Comparing GFF520 FitnessBrowser__Marino:GFF520 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 9 hits to proteins with known functional sites (download)
P0A7B5 Glutamate 5-kinase; Gamma-glutamyl kinase; GK; EC 2.7.2.11 from Escherichia coli (strain K12) (see paper)
43% identity, 98% coverage: 7:372/374 of query aligns to 1:365/367 of P0A7B5
2j5tD Glutamate 5-kinase from escherichia coli complexed with glutamate (see paper)
44% identity, 97% coverage: 10:372/374 of query aligns to 2:363/365 of 2j5tD
2j5vB Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
40% identity, 97% coverage: 10:372/374 of query aligns to 2:323/325 of 2j5vB
2j5vA Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
39% identity, 97% coverage: 10:372/374 of query aligns to 2:321/323 of 2j5vA
7wx3B Gk domain of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
35% identity, 70% coverage: 1:261/374 of query aligns to 3:256/258 of 7wx3B
7f5xA Gk domain of drosophila p5cs filament with glutamate (see paper)
36% identity, 66% coverage: 1:248/374 of query aligns to 3:233/236 of 7f5xA
2akoA Crystal structure of glutamate 5-kinase from campylobacter jejuni
33% identity, 59% coverage: 11:229/374 of query aligns to 1:206/241 of 2akoA
Q8U122 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see paper)
30% identity, 29% coverage: 155:263/374 of query aligns to 120:225/225 of Q8U122
Sites not aligning to the query:
2bmuB Ump kinase from pyrococcus furiosus complexed with its substrate ump and its substrate analog amppnp (see paper)
30% identity, 29% coverage: 155:263/374 of query aligns to 121:226/226 of 2bmuB
Sites not aligning to the query:
>GFF520 FitnessBrowser__Marino:GFF520
MTERLQLRQARRLVIKIGSALLTNDGRGLDVAALGLWVDQIAELIEDGVEVVVVSSGSVA
EGMSRLGWTVRPEQLHELQAAAAVGQMGLVQTWEAQFKRHDIHTAQILLTHDDLSDRKRY
LNGRGTLRALLNLGVVPIVNENDTVVTDEIRFGDNDTLGALVANLIEADGLIILTDQLGL
FDKDPRKHSDACLVTERRAGDRELDAMAGGGAGVLGRGGMQTKLRAARLAARSGAFTVIV
GGRIEGVIGRLRQGDVIGTLLLPEQGRIAARKQWLASHLQTRGRLTLDDGAVKVLCLGGR
SLLPVGVKGVSGQFRRGEMVSCFDQSGREIARGLVNYDADEARAIAGRSSDRITEILGYM
SGEEMIHRDNLVIV
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory