Comparing GFF4778 FitnessBrowser__WCS417:GFF4778 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q88JU3 3-dehydroshikimate dehydratase; DSD; EC 4.2.1.118 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
83% identity, 100% coverage: 1:633/633 of query aligns to 1:635/635 of Q88JU3
5hmqD Xylose isomerase-like tim barrel/4-hydroxyphenylpyruvate dioxygenase fusion protein
83% identity, 99% coverage: 1:625/633 of query aligns to 3:624/624 of 5hmqD
1cjxA Crystal structure of pseudomonas fluorescens hppd (see paper)
34% identity, 52% coverage: 295:624/633 of query aligns to 9:345/352 of 1cjxA
7xntA Crystal structure of pfhppd-y13161 complex
34% identity, 52% coverage: 295:624/633 of query aligns to 12:341/341 of 7xntA
7x8eA Crystal structure of pfhppd-y13287 complex
35% identity, 52% coverage: 295:624/633 of query aligns to 11:337/341 of 7x8eA
7xntC Crystal structure of pfhppd-y13161 complex
35% identity, 50% coverage: 295:612/633 of query aligns to 11:313/320 of 7xntC
Sites not aligning to the query:
O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
31% identity, 53% coverage: 296:630/633 of query aligns to 6:357/357 of O52791
2r5vA Hydroxymandelate synthase crystal structure (see paper)
30% identity, 52% coverage: 296:626/633 of query aligns to 5:346/346 of 2r5vA
7yvvA Acmp1, r-4-hydroxymandelate synthase
27% identity, 43% coverage: 354:624/633 of query aligns to 66:334/335 of 7yvvA
1t47A Structure of fe2-hppd bound to ntbc (see paper)
27% identity, 47% coverage: 327:624/633 of query aligns to 44:360/362 of 1t47A
3zgjB S221m v223f y359a mutant of 4-hydroxymandelate synthase from streptomyces coelicolor (see paper)
27% identity, 49% coverage: 313:624/633 of query aligns to 22:342/343 of 3zgjB
Q02110 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Sus scrofa (Pig) (see paper)
29% identity, 28% coverage: 435:612/633 of query aligns to 177:363/393 of Q02110
Sites not aligning to the query:
5ec3A Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase
28% identity, 27% coverage: 439:612/633 of query aligns to 173:355/376 of 5ec3A
8im3A Crystal structure of human hppd complexed with compound a10 (see paper)
28% identity, 27% coverage: 439:612/633 of query aligns to 175:357/371 of 8im3A
Sites not aligning to the query:
8im2A Crystal structure of human hppd complexed with ntbc (see paper)
28% identity, 27% coverage: 439:612/633 of query aligns to 175:357/374 of 8im2A
Sites not aligning to the query:
P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 28% coverage: 433:612/633 of query aligns to 175:363/393 of P32755
Sites not aligning to the query:
5yy6A Crystal structure of arabidopsis thaliana hppd truncated mutant complexed with benquitrione (see paper)
28% identity, 42% coverage: 334:601/633 of query aligns to 73:344/371 of 5yy6A
Sites not aligning to the query:
1sqdA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
28% identity, 42% coverage: 334:601/633 of query aligns to 73:347/373 of 1sqdA
1tfzA Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4- hydroxyphenylpyruvate dioxygenases (see paper)
27% identity, 42% coverage: 334:601/633 of query aligns to 72:342/364 of 1tfzA
Sites not aligning to the query:
7ezqA Complex structure of athppd with inhibitor y15832
28% identity, 42% coverage: 334:601/633 of query aligns to 73:349/382 of 7ezqA
Sites not aligning to the query:
>GFF4778 FitnessBrowser__WCS417:GFF4778
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPREVRQMCADLGIAITLF
QPFRDFEGCRRDRLARNLERAERKFDLMQELGTDLVLVCSNASADCVGDERILLDDLSLL
AEHAGRRGLRIGYEALAWGKHVNTWQQVWNLVRQVDHPNLGVLLDSFHTLSLKGDPSAIA
EIPGDKIFFVQMADAPILAMDVLEWSRHFRCFPGQGEFDLAGFLAPIIKSGYTGPLSLEI
FNDGFRAAPTRANAADGLRSLLYLEEKTRERLQQEAPAQPLDILFDTPAASEYDGIEFLE
FAVDESLGAKLTYWLERLGFVKAGQHRSKSVSLLRQGDINLILNCEPYSFAHNFFEAHGP
SLCATAIRVKDSAKALERAMAYKGQPYRGLVGPNELELAAVRAPDGSLIYLVDPSEGGLY
DTDFNLQPAASSSGGLLRIDHMAMALPADSLDSWVLFYKSLLDFEADDEVVLPDPYGLVK
SRALRSRCSSIRLPLNISENRNTAISHALSSYRGSGVHHIAFDCADIFAEVRRAKEAGVP
LLDIPLNYYDDLAARFDFDDEFLSELAYYNVLYDRDAQGGELFHVYTEPFEGRFFFEIIQ
RKNGYAGYGAANVAVRLAAMAKSRSGAVRQARL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory