Comparing GFF785 FitnessBrowser__Marino:GFF785 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 19 hits to proteins with known functional sites (download)
Q5F8J4 NAD(+)-dependent homoserine dehydrogenase; NAD(+)-dependent HSD; NgHSD; EC 1.1.1.3 from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) (see paper)
52% identity, 95% coverage: 22:433/433 of query aligns to 22:434/435 of Q5F8J4
6dzsA Mycobacterial homoserine dehydrogenase thra in complex with NADP
38% identity, 96% coverage: 2:417/433 of query aligns to 3:416/431 of 6dzsA
4pg7A Crystal structure of s. Aureus homoserine dehydrogenase at ph7.5 (see paper)
38% identity, 79% coverage: 1:340/433 of query aligns to 2:329/402 of 4pg7A
Sites not aligning to the query:
6a0tB Homoserine dehydrogenase k99a mutant from thermus thermophilus hb8 complexed with hse and NADP+ (see paper)
35% identity, 67% coverage: 1:292/433 of query aligns to 1:283/332 of 6a0tB
Sites not aligning to the query:
6a0sA Homoserine dehydrogenase from thermus thermophilus hb8 complexed with hse and NADPH (see paper)
35% identity, 67% coverage: 1:292/433 of query aligns to 1:283/331 of 6a0sA
Sites not aligning to the query:
2ejwA Homoserine dehydrogenase from thermus thermophilus hb8
35% identity, 67% coverage: 1:292/433 of query aligns to 1:283/331 of 2ejwA
7f4cA The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon sulfurisphaera tokodaii. (see paper)
36% identity, 52% coverage: 91:316/433 of query aligns to 90:297/300 of 7f4cA
Sites not aligning to the query:
5x9dA Crystal structure of homoserine dehydrogenase in complex with l- cysteine and NAD (see paper)
37% identity, 52% coverage: 91:316/433 of query aligns to 90:299/302 of 5x9dA
Sites not aligning to the query:
4xb1A Hyperthermophilic archaeal homoserine dehydrogenase in complex with NADPH (see paper)
28% identity, 71% coverage: 4:312/433 of query aligns to 3:309/319 of 4xb1A
4xb2A Hyperthermophilic archaeal homoserine dehydrogenase mutant in complex with NADPH (see paper)
28% identity, 71% coverage: 4:312/433 of query aligns to 3:309/319 of 4xb2A
3jsaA Homoserine dehydrogenase from thermoplasma volcanium complexed with NAD
32% identity, 52% coverage: 1:225/433 of query aligns to 1:239/321 of 3jsaA
Sites not aligning to the query:
3ingA Crystal structure of homoserine dehydrogenase (np_394635.1) from thermoplasma acidophilum at 1.95 a resolution
35% identity, 30% coverage: 82:212/433 of query aligns to 91:223/319 of 3ingA
Sites not aligning to the query:
O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
29% identity, 53% coverage: 92:322/433 of query aligns to 662:916/916 of O81852
Sites not aligning to the query:
P31116 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
31% identity, 33% coverage: 92:232/433 of query aligns to 106:268/359 of P31116
Sites not aligning to the query:
1tveA Homoserine dehydrogenase in complex with 4-(4-hydroxy-3- isopropylphenylthio)-2-isopropylphenol (see paper)
31% identity, 33% coverage: 92:232/433 of query aligns to 105:267/358 of 1tveA
Sites not aligning to the query:
1q7gA Homoserine dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-oxonorvaline (see paper)
31% identity, 33% coverage: 92:232/433 of query aligns to 105:267/358 of 1q7gA
Sites not aligning to the query:
1ebuD Homoserine dehydrogenase complex with NAD analogue and l-homoserine (see paper)
31% identity, 33% coverage: 92:232/433 of query aligns to 105:267/358 of 1ebuD
Sites not aligning to the query:
1ebfA Homoserine dehydrogenase from s. Cerevisiae complex with NAD+ (see paper)
31% identity, 33% coverage: 92:232/433 of query aligns to 105:267/358 of 1ebfA
Sites not aligning to the query:
O94671 Probable homoserine dehydrogenase; HDH; EC 1.1.1.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
33% identity, 26% coverage: 97:207/433 of query aligns to 117:236/376 of O94671
>GFF785 FitnessBrowser__Marino:GFF785
MKDVSVGICGLGTVGGGTFNVLTRNARLIAGRAGCNIRITRVASRRAREDMDLGDVPFST
DIYDVVNDPDVDIVVELIGGYDAAKELVLAAIRNGKHVVTANKALIAVHGNEIFEAAEKA
GVVVAYEAGVAGGIPVIKAVREGMAANRIDWIAGIINGTGNYILTEMRAGREFSEVLKEA
QDLGYAEADPTFDVEGIDAAHKLTILASAGFGVPLQFEKGFTEGISKITPYDIAHAELLG
YRIKHLGIARRRDDGIELRVHPTLVPQSHLIAQVDGVLNAVLVDGDAVGQTMYYGPGAGD
EATGSAVIADIVDVARAVATESKLRVPYLGFSPDAMEDLDVLSMEDIQSAYYLRITALDR
PGVLAKIASILSEHGINIESIMQKESELKDGRIPVIILTHTVQERQINRAIEELEALSDT
DGHVVRIRAENFN
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory