SitesBLAST
Comparing GFF964 HP15_943 aldehyde dehydrogenase family protein to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
70% identity, 98% coverage: 12:504/505 of query aligns to 3:495/495 of 5iuwA
- active site: N166 (= N175), K189 (= K198), E265 (= E274), C300 (= C309), E399 (= E408), D476 (= D485)
- binding 1h-indol-3-ylacetic acid: F167 (= F176), M170 (≠ I179), C300 (= C309), D457 (= D466), F465 (= F474)
- binding nicotinamide-adenine-dinucleotide: I162 (= I171), V163 (= V172), P164 (= P173), W165 (= W174), N166 (= N175), K189 (= K198), G222 (= G231), G226 (= G235), K227 (= K236), F240 (= F249), T241 (= T250), G242 (= G251), S243 (= S252), I246 (≠ V255), Y253 (= Y262), E265 (= E274), A266 (= A275), C300 (= C309), E399 (= E408), F401 (= F410)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
70% identity, 98% coverage: 12:504/505 of query aligns to 3:495/495 of 5iuvA
- active site: N166 (= N175), K189 (= K198), E265 (= E274), C300 (= C309), E399 (= E408), D476 (= D485)
- binding nicotinamide-adenine-dinucleotide: I162 (= I171), V163 (= V172), P164 (= P173), W165 (= W174), N166 (= N175), K189 (= K198), S191 (= S200), G222 (= G231), G226 (= G235), K227 (= K236), F240 (= F249), T241 (= T250), G242 (= G251), S243 (= S252), I246 (≠ V255), Y253 (= Y262), E265 (= E274), A266 (= A275), C300 (= C309), E399 (= E408), F401 (= F410)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
70% identity, 98% coverage: 12:504/505 of query aligns to 3:495/495 of 7jsoA
- active site: N166 (= N175), E265 (= E274), A300 (≠ C309), D476 (= D485)
- binding 1h-indol-3-ylacetic acid: F167 (= F176), W174 (= W183), V299 (= V308), A300 (≠ C309), T301 (= T310), D457 (= D466), F465 (= F474)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (= I171), V163 (= V172), P164 (= P173), W165 (= W174), K189 (= K198), E192 (= E201), G222 (= G231), G226 (= G235), K227 (= K236), F240 (= F249), G242 (= G251), S243 (= S252), I246 (≠ V255), A266 (= A275), G267 (= G276), A300 (≠ C309), E399 (= E408), F401 (= F410)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
46% identity, 97% coverage: 12:502/505 of query aligns to 6:493/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (≠ I171), L166 (≠ V172), P167 (= P173), W168 (= W174), K192 (= K198), G225 (= G231), G229 (= G235), F243 (= F249), G245 (= G251), S246 (= S252), T249 (≠ V255), L252 (≠ Q258), F253 (≠ L259), Y256 (= Y262), C269 (≠ A275), G270 (= G276), C303 (= C309), H350 (≠ Q356), K353 (≠ R359), F400 (= F410)
O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 6 papers)
45% identity, 93% coverage: 28:498/505 of query aligns to 39:507/518 of O94788
- E50 (≠ A39) to G: in dbSNP:rs34266719
- A110 (= A98) to V: in dbSNP:rs35365164
- Q182 (≠ A170) to K: in DIH4; decreased retinoic acid biosynthetic process
- IPW 184:186 (≠ VPW 172:174) binding
- KPAE 210:213 (≠ KPSE 198:201) binding
- STE 264:266 (≠ STN 252:254) binding
- C320 (= C309) active site, Nucleophile
- R347 (≠ W336) to H: in DIH4; decreased expression; dbSNP:rs141245344
- V348 (≠ R337) to I: in dbSNP:rs4646626
- KQYNK 366:370 (≠ AQLDR 355:359) binding
- A383 (= A372) to T: in DIH4; uncertain significance; dbSNP:rs749124508
- E417 (= E408) binding
- E436 (≠ A427) to K: in dbSNP:rs34744827
- S461 (≠ A452) to Y: in DIH4; decreased retinoic acid biosynthetic process
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
45% identity, 93% coverage: 28:498/505 of query aligns to 13:481/492 of 6b5hA
- active site: N161 (= N175), E260 (= E274), C294 (= C309), E468 (≠ D485)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (= V126), G116 (≠ A130), F162 (= F176), W169 (= W183), Q284 (≠ S299), F288 (= F303), T295 (= T310), N449 (≠ D466), L451 (≠ G468), N452 (≠ D469), F457 (= F474)
- binding nicotinamide-adenine-dinucleotide: I157 (= I171), I158 (≠ V172), W160 (= W174), N161 (= N175), K184 (= K198), G217 (= G231), G221 (= G235), F235 (= F249), T236 (= T250), G237 (= G251), S238 (= S252), V241 (= V255), E260 (= E274), L261 (≠ A275), C294 (= C309), F393 (= F410)
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118) (see paper)
45% identity, 93% coverage: 28:498/505 of query aligns to 13:481/492 of 6b5gA
- active site: N161 (= N175), E260 (= E274), C294 (= C309), E468 (≠ D485)
- binding (3-ethoxythiophen-2-yl){4-[4-nitro-3-(pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone: F162 (= F176), L165 (≠ I179), W169 (= W183), F288 (= F303), C293 (≠ V308), C294 (= C309), T295 (= T310), N449 (≠ D466), L451 (≠ G468)
- binding nicotinamide-adenine-dinucleotide: I157 (= I171), I158 (≠ V172), P159 (= P173), W160 (= W174), N161 (= N175), M166 (= M180), K184 (= K198), E187 (= E201), G217 (= G231), G221 (= G235), F235 (= F249), T236 (= T250), G237 (= G251), S238 (= S252), V241 (= V255), E260 (= E274), L261 (≠ A275), C294 (= C309), E391 (= E408), F393 (= F410)
6aljA Aldh1a2 liganded with NAD and compound win18,446 (see paper)
45% identity, 93% coverage: 28:498/505 of query aligns to 13:481/492 of 6aljA
- active site: N161 (= N175), E260 (= E274), C294 (= C309), E468 (≠ D485)
- binding N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide): G116 (≠ A130), F162 (= F176), L165 (≠ I179), M166 (= M180), W169 (= W183), E260 (= E274), C293 (≠ V308), C294 (= C309), L451 (≠ G468), N452 (≠ D469), A453 (≠ M470)
- binding nicotinamide-adenine-dinucleotide: I157 (= I171), I158 (≠ V172), P159 (= P173), W160 (= W174), N161 (= N175), K184 (= K198), E187 (= E201), G217 (= G231), G221 (= G235), F235 (= F249), G237 (= G251), S238 (= S252), V241 (= V255), Q341 (= Q356), K344 (≠ R359), E391 (= E408), F393 (= F410)
Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
44% identity, 93% coverage: 28:498/505 of query aligns to 39:507/518 of Q63639
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
46% identity, 94% coverage: 28:500/505 of query aligns to 12:484/494 of 4pz2B
- active site: N159 (= N175), K182 (= K198), E258 (= E274), C292 (= C309), E392 (= E408), D469 (= D485)
- binding nicotinamide-adenine-dinucleotide: I155 (= I171), I156 (≠ V172), P157 (= P173), W158 (= W174), N159 (= N175), M164 (= M180), K182 (= K198), A184 (≠ S200), E185 (= E201), G215 (= G231), G219 (= G235), F233 (= F249), T234 (= T250), G235 (= G251), S236 (= S252), V239 (= V255), E258 (= E274), L259 (≠ A275), C292 (= C309), E392 (= E408), F394 (= F410)
7radA Crystal structure analysis of aldh1b1
45% identity, 93% coverage: 30:498/505 of query aligns to 16:482/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I171), I159 (≠ V172), P160 (= P173), W161 (= W174), N162 (= N175), M167 (= M180), K185 (= K198), E188 (= E201), G218 (= G231), G222 (= G235), A223 (≠ K236), T237 (= T250), G238 (= G251), S239 (= S252), V242 (= V255), E261 (= E274), L262 (≠ A275), C295 (= C309), E392 (= E408), F394 (= F410)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ V126), E117 (≠ A130), F163 (= F176), E285 (≠ S299), F289 (= F303), N450 (≠ D466), V452 (≠ G468)
7mjdA Crystal structure analysis of aldh1b1
45% identity, 93% coverage: 30:498/505 of query aligns to 16:482/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I171), I159 (≠ V172), P160 (= P173), W161 (= W174), N162 (= N175), M167 (= M180), K185 (= K198), E188 (= E201), G218 (= G231), G222 (= G235), F236 (= F249), T237 (= T250), G238 (= G251), S239 (= S252), V242 (= V255), E261 (= E274), L262 (≠ A275), C295 (= C309), E392 (= E408), F394 (= F410)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ A130), E285 (≠ S299), F289 (= F303), N450 (≠ D466), V452 (≠ G468)
7mjcA Crystal structure analysis of aldh1b1
45% identity, 93% coverage: 30:498/505 of query aligns to 16:482/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I171), I159 (≠ V172), P160 (= P173), W161 (= W174), N162 (= N175), K185 (= K198), E188 (= E201), G218 (= G231), G222 (= G235), T237 (= T250), G238 (= G251), S239 (= S252), V242 (= V255), E261 (= E274), L262 (≠ A275), C295 (= C309), E392 (= E408), F394 (= F410)
7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
44% identity, 94% coverage: 28:504/505 of query aligns to 15:489/489 of 7a6qB
- active site: N163 (= N175), E262 (= E274), C296 (= C309), E470 (≠ D485)
- binding nicotinamide-adenine-dinucleotide: I159 (= I171), W162 (= W174), K186 (= K198), E189 (= E201), G219 (= G231), G223 (= G235), S240 (= S252), V243 (= V255), K342 (≠ A355)
- binding (3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium: A32 (≠ T45), T33 (≠ S46), C34 (≠ V47), P36 (= P49), D103 (= D115), E189 (= E201), Q190 (≠ K202), F218 (≠ Y230), I339 (≠ V352), D340 (= D353)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (≠ A130), D141 (≠ P153), N143 (= N155), N451 (≠ D466), L453 (≠ G468), A455 (≠ M470)
7a6qA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
44% identity, 94% coverage: 28:504/505 of query aligns to 15:489/489 of 7a6qA
- active site: N163 (= N175), E262 (= E274), C296 (= C309), E470 (≠ D485)
- binding nicotinamide-adenine-dinucleotide: I159 (= I171), T160 (≠ V172), W162 (= W174), K186 (= K198), A188 (≠ S200), E189 (= E201), G219 (= G231), G223 (= G235), S240 (= S252), V243 (= V255), K342 (≠ A355), K346 (≠ R359)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (≠ A130), D141 (≠ P153), N143 (= N155), N451 (≠ D466), L453 (≠ G468), Y454 (≠ D469)
5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid (see paper)
44% identity, 94% coverage: 28:504/505 of query aligns to 15:489/489 of 5fhzA
- active site: N163 (= N175), K186 (= K198), E262 (= E274), C296 (= C309), E393 (= E408), E470 (≠ D485)
- binding nicotinamide-adenine-dinucleotide: I159 (= I171), T160 (≠ V172), W162 (= W174), K186 (= K198), E189 (= E201), G219 (= G231), G223 (= G235), F237 (= F249), G239 (= G251), S240 (= S252), T241 (= T253), V243 (= V255), G264 (= G276), Q343 (= Q356), E393 (= E408)
- binding retinoic acid: G118 (≠ A130), R121 (= R133), F164 (= F176), M168 (= M180), W171 (= W183), C295 (≠ V308), C296 (= C309), L453 (≠ G468)
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
44% identity, 94% coverage: 28:504/505 of query aligns to 14:488/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (= I171), T159 (≠ V172), P160 (= P173), W161 (= W174), K185 (= K198), E188 (= E201), G218 (= G231), G222 (= G235), F236 (= F249), S239 (= S252), V242 (= V255)
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
44% identity, 94% coverage: 28:504/505 of query aligns to 33:507/512 of P47895
- R89 (≠ S83) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K198) binding
- E207 (= E201) binding
- GSTEVG 257:262 (≠ GSTNVA 251:256) binding
- Q361 (= Q356) binding
- E411 (= E408) binding
- A493 (= A490) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
6tgwA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with a selective inhibitor (see paper)
44% identity, 94% coverage: 28:504/505 of query aligns to 7:478/478 of 6tgwA
- active site: N155 (= N175), E254 (= E274), C288 (= C309), E459 (≠ D485)
- binding methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate: I106 (≠ V126), G110 (≠ A130), F156 (= F176), Q278 (≠ S299), F282 (= F303), L442 (≠ G468), A444 (≠ M470)
- binding nicotinamide-adenine-dinucleotide: I151 (= I171), T152 (≠ V172), P153 (= P173), W154 (= W174), K178 (= K198), G211 (= G231), G215 (= G235), F229 (= F249), G231 (= G251), S232 (= S252), V235 (= V255)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
45% identity, 93% coverage: 28:498/505 of query aligns to 7:474/486 of 4pxlA
- active site: N154 (= N175), K177 (= K198), E253 (= E274), C287 (= C309), E384 (= E408), D461 (= D485)
- binding nicotinamide-adenine-dinucleotide: I150 (= I171), V151 (= V172), P152 (= P173), W153 (= W174), K177 (= K198), E180 (= E201), G210 (= G231), G214 (= G235), A215 (≠ K236), F228 (= F249), G230 (= G251), S231 (= S252), V234 (= V255), E253 (= E274), G255 (= G276), C287 (= C309), Q334 (= Q356), K337 (≠ R359), E384 (= E408), F386 (= F410)
Query Sequence
>GFF964 HP15_943 aldehyde dehydrogenase family protein
MNQPVSSSTPTSQAEWQALATNLTLEGRAYLNGTYQWAANGEAFTSVSPIDGRELASIAS
CDQSDADQAVMAARAAFEAGIWSQLAPAKRKAVLLRFAELIEAHGDELALLETLDMGKPI
NHASNVDVPATARAIRWTAEAIDKVYGELAPTPHNQIGMISREPMGVVAAIVPWNFPMIM
AAWKIAPALATGNSVILKPSEKSPLSAIRLAALAGEAGVPAGVFNVLPGYGHTVGKALAL
HMDVDCLVFTGSTNVAKQLMIYAGQSNMKRVWLEAGGKSPNIVFADAPDLKKAAAEAASA
IAFNQGEVCTAGSRLLVENSIRAEFVRLICEALKTWRPGHPLDPATTCGAIVDQAQLDRI
IDYIGIGQSEGARLVEGGQRILENTGGLFVQPTVFDGVNNQMRIASEEIFGPVLSVIGFD
TADEAVAIANDSIYGLAAAVWTSNINTAHKVAKALRAGSVWINHYDGGDMTAPFGGFKQS
GNGRDKSVHAFDKYTELKATWLVLE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory