SitesBLAST
Comparing Ga0059261_0068 Ga0059261_0068 acetolactate synthase, large subunit (EC 2.2.1.6) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
46% identity, 97% coverage: 4:565/581 of query aligns to 94:660/667 of P09342
- C161 (≠ V71) modified: Disulfide link with 307
- P194 (= P104) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V215) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
46% identity, 97% coverage: 4:565/581 of query aligns to 91:657/664 of P09114
- P191 (= P104) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (= W483) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
46% identity, 99% coverage: 5:578/581 of query aligns to 15:592/599 of 6denA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (= A29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K230 (≠ Q224), M266 (= M260), V293 (= V287), V409 (= V394), L434 (= L419), G435 (= G420), M437 (= M422), D462 (≠ E447), N489 (= N474), E491 (≠ Y476), Q492 (≠ M477), M494 (= M479), V495 (= V480), W498 (= W483), L520 (= L506), N525 (≠ G511), V526 (≠ W512)
- binding flavin-adenine dinucleotide: R163 (= R153), G219 (= G212), A220 (≠ G213), G221 (= G214), N224 (= N217), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G286 (= G280), A287 (= A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (= V287), E319 (≠ D304), I320 (= I305), N324 (≠ S309), D338 (= D323), V339 (= V324), M414 (= M399), G432 (= G417)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M260), D291 (= D285), R292 (= R286), W498 (= W483)
- binding magnesium ion: D462 (≠ E447), N489 (= N474), E491 (≠ Y476)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V394), G410 (= G395), Q411 (= Q396), H412 (= H397), G435 (= G420), M437 (= M422), G461 (= G446), D462 (≠ E447), A463 (= A448), S464 (= S449), N489 (= N474), E491 (≠ Y476), Q492 (≠ M477), G493 (= G478), M494 (= M479), V495 (= V480)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
46% identity, 99% coverage: 5:578/581 of query aligns to 13:590/597 of 6demA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K228 (≠ Q224), M264 (= M260), V291 (= V287), V407 (= V394), L432 (= L419), G433 (= G420), M435 (= M422), D460 (≠ E447), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), M492 (= M479), V493 (= V480), W496 (= W483), L518 (= L506), N523 (≠ G511), V524 (≠ W512)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M479), W496 (= W483), A567 (≠ S555)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G212), A218 (≠ G213), G219 (= G214), N222 (= N217), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (= D323), V337 (= V324), M412 (= M399), G430 (= G417)
- binding magnesium ion: D460 (≠ E447), N487 (= N474), E489 (≠ Y476)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V394), G408 (= G395), Q409 (= Q396), H410 (= H397), M435 (= M422), G459 (= G446), D460 (≠ E447), A461 (= A448), S462 (= S449), M465 (= M452), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), G491 (= G478), M492 (= M479), V493 (= V480)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
46% identity, 99% coverage: 5:578/581 of query aligns to 13:590/597 of 6delA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K228 (≠ Q224), M264 (= M260), V291 (= V287), V407 (= V394), L432 (= L419), G433 (= G420), M435 (= M422), D460 (≠ E447), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), M492 (= M479), V493 (= V480), W496 (= W483), L518 (= L506), N523 (≠ G511), V524 (≠ W512)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D285), R290 (= R286), W496 (= W483)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G212), A218 (≠ G213), G219 (= G214), N222 (= N217), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (= D323), V337 (= V324), M412 (= M399), G430 (= G417)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V394), G408 (= G395), Q409 (= Q396), H410 (= H397), G433 (= G420), M435 (= M422), G459 (= G446), D460 (≠ E447), A461 (= A448), S462 (= S449), M465 (= M452), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), G491 (= G478), M492 (= M479), V493 (= V480)
- binding magnesium ion: D460 (≠ E447), N487 (= N474), E489 (≠ Y476)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V394), G408 (= G395), Q409 (= Q396), H410 (= H397), G433 (= G420), M435 (= M422), G459 (= G446), D460 (≠ E447), A461 (= A448), S462 (= S449), M465 (= M452), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), G491 (= G478), M492 (= M479), V493 (= V480)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
47% identity, 99% coverage: 5:578/581 of query aligns to 11:586/593 of 6deoA
- active site: Y31 (= Y25), G33 (= G27), G34 (= G28), A35 (= A29), I36 (≠ V30), E57 (= E51), T80 (= T74), F119 (= F113), Q120 (= Q114), E121 (= E115), K169 (= K163), K224 (≠ Q224), M260 (= M260), V287 (= V287), V403 (= V394), L428 (= L419), G429 (= G420), M431 (= M422), D456 (≠ E447), N483 (= N474), E485 (≠ Y476), Q486 (≠ M477), M488 (= M479), V489 (= V480), W492 (= W483), L514 (= L506), N519 (≠ G511), V520 (≠ W512)
- binding flavin-adenine dinucleotide: R159 (= R153), G213 (= G212), A214 (≠ G213), G215 (= G214), N218 (= N217), T240 (= T240), L241 (= L241), Q242 (≠ M242), L258 (= L258), G280 (= G280), A281 (= A281), R282 (= R282), D284 (= D284), R286 (= R286), V287 (= V287), E313 (≠ D304), I314 (= I305), N318 (≠ S309), D332 (= D323), V333 (= V324), M408 (= M399), G426 (= G417)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M260), D285 (= D285), R286 (= R286), M488 (= M479), W492 (= W483)
- binding magnesium ion: D456 (≠ E447), N483 (= N474), E485 (≠ Y476)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V394), G404 (= G395), Q405 (= Q396), H406 (= H397), G429 (= G420), M431 (= M422), G455 (= G446), D456 (≠ E447), A457 (= A448), S458 (= S449), M461 (= M452), N483 (= N474), E485 (≠ Y476), Q486 (≠ M477), G487 (= G478), M488 (= M479), V489 (= V480)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
46% identity, 99% coverage: 5:578/581 of query aligns to 13:591/598 of 6desA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K229 (≠ Q224), M265 (= M260), V292 (= V287), V408 (= V394), L433 (= L419), G434 (= G420), M436 (= M422), D461 (≠ E447), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), M493 (= M479), V494 (= V480), W497 (= W483), L519 (= L506), N524 (≠ G511), V525 (≠ W512)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M260), D290 (= D285), R291 (= R286), W497 (= W483)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G212), A219 (≠ G213), G220 (= G214), N223 (= N217), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G285 (= G280), A286 (= A281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (= V287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (= D323), V338 (= V324), Q412 (= Q398), M413 (= M399), G431 (= G417)
- binding magnesium ion: D461 (≠ E447), N488 (= N474), E490 (≠ Y476)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V394), G409 (= G395), Q410 (= Q396), H411 (= H397), G434 (= G420), M436 (= M422), G460 (= G446), D461 (≠ E447), A462 (= A448), S463 (= S449), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), G492 (= G478), M493 (= M479), V494 (= V480)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
46% identity, 99% coverage: 5:578/581 of query aligns to 13:591/598 of 6depA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K229 (≠ Q224), M265 (= M260), V292 (= V287), V408 (= V394), L433 (= L419), G434 (= G420), M436 (= M422), D461 (≠ E447), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), M493 (= M479), V494 (= V480), W497 (= W483), L519 (= L506), N524 (≠ G511), V525 (≠ W512)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D285), R291 (= R286), M493 (= M479), W497 (= W483)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G212), A219 (≠ G213), G220 (= G214), N223 (= N217), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G264 (= G259), G285 (= G280), A286 (= A281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (= V287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (= D323), V338 (= V324), M413 (= M399), G431 (= G417)
- binding magnesium ion: D461 (≠ E447), N488 (= N474), E490 (≠ Y476)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V394), G409 (= G395), Q410 (= Q396), H411 (= H397), G434 (= G420), M436 (= M422), G460 (= G446), D461 (≠ E447), A462 (= A448), S463 (= S449), M466 (= M452), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), G492 (= G478), M493 (= M479), V494 (= V480)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V394), G409 (= G395), Q410 (= Q396), H411 (= H397), G434 (= G420), M436 (= M422), G460 (= G446), D461 (≠ E447), A462 (= A448), S463 (= S449), M466 (= M452), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), G492 (= G478), M493 (= M479), V494 (= V480)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
46% identity, 99% coverage: 5:578/581 of query aligns to 15:593/600 of 6derA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (= A29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K231 (≠ Q224), M267 (= M260), V294 (= V287), V410 (= V394), L435 (= L419), G436 (= G420), M438 (= M422), D463 (≠ E447), N490 (= N474), E492 (≠ Y476), Q493 (≠ M477), M495 (= M479), V496 (= V480), W499 (= W483), L521 (= L506), N526 (≠ G511), V527 (≠ W512)
- binding flavin-adenine dinucleotide: R163 (= R153), G220 (= G212), A221 (≠ G213), G222 (= G214), N225 (= N217), T247 (= T240), L248 (= L241), Q249 (≠ M242), L265 (= L258), H268 (= H261), G287 (= G280), A288 (= A281), R289 (= R282), D291 (= D284), R293 (= R286), V294 (= V287), E320 (≠ D304), I321 (= I305), N325 (≠ S309), G338 (≠ A322), D339 (= D323), V340 (= V324), Q414 (= Q398), M415 (= M399), G433 (= G417)
- binding Metosulam: R293 (= R286), M495 (= M479), W499 (= W483), A570 (≠ S555)
- binding magnesium ion: D463 (≠ E447), N490 (= N474), E492 (≠ Y476)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V394), G411 (= G395), Q412 (= Q396), H413 (= H397), G436 (= G420), M438 (= M422), G462 (= G446), D463 (≠ E447), A464 (= A448), S465 (= S449), N490 (= N474), E492 (≠ Y476), Q493 (≠ M477), G494 (= G478), M495 (= M479), V496 (= V480)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V394), G411 (= G395), Q412 (= Q396), H413 (= H397), G436 (= G420), M438 (= M422), G462 (= G446), D463 (≠ E447), A464 (= A448), S465 (= S449), M468 (= M452), N490 (= N474), E492 (≠ Y476), Q493 (≠ M477), G494 (= G478), V496 (= V480)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
46% identity, 99% coverage: 5:578/581 of query aligns to 15:594/601 of 6deqA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (= A29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K232 (≠ Q224), M268 (= M260), V295 (= V287), V411 (= V394), L436 (= L419), G437 (= G420), M439 (= M422), D464 (≠ E447), N491 (= N474), E493 (≠ Y476), Q494 (≠ M477), M496 (= M479), V497 (= V480), W500 (= W483), L522 (= L506), N527 (≠ G511), V528 (≠ W512)
- binding flavin-adenine dinucleotide: R163 (= R153), G221 (= G212), A222 (≠ G213), G223 (= G214), N226 (= N217), T248 (= T240), L249 (= L241), Q250 (≠ M242), L266 (= L258), G288 (= G280), A289 (= A281), R290 (= R282), D292 (= D284), R294 (= R286), V295 (= V287), E321 (≠ D304), I322 (= I305), D340 (= D323), V341 (= V324), M416 (= M399), G434 (= G417)
- binding magnesium ion: D464 (≠ E447), N491 (= N474), E493 (≠ Y476)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M260), R294 (= R286), M496 (= M479), V497 (= V480), W500 (= W483), A571 (≠ S555)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V394), G412 (= G395), Q413 (= Q396), H414 (= H397), M439 (= M422), G463 (= G446), D464 (≠ E447), A465 (= A448), S466 (= S449), N491 (= N474), E493 (≠ Y476), Q494 (≠ M477), G495 (= G478), M496 (= M479), V497 (= V480)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
47% identity, 97% coverage: 5:569/581 of query aligns to 9:579/595 of 1t9bB
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R226 (≠ Q224), M262 (= M260), V289 (= V287), V405 (= V394), L430 (= L419), G431 (= G420), M433 (= M422), D458 (≠ E447), N485 (= N474), E487 (≠ Y476), Q488 (≠ M477), M490 (= M479), V491 (= V480), W494 (= W483), L516 (= L506), G521 (= G511), L522 (≠ W512), K555 (= K545)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V103), P108 (= P104), D287 (= D285), R288 (= R286), M490 (= M479), W494 (= W483)
- binding flavin-adenine dinucleotide: R157 (= R153), G215 (= G212), A216 (≠ G213), G217 (= G214), N220 (= N217), T242 (= T240), L243 (= L241), Q244 (≠ M242), M259 (= M257), L260 (= L258), M262 (= M260), H263 (= H261), G282 (= G280), A283 (= A281), R284 (= R282), D286 (= D284), R288 (= R286), V289 (= V287), E315 (≠ D304), V316 (≠ I305), N320 (≠ S309), G333 (≠ A322), D334 (= D323), A335 (≠ V324), Q409 (= Q398), M410 (= M399), G428 (= G417), G429 (= G418)
- binding magnesium ion: D458 (≠ E447), N485 (= N474), E487 (≠ Y476)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
47% identity, 97% coverage: 5:569/581 of query aligns to 9:580/596 of 1t9cA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R227 (≠ Q224), M263 (= M260), V290 (= V287), V406 (= V394), L431 (= L419), G432 (= G420), M434 (= M422), D459 (≠ E447), N486 (= N474), E488 (≠ Y476), Q489 (≠ M477), M491 (= M479), V492 (= V480), W495 (= W483), L517 (= L506), G522 (= G511), L523 (≠ W512), K556 (= K545)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G28), V107 (= V103), P108 (= P104), F117 (= F113), K167 (= K163), D288 (= D285), R289 (= R286), W495 (= W483)
- binding flavin-adenine dinucleotide: R157 (= R153), G216 (= G212), A217 (≠ G213), G218 (= G214), N221 (= N217), T243 (= T240), L244 (= L241), Q245 (≠ M242), L261 (= L258), M263 (= M260), H264 (= H261), G283 (= G280), A284 (= A281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (= V287), E316 (≠ D304), V317 (≠ I305), N321 (≠ S309), G334 (≠ A322), D335 (= D323), A336 (≠ V324), M411 (= M399), G429 (= G417), G430 (= G418)
- binding magnesium ion: D459 (≠ E447), N486 (= N474), E488 (≠ Y476)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
47% identity, 97% coverage: 5:569/581 of query aligns to 9:580/596 of 1t9dA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R227 (≠ Q224), M263 (= M260), V290 (= V287), V406 (= V394), L431 (= L419), G432 (= G420), M434 (= M422), D459 (≠ E447), N486 (= N474), E488 (≠ Y476), Q489 (≠ M477), M491 (= M479), V492 (= V480), W495 (= W483), L517 (= L506), G522 (= G511), L523 (≠ W512), K556 (= K545)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G28), A33 (= A29), V107 (= V103), P108 (= P104), F117 (= F113), K167 (= K163), M263 (= M260), D288 (= D285), R289 (= R286), W495 (= W483)
- binding flavin-adenine dinucleotide: R157 (= R153), G216 (= G212), A217 (≠ G213), G218 (= G214), N221 (= N217), T243 (= T240), L244 (= L241), Q245 (≠ M242), M260 (= M257), L261 (= L258), H264 (= H261), G283 (= G280), A284 (= A281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (= V287), E316 (≠ D304), V317 (≠ I305), N321 (≠ S309), G334 (≠ A322), D335 (= D323), A336 (≠ V324), Q410 (= Q398), M411 (= M399), G429 (= G417), G430 (= G418)
- binding magnesium ion: D459 (≠ E447), N486 (= N474), E488 (≠ Y476)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E51), P81 (= P77), Q118 (= Q114), G432 (= G420), M434 (= M422), M464 (= M452)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
47% identity, 97% coverage: 5:569/581 of query aligns to 10:581/597 of 1t9aA
- active site: Y30 (= Y25), G32 (= G27), G33 (= G28), A34 (= A29), I35 (≠ V30), E56 (= E51), T79 (= T74), F118 (= F113), Q119 (= Q114), E120 (= E115), K168 (= K163), R228 (≠ Q224), M264 (= M260), V291 (= V287), V407 (= V394), L432 (= L419), G433 (= G420), M435 (= M422), D460 (≠ E447), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), M492 (= M479), V493 (= V480), W496 (= W483), L518 (= L506), G523 (= G511), L524 (≠ W512), K557 (= K545)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G28), V108 (= V103), P109 (= P104), F118 (= F113), K168 (= K163), M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M479), V493 (= V480), W496 (= W483)
- binding flavin-adenine dinucleotide: R158 (= R153), G217 (= G212), A218 (≠ G213), G219 (= G214), N222 (= N217), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), M264 (= M260), H265 (= H261), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D304), V318 (≠ I305), N322 (≠ S309), G335 (≠ A322), D336 (= D323), A337 (≠ V324), Q411 (= Q398), M412 (= M399), G430 (= G417), G431 (= G418)
- binding magnesium ion: D460 (≠ E447), N487 (= N474), E489 (≠ Y476)
- binding propyl trihydrogen diphosphate: V407 (= V394), G408 (= G395), Q409 (= Q396), H410 (= H397), M435 (= M422), G459 (= G446), D460 (≠ E447), A461 (= A448), S462 (= S449), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), G491 (= G478), M492 (= M479)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G420), M435 (= M422), M465 (= M452)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
47% identity, 97% coverage: 5:569/581 of query aligns to 11:583/599 of 1n0hA
- active site: Y31 (= Y25), G33 (= G27), G34 (= G28), A35 (= A29), I36 (≠ V30), E57 (= E51), T80 (= T74), F119 (= F113), Q120 (= Q114), E121 (= E115), K169 (= K163), R230 (≠ Q224), M266 (= M260), V293 (= V287), V409 (= V394), L434 (= L419), G435 (= G420), M437 (= M422), D462 (≠ E447), N489 (= N474), E491 (≠ Y476), Q492 (≠ M477), M494 (= M479), V495 (= V480), W498 (= W483), L520 (= L506), G525 (= G511), L526 (≠ W512), K559 (= K545)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V394), G410 (= G395), Q411 (= Q396), H412 (= H397), G435 (= G420), M437 (= M422), G461 (= G446), D462 (≠ E447), A463 (= A448), S464 (= S449), M467 (= M452), N489 (= N474), E491 (≠ Y476), Q492 (≠ M477), G493 (= G478), V495 (= V480)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G28), A35 (= A29), V109 (= V103), P110 (= P104), F119 (= F113), K169 (= K163), M266 (= M260), D291 (= D285), R292 (= R286), V495 (= V480), W498 (= W483)
- binding flavin-adenine dinucleotide: R159 (= R153), G219 (= G212), A220 (≠ G213), G221 (= G214), N224 (= N217), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G265 (= G259), M266 (= M260), H267 (= H261), G286 (= G280), A287 (= A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (= V287), E319 (≠ D304), V320 (≠ I305), N324 (≠ S309), G337 (≠ A322), D338 (= D323), A339 (≠ V324), M414 (= M399), G432 (= G417), G433 (= G418)
- binding magnesium ion: D462 (≠ E447), N489 (= N474), E491 (≠ Y476)
- binding thiamine diphosphate: Y31 (= Y25), E57 (= E51), P83 (= P77)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
46% identity, 97% coverage: 5:569/581 of query aligns to 93:671/687 of P07342
- R241 (= R153) binding
- 355:376 (vs. 261:282, 59% identical) binding
- 407:426 (vs. 304:323, 20% identical) binding
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
46% identity, 97% coverage: 5:569/581 of query aligns to 13:591/607 of 6u9dB
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M274 (= M260), V301 (= V287), V417 (= V394), G443 (= G420), M445 (= M422), D470 (≠ E447), N497 (= N474), E499 (≠ Y476), Q500 (≠ M477), M502 (= M479), V503 (= V480), W506 (= W483)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G28), V111 (= V103), P112 (= P104), F121 (= F113), K171 (= K163), D299 (= D285), R300 (= R286), M502 (= M479), W506 (= W483)
- binding flavin-adenine dinucleotide: R161 (= R153), A228 (≠ G213), G229 (= G214), N232 (= N217), T254 (= T240), L255 (= L241), Q256 (≠ M242), L272 (= L258), M274 (= M260), G294 (= G280), R296 (= R282), D298 (= D284), R300 (= R286), V301 (= V287), E327 (≠ D304), V328 (≠ I305), N332 (≠ S309), D346 (= D323), A347 (≠ V324), M422 (= M399), G440 (= G417), G441 (= G418)
- binding magnesium ion: D470 (≠ E447), N497 (= N474)
- binding thiamine diphosphate: E59 (= E51), P85 (= P77), V417 (= V394), G418 (= G395), Q419 (= Q396), H420 (= H397), G443 (= G420), M445 (= M422), A471 (= A448), S472 (= S449), N497 (= N474), E499 (≠ Y476), Q500 (≠ M477), G501 (= G478), M502 (= M479), V503 (= V480)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
44% identity, 97% coverage: 4:565/581 of query aligns to 97:663/670 of P17597
- A122 (= A29) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L31) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E51) binding
- S186 (= S93) binding
- P197 (= P104) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ H106) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q114) binding
- K220 (= K127) binding
- R246 (= R153) binding ; binding
- K256 (= K163) binding
- G308 (= G213) binding
- TL 331:332 (= TL 240:241) binding
- C340 (≠ A249) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 258:261) binding
- GVRFD 371:375 (≠ GARFD 280:284) binding
- DR 376:377 (= DR 285:286) binding
- DI 395:396 (= DI 304:305) binding
- DV 414:415 (= DV 323:324) binding
- QH 487:488 (= QH 396:397) binding
- GG 508:509 (= GG 417:418) binding
- GAM 511:513 (≠ GTM 420:422) binding
- D538 (≠ E447) binding
- DGS 538:540 (≠ EAS 447:449) binding
- N565 (= N474) binding
- NQHLGM 565:570 (≠ NEYMGM 474:479) binding
- H567 (≠ Y476) binding
- W574 (= W483) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (= S555) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
47% identity, 97% coverage: 5:569/581 of query aligns to 9:575/591 of 5wkcA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R222 (≠ Q224), M258 (= M260), V285 (= V287), V401 (= V394), L426 (= L419), G427 (= G420), M429 (= M422), D454 (≠ E447), N481 (= N474), E483 (≠ Y476), Q484 (≠ M477), M486 (= M479), V487 (= V480), W490 (= W483), L512 (= L506), G517 (= G511), L518 (≠ W512), K551 (= K545)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V394), G402 (= G395), Q403 (= Q396), H404 (= H397), G427 (= G420), M429 (= M422), G453 (= G446), D454 (≠ E447), A455 (= A448), S456 (= S449), M459 (= M452), N481 (= N474), E483 (≠ Y476), Q484 (≠ M477), G485 (= G478), M486 (= M479), V487 (= V480)
- binding ethaneperoxoic acid: G32 (= G28), Q118 (= Q114)
- binding flavin-adenine dinucleotide: R157 (= R153), G211 (= G212), A212 (≠ G213), G213 (= G214), N216 (= N217), T238 (= T240), L239 (= L241), Q240 (≠ M242), L256 (= L258), M258 (= M260), G278 (= G280), A279 (= A281), R280 (= R282), R284 (= R286), V285 (= V287), E311 (≠ D304), V312 (≠ I305), N316 (≠ S309), D330 (= D323), A331 (≠ V324), M406 (= M399), G424 (= G417)
- binding magnesium ion: D454 (≠ E447), N481 (= N474), E483 (≠ Y476)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G28), A33 (= A29), V107 (= V103), F117 (= F113), K167 (= K163), M258 (= M260), R284 (= R286), M486 (= M479), W490 (= W483)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P26), E55 (= E51)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
44% identity, 97% coverage: 4:565/581 of query aligns to 12:578/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V394), G401 (= G395), Q402 (= Q396), H403 (= H397), G426 (= G420), M428 (= M422), G452 (= G446), D453 (≠ E447), G454 (≠ A448), S455 (= S449), M458 (= M452), N480 (= N474), H482 (≠ Y476), L483 (≠ M477), G484 (= G478), M485 (= M479), V486 (= V480)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), M266 (= M260), H267 (= H261), G286 (= G280), V287 (≠ A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (= V287), D310 (= D304), I311 (= I305), D329 (= D323), V330 (= V324), M405 (= M399), G423 (= G417)
- binding magnesium ion: F370 (= F363), D453 (≠ E447), M458 (= M452), Q461 (= Q455), N480 (= N474), H482 (≠ Y476), K533 (= K520)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M260), R292 (= R286), M485 (= M479), W489 (= W483), S568 (= S555)
Query Sequence
>Ga0059261_0068 Ga0059261_0068 acetolactate synthase, large subunit (EC 2.2.1.6)
VTEKSGADILIEAFNDLGVEVIFGYPGGAVLPIYDAIFQQTKIRHILVRHEQAATHAAEG
YARATGKPGVVLVTSGPGATNAVTGITDALMDSIPMVVITGQVPSHLIGSDAFQEADTVG
ITRHCTKHNYLVKDPAHLGSIVHEAFHIATSGRPGPVVIDIPKDVQIATARYSKPGPIQH
KTYRPQVKADKALIESAVEMLAAAERPVFYTGGGVINSGPQASQLLRELARITGAPVTST
LMGLGAFPASSDQWLGMLGMHGTYEANYAMNQADLIVAIGARFDDRVTGRLDAFAPHARK
IHIDIDRSSMNKTVRVDLPIVADVGHALEDMIRIWKARQHPRPDLSEWWSRIEGWRAVKC
LDFPEDSNEIMPQRAIRALWEATRDQAPIITTEVGQHQMWAAQHFHFESPNKWLTSGGLG
TMGYGLPAAIGAQLGHPDALVIDIAGEASIQMNIQELATATQYRLPVKIFILNNEYMGMV
RQWQELTYSSRYSESYSDALPDFVKLGEAYGWEGIRIEGKDQLDDGIAAMLAHDGPVIVD
CRVAKLANCFPMIPSGAAHTDMLLQSAEVSGEMDDEAKALV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory