SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing GFF5065 FitnessBrowser__WCS417:GFF5065 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
41% identity, 87% coverage: 28:394/420 of query aligns to 3:372/385 of Q9X2A5

query
sites
Q9X2A5

L

L

M

M

P

N

C

T

V

Y

A

S

R

R

P

F

P

P

H

A

V

T

F

F

V

V

R

Y

G

G

Q

K

G

G

S

S

W

W

L

I

W

Y

D

D

S

E

D

K

D

G

R

N

A

A

Y

Y

L

L

D

D

F

F

S

T

Q

S

G

G

N

I

A

A

A

V

N

N

S

V

L

L

G

G

H

H

S

S

P

H

Q

P

V

R

L

L

I

V

K

E

A

A

L

I

A

K

D

D

Q

Q

T

A

Q

E

A

K

L

L

I

I

N

H

P

C

G

S

N

N

G

L

L

F

H

W

N

N

R

R

A

P

Q

Q

L

M

N

E

L

L

A

A

E

E

R

L

L

L

C

S

H

K

R

N

T

T

G

F

S

G

D

G

Q

K

A

V

Y

F

L

F

L

A

N

N

S

T

G
|
G

A
x
T

E

E

A

A

V

N

E

E

A

A

I

I

K

K

L

I

A

A

R

R

K

K

W

Y

G

G

Q

K

L

K

H

K

R

S

G

E

G

K

A

K

Y

Y

R

R

I

I

I

L

S

S

A

A

S

H

A

N

G

S

S

F

H

H

G

G

R

R

S

T

F

L

A

G

A

S

M

L

S

T

A

A

S

T

A

-

G

G

G

Q

P

P

E

K

N

Y

R

Q

-

K

-

P

F

F

E

E

P

P

Q

L

L

V

P

P

G

G

F

F

S

E

H

Y

V

F

P

E

F

F

N

N

D

N

L

V

S

E

A

D

L

L

H

R

A

R

A

K

V

M

D

S

A

E

Q

D

T

V

V

C

A

A

I

V

L

F

L

L

E

E

P

P

I

I

Q

Q

G

G

E

E

A

S

G

G

V

I

I

V

P

P

A

A

T

T

E

K

H

E

Y

F

L

L

K

E

G

E

V

A

E

R

R

K

L

L

C

C

R

D

E

E

L

Y

G

D

I

A

L

L

I

V

L

F

D

D

E

E

V

V

Q

Q

T

C

G

G

I

M

G

G

R

R

C

T

G

G

T

K

L

L

L

F

A

A

E

Y

Q

Q

Q

K

Y

Y

G

G

V

V

R

V

A

P

D

D

I

V

I

L

T

T

L

T

G

A

K

K

G

G

L

L

G

G

V

V

P

P

L

I

A

G

A

A

L

V

L

I

A

V

R

N

G

E

K

R

A

A

C

N

C

V

F

L

E

E

V

P

G

G

E

D

L

H

E

G

G

T

T
|
T

H

F

H

G

G

G

N

N

A

P

L

L

M

A

A

C

S

R

A

A

G

G

L

V

A

T

V

V

L

I

E

K

A

E

V

L

L

T

E

K

H

E

G

G

F

F

M

L

D

E

H

E

V

V

R

E

E

E

S

K

G

G

L

N

Y

Y

L

L

G

M

E

K

G

K

L

L

A

Q

R

E

L

M

A

K

Y

E

R

E

Y

Y

D

D

-

V

H

V

G

A

Q

D

L

V

R

R

G

G

H

M

G

G

L

L

M

M

W

I

G

G

L

I

T

Q

L

F

S

R

D

E

S

V

A

S

D

N

A

R

V

E

V

V

K

A

A

T

A

K

L

C

H

F

E

E

G

N

L

K

I

L

N

V

A

V

P

P

Q

A

-

G

P

N

N

N

C

T

L

I

R

R

F

F

T

L

P

P

A

P

L

L

T

T

V

V

S

E

K

Y

S

G

N

E

I

I

D

D

GT 94:95 (≠ GA 119:120) binding
T268 (= T292) binding

2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
41% identity, 87% coverage: 28:394/420 of query aligns to 11:380/393 of 2ordA

query
sites
2ordA

L

L

M

M

P

N

C

T

V

Y

A

S

R

R

P

F

P

P

H

A

V

T

F

F

V

V

R

Y

G

G

Q

K

G

G

S

S

W

W

L

I

W

Y

D

D

S

E

D

K

D

G

R

N

A

A

Y

Y

L

L

D

D

F

F

S

T

Q

S

G

G

N

I

A

A

A

V

N

N

S

V

L

L

G

G

H

H

S

S

P

H

Q

P

V

R

L

L

I

V

K

E

A

A

L

I

A

K

D

D

Q

Q

T

A

Q

E

A

K

L

L

I

I

N

H

P

C

G

S

N

N

G

L

L

F

H

W

N

N

R

R

A

P

Q

Q

L

M

N

E

L

L

A

A

E

E

R

L

L

L

C

S

H

K

R

N

T

T

G

F

S

G

D

G

Q

K

A

V

Y

F

L

F

L

A

N

N

S
x
T

G
|
G

A
x
T

E

E

A

A

V
x
N

E

E

A

A

I

I

K

K

L

I

A

A

R

R

K

K

W

Y

G

G

Q

K

L

K

H

K

R

S

G

E

G

K

A

K

Y

Y

R

R

I

I

I

L

S

S

A

A

S

H

A

N

G

S

S
x
F

H
|
H

G
|
G

R

R

S

T

F

L

A

G

A

S

M

L

S

T

A

A

S

T

A

-

G

G

G

Q

P

P

E

K

N

Y

R

Q

-

K

-

P

F

F

E

E

P

P

Q

L

L

V

P

P

G

G

F

F

S

E

H

Y

V

F

P

E

F

F

N

N

D

N

L

V

S

E

A

D

L

L

H

R

A

R

A

K

V

M

D

S

A

E

Q

D

T

V

V

C

A

A

I

V

L

F

L

L

E
|
E

P

P

I

I

Q

Q

G

G

E
|
E

A

S

G

G

V

I

I

V

P

P

A

A

T

T

E

K

H

E

Y

F

L

L

K

E

G

E

V

A

E

R

R

K

L

L

C

C

R

D

E

E

L

Y

G

D

I

A

L

L

I

V

L

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

I

M

G

G

R

R

C

T

G

G

T

K

L

L

L

F

A

A

E

Y

Q

Q

Q

K

Y

Y

G

G

V

V

R

V

A

P

D

D

I

V

I

L

T

T

L

T

G

A

K
|
K

G

G

L

L

G

G

V

V

P

P

L

I

A

G

A

A

L

V

L

I

A

V

R

N

G

E

K

R

A

A

C

N

C

V

F

L

E

E

V

P

G

G

E

D

L

H

E

G

G
x
T

T
|
T

H

F

H

G

G

G

N

N

A

P

L

L

M

A

A

C

S

R

A

A

G

G

L

V

A

T

V

V

L

I

E

K

A

E

V

L

L

T

E

K

H

E

G

G

F

F

M

L

D

E

H

E

V

V

R

E

E

E

S

K

G

G

L

N

Y

Y

L

L

G

M

E

K

G

K

L

L

A

Q

R

E

L

M

A

K

Y

E

R

E

Y

Y

D

D

-

V

H

V

G

A

Q

D

L

V

R

R

G

G

H

M

G

G

L

L

M

M

W

I

G

G

L

I

T

Q

L

F

S

R

D

E

S

V

A

S

D

N

A

R

V

E

V

V

K

A

A

T

A

K

L

C

H

F

E

E

G

N

L

K

I

L

N

V

A

V

P

P

Q

A

-

G

P

N

N

N

C

T

L

I

R
|
R

F

F

T

L

P

P

A

P

L

L

T

T

V

V

S

E

K

Y

S

G

N

E

I

I

D

D

active site: F134 (≠ S151), E186 (= E202), D219 (= D235), Q222 (= Q238), K248 (= K264), T276 (= T292), R367 (= R381)
binding pyridoxal-5'-phosphate: T101 (≠ S118), G102 (= G119), T103 (≠ A120), N106 (≠ V123), F134 (≠ S151), H135 (= H152), G136 (= G153), E186 (= E202), E191 (= E207), D219 (= D235), V221 (= V237), Q222 (= Q238), K248 (= K264), T275 (≠ G291), T276 (= T292)

2eh6A Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
42% identity, 87% coverage: 28:394/420 of query aligns to 3:365/375 of 2eh6A

query
sites
2eh6A

L

L

M

M

P

N

C

N

V

Y

A

A

R

R

P

L

P

P

H

V

V

K

F

F

V

V

R

R

G

G

Q

K

G

G

S

V

W

Y

L

L

W

Y

D

D

S

E

D

E

D

G

R

K

A

E

Y

Y

L

L

D

D

F

F

S

V

Q

S

G

G

N

I

A

G

A

V

N

N

S

S

L

L

G

G

H

H

S

A

P

Y

Q

P

V

K

L

L

I

T

K

E

A

A

L

L

A

K

D

E

Q

Q

T

V

Q

E

A

K

L

L

I

L

N

H

P

V

G

S

N

N

G

L

L

Y

H

E

N

N

R

P

A

W

Q

Q

L

E

N

E

L

L

A

A

E

H

R

K

L

L

C

V

-

K

H

H

R

F

T

W

G

T

S

E

D

G

Q

K

A

V

Y

F

L

F

L

A

N

N

S
|
S

G
|
G

A
x
T

E

E

A

S

V

V

E

E

A

A

I

I

K

K

L

L

A

A

R

R

K

K

W

Y

G

W

Q

R

L

D

H

K

R

G

G

K

G

N

A

K

Y

W

R

K

I

F

I

I

S

S

A

F

S

E

A

N

G

S

S
x
F

H
|
H

G
|
G

R

R

S

T

F

Y

A

G

A

S

M

L

S

S

A

A

S

T

A

-

G

G

G

Q

P

P

E

K

-

F

-

H

N

K

R

G

F

F

E

E

P

P

Q

L

L

V

P

P

G

G

F

F

S

S

H

Y

V

A

P

K

F

L

N

N

D

D

L

I

S

D

A

S

L

V

H

Y

A

K

A

L

V

L

D

D

A

E

Q

E

T

T

V

A

A

G

I

I

L

I

E
|
E

P

V

I

I

Q

Q

G

G

E

E

A

G

G

G

V

V

I

N

P

E

A

A

T

S

E

E

H

D

Y

F

L

L

K

S

G

K

V

L

E

Q

R

E

L

I

C

C

R

K

E

E

L

K

G

D

I

V

L

L

I

I

L

I

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

I

I

G

G

R

R

C

T

G

G

T

E

L

F

L

Y

A

A

E

Y

Q

Q

Q

H

Y

F

G

N

V

L

R

K

A

P

D

D

I

V

I

I

T

A

L

L

G

A

K
|
K

G

G

L

L

G

G

V

V

P

P

L

I

A

G

A

A

L

I

L

L

A

A

R

R

G

E

K

E

-

V

A

A

C

Q

C

S

F

F

E

T

V

P

G

G

E

S

L

H

E

G

G
x
S

T
|
T

H
x
F

H

G

G

G

N

N

A

P

L

L

M

A

A

C

S

R

A

A

G

G

L

T

A

V

V

V

L

V

E

D

A

E

V

V

L

-

E

-

H

E

G

K

F

L

M

L

D

P

H

H

V

V

R

R

E

E

S

V

G

G

L

N

Y

Y

L

F

G

K

E

E

G

K

L

L

A

K

R

E

L

L

A

G

Y

-

R

-

Y

-

D

-

H

K

G

G

Q

K

L

V

R

K

G

G

H

R

G

G

L

L

M

M

W

L

G

G

L

L

T

E

L

L

S

E

D

R

D

E

S

C

A

K

D

D

A

Y

V

V

V

L

K

K

A

-

A

A

L

L

H

E

E

K

G

G

L

L

I

L

I

I

N

N

A

C

P

T

Q

A

P

G

N

K

C

V

L

L

R
|
R

F

F

T

L

P

P

A

P

L

L

T

I

V

I

S

Q

K

K

S

E

N

H

I

I

D

D

active site: F127 (≠ S151), E179 (= E202), D212 (= D235), Q215 (= Q238), K241 (= K264), T270 (= T292), R352 (= R381)
binding pyridoxal-5'-phosphate: S94 (= S118), G95 (= G119), T96 (≠ A120), F127 (≠ S151), H128 (= H152), G129 (= G153), E179 (= E202), D212 (= D235), V214 (= V237), Q215 (= Q238), K241 (= K264), S269 (≠ G291), T270 (= T292), F271 (≠ H293)

O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
42% identity, 87% coverage: 28:394/420 of query aligns to 4:366/376 of O66442

query
sites
O66442

L

L

M

M

P

N

C

N

V

Y

A

A

R

R

P

L

P

P

H

V

V

K

F

F

V

V

R

R

G

G

Q

K

G

G

S

V

W

Y

L

L

W

Y

D

D

S

E

D

E

D

G

R

K

A

E

Y

Y

L

L

D

D

F

F

S

V

Q

S

G

G

N

I

A

G

A

V

N

N

S

S

L

L

G

G

H

H

S

A

P

Y

Q

P

V

K

L

L

I

T

K

E

A

A

L

L

A

K

D

E

Q

Q

T

V

Q

E

A

K

L

L

I

L

N

H

P

V

G

S

N

N

G

L

L

Y

H

E

N

N

R

P

A

W

Q

Q

L

E

N

E

L

L

A

A

E

H

R

K

L

L

C

V

-

K

H

H

R

F

T

W

G

T

S

E

D

G

Q

K

A

V

Y

F

L

F

L

A

N

N

S

S

G
|
G

A
x
T

E

E

A

S

V

V

E

E

A

A

I

I

K

K

L

L

A

A

R

R

K

K

W

Y

G

W

Q

R

L

D

H

K

R

G

G

K

G

N

A

K

Y

W

R

K

I

F

I

I

S

S

A

F

S

E

A

N

G

S

S

F

H

H

G

G

R

R

S

T

F

Y

A

G

A

S

M

L

S

S

A

A

S

T

A

-

G

G

G

Q

P

P

E

K

-

F

-

H

N

K

R

G

F

F

E

E

P

P

Q

L

L

V

P

P

G

G

F

F

S

S

H

Y

V

A

P

K

F

L

N

N

D

D

L

I

S

D

A

S

L

V

H

Y

A

K

A

L

V

L

D

D

A

E

Q

E

T

T

V

A

A

G

I

I

L

I

E

E

P

V

I

I

Q

Q

G

G

E

E

A

G

G

G

V

V

I

N

P

E

A

A

T

S

E

E

H

D

Y

F

L

L

K

S

G

K

V

L

E

Q

R

E

L

I

C

C

R

K

E

E

L

K

G

D

I

V

L

L

I

I

L

I

D

D

E

E

V

V

Q

Q

T

T

G

G

I

I

G

G

R

R

C

T

G

G

T

E

L

F

L

Y

A

A

E

Y

Q

Q

Q

H

Y

F

G

N

V

L

R

K

A

P

D

D

I

V

I

I

T

A

L

L

G

A

K
|
K

G

G

L

L

G

G

V

V

P

P

L

I

A

G

A

A

L

I

L

L

A

A

R

R

G

E

K

E

-

V

A

A

C

Q

C

S

F

F

E

T

V

P

G

G

E

S

L

H

E

G

G

S

T
|
T

H

F

H

G

G

G

N

N

A

P

L

L

M

A

A

C

S

R

A

A

G

G

L

T

A

V

V

V

L

V

E

D

A

E

V

V

L

-

E

-

H

E

G

K

F

L

M

L

D

P

H

H

V

V

R

R

E

E

S

V

G

G

L

N

Y

Y

L

F

G

K

E

E

G

K

L

L

A

K

R

E

L

L

A

G

Y

-

R

-

Y

-

D

-

H

K

G

G

Q

K

L

V

R

K

G

G

H

R

G

G

L

L

M

M

W

L

G

G

L

L

T

E

L

L

S

E

D

R

D

E

S

C

A

K

D

D

A

Y

V

V

V

L

K

K

A

-

A

A

L

L

H

E

E

K

G

G

L

L

I

L

I

I

N

N

A

C

P

T

Q

A

P

G

N

K

C

V

L

L

R

R

F

F

T

L

P

P

A

P

L

L

T

I

V

I

S

Q

K

K

S

E

N

H

I

I

D

D

GT 96:97 (≠ GA 119:120) binding
K242 (= K264) modified: N6-(pyridoxal phosphate)lysine
T271 (= T292) binding

4addA Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
38% identity, 90% coverage: 26:403/420 of query aligns to 10:394/400 of 4addA

query
sites
4addA

E

E

S

W

L

M

M

I

P

P

C

V

V
x
Y

A

A

R

P

P

A

P

P

H

F

V

I

F

P

V

V

R

R

G

G

Q

E

G

G

S

S

W

R

L

L

W

W

D

D

S

Q

D

Q

D

G

R

K

A

E

Y

Y

L

I

D

D

F

F

S

A

Q

G

G

G

N
x
I

A

A

A

V

N

N

S

A

L

L

G

G

H

H

S

A

P

H

Q

P

V

E

L

L

I

R

K

E

A

A

L

L

A

N

D

E

Q

Q

T

A

Q

S

A

K

L

F

I

W

N

H

P

T

G

G

N

N

G
|
G

L

Y

H

T

N

N

R

E

A

P

Q

V

L

L

N

R

L

L

A

A

E

K

R

K

L

L

C

I

H

D

R

A

T

T

G

F

S

A

D

D

Q

R

A

V

Y

F

L

F

L

C

N

N

S
|
S

G
|
G

A
|
A

E

E

A

A

V
x
N

E

E

A

A

I

L

K

K

L

L

A

A

R

R

K

K

W

F

G

A

Q

H

L

-

H

D

R

R

G

Y

G

G

A

S

Y

H

R

K

-

S

-

G

I

I

I

V

S

A

A

F

S

K

A

N

G

A

S
x
F

H
|
H

G
|
G

R
|
R

S

T

F

L

A

-

M

F

S

T

A

V

S

S

A

A

G

G

P

Q

-

P

-

A

-

Y

E

S

N

Q

R

D

F

F

E

A

P

P

Q

L

L

P

P

A

G

D

F

I

S

R

H

H

V

A

P

A

F

Y

N

N

D

D

L

I

S

N

A

S

L

A

H

S

A

A

A

L

V

I

D

D

A

D

Q

S

T

T

V

C

A

A

I

V

L

I

L

V

E
|
E

P

P

I

I

Q

Q

G

G

E
|
E

A

G

G

G

V

V

I

V

P

P

A

A

T

S

E

N

H

A

Y

F

L

L

K

Q

G

G

V

L

E

R

R

E

L

L

C

C

R

N

E

R

L

H

G

N

I

A

L

L

I

I

L

F

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

I

V

G

G

R

R

C

T

G

G

T

E

L

L

L

Y

A

A

E

Y

Q

M

Q

H

Y

Y

G

G

V

V

R

T

A

P

D

D

I

L

T

T

L

T

G

A

K
|
K

G

A

L

L

G

G

V

F

P

P

L

V

A

G

A

A

L

L

A

A

R

T

G

E

K

E

-

C

A

A

C

R

C

V

F

M

E

T

V

V

G

G

E

T

L

H

E
x
G

G
x
T

T
|
T

H

Y

H

G

G

G

N

N

A

P

L

L

M

A

A

S

S

A

A

V

G

A

L

G

A

K

V

V

L

L

E

E

A

L

V

I

L

N

E

T

H

P

G

E

F

M

M

L

D

N

H

G

V

V

R

K

E

Q

S

R

G

H

L

D

Y

W

L

F

G

V

E

E

G

R

L

L

A

N

R

T

L

I

A

N

Y

H

R

R

Y

Y

D

G

-

L

H

F

G

S

Q

E

L

V

R

R

G

G

H

L

G

G

L

L

M

L

W

I

G

G

L

C

T

V

L

L

S

N

D

A

D

D

-

Y

-

A

-

G

S

Q

A

A

D

K

A

Q

V

I

V

S

K

Q

A

E

A

A

L

A

H

K

E

A

G

G

L

V

I

M

I

V

N

L

A

I

P

A

Q

G

P

G

N

N

C

V

L

V

R
|
R

F

F

T

A

P

P

A

A

L

L

T

N

V

V

S

S

K

E

S

E

N

E

I

V

D

T

E

T

M

G

L

L

L

D

R

R

L

F

A

A

R

A

A

A

active site: F136 (≠ S151), E188 (= E202), D221 (= D235), Q224 (= Q238), K250 (= K264), T279 (= T292), R372 (= R381)
binding pyridoxal-5'-phosphate: S102 (= S118), G103 (= G119), A104 (= A120), N107 (≠ V123), F136 (≠ S151), H137 (= H152), G138 (= G153), E188 (= E202), D221 (= D235), V223 (= V237), Q224 (= Q238), K250 (= K264), T278 (≠ G291), T279 (= T292)
binding n~2~-(3-carboxypropanoyl)-l-ornithine: Y16 (≠ V32), I46 (≠ N62), G75 (= G91), F136 (≠ S151), R139 (= R154), E193 (= E207), K250 (= K264), G277 (≠ E290), T278 (≠ G291), T279 (= T292)

4adbB Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
38% identity, 90% coverage: 26:403/420 of query aligns to 10:394/401 of 4adbB

query
sites
4adbB

E

E

S

W

L

M

M

I

P

P

C

V

V

Y

A

A

R

P

P

A

P

P

H

F

V

I

F

P

V

V

R

R

G

G

Q

E

G

G

S

S

W

R

L

L

W

W

D

D

S

Q

D

Q

D

G

R

K

A

E

Y

Y

L

I

D

D

F

F

S

A

Q

G

G

G

N

I

A

A

A

V

N

N

S

A

L

L

G

G

H

H

S

A

P

H

Q

P

V

E

L

L

I

R

K

E

A

A

L

L

A

N

D

E

Q

Q

T

A

Q

S

A

K

L

F

I

W

N

H

P

T

G

G

N

N

G

G

L

Y

H

T

N

N

R

E

A

P

Q

V

L

L

N

R

L

L

A

A

E

K

R

K

L

L

C

I

H

D

R

A

T

T

G

F

S

A

D

D

Q

R

A

V

Y

F

L

F

L

C

N

N

S
|
S

G
|
G

A
|
A

E

E

A

A

V
x
N

E

E

A

A

I

L

K

K

L

L

A

A

R

R

K

K

W

F

G

A

Q

H

L

-

H

D

R

R

G

Y

G

G

A

S

Y

H

R

K

-

S

-

G

I

I

I

V

S

A

A

F

S

K

A

N

G

A

S
x
F

H
|
H

G
|
G

R

R

S

T

F

L

A

-

M

F

S

T

A

V

S

S

A

A

G

G

P

Q

-

P

-

A

-

Y

E

S

N

Q

R

D

F

F

E

A

P

P

Q

L

L

P

P

A

G

D

F

I

S

R

H

H

V

A

P

A

F

Y

N

N

D

D

L

I

S

N

A

S

L

A

H

S

A

A

A

L

V

I

D

D

A

D

Q

S

T

T

V

C

A

A

I

V

L

I

L

V

E
|
E

P

P

I

I

Q

Q

G

G

E

E

A

G

G

G

V

V

I

V

P

P

A

A

T

S

E

N

H

A

Y

F

L

L

K

Q

G

G

V

L

E

R

R

E

L

L

C

C

R

N

E

R

L

H

G

N

I

A

L

L

I

I

L

F

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

I

V

G

G

R

R

C

T

G

G

T

E

L

L

L

Y

A

A

E

Y

Q

M

Q

H

Y

Y

G

G

V

V

R

T

A

P

D

D

I

L

T

T

L

T

G

A

K
|
K

G

A

L

L

G

G

V

F

P

P

L

V

A

G

A

A

L

L

A

A

R

T

G

E

K

E

-

C

A

A

C

R

C

V

F

M

E

T

V

V

G

G

E

T

L

H

E

G

G
x
T

T
|
T

H

Y

H

G

G

G

N

N

A

P

L

L

M

A

A

S

S

A

A

V

G

A

L

G

A

K

V

V

L

L

E

E

A

L

V

I

L

N

E

T

H

P

G

E

F

M

M

L

D

N

H

G

V

V

R

K

E

Q

S

R

G

H

L

D

Y

W

L

F

G

V

E

E

G

R

L

L

A

N

R

T

L

I

A

N

Y

H

R

R

Y

Y

D

G

-

L

H

F

G

S

Q

E

L

V

R

R

G

G

H

L

G

G

L

L

M

L

W

I

G

G

L

C

T

V

L

L

S

N

D

A

D

D

-

Y

-

A

-

G

S

Q

A

A

D

K

A

Q

V

I

V

S

K

Q

A

E

A

A

L

A

H

K

E

A

G

G

L

V

I

M

I

V

N

L

A

I

P

A

Q

G

P

G

N

N

C

V

L

V

R
|
R

F

F

T

A

P

P

A

A

L

L

T

N

V

V

S

S

K

E

S

E

N

E

I

V

D

T

E

T

M

G

L

L

L

D

R

R

L

F

A

A

R

A

A

A

active site: F136 (≠ S151), E188 (= E202), D221 (= D235), Q224 (= Q238), K250 (= K264), T279 (= T292), R372 (= R381)
binding pyridoxal-5'-phosphate: S102 (= S118), G103 (= G119), A104 (= A120), N107 (≠ V123), F136 (≠ S151), H137 (= H152), G138 (= G153), E188 (= E202), D221 (= D235), V223 (= V237), Q224 (= Q238), K250 (= K264), T278 (≠ G291), T279 (= T292)

4jevB N-acetylornithine aminotransferase from s. Typhimurium complexed with gabaculine
34% identity, 93% coverage: 18:407/420 of query aligns to 2:398/402 of 4jevB

query
sites
4jevB

A

A

P

I

S

T

E

R

T

A

S

T

S

F

S

D

E

E

S

V

L

I

M

L

P

P

C

V

V

Y

A

A

R

P

P

A

P

D

H

F

V

I

F

P

V

V

R

K

G

G

Q

K

G

G

S

S

W

R

L

V

W

W

D

D

S

Q

D

Q

D

G

R

K

A

E

Y

Y

L

I

D

D

F

F

S

A

Q

G

G

G

N
x
I

A

A

A

V

N

T

S

A

L

L

G

G

H

H

S

C

P

H

Q

P

V

A

L

L

I

V

K

E

A

A

L

L

A

K

D

S

Q

Q

T

G

Q

E

A

T

L

L

I

W

N

H

P

T

G

S

N

N

G

V

L

F

H

T

N

N

R

E

A

P

Q

A

L

L

N

R

L

L

A

G

E

R

R

K

L

L

C

I

H

D

R

A

T

T

G

F

S

A

D

E

Q

R

A

V

Y

L

L

F

L

M

N

N

S
|
S

G
|
G

A
x
T

E

E

A

A

V
x
N

E

E

A

T

A

A

I

F

K

K

L

L

A

A

R

R

K

H

W

Y

G

A

Q

C

L

V

-

R

H

H

R

S

G

P

G

F

A

K

Y

T

R

K

I

I

S

A

A

F

S

H

A

N

G

A

S
x
F

H
|
H

G
|
G

R

R

S

S

F

L

A

F

A

T

M

V

S

S

A

V

S

-

A

G

G

G

G

Q

P

P

E

K

-

Y

-

S

N

D

R

G

F

F

E

G

P

P

Q

K

L

P

P

A

G

D

F

I

S

I

H

H

V

V

P

P

F

F

N

N

D

D

L

L

S

H

A

A

L

V

H

K

A

A

A

V

V

M

D

D

A

D

Q

H

T

T

V

C

A

A

I

V

L

V

E
|
E

P

P

I

I

Q

Q

G

G

E
|
E

A

G

G

G

V

V

I

Q

P

A

A

A

T

T

E

P

H

E

Y

F

L

L

K

K

G

G

V

L

E

R

R

D

L

L

C

C

R

D

E

E

L

H

G

Q

I

A

L

L

I

V

L

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

I

M

G

G

R

R

C

T

G

G

T

D

L

L

L

F

A

A

E

Y

Q

M

Q

H

Y

Y

G

G

V

V

R

T

A

P

D

D

I

I

I

L

T

T

L

S

G

A

K
|
K

G

A

L

L

G

G

V

F

P

P

L

V

A

S

A

A

L

M

L

L

A

T

R

T

G

Q

K

E

-

I

A

A

C

S

C

A

F

F

E

H

V

V

G

G

E

S

L

H

E

G

G
x
S

T
|
T

H

Y

H

G

G

G

N

N

A

P

L

L

M

A

A

C

S

A

A

V

G

A

L

G

A

A

V

T

L

F

E

D

A

I

V

I

L

N

E

T

H

P

G

E

F

V

M

L

D

Q

H

G

V

I

R

H

E

T

S

K

G

R

L

Q

Y

Q

L

F

G

V

E

Q

G

H

L

L

A

Q

R

A

L

I

A

D

Y

E

R

Q

Y

F

D

D

-

I

H

F

G

S

Q

D

L

I

R

R

G

G

H

M

G

G

L

L

M

L

W

I

G

G

L

A

T

E

L

L

S

K

D

P

D

K

-

Y

-

K

-

G

S

R

A

A

D

R

A

D

V

F

V

L

K

Y

A

A

A

G

L

A

H

E

E

A

G

G

L

V

I

M

I

V

N

L

A

N

P

A

Q

G

P

A

N

D

C

V

L

M

R
|
R

F

F

T

A

P

P

A

S

L

L

T

V

V

V

S

E

K

E

S

A

N

D

I

I

D

H

E

E

M

G

L

M

L

Q

R

R

L

F

A

A

R

Q

A

A

F

V

S

G

R

K

V

V

active site: F136 (≠ S151), E188 (= E202), D221 (= D235), Q224 (= Q238), K250 (= K264), T279 (= T292), R372 (= R381)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: I46 (≠ N62), S102 (= S118), G103 (= G119), T104 (≠ A120), N107 (≠ V123), F136 (≠ S151), H137 (= H152), G138 (= G153), E188 (= E202), E193 (= E207), D221 (= D235), V223 (= V237), Q224 (= Q238), K250 (= K264), S278 (≠ G291), T279 (= T292), R372 (= R381)

P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
34% identity, 93% coverage: 18:407/420 of query aligns to 7:403/405 of P40732

query
sites
P40732

A

A

P

I

S

T

E

R

T

A

S

T

S

F

S

D

E

E

S

V

L

I

M

L

P

P

C

V

V

Y

A

A

R

P

P

A

P

D

H

F

V

I

F

P

V

V

R

K

G

G

Q

K

G

G

S

S

W

R

L

V

W

W

D

D

S

Q

D

Q

D

G

R

K

A

E

Y

Y

L

I

D

D

F

F

S

A

Q

G

G

G

N

I

A

A

A

V

N

T

S

A

L

L

G

G

H

H

S

C

P

H

Q

P

V

A

L

L

I

V

K

E

A

A

L

L

A

K

D

S

Q

Q

T

G

Q

E

A

T

L

L

I

W

N

H

P

T

G

S

N

N

G

V

L

F

H

T

N

N

R

E

A

P

Q

A

L

L

N

R

L

L

A

G

E

R

R

K

L

L

C

I

H

D

R

A

T

T

G

F

S

A

D

E

Q

R

A

V

Y

L

L

F

L

M

N

N

S

S

G
|
G

A
x
T

E

E

A

A

V

N

E

E

A

T

A

A

I

F

K

K

L

L

A

A

R

R

K

H

W

Y

G

A

Q

C

L

V

-

R

H

H

R

S

G

P

G

F

A

K

Y

T

R

K

I

I

S

A

A

F

S

H

A

N

G

A

S

F

H

H

G

G

R

R

S

S

F

L

A

F

A

T

M

V

S

S

A

V

S

-

A

G

G

G

G

Q

P

P

E

K

-

Y

-

S

N

D

R

G

F

F

E

G

P

P

Q

K

L

P

P

A

G

D

F

I

S

I

H

H

V

V

P

P

F

F

N

N

D

D

L

L

S

H

A

A

L

V

H

K

A

A

A

V

V

M

D

D

A

D

Q

H

T

T

V

C

A

A

I

V

L

V

E

E

P

P

I

I

Q

Q

G

G

E

E

A

G

G

G

V

V

I

Q

P

A

A

A

T

T

E

P

H

E

Y

F

L

L

K

K

G

G

V

L

E

R

R

D

L

L

C

C

R

D

E

E

L

H

G

Q

I

A

L

L

I

V

L

F

D

D

E

E

V

V

Q

Q

T

C

G

G

I

M

G

G

R

R

C

T

G

G

T

D

L

L

L

F

A

A

E

Y

Q

M

Q

H

Y

Y

G

G

V

V

R

T

A

P

D

D

I

I

I

L

T

T

L

S

G

A

K
|
K

G

A

L

L

G

G

V

F

P

P

L

V

A

S

A

A

L

M

L

L

A

T

R

T

G

Q

K

E

-

I

A

A

C

S

C

A

F

F

E

H

V

V

G

G

E

S

L

H

E

G

G

S

T
|
T

H

Y

H

G

G

G

N

N

A

P

L

L

M

A

A

C

S

A

A

V

G

A

L

G

A

A

V

A

L

F

E

D

A

I

V

I

L

N

E

T

H

P

G

E

F

V

M

L

D

Q

H

G

V

I

R

H

E

T

S

K

G

R

L

Q

Y

Q

L

F

G

V

E

Q

G

H

L

L

A

Q

R

A

L

I

A

D

Y

E

R

Q

Y

F

D

D

-

I

H

F

G

S

Q

D

L

I

R

R

G

G

H

M

G

G

L

L

M

L

W

I

G

G

L

A

T

E

L

L

S

K

D

P

D

K

-

Y

-

K

-

G

S

R

A

A

D

R

A

D

V

F

V

L

K

Y

A

A

A

G

L

A

H

E

E

A

G

G

L

V

I

M

I

V

N

L

A

N

P

A

Q

G

P

A

N

D

C

V

L

M

R

R

F

F

T

A

P

P

A

S

L

L

T

V

V

V

S

E

K

E

S

A

N

D

I

I

D

H

E

E

M

G

L

M

L

Q

R

R

L

F

A

A

R

Q

A

A

F

V

S

G

R

K

V

V

GT 108:109 (≠ GA 119:120) binding
K255 (= K264) modified: N6-(pyridoxal phosphate)lysine
T284 (= T292) binding

A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
37% identity, 89% coverage: 28:400/420 of query aligns to 11:379/390 of A0QYS9

query
sites
A0QYS9

L

M

M

M

P

N

C

N

V

Y

A

G

R

T

P

P

H

L

V

S

F

L

V

V

R

S

G

G

Q

E

G

G

S

A

W

V

L

V

W

T

D

D

S

A

D

D

D

G

R

R

A

E

Y

Y

L

L

D

D

F

L

S

L

Q

G

G

G

N

I

A

A

A

V

N

N

S

L

L

L

G

G

H

H

S

R

P

H

Q

P

V

A

L

V

I

I

K

E

A

A

L

V

A

T

D

T

Q

Q

T

L

Q

D

A

T

L

L

I

G

N

H

P

T

G

S

N

N

G

L

L

Y

H

A

N

T

R

E

A

P

Q

G

L

I

N

A

L

L

A

A

E

E

R

A

L

L

C

V

H

G

R

Q

T

L

G

G

S

T

D

Q

-

A

Q

R

A

V

Y

F

L

F

L

C

N

N

S

S

G

G

A

T

E

E

A

A

V

N

E

E

A

V

A

A

I

F

K

K

L

I

A

T

R

R

K

L

W

T

G

G

Q

K

L

-

H

-

R

-

G

-

A

-

Y

T

R

K

I

I

I

V

S

A

A

A

S

E

A

G

G

A

S

F

H

H

G

G

R

R

S

T

F

M

A

G

A

S

M

L

S

A

A

L

S

T

A

-

G

G

G

Q

P

P

E

S

N

K

R

Q

-

A

-

P

F

F

E

E

P

P

Q

-

L

L

P

P

G

G

-

N

F

V

S

M

H

H

V

V

P

P

F

Y

N

G

D

D

L

V

S

A

A

A

L

L

H

E

A

A

V

V

D

D

A

D

Q

Q

T

T

V

A

A

A

I

V

L

F

L

L

E

E

P

P

I

I

Q

M

G

G

E

E

A

G

G

G

V

V

I

V

P

V

A

P

T

P

E

A

H

G

Y

Y

L

L

K

V

G

A

V

A

E

R

R

E

L

I

C

T

R

S

E

K

L

H

G

G

I

A

L

L

I

V

L

L

D

D

E

E

V

V

Q

Q

T

T

G

G

I

V

G

G

R

R

C

T

G

G

T

A

L

F

A

A

E

H

Q

Q

Q

H

Y

D

G

G

V

I

R

V

A

P

D

D

I

V

T

T

L

M

G

A

K

K

G

G

L

L

G

G

V

L

P

P

L

I

A

G

A

A

L

C

L

L

A

A

R

V

G

G

K

A

A

T

C

G

C

D

F

L

E

L

V

T

G

P

E

G

L

L

E

H

G

G

-

S

T

T

H

F

H

G

G

G

N

N

A

P

L

V

M

C

A

T

S

A

A

A

G

G

L

L

A

A

V

V

L

L

E

K

A

T

V

L

L

A

E

A

H

E

G

D

F

L

M

V

D

A

H

R

V

A

R

G

E

V

S

L

G

G

L
x
K

Y

T

L

L

G

S

E

H

G

G

L

I

A

E

R

E

L

L

A

G

Y

H

R

P

Y

L

D

V

H

D

G

-

Q

K

L

V

R

R

G

G

H

K

G

G

L

L

M

L

W

Q

G

G

L

I

T

V

L

L

S

T

D

V

D

P

S

S

A

A

D

K

A

A

V

V

V

E

K

T

A

A

L

R

H

D

E

A

G

G

L

F

I

L

I

V

N

N

A

A

P

A

Q

A

P

P

N

E

C

V

L

V

R

R

F

L

T

A

P

P

A

P

L

L

T

I

V

I

S

T

K

E

S

G

N

Q

I

I

D

E

E

A

M

F

L

I

L

T

R

A

L

L

K304 (≠ L324) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

4jewA N-acetylornithine aminotransferase from s. Typhimurium complexed with l-canaline
34% identity, 93% coverage: 18:407/420 of query aligns to 2:393/397 of 4jewA

query
sites
4jewA

A

A

P

I

S

T

E

R

T

A

S

T

S

F

S

D

E

E

S

V

L

I

M

L

P

P

C

V

V

Y

A

A

R

P

P

A

P

D

H

F

V

I

F

P

V

V

R
x
K

G

G

Q
x
K

G

G

S

S

W

R

L

V

W
|
W

D

D

S

Q

D

Q

D
x
G

R

K

A
x
E

Y

Y

L

I

D

D

F

F

S

A

Q

G

G

G

N
x
I

A

A

A

V

N

T

S

A

L

L

G

G

H

H

S

C

P

H

Q

P

V

A

L

L

I

V

K

E

A

A

L

L

A

K

D

S

Q

Q

T

G

Q

E

A

T

L

L

I

W

N

H

P

T

G

S

N

N

G

V

L

F

H

T

N

N

R

E

A

P

Q

A

L

L

N

R

L

L

A

G

E

R

R

K

L

L

C

I

H

D

R

A

T

T

G

F

S

A

D

E

Q

R

A

V

Y

L

L

F

L

M

N

N

S
|
S

G
|
G

A
x
T

E

E

A

A

V
x
N

E

E

A

T

A

A

I

F

K

K

L

L

A

A

R

R

K

H

W

Y

G

A

Q

C

L

V

-

R

H

H

R

S

G

P

G

F

A

K

Y

T

R

K

I

I

S

A

A

F

S

H

A

N

G

A

S
x
F

H
|
H

G
|
G

R
|
R

S

S

F

L

A

F

A

T

M

V

S

S

A

V

S

-

A

G

G

G

G

Q

P

P

E

K

-

Y

-

S

N

D

R

G

F

F

E

G

P

P

Q

K

L

P

P

A

G

D

F

I

S

I

H

H

V

V

P

P

F

F

N

N

D

D

L

L

S

H

A

A

L

V

H

K

A

A

A

V

V

M

D

D

A

D

Q

H

T

T

V

C

A

A

I

V

L

V

E
|
E

P

P

I

I

Q

Q

G

G

E
|
E

A

G

G

G

V

V

I

Q

P

A

A

A

T

T

E

P

H

E

Y

F

L

L

K

K

G

G

V

L

E

R

R

D

L

L

C

C

R

D

E

E

L

H

G

Q

I

A

L

L

I

V

L

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

I

M

G

G

R

R

C

T

G

G

T

D

L

L

L

F

A

A

E

Y

Q

M

Q

H

Y

Y

G

G

V

V

R

T

A

P

D

D

I

I

I

L

T

T

L

S

G

A

K
|
K

G

A

L

L

G

G

V

F

P

P

L

V

A

S

A

A

L

M

L

L

A

T

R

T

G

Q

K

E

A

I

C

A

C

S

F

-

E

-

V

-

G

-

E

A

L

F

E

G

G

S

T
|
T

H

Y

H

G

G

G

N

N

A

P

L

L

M

A

A

C

S

A

A

V

G

A

L

G

A

A

V

T

L

F

E

D

A

I

V

I

L

N

E

T

H

P

G

E

F

V

M

L

D

Q

H

G

V

I

R

H

E

T

S

K

G

R

L

Q

Y

Q

L

F

G

V

E

Q

G

H

L

L

A

Q

R

A

L

I

A

D

Y

E

R

Q

Y

F

D

D

-

I

H

F

G

S

Q

D

L

I

R

R

G

G

H

M

G

G

L

L

M

L

W

I

G

G

L

A

T

E

L

L

S

K

D

P

D

K

-

Y

-

K

-

G

S

R

A

A

D

R

A

D

V

F

V

L

K

Y

A

A

A

G

L

A

H

E

E

A

G

G

L

V

I

M

I

V

N

L

A

N

P

A

Q

G

P

A

N

D

C

V

L

M

R
|
R

F

F

T

A

P

P

A

S

L

L

T

V

V

V

S

E

K

E

S

A

N

D

I

I

D

H

E

E

M

G

L

M

L

Q

R

R

L

F

A

A

R

Q

A

A

F

V

S

G

R

K

V

V

active site: F136 (≠ S151), E188 (= E202), D221 (= D235), Q224 (= Q238), K250 (= K264), T274 (= T292), R367 (= R381)
binding (2S)-2-azanyl-4-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxy-butanoic acid: I46 (≠ N62), S102 (= S118), G103 (= G119), T104 (≠ A120), N107 (≠ V123), F136 (≠ S151), H137 (= H152), G138 (= G153), R139 (= R154), E188 (= E202), E193 (= E207), D221 (= D235), V223 (= V237), Q224 (= Q238), K250 (= K264)
binding picric acid: K25 (≠ R41), K27 (≠ Q43), W32 (= W48), G36 (≠ D52), E38 (≠ A54)

2pb0A Structure of biosynthetic n-acetylornithine aminotransferase from salmonella typhimurium: studies on substrate specificity and inhibitor binding (see paper)
34% identity, 92% coverage: 23:407/420 of query aligns to 1:387/389 of 2pb0A

query
sites
2pb0A

S

T

S

F

S

D

E

E

S

V

L

I

M

L

P

P

C

V

V

Y

A

A

R

P

P

A

P

D

H

F

V

I

F

P

V

V

R

K

G

G

Q

K

G

G

S

S

W

R

L

V

W

W

D

D

S

Q

D

Q

D

G

R

K

A

E

Y

Y

L

I

D

D

F

F

S

A

Q

G

G

G

N

I

A

A

A

V

N

T

S

A

L

L

G

G

H

H

S

C

P

H

Q

P

V

A

L

L

I

V

K

E

A

A

L

L

A

K

D

S

Q

Q

T

G

Q

E

A

T

L

L

I

W

N

H

P

T

G

S

N

N

G

V

L

F

H

T

N

N

R

E

A

P

Q

A

L

L

N

R

L

L

A

G

E

R

R

K

L

L

C

I

H

D

R

A

T

T

G

F

S

A

D

E

Q

R

A

V

Y

L

L

F

L

M

N

N

S
|
S

G
|
G

A
x
T

E

E

A

A

V
x
N

E

E

A

T

A

A

I

F

K

K

L

L

A

A

R

R

K

H

W

Y

G

A

Q

C

L

V

-

R

H

H

R

S

G

P

G

F

A

K

Y

T

R

K

I

I

S

A

A

F

S

H

A

N

G

A

S
x
F

H
|
H

G
|
G

R

R

S

S

F

L

A

F

A

T

M

V

S

S

A

V

S

-

A

G

G

G

G

Q

P

P

E

K

-

Y

-

S

N

D

R

G

F

F

E

G

P

P

Q

K

L

P

P

A

G

D

F

I

S

I

H

H

V

V

P

P

F

F

N

N

D

D

L

L

S

H

A

A

L

V

H

K

A

A

A

V

V

M

D

D

A

D

Q

H

T

T

V

C

A

A

I

V

L

V

E
|
E

P

P

I

I

Q

Q

G

G

E

E

A

G

G

G

V

V

I

Q

P

A

A

A

T

T

E

P

H

E

Y

F

L

L

K

K

G

G

V

L

E

R

R

D

L

L

C

C

R

D

E

E

L

H

G

Q

I

A

L

L

I

V

L

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

I

M

G

G

R

R

C

T

G

G

T

D

L

L

L

F

A

A

E

Y

Q

M

Q

H

Y

Y

G

G

V

V

R

T

A

P

D

D

I

I

I

L

T

T

L

S

G

A

K
|
K

G

A

L

L

G

G

V

F

P

P

L

V

A

S

A

A

L

M

L

L

A

T

R

T

G

Q

K

E

A

I

C

A

C

S

F

-

E

-

V

-

G

-

E

A

L

F

E

G

G

S

T
|
T

H

Y

H

G

G

G

N

N

A

P

L

L

M

A

A

C

S

A

A

V

G

A

L

G

A

A

V

A

L

F

E

D

A

I

V

I

L

N

E

T

H

P

G

E

F

V

M

L

D

Q

H

G

V

I

R

H

E

T

S

K

G

R

L

Q

Y

Q

L

F

G

V

E

Q

G

H

L

L

A

Q

R

A

L

I

A

D

Y

E

R

Q

Y

F

D

D

-

I

H

F

G

S

Q

D

L

I

R

R

G

G

H

M

G

G

L

L

M

L

W

I

G

G

L

A

T

E

L

L

S

K

D

P

D

K

-

Y

-

K

-

G

S

R

A

A

D

R

A

D

V

F

V

L

K

Y

A

A

A

G

L

A

H

E

E

A

G

G

L

V

I

M

I

V

N

L

A

N

P

A

Q

G

P

A

N

D

C

V

L

M

R
|
R

F

F

T

A

P

P

A

S

L

L

T

V

V

V

S

E

K

E

S

A

N

D

I

I

D

H

E

E

M

G

L

M

L

Q

R

R

L

F

A

A

R

Q

A

A

F

V

S

G

R

K

V

V

active site: F130 (≠ S151), E182 (= E202), D215 (= D235), Q218 (= Q238), K244 (= K264), T268 (= T292), R361 (= R381)
binding pyridoxal-5'-phosphate: S96 (= S118), G97 (= G119), T98 (≠ A120), N101 (≠ V123), F130 (≠ S151), H131 (= H152), G132 (= G153), E182 (= E202), D215 (= D235), V217 (= V237), Q218 (= Q238), K244 (= K264)

Q9M8M7 Acetylornithine aminotransferase, chloroplastic/mitochondrial; ACOAT; Acetylornithine transaminase; AOTA; Protein HOPW1-1-INTERACTING 1; EC 2.6.1.11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
34% identity, 86% coverage: 33:394/420 of query aligns to 74:443/457 of Q9M8M7

query
sites
Q9M8M7

A

A

R

R

P

A

P

P

H

V

V

V

F

L

V

S

R

S

G

G

Q

K

G

G

S

C

W

K

L

L

W

F

D

D

S

P

D

E

D

G

R

K

A

E

Y

Y

L

L

D

D

F

C

S

A

Q

S

G

G

N

I

A

A

A

V

N

N

S

A

L

L

G

G

H

H

S

G

P

D

Q

P

V

D

L

W

I

L

K

R

A

A

L

V

A

T

D

E

Q

Q

T

A

Q

G

A

V

L

L

I

A

N

H

P

V

G

S

N

N

G

V

L

Y

H

Y

N

T

R

I

A

P

Q

Q

L

I

N

E

L

L

A

A

E

K

R

R

L

L

C

V

H

A

R

S

T

S

G

F

S

A

D

D

Q

R

A

V

Y

F

L

F

L

C

N

N

S

S

G

G

A

T

E

E

A

A

V

N

E

E

A

A

I

I

K

K

L

F

A

S

R

R

K

K

W

F

G

Q

Q

R

L

F

-

T

-

H

-

P

-

E

H

D

R

K

G

E

G

V

A

A

Y

T

R

G

I

F

I

I

S

A

A

F

S

T

A

N

G

S

S

F

H

H

G

G

R

R

S

T

F

L

A

G

A

A

M

L

S

A

-

L

A

T

S

S

A

K

G

E

G

Q

P

Y

E

R

N

T

R

P

F

F

E

E

P

P

Q

I

L

M

P

P

G

G

F

V

S

T

H

F

V

L

P

E

F

Y

N

G

D

N

L

I

S

Q

A

A

L

A

H

T

A

D

A

L

V

I

-

R

D

S

A

G

Q

K

T

I

V

A

A

A

I

V

L

F

L

V

E

E

P

P

I

I

Q

Q

G

G

E

E

A

G

G

G

V

I

I

Y

P

S

A

A

T

T

E

K

H

E

Y

F

L

L

K

Q

G

S

V

L

E

R

R

S

L

A

C

C

R

D

E

A

L

A

G

G

I

S

L

L

I

V

L

F

D

D

E

E

V

V

Q

Q

T

C

G

G

I

L

G

G