SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing GFF948 HP15_927 branched-chain amino acid ABC transporter, ATP-binding protein to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
44% identity, 95% coverage: 12:240/240 of query aligns to 7:239/240 of 1ji0A

query
sites
1ji0A

L

L

R

E

L

V

S

Q

G

S

L

L

H

H

A

V

F

Y

Y
|
Y

G

G

E

A

S

I

H

H

I

A

L

I

H

K

G

G

I

I

D

D

M

L

V

K

V

V

N

P

R

R

G

G

E

Q

L

I

V

V

T

T

L

L

L

I

G

G

R

A

N

N

G
|
G

A

A

G
|
G

R
x
K

S
x
T

T
|
T

T

T

L

L

K

S

A

A

I

I

M

A

N

G

M

L

V

V

G

R

R

A

R

Q

T

K

G

G

S

K

I

I

M

I

I

F

N

N

G

G

E

Q

E

D

T

I

M

T

S

N

C

K

A

P

P

A

H

H

H

V

I

I

A

N

R

R

L

M

G

G

V

I

G

A

Y

L

C

V

P

P

E
|
E

H

G

R

R

G

R

I

I

F

F

S

P

S

E

L

L

S

T

V

V

Q

Y

E

E

N

N

L

L

T

M

L

M

P

G

P

A

V

Y

V

N

R

R

S

K

G

D

G

K

-

E

-

G

-

I

-

K

M

R

S

D

L

L

E

E

E

W

I

I

Y

F

N

S

M

L

F

F

P

P

N

R

L

L

Y

K

E

E

R

R

R

L

F

K

S

Q

Q

L

G

G

T

G

K

T

L

L

S

S

G

G

E

E

Q

Q

M

M

L

L

A

A

M

I

A

G

R

R

I

A

L

L

R

M

T

S

G

R

A

P

N

K

M

L

L

L

L

M

D

D

E
|
E

I

P

T

S

E

L

G

G

L

L

A

A

P

P

V

I

I

L

V

V

E

S

K

E

L

V

G

F

E

E

V

V

L

I

I

Q

A

K

L

I

K

N

N

Q

K

E

G

G

L

T

T

T

I

I

V

L

L

L

V

V

E

E

Q

Q

N

N

F

A

H

L

F

G

A

A

A

L

P

K

L

V

A

A

D

H

R

Y

H

G

Y

Y

V

V

V

L

E

E

H

T

G

G

Q

Q

I

I

V

V

E

L

E

E

V

G

S

K

A

A

N

S

E

E

L

L

S

L

A

D

K

N

Q

E

S

M

V

V

L

R

D

K

G

A

Y

Y

L

L

G

G

V

V

binding adenosine-5'-triphosphate: Y16 (= Y21), G42 (= G47), G44 (= G49), K45 (≠ R50), T46 (≠ S51), T47 (= T52), E88 (= E93), E165 (= E166)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
28% identity, 95% coverage: 12:239/240 of query aligns to 3:235/240 of 6mjpA

query
sites
6mjpA

L

L

R

K

L

A

S

Q

G

H

L

L

H

A

A

K

F

S

Y

Y

G

K

E

K

S

R

H

K

I

V

L

V

H

S

G

D

I

V

D

S

M

L

V

Q

V

V

N

E

R

S

G

G

E

Q

L

I

V

V

T

G

L

L

G

G

R

P

N

N

G

G

A

A

G

G

R

K

S

T

T

T

T

S

L

F

K

Y

A

M

I

I

M

V

N

G

M

L

V

V

G

A

R

R

R

D

T

E

G

G

S

T

I

I

M

T

I

I

N

D

G

D

E

N

E

D

T

I

M

S

S

I

C

L

A

P

P

M

H

H

H

S

I

R

A

S

R

R

L

M

G

G

V

I

G

G

Y

Y

C

L

P

P

E

Q

H

E

R

A

G

S

I

I

F

F

S

R

S

K

L

L

S

S

V

V

Q

E

E

D

N

N

L

I

T

M

L

A

P

V

P

L

V

Q

V

T

R

R

S

E

G

-

G

E

M

L

S

T

L

H

E
|
E

E

E

I

R

Y

Q

N
x
D

M

K

F

L

P

E

N

D

L

L

Y

L

E

E

R

E

-

F

-

H

-

I

-

Q

-

H

-

I

R

R

F

K

S

S

Q

A

G

G

T

M

K

A

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

N

Q

M

F

L

I

L

L

D

D

E

Q

I

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

E

I

K

D

L

I

G

K

E

K

V

I

L

I

I

E

A

H

L

L

K

R

N

D

K

R

G

G

L

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

F

V

H

R

F

E

A

T

A

L

P

D

L

V

A

C

D

E

R

K

H

A

Y

Y

V

I

V

V

E

S

H

Q

G

G

Q

R

I

L

V

I

E

A

E

E

V

G

S

T

A

P

N

Q

E

D

L

V

S

L

A

N

K

N

Q

E

S

Q

V

V

L

K

D

Q

G

V

Y

Y

L

L

G

G

binding calcium ion: E111 (= E121), D115 (≠ N125)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
31% identity, 95% coverage: 12:239/240 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

R

T

L

A

S

K

G

N

L

L

H

A

A

K

F

A

Y
|
Y

G

K

E

G

S

R

H

R

I

V

L

V

H

E

G

D

I

V

D

S

M

L

V

T

V

V

N

N

R

S

G

G

E

E

L

I

V

V

T

G

L

L

G

G

R

P

N
|
N

G
|
G

A

A

G
|
G

R
x
K

S
x
T

T
|
T

T

T

L

F

K

Y

A

M

I

V

M

V

N

G

M

I

V

V

G

P

R

R

R

D

T

A

G

G

S

N

I

I

M

I

I

I

N

D

G

D

E

D

T

I

M

S

S

L

C

L

A

P

P

L

H

H

H

A

I

R

A

A

R

R

L

R

G

G

V

I

G

G

Y

Y

C

L

P

P

E
x
Q

H

E

R

A

G

S

I

I

F

F

S

R

L

L

S

S

V

V

Q

Y

E

D

N

N

L

L

T

M

L

A

P

V

P

L

V

Q

V

I

R

R

S

D

G

-

G

D

M

L

S

S

L

A

E

E

E

Q

I

R

Y

E

N

D

M

R

F

A

P

N

N

E

L

L

Y

M

E

E

R

E

-

F

-

H

-

I

-

E

-

H

-

L

R

R

F

D

S

S

Q

M

G

G

T

Q

K
x
S

L

L

S
|
S

G
|
G

E

E

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

N

K

M

F

L

I

L

L

D

D

E
|
E

I

P

T

F

E

A

G
|
G

L

V

A

D

P

P

V

I

I

S

V

V

E

I

K

D

L

I

G

K

E

R

V

I

L

I

I

E

A

H

L

L

K

R

N

D

K

S

G

G

L

L

T

G

I

V

V

L

L

I

V

T

E

D

Q
x
H

N

N

F

V

H

R

F

E

A

T

A

L

P

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

V

V

E

S

H

Q

G

G

Q

H

I

L

V

I

E

A

E

H

V

G

S

T

A

P

N

T

E

E

L

I

S

L

A

Q

K

D

Q

E

S

H

V

V

L

K

D

R

G

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y21), N37 (= N46), G38 (= G47), G40 (= G49), K41 (≠ R50), T42 (≠ S51), T43 (= T52), Q84 (≠ E93), S136 (≠ K140), S138 (= S142), G139 (= G143), G140 (= G144), E162 (= E166), G166 (= G170), H194 (≠ Q198)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
31% identity, 91% coverage: 21:239/240 of query aligns to 12:235/238 of 6s8nB

query
sites
6s8nB

Y

Y

G

K

E

G

S

R

H

R

I

V

L

V

H

E

G

D

I

V

D

S

M

L

V

T

V

V

N

N

R

S

G

G

E

E

L

I

V

V

T

G

L

L

G

G

R

P

N

N

G

G

A

A

G

G

R

K

S

T

T

T

L

F

K

Y

A

M

I

V

M

V

N

G

M

I

V

V

G

P

R

R

R

D

T

A

G

G

S

N

I

I

M

I

I

I

N

D

G

D

E

D

T

I

M

S

S

L

C

L

A

P

P

L

H

H

H

A

I

R

A

A

R

R

L

R

G

G

V

I

G

G

Y

Y

C

L

P

P

E

Q

H

E

R

A

G

S

I

I

F

F

S
x
R

S

R

L

L

S

S

V

V

Q

Y

E

D

N

N

L

L

T

M

L

A

P

V

P

L

V

Q

V

I

R

R

S

D

G

-

G

D

M

L

S

S

L

A

E

E

E

Q

I

R

Y

E

N

D

M

R

F

A

P

N

N

E

L

L

Y

M

E

E

R

E

-

F

-

H

-

I

-

E

-

H

-

L

R

R

F

D

S

S

Q
x
M

G
|
G

T
x
Q

K

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

N

K

M

F

L

I

L

L

D

D

E

E

I

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

E

I

K

D

L

I

G

K

E

R

V

I

L

I

I

E

A

H

L

L

K

R

N

D

K

S

G

G

L

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

F

V

H

R

F

E

A

T

A

L

P

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

V

V

E

S

H

Q

G

G

Q

H

I

L

V

I

E

A

E

H

V

G

S

T

A

P

N

T

E

E

L

I

S

L

A

Q

K

D

Q

E

S

H

V

V

L

K

D

R

G

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ S99), M133 (≠ Q137), G134 (= G138), Q135 (≠ T139)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
31% identity, 91% coverage: 21:239/240 of query aligns to 12:235/238 of 6s8gA

query
sites
6s8gA

Y
|
Y

G

K

E

G

S
x
R

H

R

I

V

L

V

H

E

G

D

I

V

D

S

M

L

V

T

V

V

N

N

R

S

G

G

E

E

L

I

V

V

T

G

L

L

G

G

R

P

N
|
N

G

G

A

A

G
|
G

R
x
K

S
x
T

T
|
T

T

T

L

F

K

Y

A

M

I

V

M

V

N

G

M

I

V

V

G

P

R

R

R

D

T

A

G

G

S

N

I

I

M

I

I

I

N

D

G

D

E

D

T

I

M

S

S

L

C

L

A

P

P

L

H

H

H

A

I

R

A

A

R

R

L

R

G

G

V

I

G

G

Y

Y

C

L

P

P

E
x
Q

H

E

R

A

G

S

I

I

F

F

S

R

L

L

S

S

V

V

Q

Y

E

D

N

N

L

L

T

M

L

A

P

V

P

L

V

Q

V

I

R

R

S

D

G

-

G

D

M

L

S

S

L

A

E

E

E

Q

I

R

Y

E

N

D

M

R

F

A

P

N

N

E

L

L

Y

M

E

E

R

E

-

F

-

H

-

I

-

E

-

H

-

L

R

R

F

D

S

S

Q

M

G

G

T

Q

K
x
S

L

L

S
|
S

G

G

E
|
E

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

N

K

M

F

L

I

L

L

D

D

E

E

I

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

E

I

K

D

L

I

G

K

E

R

V

I

L

I

I

E

A

H

L

L

K

R

N

D

K

S

G

G

L

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

F

V

H

R

F

E

A

T

A

L

P

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

V

V

E

S

H

Q

G

G

Q

H

I

L

V

I

E

A

E

H

V

G

S

T

A

P

N

T

E

E

L

I

S

L

A

Q

K

D

Q

E

S

H

V

V

L

K

D

R

G

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y21), R15 (≠ S24), N37 (= N46), G40 (= G49), K41 (≠ R50), T42 (≠ S51), T43 (= T52), Q84 (≠ E93), S136 (≠ K140), S138 (= S142), E141 (= E145)

6mbnA Lptb e163q in complex with atp (see paper)
31% identity, 91% coverage: 21:239/240 of query aligns to 13:236/241 of 6mbnA

query
sites
6mbnA

Y
|
Y

G

K

E

G

S
x
R

H

R

I
x
V

L

V

H

E

G

D

I

V

D

S

M

L

V

T

V

V

N

N

R

S

G

G

E

E

L

I

V

V

T

G

L

L

G

G

R

P

N
|
N

G
|
G

A

A

G
|
G

R
x
K

S
x
T

T
|
T

T

T

L

F

K

Y

A

M

I

V

M

V

N

G

M

I

V

V

G

P

R

R

R

D

T

A

G

G

S

N

I

I

M

I

I

I

N

D

G

D

E

D

T

I

M

S

S

L

C

L

A

P

P

L

H

H

H

A

I

R

A

A

R

R

L

R

G

G

V

I

G

G

Y

Y

C

L

P

P

E

Q

H

E

R

A

G

S

I

I

F

F

S

R

L

L

S

S

V

V

Q

Y

E

D

N

N

L

L

T

M

L

A

P

V

P

L

V

Q

V

I

R

R

S

D

G

-

G

D

M

L

S

S

L

A

E

E

E

Q

I

R

Y

E

N

D

M

R

F

A

P

N

N

E

L

L

Y

M

E

E

R

E

-

F

-

H

-

I

-

E

-

H

-

L

R

R

F

D

S

S

Q

M

G

G

T

Q

K

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

N

K

M

F

L

I

L

L

D

D

E

Q

I

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

E

I

K

D

L

I

G

K

E

R

V

I

L

I

I

E

A

H

L

L

K

R

N

D

K

S

G

G

L

L

T

G

I

V

V

L

L

I

V

T

E

D

Q
x
H

N

N

F

V

H

R

F

E

A

T

A

L

P

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

V

V

E

S

H

Q

G

G

Q

H

I

L

V

I

E

A

E

H

V

G

S

T

A

P

N

T

E

E

L

I

S

L

A

Q

K

D

Q

E

S

H

V

V

L

K

D

R

G

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (= Y21), R16 (≠ S24), V18 (≠ I26), N38 (= N46), G39 (= G47), G41 (= G49), K42 (≠ R50), T43 (≠ S51), T44 (= T52), H195 (≠ Q198)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
31% identity, 89% coverage: 14:227/240 of query aligns to 4:223/240 of 4ymuJ

query
sites
4ymuJ

L

V

S

N

G

D

L

V

H

Y

A

K

F

N

Y
x
F

G

G

E

S

S

L

H

E

I
x
V

L

L

H

K

G

G

I

V

D

T

M

L

V

K

V

V

N

N

R

K

G

G

E

E

L

V

V

V

T

V

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

R
x
K

S
|
S

T
|
T

T

L

L

L

K

R

A

C

I

I

M

N

N

L

M

L

V

E

G

E

R

P

R

T

T

K

G

G

S

E

I

V

M

F

I

I

N

D

G

G

E

V

E

K

T

I

M

N

S

N

C

G

A

K

P

V

H

N

-

I

H

N

I

K

A

V

R

R

L

Q

G

K

V

V

G

G

Y

M

C

V

P

F

E

Q

H

H

R

F

G

N

I

L

F

F

S

P

S

H

L

L

S

T

V

A

Q

I

E

E

N

N

L

I

T

T

L

L

P

A

P

P

V

V

V

-

R

K

S

V

G

K

M

M

S

N

L

K

E

K

E

E

I

A

Y

E

N

E

M

L

F

A

P

V

N

D

L

L

Y

L

-

A

-

K

-

V

-

G

-

L

E

D

R

K

F

D

S

Q

Q

Y

G

P

T

I

K

K

L

L

S

S

G

G

E

Q

Q

K

Q

Q

M

R

L

L

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

Q

A

P

N

E

M

V

L

M

L

L

L

F

D

D

E
|
E

I

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

E

K

K

E

L

V

G

L

E

N

V

V

L

M

I

K

A

Q

L

L

K

A

N

N

K

E

G

G

L

M

T

T

I

M

V

V

L

V

V

V

E

T

Q
x
H

N

E

F

M

H

G

F

F

A

A

A

R

P

E

L

V

A

G

D

D

R

R

H

V

Y

I

V

F

V

M

E

D

H

D

G

G

Q

V

I

I

V

V

E

E

V

G

S

T

A

P

N

E

E

E

L

I

binding adenosine-5'-triphosphate: F11 (≠ Y21), V16 (≠ I26), S36 (≠ N46), G37 (= G47), S38 (≠ A48), G39 (= G49), K40 (≠ R50), S41 (= S51), T42 (= T52), E162 (= E166), H194 (≠ Q198)
binding magnesium ion: S41 (= S51), E162 (= E166)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
32% identity, 91% coverage: 12:230/240 of query aligns to 3:226/241 of 4u00A

query
sites
4u00A

L

I

R

R

L

I

S

R

G

N

L

L

H

H

A

K

F

W

Y
x
F

G

G

E

P

S

L

H

H

I
x
V

L

L

H

K

G

G

I

I

D

H

M

L

V

E

V

V

N

A

R

P

G

G

E

E

L

K

V

L

T

V

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

R
x
K

S
|
S

T
|
T

T

L

L

I

K

R

A

T

I

I

M

N

N

R

M

L

V

E

G

D

R

F

R

Q

T

E

G

G

S

E

I

V

M

V

I

V

N

D

G

G

E

L

E

S

T

V

M

K

S

D

C

D

A

R

P

A

H

L

H

R

I

E

A

I

R

R

L

R

G

E

V

V

G

G

Y

M

C

V

P

F

E

Q

H

Q

R

F

G

N

I

L

F

F

S

P

S

H

L

M

S

T

V

V

Q

L

E

E

N

N

L

V

T

T

L

L

P

A

P

P

V

M

V

-

R

R

S

V

G

R

M

W

S

P

L

R

E

E

E

K

I

A

Y

E

N

K

M

K

F

A

P

L

N

E

L

L

Y

L

E

E

R

R

R

V

-

G

-

I

F

L

S

D

Q

Q

G

A

T

R

K

K

-

Y

-

P

-

A

-

Q

L

L

S

S

G

G

E

Q

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

N

K

M

I

L

M

L

L

L

F

D

D

E

E

I

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

E

G

K

E

L

V

G

L

E

D

V

V

L

M

I

R

A

D

L

L

K

A

N

Q

K

G

G

G

L

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

F

M

H

G

F

F

A

A

A

R

P

E

L

V

A

A

D

D

R

R

H

V

Y

V

V

F

V

M

E

D

H

G

G

G

Q

Q

I

I

V

V

E

E

V

G

S

R

A

P

N

E

E

E

L

I

S

F

A

T

K

R

binding adenosine-5'-diphosphate: F12 (≠ Y21), V17 (≠ I26), S37 (≠ N46), G38 (= G47), S39 (≠ A48), G40 (= G49), K41 (≠ R50), S42 (= S51), T43 (= T52)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
30% identity, 95% coverage: 12:238/240 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

R

T

L

A

S

K

G

N

L

L

H

A

A

K

F

A

Y
|
Y

G

K

E

G

S
x
R

H

R

I
x
V

L

V

H

E

G

D

I

V

D

S

M

L

V

T

V

V

N

N

R

S

G

G

E

E

L

I

V

V

T

G

L

L

G

G

R

P

N
|
N

G
|
G

A

A

G
|
G

R
x
K

S
x
T

T
|
T

T

T

L

F

K

Y

A

M

I

V

M

V

N

G

M

I

V

V

G

P

R

R

R

D

T

A

G

G

S

N

I

I

M

I

I

I

N

D

G

D

E

D

T

I

M

S

S

L

C

L

A

P

P
x
L

H
|
H

H

A

I

R

A

A

R

R

L

R

G

G

V

I

G

G

Y

Y

C

L

P
|
P

E
x
Q

H

E

R
x
A

G
x
S

I

I

F
|
F

S
x
R

L
|
L

S

S

V

V

Q

Y

E

D

N

N

L

L

T

M

L

A

P
x
V

P

L

V

Q

V

I

R

R

S

D

G

-

G

D

M

L

S

S

L

A

E

E

E

Q

I

R

Y

E

N

D

M

R

F

A

P

N

N

E

L

L

Y

M

E

E

R

E

-

F

-

H

-

I

-

E

-

H

-

L

R

R

F

D

S

S

Q

M

G

G

T
x
Q

K

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

A

A

R
|
R

I

A

L

L

R

A

T

A

G

N

A

P

N

K

M

F

L

I

L

L

D

D

E

E

I

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

E

I

K

D

L

I

G

K

E

R

V

I

L

I

I

E

A

H

L

L

K

R

N

D

K

S

G

G

L

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

F

V

H

R

F

E

A

T

A

L

P

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

V

V

E

S

H

Q

G

G

Q

H

I

L

V

I

E

A

E

H

V

G

S

T

A

P

N

T

E

E

L

I

S

L

A

Q

K

D

Q

E

S

H

V

V

L

K

D

R

G

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y21), R15 (≠ S24), V17 (≠ I26), N37 (= N46), G38 (= G47), G40 (= G49), K41 (≠ R50), T42 (≠ S51), T43 (= T52)
binding magnesium ion: T42 (≠ S51), Q84 (≠ E93)
binding novobiocin: L71 (≠ P80), H72 (= H81), P83 (= P92), A86 (≠ R95), S87 (≠ G96), F89 (= F98), R90 (≠ S99), R91 (≠ S100), L92 (= L101), V101 (≠ P110), Q135 (≠ T139), R149 (= R153)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
30% identity, 95% coverage: 12:238/240 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

R

T

L

A

S

K

G

N

L

L

H

A

A

K

F

A

Y
|
Y

G

K

E

G

S
x
R

H

R

I
x
V

L

V

H

E

G

D

I

V

D

S

M

L

V

T

V

V

N

N

R

S

G

G

E

E

L

I

V

V

T

G

L

L

G

G

R

P

N

N

G
|
G

A

A

G
|
G

R
x
K

S
x
T

T
|
T

T

T

L

F

K

Y

A

M

I

V

M

V

N

G

M

I

V

V

G

P

R

R

R

D

T

A

G

G

S

N

I

I

M

I

I

I

N

D

G

D

E

D

T

I

M

S

S

L

C

L

A

P

P

L

H

H

H

A

I

R

A

A

R

R

L

R

G

G

V

I

G

G

Y

Y

C

L

P

P

E
x
Q

H

E

R

A

G

S

I

I

F

F

S

R

L

L

S

S

V

V

Q

Y

E

D

N

N

L

L

T

M

L

A

P

V

P

L

V

Q

V

I

R

R

S

D

G

-

G

D

M

L

S

S

L

A

E

E

E

Q

I

R

Y

E

N

D

M

R

F

A

P

N

N

E

L

L

Y

M

E

E

R

E

-

F

-

H

-

I

-

E

-

H

-

L

R

R

F

D

S

S

Q

M

G

G

T

Q

K

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

N

K

M

F

L

I

L

L

D

D

E

E

I

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

E

I

K

D

L

I

G

K

E

R

V

I

L

I

I

E

A

H

L

L

K

R

N

D

K

S

G

G

L

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

F

V

H

R

F

E

A

T

A

L

P

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

V

V

E

S

H

Q

G

G

Q

H

I

L

V

I

E

A

E

H

V

G

S

T

A

P

N

T

E

E

L

I

S

L

A

Q

K

D

Q

E

S

H

V

V

L

K

D

R

G

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y21), R15 (≠ S24), V17 (≠ I26), G38 (= G47), G40 (= G49), K41 (≠ R50), T42 (≠ S51), T43 (= T52)
binding magnesium ion: T42 (≠ S51), Q84 (≠ E93)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
30% identity, 93% coverage: 12:233/240 of query aligns to 3:229/233 of 6b8bA

query
sites
6b8bA

L

L

R

T

L

A

S

K

G

N

L

L

H

A

A

K

F

A

Y
|
Y

G

K

E

G

S
x
R

H

R

I
x
V

L

V

H

E

G

D

I

V

D

S

M

L

V

T

V

V

N

N

R

S

G

G

E

E

L

I

V

V

T

G

L

L

G

G

R

P

N

N

G
|
G

A

A

G
|
G

R
x
K

S
x
T

T
|
T

T

T

L

F

K

Y

A

M

I

V

M

V

N

G

M

I

V

V

G

P

R

R

R

D

T

A

G

G

S

N

I

I

M

I

I

I

N

D

G

D

E

D

T

I

M

S

S

L

C

L

A

P

P

L

H

H

H

A

I

R

A

A

R

R

L

R

G

G

V

I

G

G

Y

Y

C

L

P

P

E

Q

H

E

R

A

G

S

I

I

F
|
F

S
x
R

L

L

S

S

V

V

Q

Y

E

D

N

N

L

L

T

M

L

A

P

V

P

L

V

Q

V

I

R

R

S

D

G

-

G

D

M

L

S

S

L

A

E

E

E

Q

I

R

Y

E

N

D

M

R

F

A

P

N

N

E

L

L

Y

M

E

E

R

E

-

F

-

H

-

I

-

E

-

H

-

L

R

R

F

D

S

S

Q

M

G

G

T

Q

K

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

N

K

M

F

L

I

L

L

D

D

E

E

I

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

V

V

E

I

K

D

L

I

G

K

E

R

V

I

L

I

I

E

A

H

L

L

K

R

N

D

K

S

G

G

L

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

F

V

H

R

F

E

A

T

A

L

P

A

L

V

A

C

D

E

R

R

H

A

Y

Y

V

I

V

V

E

S

H

Q

G

G

Q

H

I

L

V

I

E

A

E

H

V

G

S

T

A

P

N

T

E

E

L

I

S

L

A

Q

K

D

Q

E

S

H

V

V

binding adenosine-5'-diphosphate: Y12 (= Y21), R15 (≠ S24), V17 (≠ I26), G38 (= G47), G40 (= G49), K41 (≠ R50), T42 (≠ S51), T43 (= T52)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F98), R90 (≠ S99), R91 (≠ S100)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
28% identity, 91% coverage: 12:229/240 of query aligns to 4:231/592 of 5lj7A

query
sites
5lj7A

L

I

R

E

L

I

S

K

G

Q

L

L

H

N

A

R

F

Y

Y

F

G

G

E

E

S

G

-

E

-

N

-

R

-

V

H

H

I
x
V

L

L

H

K

G

D

I

I

D

S

M

L

V

S

V

I

N

E

R

R

G

G

E

D

L

F

V

V

T

A

L

I

L

M

G

G

R

Q

N
x
S

G
|
G

A

S

G
|
G

R
x
K

S
|
S

T
|
T

T

L

L

M

K

N

A

I

I

I

M

G

N

C

M

L

V

D

G

T

R

A

R

T

T

G

G

G

S

S

I

S

M

K

I

I

N

D

G

G

E

K

E

E

T

T

M

I

S

E

C

L

A

T

P

N

H

D

H

Q

I

L

A

S

R

D

L

L

-

R

-

S

-

Q

G

K

V

F

G

G

Y

F

C

I

P

F

E
x
Q

H

R

R

Y

G

N

I

L

F

L

S

S

L

L

S

T

V

A

Q

A

E

E

N

N

L

V

T

A

L

L

P

P

P

A

V

I

V

Y

R

-

S

-

G

A

G

G

M

M

S

P

-

Q

-

S

-

Q

-

R

L

L

E

E

E

R

I

A

Y

K

N

Q

M

L

F

L

P

E

N

K

L

L

Y

G

-

L

-

G

E

D

R
x
K

R

W

F

Q

S

N

Q

K

G

P

T

N

K
x
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

M

R

L

V

A

S

M

I

A

A

R

R

I

A

L

L

R

M

T

N

G

G

A

G

N

E

M

I

L

I

L

L

L

A

D

D

E

Q

I

P

T

T

E

G

G

A

L

L

A

D

P

S

V

H

I

S

V

G

E

E

K

N

L

V

G

M

E

E

V

I

L

L

I

R

A

Q

L

L

K

H

N

E

K

E

G

G

L

H

T

T

I

I

V

I

L

M

V

V

E

T

Q

H

N

D

F

K

H

H

F

I

A

A

P

S

L

-

A

A

D

N

R

R

H

I

Y

I

V

E

V

I

E

K

H

D

G

G

Q

E

I

I

V

I

E

S

E

D

V

T

S

Q

A

K

N

R

E

Q

L

V

S

K

A

S

binding adenosine-5'-triphosphate: V22 (≠ I26), S42 (≠ N46), G43 (= G47), G45 (= G49), K46 (≠ R50), S47 (= S51), T48 (= T52), Q92 (≠ E93), K136 (≠ R133), Q143 (≠ K140), S145 (= S142), G147 (= G144), Q148 (≠ E145)
binding magnesium ion: S47 (= S51), Q92 (≠ E93)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
28% identity, 91% coverage: 12:229/240 of query aligns to 4:231/615 of 5lilA

query
sites
5lilA

L

I

R

E

L

I

S

K

G

Q

L

L

H

N

A

R

F

Y

Y
x
F

G

G

E

E

S

G

-

E

-

N

-

R

-

V

H

H

I
x
V

L

L

H

K

G

D

I

I

D

S

M

L

V

S

V

I

N

E

R

R

G

G

E

D

L

F

V

V

T

A

L

I

L

M

G

G

R

Q

N
x
S

G
|
G

A

S

G
|
G

R
x
K

S
|
S

T
|
T

T

L

L

M

K

N

A

I

I

I

M

G

N

C

M

L

V

D

G

T

R

A

R

T

T

G

G

G

S

S

I

S

M

K

I

I

N

D

G

G

E

K

E

E

T

T

M

I

S

E

C

L

A

T

P

N

H

D

H

Q

I

L

A

S

R

D

L

L

-

R

-

S

-

Q

G

K

V

F

G

G

Y

F

C

I

P

F

E
x
Q

H

R

R

Y

G

N

I

L

F

L

S

S

L

L

S

T

V

A

Q

A

E

E

N

N

L

V

T

A

L

L

P

P

P

A

V

I

V

Y

R

-

S

-

G

A

G

G

M

M

S

P

-

Q

-

S

-

Q

-

R

L

L

E

E

E

R

I

A

Y

K

N

Q

M

L

F

L

P

E

N

K

L

L

Y

G

-

L

-

G

E

D

R
x
K

R

W

F

Q

S

N

Q

K

G

P

T

N

K
x
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

M

R

L

V

A

S

M

I

A

A

R

R

I

A

L

L

R

M

T

N

G

G

A

G

N

E

M

I

L

I

L

L

L

A

D

D

E

Q

I

P

T

T

E

G

G

A

L

L

A

D

P

S

V

H

I

S

V

G

E

E

K

N

L

V

G

M

E

E

V

I

L

L

I

R

A

Q

L

L

K

H

N

E

K

E

G

G

L

H

T

T

I

I

V

I

L

M

V

V

E

T

Q

H

N

D

F

K

H

H

F

I

A

A

P

S

L

-

A

A

D

N

R

R

H

I

Y

I

V

E

V

I

E

K

H

D

G

G

Q

E

I

I

V

I

E

S

E

D

V

T

S

Q

A

K

N

R

E

Q

L

V

S

K

A

S

binding adenosine-5'-triphosphate: F13 (≠ Y21), V22 (≠ I26), S42 (≠ N46), G43 (= G47), G45 (= G49), K46 (≠ R50), S47 (= S51), T48 (= T52), Q92 (≠ E93), K136 (≠ R133), Q143 (≠ K140), S145 (= S142), G147 (= G144), Q148 (≠ E145)
binding magnesium ion: S47 (= S51), Q92 (≠ E93)

3c4jA Abc protein artp in complex with atp-gamma-s
29% identity, 88% coverage: 17:227/240 of query aligns to 9:225/242 of 3c4jA

query
sites
3c4jA

L

L

H

K

A

K

F

S

Y
x
F

G

G

E

S

S

L

H

E

I
x
V

L

L

H

K

G

G

I

I

D

N

M

V

V

H

V

I

N

R

R

E

G

G

E

E

L

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

R
x
K

S
|
S

T
|
T

T

F

L

L

K

R

A

C

I

L

M

N

N

L

M

L

V

E

G

D

R

F

R

D

T

E

G

G

S

E

I

I

M

I

I

I

N

D

G

G

E

I

E

N

T

L

M

K

S

A

C

K

A

D

P

T

H

N

-

L

H

N

I

K

A

V

R

R

L

E

G

E

V

V

G

G

Y

M

C

V

P

F

E

Q

H

R

R

F

G

N

I

L

F

F

S

P

S

H

L

M

S

T

V

V

Q

L

E

N

N

N

L

I

T

T

L

L

P

A

P

P

V

M

-

K

V

V

R

R

S

K

G

W

G

P

M

R

S

E

L

K

E

A

E

E

I

A

Y

K

N

A

M

M

-

E

-

L

-

D

F

K

P

V

N

G

L

L

Y

K

E

D

R

K

R

A

F

H

S

A

Q

Y

G

P

T

D

K

S

L

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

N

K

M

I

L

M

L

L

L

F

D

D

E

E

I

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

E

G

K

E

L

V

G

L

E

S

V

V

L

M

I

K

A

Q

L

L

K

A

N

N

K

E

G

G

L

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

F

M

H

G

F

F

A

A

A

R

P

E

L

V

A

G

D

D

R

R

H

V

Y

L

V

F

V

M

E

D

H

G

G

G

Q

Y

I

I

V

I

E

E

V

G

S

K

A

P

N

E

E

D

L

L

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y21), V18 (≠ I26), S38 (≠ N46), G39 (= G47), S40 (≠ A48), G41 (= G49), K42 (≠ R50), S43 (= S51), T44 (= T52)

3c41J Abc protein artp in complex with amp-pnp/mg2+
29% identity, 88% coverage: 17:227/240 of query aligns to 9:225/242 of 3c41J

query
sites
3c41J

L

L

H

K

A

K

F

S

Y
x
F

G

G

E

S

S

L

H

E

I
x
V

L

L

H

K

G

G

I

I

D

N

M

V

V

H

V

I

N

R

R

E

G

G

E

E

L

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

A

S

G
|
G

R
x
K

S
|
S

T
|
T

T

F

L

L

K

R

A

C

I

L

M

N

N

L

M

L

V

E

G

D

R

F

R

D

T

E

G

G

S

E

I

I

M

I

I

I

N

D

G

G

E

I

E

N

T

L

M

K

S

A

C

K

A

D

P

T

H

N

-

L

H

N

I

K

A

V

R

R

L

E

G

E

V

V

G

G

Y

M

C

V

P

F

E

Q

H

R

R

F

G

N

I

L

F

F

S

P

S

H

L

M

S

T

V

V

Q

L

E

N

N

N

L

I

T

T

L

L

P

A

P

P

V

M

-

K

V

V

R

R

S

K

G

W

G

P

M

R

S

E

L

K

E

A

E

E

I

A

Y

K

N

A

M

M

-

E

-

L

-

D

F

K

P

V

N

G

L

L

Y

K

E

D

R

K

R

A

F

H

S

A

Q

Y

G

P

T

D

K

S

L

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

N

K

M

I

L

M

L

L

L

F

D
|
D

E

E

I

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

E

G

K

E

L

V

G

L

E

S

V

V

L

M

I

K

A

Q

L

L

K

A

N

N

K

E

G

G

L

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

F

M

H

G

F

F

A

A

A

R

P

E

L

V

A

G

D

D

R

R

H

V

Y

L

V

F

V

M

E

D

H

G

G

G

Q

Y

I

I

V

I

E

E

V

G

S

K

A

P

N

E

E

D

L

L

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y21), V18 (≠ I26), S38 (≠ N46), G39 (= G47), G41 (= G49), K42 (≠ R50), S43 (= S51), T44 (= T52)
binding magnesium ion: S43 (= S51), D163 (= D165)

2olkA Abc protein artp in complex with adp-beta-s
29% identity, 88% coverage: 17:227/240 of query aligns to 9:225/242 of 2olkA

query
sites
2olkA

L

L

H

K

A

K

F

S

Y
x
F

G

G

E

S

S

L

H

E

I
x
V

L

L

H

K

G

G

I

I

D

N

M

V

V

H

V

I

N

R

R

E

G

G

E

E

L

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

R
x
K

S
|
S

T
|
T

T

F

L

L

K

R

A

C

I

L

M

N

N

L

M

L

V

E

G

D

R

F

R

D

T

E

G

G

S

E

I

I

M

I

I

I

N

D

G

G

E

I

E

N

T

L

M

K

S

A

C

K

A

D

P

T

H

N

-

L

H

N

I

K

A

V

R

R

L

E

G

E

V

V

G

G

Y

M

C

V

P

F

E

Q

H

R

R

F

G

N

I

L

F

F

S

P

S

H

L

M

S

T

V

V

Q

L

E

N

N

N

L

I

T

T

L

L

P

A

P

P

V

M

-

K

V

V

R

R

S

K

G

W

G

P

M

R

S

E

L

K

E

A

E

E

I

A

Y

K

N

A

M

M

-

E

-

L

-

D

F

K

P

V

N

G

L

L

Y

K

E

D

R

K

R

A

F

H

S

A

Q

Y

G

P

T

D

K

S

L

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

N

K

M

I

L

M

L

L

L

F

D

D

E

E

I

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

E

G

K

E

L

V

G

L

E

S

V

V

L

M

I

K

A

Q

L

L

K

A

N

N

K

E

G

G

L

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

F

M

H

G

F

F

A

A

A

R

P

E

L

V

A

G

D

D

R

R

H

V

Y

L

V

F

V

M

E

D

H

G

G

G

Q

Y

I

I

V

I

E

E

V

G

S

K

A

P

N

E

E

D

L

L

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y21), V18 (≠ I26), S38 (≠ N46), G39 (= G47), S40 (≠ A48), G41 (= G49), K42 (≠ R50), S43 (= S51), T44 (= T52)

2oljA Abc protein artp in complex with adp/mg2+
29% identity, 88% coverage: 17:227/240 of query aligns to 9:225/242 of 2oljA

query
sites
2oljA

L

L

H

K

A

K

F

S

Y
x
F

G

G

E

S

S

L

H

E

I
x
V

L

L

H

K

G

G

I

I

D

N

M

V

V

H

V

I

N

R

R

E

G

G

E

E

L

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

A
x
S

G
|
G

R
x
K

S
|
S

T
|
T

T

F

L

L

K

R

A

C

I

L

M

N

N

L

M

L

V

E

G

D

R

F

R

D

T

E

G

G

S

E

I

I

M

I

I

I

N

D

G

G

E

I

E

N

T

L

M

K

S

A

C

K

A

D

P

T

H

N

-

L

H

N

I

K

A

V

R

R

L

E

G

E

V

V

G

G

Y

M

C

V

P

F

E

Q

H

R

R

F

G

N

I

L

F

F

S

P

S

H

L

M

S

T

V

V

Q

L

E

N

N

N

L

I

T

T

L

L

P

A

P

P

V

M

-

K

V

V

R

R

S

K

G

W

G

P

M

R

S

E

L

K

E

A

E

E

I

A

Y

K

N

A

M

M

-

E

-

L

-

D

F

K

P

V

N

G

L

L

Y

K

E

D

R

K

R

A

F

H

S

A

Q

Y

G

P

T

D

K

S

L

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

N

K

M

I

L

M

L

L

L

F

D

D

E

E

I

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

V

V

E

G

K

E

L

V

G

L

E

S

V

V

L

M

I

K

A

Q

L

L

K

A

N

N

K

E

G

G

L

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

F

M

H

G

F

F

A

A

A

R

P

E

L

V

A

G

D

D

R

R

H

V

Y

L

V

F

V

M

E

D

H

G

G

G

Q

Y

I

I

V

I

E

E

V

G

S

K

A

P

N

E

E

D

L

L

binding adenosine-5'-diphosphate: F13 (≠ Y21), V18 (≠ I26), S38 (≠ N46), G39 (= G47), S40 (≠ A48), G41 (= G49), K42 (≠ R50), S43 (= S51), T44 (= T52)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
28% identity, 88% coverage: 12:221/240 of query aligns to 5:222/501 of P04983

query
sites
P04983

L

L

R

Q

L

L

S

K

G

G

L

I

H

D

A

K

F

A

Y

F

G

P

E

G

S

V

H

K

I

A

L

L

H

S

G

G

I

A

D

A

M

L

V

N

V

V

N

Y

R

P

G

G

E

R

L

V

V

M

T

A

L

L

L

V

G

G

R

E

N

N

G

G

A

A

G

G

R
x
K

S

S

T

T

T

M

L

M

K

K

A

V

I

L

M

T

N

G

M

I

V

Y

G

T

R

R

R

D

T

A

G

G

S

T

I

L

M

L

I

W

N

L

G

G

E

K

E

E

T

T

M

T

S

F

C

T

A

G

P

P

H

K

H

S

I

S

A

Q

R

E

L

A

G

G

V

I

G

G

Y

I

C

I

P

H

E

Q

H

E

R

L

G

N

I

L

F

I

S

P

S

Q

L

L

S

T

V

I

Q

A

E

E

N

N

L

I

T

F

L

L

-

G

-

R

P

E

P

F

V

V

V

N

R

R

S

F

G

G

G

K

M

I

S

D

L

W

E

K

E

T

I

M

Y

Y

N

A

M

E

F

A

P

D

N

K

L

L

Y

L

E

A

R

K

-

L

-

N

-

L

R

R

F

F

S

K

Q

S

G

D

T

K

-

L

-

V

-

G

K

D

L

L

S

S

G

I

G

G

E

D

Q

Q

M

M

L

V

A

E

M

I

A

A

R

K

I

V

L

L

R

S

T

F

G

E

A

S

N

K

M

V

L

I

L

M

D

D

E

E

I

P

T

T

E

D

G

A

L

L

A

T

P

D

V

T

I

E

V

T

E

E

K

S

L

L

G

F

E

R

V

V

L

I

I

R

A

E

L

L

K

K

N

S

K

Q

G

G

L

R

T

G

I

I

V

V

L

Y

V

I

E

S

Q

H

N

R

F

M

H

K

F

E

A

I

A

F

P

E

L

I

A

C

D

D

R

D

H

V

Y

T

V

V

V

F

E

R

H

D

G

G

Q

Q

I

F

V

I

E

A

E

E

K43 (≠ R50) mutation to R: Loss of transport.

3vx4D Crystal structure of the nucleotide-binding domain of s. Mutans coma, a bifunctional atp-binding cassette transporter involved in the quorum-sensing pathway (see paper)
29% identity, 85% coverage: 27:231/240 of query aligns to 24:232/240 of 3vx4D

query
sites
3vx4D

L

L

H

S

G

D

I

I

D

N

M

L

V

S

V

I

N

K

R

K

G

G

E

S

L

K

V

V

T

S

L

L

L

V

G

G

R

A

N
x
S

G
|
G

A

S

G
|
G

R
x
K

S
x
T

T
|
T

T

L

L

A

K

K

A

L

I

I

M

V

N

N

M

F

V

Y

G

E

R

P

R

N

T

K

G

G

S

I

I

V

M

R

I

I

N

N

G

G

E

N

E

D

T

-

M

L

S

K

C

V

A

I

P

D

H

K

H

T

I

A

A

L

R

R

L

R

G

H

V

I

G

S

Y

Y

C

L

P

P

E
x
Q

H

Q

R

A

G

Y

I

V

F

F

S

S

S

G

L

-

S

S

V

I

Q

M

E

D

N

N

L

L

T

V

L

L

-

G

-

A

-

K

-

E

-

G

-

T

-

S

-

Q

P

E

P

D

V

I

R

R

S

A

G

C

G

E

M

I

S

A

-

E

L

I

E

R

E

S

I

D

Y

I

N

E

M

Q

F

M

P

P

N

Q

L

G

Y

Y

E

Q

R

T

R

E

F

L

S

S

Q

D

G

G

T

A

K
x
G

L
x
I

S
|
S

G

G

G
|
G

E
x
Q

Q

K

Q

Q

M

R

L

I

A

A

M

L

A

A

R

R

I

A

L

L

R

L

T

T

G

Q

A

A

N

P

M

V

L

L

L

I

L

L

D

D

E

A

I

A

T

T

E

S

G

S

L

L

A

D

P

I

V

L

I

T

V

E

E

K

K

K

L

I

G

I

E

S

V

N

L

L

I

L

A

Q

L

M

K

T

N

E

K

K

G

-

L

-

T

T

I

I

V

I

L

F

V

V

E

A

Q
x
H

N

R

F

L

H

S

F

I

A

S

A

Q

P

R

L

-

A

T

D

D

R

E

H

V

Y

I

V

V

V

M

E

D

H

Q

G

G

Q

K

I

I

V

V

E

E

E

Q

V

G

S

T

A

H

N

K

E

E

L

L

S

L

A

A

K

K

Q

Q

binding adenosine-5'-triphosphate: S43 (≠ N46), G44 (= G47), G46 (= G49), K47 (≠ R50), T48 (≠ S51), T49 (= T52), Q89 (≠ E93), G144 (≠ K140), I145 (≠ L141), S146 (= S142), G148 (= G144), Q149 (≠ E145), H200 (≠ Q198)
binding magnesium ion: T48 (≠ S51), Q89 (≠ E93)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 17, 23

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
25% identity, 96% coverage: 10:239/240 of query aligns to 3:253/254 of 1g6hA

query
sites
1g6hA

E

E

Q

I

L

L

R

R

L

T

S

E

G

N

L

I

H

V

A

K

F

Y

Y
x
F

G

G

E

E

S
x
F

H

K

I

A

L

L

H

D

G

G

I

V

D

S

M

I

V

S

V

V

N

N

R

K

G

G

E

D

L

V

V

T

T

L

L

I

G

G

R

P

N
|
N

G
|
G

A

S

G
|
G

R
x
K

S
|
S

T
|
T

T

L

L

I

K

N

A

V

I

I

M

T

N

G

M

F

V

L

G

K

R

A

R

D

T

E

G

G

S

R

I

V

M

Y

I

F

N

E

G

N

E

K

E

D

T

I

M

T

S

N

C

K

A

E

P

P

H

A

H

E

I

L

A

Y

R

H

L

Y

G

G

V

I

G

V

Y

R

C

T

P

F

E

Q

H

T

R

P

G

Q

I

P

F

L

S

K

S

E

L

M

S

T

V

V

Q

L

E

E

N

N

L

L

T

L

L

I

P

G

P

E

V

I

V

C

R

-

S

P

G

G

G

E

M

S

S

P

L

L

E

N

E

S

I

L

Y

F

-

Y

-

K

N

K

M

W

F

I

P

P

-

K

-

E

-

M

-

V

-

E

-

K

-

A

-

F

-

K

-

I

-

L

-

E

-

F

-

L

-

K

-

L

-

S

N

H

L

L

Y

Y

E

D

R

R

R

K

F

A

S

G

Q

E

G

-

T

-

K

-

L

L

S

S

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

M

I

A

G

R

R

I

A

L

L

R

M

T

T

G

N

A

P

N

K

M

M

L

I

L

V

L

M

D

D

E

E

I

P

T

I

E

A

G

G

L

V

A

A

P

P

V

G

I

L

V

A

E

H

K

D

L

I

G

F

E

N

V

H

L

V

I

L

A

E

L

L

K

K

N

A

K

K

G

G

L

I

T

T

I

F

V

L

L

I

V

I

E

E

Q

H

N

R

F

L

H

D

F

I

A

V

A

L

P

N

L

Y

A

I

D

D

R

H

H

L

Y

Y

V

V

V

M

E

F

H

N

G

G

Q

Q

I

I

V

I

-

A

-

E

-

G

-

R

-

G

E

E

V

E

S

I

A

K

N

N

E

V

L

L

S

S

A

D

K

P

Q

K

S

-

V

V

L

V

D

E

G

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y21), F17 (≠ S24), N39 (= N46), G40 (= G47), G42 (= G49), K43 (≠ R50), S44 (= S51), T45 (= T52)

Query Sequence

>GFF948 HP15_927 branched-chain amino acid ABC transporter, ATP-binding protein
MTTKSDREYEQLRLSGLHAFYGESHILHGIDMVVNRGELVTLLGRNGAGRSTTLKAIMNM
VGRRTGSIMINGEETMSCAPHHIARLGVGYCPEHRGIFSSLSVQENLTLPPVVRSGGMSL
EEIYNMFPNLYERRFSQGTKLSGGEQQMLAMARILRTGANMLLLDEITEGLAPVIVEKLG
EVLIALKNKGLTIVLVEQNFHFAAPLADRHYVVEHGQIVEEVSANELSAKQSVLDGYLGV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory