

I

V

V

V

C

-

D

-

D

E

V

V

D

E

A

E

M

L

E

E

A

D

R

F

C

T

N

L

E

Q

M

M

L

A

Q

H

L

I

A

S

M

E

N

K

G

A

P

P

E

L

A

A

M

I

K

A

A

V

A

I

K

K

D

E

-

E

-

L

L

R

V

V

F

L

A

G

V

E

S

A

H

H

K

T

P

-

I

M

N

N

D

S

D

D

V

E

I

F

D
x
E

D

R

T

I

A

Q

H

G

R

M

I

R

A

R

D

A

I

V

R
x
Y

V

D

G

S

E

E

E

D

G

Y

Q

Q

E

E

G

G

L

M

S

N

A

A

F

F

L

L

N

E

K
|
K

R

R

K

K

A

P

N

N

W

F

V

V

active site: H66 (≠ A35), L71 (≠ M40), D82 (≠ N51), R86 (= R56), G110 (= G83), E113 (≠ G86), P133 (≠ E106), V138 (≠ L111), Y140 (≠ P113), N141 (≠ A114), E228 (≠ D200), Y238 (≠ R210)
binding 2-carboxypropyl-coenzyme a: A64 (= A33), H66 (≠ A35), D67 (= D36), I68 (≠ L37), H69 (≠ G38), W108 (≠ F81), G110 (= G83), T132 (≠ S105), P133 (≠ E106), K253 (= K225)

P52045 Methylmalonyl-CoA decarboxylase; MMCD; Transcarboxylase; EC 4.1.1.- from Escherichia coli (strain K12) (see paper)
27% identity, 98% coverage: 1:231/235 of query aligns to 31:259/261 of P52045

query
sites
P52045

M

V

I

F

I

I

Q

D

L

L

I

M

S

Q

T

A

L

L

T

S

E

D

V

L

N

N

A

R

D

P

N

-

S

E

V

I

K

R

V

C

V

I

I

I

L

L

R

R

-

A

-

P

S

S

E

G

G

S

K

K

H

V

F

F

S

S

A

A

G

G

A

H

D

D

L

I

G

H

W

E

M

L

R

P

R

S

M

G

A

G

E

R

N

D

S

P

R

L

Q

S

E

Y

N

D

L

-

D

D

D

P

S

L

R

R

E

Q

L

I

A

T

R

R

L

M

M

-

N

-

V

-

L

I

N

Q

H

K

L

F

S

P

K

K

P

P

V

I

I

I

G

S

L

M

V

V

Q

E

G

G

A

S

A

V

F

W

G

G

G
|
G

A

A

V

F

G

E

L

M

A

I

A

M

C

S

D

D

I

L

V

I

I

I

A

A

T

A

E

S

K

T

S

S

S

T

F

F

C

S

L

M

S
x
T

E

P

V

V

K

N

L

L

G

G

L

V

I

P

P

Y

A

N

V

L

I

V

S

G

P

I

Y

H

-

N

V

L

V

T

R

R

A

D

I

A

G

G

E

F

R

H

Q

I

A

V

R

K

R

E

Y

L

F

I

I

F

S

T

A

A

E

S

V

P

F

I

T

T

A

A

R

Q

Q

R

A

A

Q

L

E

A

Y

V

G

G

L

I

V

L

-

N

H

H

I

V

V

V

C

-

D

-

D

E

V

V

D

E

A

E

M

L

E

E

A

D

R

F

C

T

N

L

E

Q

M

M

L

A

Q

H

L

I

A

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M

E

N

K

G

A

P

P

E

L

A

A

M

I

K

A

A

V

A

I

K

K

D

E

-

E

-

L

L

R

V

V

F

L

A

G

V

E

S

A

H

H

K

T

P

-

I

M

N

N

D

S

D

D

V

E

I

F

D

E

D

R

T

I

A

Q

H

G

R

M

I

R

A

R

D

A

I

V

R

Y

V

D

G

S

E

E

E

D

G

Y

Q

Q

E

E

G

G

L

M

S

N

A

A

F

F

L

L

N

E

K
|
K

R

R

K

K

A

P

N

N

W

F

V

V

G110 (= G83) binding
T132 (≠ S105) binding
K253 (= K225) binding

P14604 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Rattus norvegicus (Rat) (see 3 papers)
28% identity, 97% coverage: 2:230/235 of query aligns to 65:287/290 of P14604

query
sites
P14604

I

L

I

I

Q

E

L

L

I

N

S

Q

T

A

L

L

T

E

E

T

V

F

N

E

A

E

D

D

N

P

S

A

V

V

K

G

V

A

V

I

I

V

L

L

R

T

S

G

E

G

G

E

K

K

H

A

F

F

S

A

A

A

G

G

A

A

D

D

L

I

G

K

W

E

M

M

R

-

M

-

A

-

E

Q

N

N

S

R

R

T

Q

F

E

Q

N

D

L

C

D

Y

D

S

S

G

R

K

E

F

L

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A

S

R

H

L

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M

D

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H

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I

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-

N

T

H

R

L

I

S

K

K

K

P

P

V

V

I

I

G

A

L

A

V

V

Q

N

G

G

A

Y

A

A

F

L

G

G

A

G

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C

G
x
E

L

L

A

A

A

M

C

M

C

C

D

D

I

I

V

I

I

Y

A

A

T

G

E

E

K

K

S

A

S

Q

F

F

C

G

L

Q

S

P

E
|
E

V

I

K

L

L

L

G

G

L

T

I

I

P

P

-

G

A

A

V

G

I

G

S

T

P

Q

Y

R

V

L

V

T

R

R

A

A

I

V

G

G

E

K

R

S

Q

L

A

A

R

M

R

E

Y

M

F

V

I

L

S

T

A

G

E

D

V

R

F

I

T

S

A

A

R

Q

Q

D

A

A

Q

K

E

Q

Y

A

G

G

L

L

V

V

H

S

I

K

V

I

C

F

D

-

D

P

V

V

D

E

A

T

M

L

E

V

A

E

R

E

C

A

N

I

E

Q

M

C

L

A

Q

E

Q

K

L

I

A

A

M

N

N

N

G

S

P

K

E

I

A

I

M

V

K

A

A

M

A

A

K

K

D

E

L

S

V

V

F

N

A

A

V

A

S

F

H

E

K

M

P

T

I

L

N

T

D

E

D

G

V

N

I

K

D

L

D

E

T

K

A

K

H

L

R

F

I

Y

A

S

D

T

I

F

R

A

V

T

G

-

E

D

G

R

Q

R

E

E

G

G

L

M

S

S

A

A

F

F

L

V

N

E

K

K

R

R

K

K

A

A

N

N

W

F

E144 (≠ G86) mutation to D: Reduces activity 50-fold.; mutation to Q: Reduces activity 3300-fold.
E164 (= E106) mutation to D: Reduces activity 1250-fold.; mutation to Q: Reduces activity 330000-fold.

Sites not aligning to the query:

1:29 modified: transit peptide, Mitochondrion

1dubA 2-enoyl-coa hydratase, data collected at 100 k, ph 6.5 (see paper)
28% identity, 97% coverage: 2:230/235 of query aligns to 35:257/260 of 1dubA

query
sites
1dubA

I

L

I

I

Q

E

L

L

I

N

S

Q

T

A

L

L

T

E

E

T

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F

N

E

A

E

D

D

N

P

S

A

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K

G

V

A

V

I

I

V

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L

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T

S

G

E

G

G

E

K

K

H

A

F

F

S

A

A
|
A

G

G

A
|
A

D
|
D

L
x
I

G

K

W

E

M
|
M

R

-

M

-

A

-

E

Q

N

N

S

R

R

T

Q

F

E

Q

N

D

L

C

D

Y

D
x
S

S

G

R

K

E

F

L
|
L

A

S

R

H

L

W

M

D

N

H

V

I

L

-

N

T

H

R

L

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S

K

K

K

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P

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I

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A

L

A

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N

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G

A
x
Y

A

A

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|
G

A

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G
x
E

L

L

A

A

A

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C

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D

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Y

A

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E

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E

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L

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P

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x
G

A

A

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G

I

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Y

R

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L

V

T

R

R

A

A

I

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A

A

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E

Y

M

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I

L

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A

G

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D

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S

A

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D

A

A

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A

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C

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D

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D

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A

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I

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L

I

A

A

M

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N

N

G

S

P

K

E

I

A

I

M

V

K

A

A

M

A

A

K

K

D

E

L

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V

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N

A

A

V

A

S

F

H

E

K

M

P

T

I

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N

T

D

E

D

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V

N

I
x
K

D

L

D

E

T

K

A

K

H

L

R
x
F

I

Y

A

S

D

T

I
x
F

R

A

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T

G

-

E

D

G

R

Q

R

E

E

G

G

L

M

S

S

A

A

F
|
F

L

V

N

E

K

K

R

R

K

K

A

A

N

N

W

F

active site: A68 (= A35), M73 (= M40), S83 (≠ D54), L87 (= L58), G111 (= G83), E114 (≠ G86), P133 (≠ S105), E134 (= E106), T139 (≠ L111), P141 (= P113), G142 (vs. gap), K227 (≠ I199), F237 (≠ I209)
binding acetoacetyl-coenzyme a: A66 (= A33), A68 (= A35), D69 (= D36), I70 (≠ L37), Y107 (≠ A79), G110 (= G82), G111 (= G83), E114 (≠ G86), P133 (≠ S105), E134 (= E106), L137 (= L109), G142 (vs. gap), F233 (≠ R205), F249 (= F222)

Sites not aligning to the query:

binding acetoacetyl-coenzyme a: 26, 27, 28, 30

1mj3A Crystal structure analysis of rat enoyl-coa hydratase in complex with hexadienoyl-coa (see paper)
28% identity, 97% coverage: 2:230/235 of query aligns to 35:255/258 of 1mj3A

query
sites
1mj3A

I

L

I

I

Q

E

L

L

I

N

S

Q

T

A

L

L

T

E

E

T

V

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N

E

A

E

D

D

N

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S

A

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V

K

G

V

A

V

I

I

V

L

L

R

T

S

G

E

G

G

E

K

K

H

A

F

F

S

A

A
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A

G
|
G

A
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A

D
|
D

L
x
I

G

K

W

E

M
|
M

R

Q

R

N

M

R

A

T

E

F

N

Q

S

D

R

C

Q

Y

E
x
S

N

G

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L

D

S

D

H

S

W

R

D

E

H

L

I

A

T

R

R

L

I

M

-

N

-

V

-

L

-

N

-

H

-

L

-

S

K

K

K

P

P

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V

I

I

G

A

L

A

V

V

Q

N

G

G

A

Y

A

A

F

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G

G

G
|
G

A

G

V

C

G
x
E

L

L

A

A

A

M

C

M

C

C

D

D

I

I

V

I

I

Y

A

A

T

G

E

E

K

K

S

A

S

Q

F

F

C

G

L

Q

S
x
P

E
|
E

V

I

K

L

L
|
L

G

G

L
x
T

I

I

P
|
P

-
x
G

A

A

V

G

I

G

S

T

P

Q

Y

R

V

L

V

T

R

R

A

A

I

V

G

G

E

K

R

S

Q

L

A

A

R

M

R

E

Y

M

F

V

I

L

S

T

A

G

E

D

V

R

F

I

T

S

A

A

R

Q

Q

D

A

A

Q

K

E

Q

Y

A

G

G

L

L

V

V

H

S

I

K

V

I

C

F

D

-

D

P

V

V

D

E

A

T

M

L

E

V

A

E

R

E

C

A

N

I

E

Q

M

C

L

A

Q

E

Q

K

L

I

A

A

M

N

N

N

G

S

P

K

E

I

A

I

M

V

K

A

A

M

A

A

K

K

D

E

L

S

V

V

F

N

A

A

V

A

S

F

H

E

K

M

P

T

I

L

N

T

D

E

D

G

V

N

I
x
K

D

L

D

E

T

K

A

K

H

L

R

F

I

Y

A

S

D

T

I
x
F

R

A

V

T

G

-

E

D

G

R

Q

R

E

E

G

G

L

M

S

S

A

A

F

F

L

V

N

E

K

K

R

R

K

K

A

A

N

N

W

F

active site: A68 (= A35), M73 (= M40), S83 (≠ E50), L85 (= L52), G109 (= G83), E112 (≠ G86), P131 (≠ S105), E132 (= E106), T137 (≠ L111), P139 (= P113), G140 (vs. gap), K225 (≠ I199), F235 (≠ I209)
binding hexanoyl-coenzyme a: A66 (= A33), G67 (= G34), A68 (= A35), D69 (= D36), I70 (≠ L37), G109 (= G83), P131 (≠ S105), E132 (= E106), L135 (= L109), G140 (vs. gap)

Sites not aligning to the query:

binding hexanoyl-coenzyme a: 26, 27, 28, 30

7xwvA Feruloyl-coa hydratase/lyase complexed with vanillin and coenzyme a (see paper)
29% identity, 93% coverage: 4:222/235 of query aligns to 35:243/244 of 7xwvA

query
sites
7xwvA

Q

R

Q

Q

L

M

I

L

S

K

T

V

L

L

T

T

E

E

V

L

N

E

A

F

D

R

N

D

S

D

V

V

K

G

V

V

V

L

I

V

L

L

R

G

S

G

E

E

G

G

K

P

H

A

F

W

S

C

A
|
A

G
|
G

A
x
M

D
|
D

L
|
L

G

-

W

-

M

-

R

K

R

E

M
x
Y

A
x
F

E

R

N

E

S

T

R

E

Q

A

E

E

N

G

L

L

D

A

D

G

S

T

R

R

E

K

L

A

A

Q

R

R

-

E

-

A

-

Y

-

T

L

W

M

W

N

E

V

R

L

L

N

R

H

W

L

Y

S

Q

K

K

P

P

V

T

I

I

G

A

L

M

V

V

Q

H

G

G

A
x
W

A

C

F
|
F

G
|
G

A

A

V

Y

G

G

L

P

A

L

A

F

C

A

C

C

D

D

I

L

V

A

I

F

A

A

T

A

E

D

K

E

S

A

S

Q

F

F

C

G

L

L

S
|
S

E
|
E

V

V

K

N

L

W

G

G

L

I

I

L

P

P

A
x
G

V
x
G

I

G

S

A

P

T

Y

K

V

V

-

A

V

V

R

D

A

L

I

M

G

P

E

M

R

R

Q

V

A

A

R

M

R

Y

Y

H

F

A

I

M

S

M

A

G

E

E

V

N

F

L

T

S

A

G

R

Q

Q

D

A

A

Q

A

E

R

Y

Y

G

N

L

L

V

V

H

N

I

E

V

S

C

M

D

-

D

P

V

A

D

D

A

Q

M

L

E

K

A

A

R

R

C

V

N

K

E

Q

M

V

L

A

Q

E

Q

T

L

L

A

I

M

Q

N

K

G

N

P

W

E

A

A

T

M

V

K

K

A

Y

A

T

K

K

D

D

L

A

V

V

F

R

A

R

V

V

S

-

H

-

K

K

P

E

I

M

N

T

D

Y

D

D

V

N

I

A

D

E

D

D

T

Y

A

L

H

I

R

R

I

L

A

-

D

-

I

-

R

-

V

-

G

-

E

-

G

-

Q

Q

E

E

G

G

L

L

S

N

A

W

F

F

binding coenzyme a: A64 (= A33), G65 (= G34), M66 (≠ A35), D67 (= D36), L68 (= L37), W111 (≠ A79), F113 (= F81), G114 (= G82), G115 (= G83), S137 (= S105)
binding 4-hydroxy-3-methoxybenzaldehyde: M66 (≠ A35), Y71 (≠ M43), F72 (≠ A44), E138 (= E106), G146 (≠ A114), G147 (≠ V115)

Sites not aligning to the query:

binding coenzyme a: 24, 25, 26

Query Sequence

>GFF4240 FitnessBrowser__Marino:GFF4240
MIIQQLISTLTEVNADNSVKVVILRSEGKHFSAGADLGWMRRMAENSRQENLDDSRELAR
LMNVLNHLSKPVIGLVQGAAFGGAVGLAACCDIVIATEKSSFCLSEVKLGLIPAVISPYV
VRAIGERQARRYFISAEVFTARQAQEYGLVHIVCDDVDAMEARCNEMLQQLAMNGPEAMK
AAKDLVFAVSHKPINDDVIDDTAHRIADIRVGEEGQEGLSAFLNKRKANWVPEEE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory