Comparing GFF840 FitnessBrowser__psRCH2:GFF840 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
1mxsA Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. (see paper)
67% identity, 87% coverage: 10:223/245 of query aligns to 2:215/216 of 1mxsA
P00885 2-dehydro-3-deoxy-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase; EC 4.1.2.14 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
66% identity, 87% coverage: 10:223/245 of query aligns to 12:225/226 of P00885
Sites not aligning to the query:
1euaA Schiff base intermediate in kdpg aldolase from escherichia coli (see paper)
52% identity, 73% coverage: 40:219/245 of query aligns to 30:209/213 of 1euaA
P0A955 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) (see 3 papers)
52% identity, 73% coverage: 40:219/245 of query aligns to 30:209/213 of P0A955
1wauA Structure of kdpg aldolase e45n mutant (see paper)
52% identity, 73% coverage: 40:219/245 of query aligns to 30:209/213 of 1wauA
2c0aB Mechanism of the class i kdpg aldolase (see paper)
52% identity, 73% coverage: 40:219/245 of query aligns to 31:210/214 of 2c0aB
Sites not aligning to the query:
6oviA Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate
48% identity, 77% coverage: 23:210/245 of query aligns to 10:197/210 of 6oviA
3vcrA Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica (see paper)
47% identity, 82% coverage: 18:217/245 of query aligns to 4:207/216 of 3vcrA
5xsfA Crystal structure of the 2-keto-3-deoxy-6-phosphogluconate aldolase of zymomonas mobilis zm4 with 3-phosphoglycerate
50% identity, 74% coverage: 18:199/245 of query aligns to 5:185/209 of 5xsfA
1wa3D Mechanism of the class i kdpg aldolase (see paper)
33% identity, 60% coverage: 45:192/245 of query aligns to 29:175/203 of 1wa3D
Sites not aligning to the query:
Q6BF16 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Escherichia coli (strain K12) (see paper)
28% identity, 67% coverage: 20:183/245 of query aligns to 2:166/205 of Q6BF16
2v82A Kdpgal complexed to kdpgal (see paper)
28% identity, 67% coverage: 20:183/245 of query aligns to 1:165/205 of 2v82A
Sites not aligning to the query:
>GFF840 FitnessBrowser__psRCH2:GFF840
MTSIQTSAEAMNDKIALIDQWCSAARILPVITIEREADILPLADALAAGGLRVLEITLRS
ALGLRAIRLLREQRPELIVGAGTVLDANMLEQAEAAGAQFIVSPGSTPALLEAALQGPLP
LLPGVASASEIMLGYAMGYRRFKLFPAEICGGVAALKALGGPFGDIRFCPTGGVNARNAR
DYLSLANVMCVGGTWMVDAKAVRAGDWAAIESATRQALQALDSAPAAELPRDFDLRAERA
EQREL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory