SitesBLAST
Comparing GFF722 PGA1_c07370 putative short chain dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5wjsA Crystal structure of oxidoreductase (short chain dehydrogenase/reductase family) from burkholderia thailandensis complexed with nadh
50% identity, 96% coverage: 5:251/256 of query aligns to 9:256/258 of 5wjsA
- active site: G27 (= G23), S152 (= S147), Y162 (= Y157), Y165 (= Y160), K169 (≠ N164)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G23 (= G19), T26 (≠ S22), I28 (= I24), D47 (≠ G43), L48 (≠ R44), D73 (= D68), L74 (≠ I69), N100 (= N95), A102 (= A97), L150 (≠ F145), G151 (≠ T146), S152 (= S147), K169 (≠ N164), P195 (= P190), G196 (= G191), W197 (= W192), V198 (= V193), K202 (= K197)
7wwxA Crystal structure of herbaspirillum huttiense l-arabinose 1- dehydrogenase (NAD bound form) (see paper)
48% identity, 97% coverage: 5:253/256 of query aligns to 4:254/254 of 7wwxA
- binding nicotinamide-adenine-dinucleotide: G18 (= G19), T21 (≠ S22), I23 (= I24), D42 (≠ G43), I43 (vs. gap), C68 (= C67), D69 (= D68), L70 (≠ I69), N96 (= N95), A98 (= A97), F146 (= F145), S147 (≠ T146), S148 (= S147), Y161 (= Y160), K165 (≠ N164), P191 (= P190), G192 (= G191), W193 (= W192), V194 (= V193), R198 (≠ K197)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
35% identity, 96% coverage: 10:254/256 of query aligns to 3:247/247 of 4jroC
- active site: G16 (= G23), S142 (= S147), Q152 (≠ Y157), Y155 (= Y160), K159 (≠ N164)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G19), S14 (≠ G21), R15 (≠ S22), G16 (= G23), I17 (= I24), N35 (≠ V42), Y36 (vs. gap), N37 (vs. gap), G38 (= G43), S39 (≠ R44), N63 (≠ D68), V64 (≠ I69), N90 (= N95), A91 (= A96), I93 (≠ N98), I113 (= I118), S142 (= S147), Y155 (= Y160), K159 (≠ N164), P185 (= P190), I188 (≠ V193), T190 (= T195)
7krmC Putative fabg bound to nadh from acinetobacter baumannii
37% identity, 96% coverage: 10:254/256 of query aligns to 3:243/244 of 7krmC
- active site: G18 (= G23), S140 (= S147), Y155 (= Y160)
- binding nicotinamide-adenine-dinucleotide: G12 (= G19), S15 (= S22), G18 (= G23), I19 (= I24), D38 (≠ G43), L39 (≠ T48), A60 (≠ C67), N61 (≠ D68), V62 (≠ I69), N88 (= N95), V111 (≠ I118), S140 (= S147), Y155 (= Y160), K159 (≠ N164), I188 (≠ V193), T190 (= T195)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
35% identity, 96% coverage: 10:254/256 of query aligns to 5:244/244 of 4nbuB
- active site: G18 (= G23), N111 (= N119), S139 (= S147), Q149 (≠ Y157), Y152 (= Y160), K156 (≠ N164)
- binding acetoacetyl-coenzyme a: D93 (= D99), K98 (≠ T104), S139 (= S147), N146 (= N154), V147 (≠ N155), Q149 (≠ Y157), Y152 (= Y160), F184 (≠ W192), M189 (≠ K197), K200 (≠ H211)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G19), N17 (≠ S22), G18 (= G23), I19 (= I24), D38 (≠ G43), F39 (≠ R44), V59 (≠ C67), D60 (= D68), V61 (≠ I69), N87 (= N95), A88 (= A96), G89 (vs. gap), I90 (vs. gap), T137 (≠ F145), S139 (= S147), Y152 (= Y160), K156 (≠ N164), P182 (= P190), F184 (≠ W192), T185 (≠ V193), T187 (= T195), M189 (≠ K197)
1vl8B Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
29% identity, 95% coverage: 9:251/256 of query aligns to 3:248/252 of 1vl8B
- active site: G17 (= G23), S143 (= S147), I154 (≠ Y157), Y157 (= Y160), K161 (≠ N164)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G19), R16 (≠ S22), G17 (= G23), L18 (≠ I24), S37 (≠ G43), R38 (= R44), C63 (= C67), D64 (= D68), V65 (≠ I69), A91 (≠ N95), A92 (= A96), G93 (≠ A97), I94 (≠ N98), V114 (≠ I118), I141 (≠ F145), S143 (= S147), Y157 (= Y160), K161 (≠ N164), P187 (= P190), G188 (= G191), Y190 (≠ V193), T192 (= T195), M194 (≠ K197), T195 (≠ Q198)
Q5P5I4 (S)-1-Phenylethanol dehydrogenase; EC 1.1.1.311 from Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) (see 2 papers)
36% identity, 95% coverage: 10:253/256 of query aligns to 5:247/249 of Q5P5I4
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
2ewmB Crystal structure of the (s)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain ebn1 (see paper)
36% identity, 95% coverage: 10:253/256 of query aligns to 3:245/247 of 2ewmB
- active site: G16 (= G23), S139 (= S147), Y149 (= Y157), Y152 (= Y160), K156 (≠ N164)
- binding nicotinamide-adenine-dinucleotide: G12 (= G19), N15 (≠ S22), G16 (= G23), I17 (= I24), D36 (= D49), L37 (≠ F50), C59 (= C67), D60 (= D68), V61 (≠ I69), N87 (= N95), S139 (= S147), Y152 (= Y160), K156 (≠ N164), P182 (= P190), S183 (≠ G191), L184 (≠ W192), V185 (= V193), T189 (= T204)
6t62A Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
32% identity, 93% coverage: 16:252/256 of query aligns to 9:241/244 of 6t62A
- active site: G16 (= G23), S138 (= S147), Y151 (= Y160)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G19), S14 (≠ G21), R15 (≠ S22), A36 (≠ S45), T37 (≠ D46), L58 (≠ C67), D59 (= D68), V60 (≠ I69), N86 (= N95), A87 (= A96), G88 (≠ A97), I89 (≠ N98), I136 (≠ F145), S137 (≠ T146), S138 (= S147), Y151 (= Y160), K155 (≠ N164), P181 (= P190), G182 (= G191), I184 (≠ V193), M188 (≠ T204)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii (see paper)
32% identity, 93% coverage: 16:252/256 of query aligns to 9:241/244 of 6wprA
- active site: G16 (= G23), S138 (= S147), Y151 (= Y160)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G19), S14 (≠ G21), R15 (≠ S22), T37 (≠ D46), L58 (≠ C67), D59 (= D68), V60 (≠ I69), N86 (= N95), A87 (= A96), G88 (≠ A97), I89 (≠ N98), I136 (≠ F145), Y151 (= Y160), K155 (≠ N164), P181 (= P190)
4za2D Crystal structure of pectobacterium carotovorum 2-keto-3-deoxy-d- gluconate dehydrogenase complexed with NAD+ (see paper)
32% identity, 95% coverage: 9:251/256 of query aligns to 7:243/247 of 4za2D
- binding nicotinamide-adenine-dinucleotide: G17 (= G19), D19 (≠ G21), L22 (≠ I24), I42 (≠ R44), D65 (= D68), M66 (≠ I69), N92 (= N95), A93 (= A96), G94 (≠ A97), L115 (≠ I118), I143 (≠ F145), S145 (= S147), Y158 (= Y160), K162 (≠ N164), G189 (= G191), M191 (≠ V193), T193 (= T195), N195 (≠ K197)
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
34% identity, 95% coverage: 10:251/256 of query aligns to 2:256/260 of 5b4tA
- active site: G15 (= G23), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (≠ N164), I200 (≠ W202)
- binding (3R)-3-hydroxybutanoic acid: Q94 (≠ D99), S142 (= S147), H144 (≠ S149), K152 (≠ Y157), Y155 (= Y160), W187 (= W192), Q196 (= Q198)
- binding nicotinamide-adenine-dinucleotide: G11 (= G19), T13 (≠ G21), G15 (= G23), I16 (= I24), F36 (≠ R44), D63 (= D68), L64 (≠ I69), N90 (= N95), G92 (≠ A97), L113 (≠ I118), I140 (≠ F145), Y155 (= Y160), K159 (≠ N164), P185 (= P190), G186 (= G191), W187 (= W192), V188 (= V193), T190 (vs. gap), L192 (= L194), V193 (≠ T195)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
34% identity, 95% coverage: 10:251/256 of query aligns to 2:256/260 of 3w8dA
- active site: G15 (= G23), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (≠ N164), I200 (≠ W202)
- binding methylmalonic acid: Q94 (≠ D99), S142 (= S147), H144 (≠ S149), K152 (≠ Y157), Y155 (= Y160), W187 (= W192), Q196 (= Q198)
- binding nicotinamide-adenine-dinucleotide: G11 (= G19), T13 (≠ G21), S14 (= S22), G15 (= G23), I16 (= I24), F36 (≠ R44), A62 (≠ C67), D63 (= D68), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (≠ A97), L113 (≠ I118), S142 (= S147), Y155 (= Y160), K159 (≠ N164), P185 (= P190), G186 (= G191), W187 (= W192), V188 (= V193), T190 (vs. gap), L192 (= L194), V193 (≠ T195)
Sites not aligning to the query:
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
34% identity, 95% coverage: 10:251/256 of query aligns to 2:256/260 of 3vdrA
- active site: G15 (= G23), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (≠ N164), I200 (≠ W202)
- binding (3R)-3-hydroxybutanoic acid: Q94 (≠ D99), H144 (≠ S149), K152 (≠ Y157), Y155 (= Y160), W187 (= W192), Q196 (= Q198)
- binding acetoacetic acid: Q94 (≠ D99), H144 (≠ S149), K152 (≠ Y157), Y155 (= Y160), W187 (= W192), Q196 (= Q198)
- binding nicotinamide-adenine-dinucleotide: G11 (= G19), T13 (≠ G21), I16 (= I24), F36 (≠ R44), D63 (= D68), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (≠ A97), L113 (≠ I118), K159 (≠ N164), G186 (= G191), V188 (= V193), T190 (vs. gap), L192 (= L194), V193 (≠ T195)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G19), T13 (≠ G21), I16 (= I24), F36 (≠ R44), D63 (= D68), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (≠ A97), L113 (≠ I118), S142 (= S147), Y155 (= Y160), K159 (≠ N164), G186 (= G191), V188 (= V193), T190 (vs. gap), L192 (= L194), V193 (≠ T195)
Sites not aligning to the query:
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
34% identity, 95% coverage: 10:251/256 of query aligns to 2:256/260 of 3vdqA
- active site: G15 (= G23), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (≠ N164), I200 (≠ W202)
- binding acetate ion: Q94 (≠ D99), H144 (≠ S149), K152 (≠ Y157), W187 (= W192), L192 (= L194), Q196 (= Q198)
- binding nicotinamide-adenine-dinucleotide: G11 (= G19), S14 (= S22), I16 (= I24), F36 (≠ R44), D63 (= D68), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (≠ A97), L113 (≠ I118), I140 (≠ F145), S142 (= S147), Y155 (= Y160), K159 (≠ N164), P185 (= P190), G186 (= G191), W187 (= W192), V188 (= V193), T190 (vs. gap), L192 (= L194), V193 (≠ T195)
4nbtA Crystal structure of fabg from acholeplasma laidlawii (see paper)
33% identity, 95% coverage: 10:252/256 of query aligns to 3:237/239 of 4nbtA
- active site: G16 (= G23), S132 (= S147), Y145 (= Y160), K149 (≠ N164)
- binding nicotinamide-adenine-dinucleotide: G12 (= G19), K15 (≠ S22), G16 (= G23), L17 (≠ I24), D36 (≠ G43), L37 (≠ R44), L52 (≠ C67), N53 (≠ D68), V54 (≠ I69), N80 (= N95), A81 (= A96), G82 (≠ A97), I130 (≠ F145), S132 (= S147), Y145 (= Y160), K149 (≠ N164), P177 (= P190), G178 (= G191), I180 (≠ V193), T182 (= T195)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
32% identity, 96% coverage: 7:252/256 of query aligns to 3:240/243 of 4i08A
- active site: G19 (= G23), N113 (= N119), S141 (= S147), Q151 (≠ Y157), Y154 (= Y160), K158 (≠ N164)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G19), S17 (≠ G21), R18 (≠ S22), I20 (= I24), T40 (≠ D46), N62 (≠ D68), V63 (≠ I69), N89 (= N95), A90 (= A96), G140 (≠ T146), S141 (= S147), Y154 (= Y160), K158 (≠ N164), P184 (= P190), G185 (= G191), T189 (= T195)
7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
31% identity, 96% coverage: 10:254/256 of query aligns to 6:247/247 of 7tzpG
- binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G19), R18 (≠ S22), G19 (= G23), I20 (= I24), D39 (≠ G43), R40 (= R44), C63 (= C67), I65 (= I69), N91 (= N95), G93 (≠ A97), I94 (≠ N98), V114 (≠ I118), Y155 (= Y160), K159 (≠ N164), I188 (≠ V193), T190 (= T195), T193 (≠ Q198)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
33% identity, 93% coverage: 14:252/256 of query aligns to 6:244/246 of 3osuA
2d1yA Crystal structure of tt0321 from thermus thermophilus hb8 (see paper)
33% identity, 95% coverage: 12:255/256 of query aligns to 5:239/240 of 2d1yA
- active site: G16 (= G23), S135 (= S147), N145 (≠ Y157), Y148 (= Y160), K152 (≠ N164)
- binding nicotinamide-adenine-dinucleotide: G12 (= G19), R15 (≠ S22), I17 (= I24), D36 (≠ G43), L37 (vs. gap), R38 (= R44), V55 (≠ C67), D56 (= D68), L57 (≠ I69), N83 (= N95), A84 (= A96), A85 (= A97), I86 (≠ N98), V133 (≠ F145), S135 (= S147), Y148 (= Y160), K152 (≠ N164), P178 (= P190), G179 (= G191), I181 (≠ V193), T183 (= T195), A185 (≠ K197), V186 (≠ Q198)
Query Sequence
>GFF722 PGA1_c07370 putative short chain dehydrogenase
MSDTAIFPDLKGASVFITGGGSGIGAALSEGFLRQGAKVAFVGRSDATDFVERMEAETGN
RPLFIQCDITDIPALKAAIKQAAEAHGPITTLVNNAANDQRHATLDVDEEFWDWAQAINL
KAYFFACQAVLPGMQAAGGGSIVNFTSISYMMGNNGYPAYTTANAGINGMTRSLAREFGP
DRIRVNALAPGWVLTDKQLDQWATPEALAAHLERQCLKDHLAPQDIVGSTLFLASATSRM
VTGQTLVVDGGVVVTG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory