SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ga0059261_0562 FitnessBrowser__Korea:Ga0059261_0562 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
47% identity, 88% coverage: 28:232/232 of query aligns to 22:227/648 of P75831

query
sites
P75831

E

E

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V

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L

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K

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A

K47 (= K53) mutation to L: Lack of activity.
D169 (= D173) mutation to N: Lack of activity.

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
41% identity, 95% coverage: 11:231/232 of query aligns to 4:225/226 of 5xu1B

query
sites
5xu1B

I

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S

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A

binding magnesium ion: G45 (= G52), K46 (= K53), S47 (= S54)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
44% identity, 87% coverage: 28:229/232 of query aligns to 17:219/223 of 2pclA

query
sites
2pclA

E

E

I

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L

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K

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G

G

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D

E

binding magnesium ion: E165 (= E174), P166 (= P175), T167 (= T176), T196 (= T206)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
41% identity, 92% coverage: 11:224/232 of query aligns to 2:221/232 of 1f3oA

query
sites
1f3oA

I

I

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K

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G

binding adenosine-5'-diphosphate: Y11 (≠ L20), G41 (= G50), G43 (= G52), K44 (= K53), S45 (= S54), T46 (≠ S55)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
40% identity, 92% coverage: 11:224/232 of query aligns to 2:221/230 of 1l2tA

query
sites
1l2tA

I

I

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K

A

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K

N

N

V

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E

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S

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S
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A

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E

E

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L

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I

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M

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S

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G

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x
Q

Q

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A

A

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H
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G

binding adenosine-5'-triphosphate: Y11 (≠ L20), S40 (= S49), G41 (= G50), S42 (= S51), G43 (= G52), K44 (= K53), S45 (= S54), T46 (≠ S55), F138 (≠ L142), Q145 (= Q148), S147 (= S150), G149 (= G152), Q150 (≠ E153), H204 (= H207)

7mdyC Lolcde nucleotide-bound
41% identity, 95% coverage: 9:229/232 of query aligns to 1:223/226 of 7mdyC

query
sites
7mdyC

I

I

A

L

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L

R

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D

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S
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T

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A

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E

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N

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M

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P

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L

E

L

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G

K

A

K

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D

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A

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-

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A

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K

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H

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x
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S
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S

G
|
G

G
|
G

E

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

A

V

G

N

R

N

P

P

E

R

I

L

L

V

F

L

A

A

D

D

E
|
E

P

P

T

T

G

G

N
|
N

L

L

D

D

G

A

A

R

T

N

S

A

G

D

A

S

I

I

V

F

D

Q

L

L

L

L

F

G

D

E

R

L

Q

N

R

R

A

L

A

Q

D

G

A

T

T

A

L

F

L

L

I

V

I

V

T

T

H
|
H

D

D

P

L

A

Q

L

L

A

A

E

K

R

R

C

M

D

S

R

R

V

Q

L

L

T

E

M

M

R

R

D

D

G

G

L

R

I

L

V

T

A

A

D

E

binding adp orthovanadate: Y12 (≠ L20), G42 (= G50), S43 (= S51), G44 (= G52), K45 (= K53), S46 (= S54), T47 (≠ S55), Q91 (= Q99), H138 (= H144), E142 (≠ Q148), S144 (= S150), G145 (= G151), G146 (= G152), E168 (= E174), N172 (= N178), H201 (= H207)
binding magnesium ion: S46 (= S54), Q91 (= Q99)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
41% identity, 95% coverage: 9:229/232 of query aligns to 4:226/233 of P75957

query
sites
P75957

I

I

A

L

I

L

R

Q

A

C

R

D

N

N

V

L

T

C

L

K

T

R

L

Y

G

Q

T

E

R

G

E

S

A

V

P

Q

T

T

E

D

I

V

L

L

K

H

G

N

I

V

D

S

V

F

D

S

I

V

A

G

R

E

G

G

S

E

S

M

V

M

A

A

I

I

L

V

G
|
G

P

S

S

S

G

G

S

S

G

G

K

K

S

S

S

T

L

L

M

L

A

H

I

L

L

L

S

G

G

G

L

L

E

D

R

T

A

P

S

T

G

S

G

G

E

D

V

V

S

I

V

F

A

N

G

G

I

Q

A

P

Y

M

G

S

T

K

L

L

D

S

E

S

D

A

G

A

L

K

A

A

R

E

A

L

R

R

R

N

G

Q

R

K

V

L

G

G

I

F

V

I

L

Y

Q

Q

A

F

F

H

H

H

L

L

L

L

P

P

T

D

M

F

T

T

A

A

H

L

E

E

N

N

V

V

A

A

V

M

P

P

L

L

E

L

L

I

A

G

G

K

A

K

P

K

D

P

A

A

-

E

-

I

F

N

A

S

R

R

A

A

G

L

A

E

E

M

L

L

D

K

A

A

V

V

G

G

L

L

G

D

H

H

R

R

L

A

T

N

H

H

Y

R

P

P

V

S

Q

E

L

L

S

S

G

G

G

G

E

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

A

V

G

N

R

N

P

P

E

R

I

L

L

V

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

A

A

R

T

N

S

A

G

D

A

S

I

I

V

F

D

Q

L

L

L

L

F

G

D

E

R

L

Q

N

R

R

A

L

A

Q

D

G

A

T

T

A

L

F

L

L

I

V

I

V

T

T

H

H

D

D

P

L

A

Q

L

L

A

A

E

K

R

R

C

M

D

S

R

R

V

Q

L

L

T

E

M

M

R

R

D

D

G

G

L

R

I

L

V

T

A

A

D

E

G42 (= G47) mutation to D: Loss of lipoprotein release when overexpressed.

7arlD Lolcde in complex with lipoprotein and adp (see paper)
41% identity, 95% coverage: 9:228/232 of query aligns to 1:222/222 of 7arlD

query
sites
7arlD

I

I

A

L

I

L

R

Q

A

C

R

D

N

N

V

L

T

C

L

K

T

R

L

Y

G

Q

T

E

R

G

E

S

A

V

P

Q

T

T

E

D

I

V

L

L

K

H

G

N

I

V

D

S

V

F

D

S

I

V

A

G

R

E

G

G

S

E

S

M

V

M

A

A

I

I

L

V

G

G

P

S

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

S

T

L

L

M

L

A

H

I

L

L

L

S

G

G

G

L

L

E

D

R

T

A

P

S

T

G

S

G

G

E

D

V

V

S

I

V

F

A

N

G

G

I

Q

A

P

Y

M

G

S

T

K

L

L

D

S

E

S

D

A

G

A

L

K

A

A

R

E

A

L

R

R

R

N

G

Q

R

K

V

L

G

G

I

F

V

I

L

Y

Q

Q

A

F

F

H

H

H

L

L

L

L

P

P

T

D

M

F

T

T

A

A

H

L

E

E

N

N

V

V

A

A

V

M

P

P

L

L

E

L

L

I

A

G

G

K

A

K

P

K

D

P

A

A

-

E

-

I

F

N

A

S

R

R

A

A

G

L

A

E

E

M

L

L

D

K

A

A

V

V

G

G

L

L

G

D

H

H

R

R

L

A

T

N

H

H

Y

R

P

P

V

S

Q

E

L

L

S

S

G

G

G

G

E

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

A

V

G

N

R

N

P

P

E

R

I

L

L

V

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

A

A

R

T

N

S

A

G

D

A

S

I

I

V

F

D

Q

L

L

L

L

F

G

D

E

R

L

Q

N

R

R

A

L

A

Q

D

G

A

T

T

A

L

F

L

L

I

V

I

V

T

T

H

H

D

D

P

L

A

Q

L

L

A

A

E

K

R

R

C

M

D

S

R

R

V

Q

L

L

T

E

M

M

R

R

D

D

G

G

L

R

I

L

V

T

A

A

binding adenosine-5'-diphosphate: G42 (= G50), G44 (= G52), K45 (= K53), S46 (= S54)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
40% identity, 95% coverage: 9:229/232 of query aligns to 3:225/229 of 7v8iD

query
sites
7v8iD

I

I

A

L

I

L

R

Q

A

C

R

D

N

N

V

L

T

C

L

K

T

R

L

Y

G

Q

T

E

R

G

E

S

A

V

P

Q

T

T

E

D

I
x
V

L

L

K

H

G

N

I

V

D

S

V

F

D

S

I

V

A

G

R

E

G

G

S

E

S

M

V

M

A

A

I

I

L

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

M

L

A

H

I

L

L

L

S

G

G

G

L

L

E

D

R

T

A

P

S

T

G

S

G

G

E

D

V

V

S

I

V

F

A

N

G

G

I

Q

A

P

Y

M

G

S

T

K

L

L

D

S

E

S

D

A

G

A

L

K

A

A

R

E

A

L

R

R

R

N

G

Q

R

K

V

L

G

G

I

F

V

I

L

Y

Q
|
Q

A

F

F

H

H

H

L

L

L

L

P

P

T

D

M

F

T

T

A

A

H

L

E

E

N

N

V

V

A

A

V

M

P

P

L

L

E

L

L

I

A

G

G

K

A

K

P

K

D

P

A

A

-

E

-

I

F

N

A

S

R

R

A

A

G

L

A

E

E

M

L

L

D

K

A

A

V

V

G

G

L

L

G

D

H

H

R
|
R

L

A

T

N

H
|
H

Y

R

P

P

V

S

Q
x
E

L

L

S
|
S

G

G

G
|
G

E
|
E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

A

V

G

N

R

N

P

P

E

R

I

L

L

V

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

N

L

L

D

D

G

A

A

R

T

N

S

A

G

D

A

S

I

I

V

F

D

Q

L

L

L

L

F

G

D

E

R

L

Q

N

R

R

A

L

A

Q

D

G

A

T

T

A

L

F

L

L

I

V

I

V

T

T

H
|
H

D

D

P

L

A

Q

L

L

A

A

E

K

R

R

C

M

D

S

R

R

V

Q

L

L

T

E

M

M

R

R

D

D

G

G

L

R

I

L

V

T

A

A

D

E

binding phosphoaminophosphonic acid-adenylate ester: V23 (≠ I29), S43 (= S49), G44 (= G50), G46 (= G52), K47 (= K53), S48 (= S54), T49 (≠ S55), Q93 (= Q99), R137 (= R141), H140 (= H144), E144 (≠ Q148), S146 (= S150), G148 (= G152), E149 (= E153), H203 (= H207)
binding magnesium ion: S48 (= S54), Q93 (= Q99)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
44% identity, 89% coverage: 24:229/232 of query aligns to 18:224/650 of 5ws4A

query
sites
5ws4A

E

E

A

S

P

T

T

I

E

Q

I

I

L

L

K

K

G

G

I

I

D

D

V

L

D

T

I

I

A

Y

R

E

G

G

S

E

S

L

V

V

A

A

I

I

L

V

G

G

P

Q

S
|
S

G
|
G

S

S

G

G

K

K

S
|
S

S

T

L

L

M

M

A

N

I

I

L

L

S

G

G

C

L

L

E

D

R

R

A

P

S

T

G

S

G

G

E

S

V

Y

S

K

V

V

A

N

G

G

I

Q

A

E

Y

T

G

G

T

K

L

L

D

E

E

P

D

D

G

Q

L

L

A

A

R

Q

A

L

R

R

R

R

G

E

R

Y

V

F

G

G

I

F

V

I

L

F

Q

Q

A

R

F

Y

H

H

L

L

L

L

P

G

T

D

M

L

T

S

A

A

H

E

E

G

N

N

V

V

A

E

V

V

P

P

L

A

E

V

L

Y

A

A

G

G

A

V

P

T

-

P

-

A

D

D

A

R

F

K

A

Q

R

R

A

A

G

T

A

A

E

L

L

L

D

T

A

E

V

L

G

G

L

L

G

G

H

T

R

K

L

T

T

Q

H

N

Y

R

P

P

V

S

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

V

L

A

M

G

N

R

G

P

G

E

D

I

V

L

I

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

G

-

A

S

T

H

S

S

G

G

A

V

I

E

V

V

D

M

L

R

L

I

F

L

D

R

R

E

Q

L

R

N

A

A

A

A

D

G

A

H

T

T

L

I

L

I

I

L

I

V

T

T

H

H

D

D

P

M

A

Q

L

V

A

A

E

K

R

N

C

A

D

T

R

R

V

I

L

I

T

E

M

I

R

S

D

D

G

G

L

E

I

I

V

I

A

S

D

D

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S49), G44 (= G50), S48 (= S54)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
39% identity, 95% coverage: 11:230/232 of query aligns to 4:224/615 of 5lilA

query
sites
5lilA

I

I

R

E

A

I

R

K

N

Q

V

L

T

N

L

R

T

Y

L
x
F

G

G

T

E

R

G

E

E

A

N

P

R

T

V

E

H

I
x
V

L

L

K

K

G

D

I

I

D

S

V

L

D

S

I

I

A

E

R

R

G

G

S

D

S

F

V

V

A

A

I

I

L

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

M

M

A

N

I

I

L

I

S

G

G

C

L

L

E

D

R

T

A

A

S

T

G

G

G

G

E

S

V

S

S

K

V

I

A

D

G

G

I

K

A

E

Y

T

G

I

T

E

L

L

D

T

E

N

D

D

G

Q

L

L

A

S

R

D

A

L

R

R

R

S

G

Q

R

K

V

F

G

G

I

F

V

I

L

F

Q
|
Q

A

R

F

Y

H

N

L

L

L

L

P

S

T

S

M

L

T

T

A

A

H

A

E

E

N

N

V

V

A

A

V

L

P

P

L

A

E

I

L

Y

A

A

G

G

A

M

P

P

D

Q

A

S

-

Q

-

R

F

L

A

E

R

R

A

A

G

K

A

Q

E

L

L

L

D

E

A

K

V

L

G

G

L

L

G

G

H

D

R
x
K

L

W

T

Q

H

N

Y

K

P

P

V

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

V

L

A

M

G

N

R

G

P

G

E

E

I

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

H

T

S

S

G

G

E

A

N

I

V

V

M

D

E

L

I

L

L

F

-

D

-

R

R

Q

Q

R

L

A

H

A

E

D

E

A

G

-

H

T

T

L

I

L

I

I

M

I

V

T

T

H

H

D

D

P

K

A

H

L

I

A

A

E

A

R

S

C

A

D

N

R

R

V

I

L

I

T

E

M

I

R

K

D

D

G

G

L

E

I

I

V

I

A

S

D

D

S

T

binding adenosine-5'-triphosphate: F13 (≠ L20), V22 (≠ I29), S42 (= S49), G43 (= G50), G45 (= G52), K46 (= K53), S47 (= S54), T48 (≠ S55), Q92 (= Q99), K136 (≠ R141), Q143 (= Q148), S145 (= S150), G147 (= G152), Q148 (≠ E153)
binding magnesium ion: S47 (= S54), Q92 (= Q99)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
39% identity, 95% coverage: 11:230/232 of query aligns to 4:224/592 of 5lj7A

query
sites
5lj7A

I

I

R

E

A

I

R

K

N

Q

V

L

T

N

L

R

T

Y

L

F

G

G

T

E

R

G

E

E

A

N

P

R

T

V

E

H

I
x
V

L

L

K

K

G

D

I

I

D

S

V

L

D

S

I

I

A

E

R

R

G

G

S

D

S

F

V

V

A

A

I

I

L

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

M

M

A

N

I

I

L

I

S

G

G

C

L

L

E

D

R

T

A

A

S

T

G

G

G

G

E

S

V

S

S

K

V

I

A

D

G

G

I

K

A

E

Y

T

G

I

T

E

L

L

D

T

E

N

D

D

G

Q

L

L

A

S

R

D

A

L

R

R

R

S

G

Q

R

K

V

F

G

G

I

F

V

I

L

F

Q
|
Q

A

R

F

Y

H

N

L

L

L

L

P

S

T

S

M

L

T

T

A

A

H

A

E

E

N

N

V

V

A

A

V

L

P

P

L

A

E

I

L

Y

A

A

G

G

A

M

P

P

D

Q

A

S

-

Q

-

R

F

L

A

E

R

R

A

A

G

K

A

Q

E

L

L

L

D

E

A

K

V

L

G

G

L

L

G

G

H

D

R
x
K

L

W

T

Q

H

N

Y

K

P

P

V

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

V

L

A

M

G

N

R

G

P

G

E

E

I

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

H

T

S

S

G

G

E

A

N

I

V

V

M

D

E

L

I

L

L

F

-

D

-

R

R

Q

Q

R

L

A

H

A

E

D

E

A

G

-

H

T

T

L

I

L

I

I

M

I

V

T

T

H

H

D

D

P

K

A

H

L

I

A

A

E

A

R

S

C

A

D

N

R

R

V

I

L

I

T

E

M

I

R

K

D

D

G

G

L

E

I

I

V

I

A

S

D

D

S

T

binding adenosine-5'-triphosphate: V22 (≠ I29), S42 (= S49), G43 (= G50), G45 (= G52), K46 (= K53), S47 (= S54), T48 (≠ S55), Q92 (= Q99), K136 (≠ R141), Q143 (= Q148), S145 (= S150), G147 (= G152), Q148 (≠ E153)
binding magnesium ion: S47 (= S54), Q92 (= Q99)

8g4cB Bceabs atpgs high res tm (see paper)
34% identity, 93% coverage: 9:224/232 of query aligns to 2:219/248 of 8g4cB

query
sites
8g4cB

I

V

A

I

I

L

R

E

A

A

R

N

N

K

V

I

T

R

L

K

T

S

L
x
Y

G

G

T

N

R

K

E

L

A

N

P

K

T

Q

E

E

I

V

L

L

K

K

G

G

I

I

D

D

V

I

D

H

I

I

A

E

R

K

G

G

S

E

S

F

V

V

A

S

I

I

L

M

G

G

P

A

S
|
S

G

G

S
|
S

G

G

K

K

S
x
T

S

T

L

L

M

L

A

N

I

V

L

L

S

S

G

S

L

I

E

D

R

Q

A

V

S

S

G

H

G

G

E

T

V

I

S

H

V

I

A

N

G

G

I

N

A

D

Y

M

G

T

T

A

L

M

D

K

E

E

D

K

G

Q

L

L

A

A

R

E

A

F

R

R

R

K

G

Q

R

H

V

L

G

G

I

F

V

I

L

F

Q

Q

A

D

F

Y

H

N

L

L

L

L

P

D

T

T

M

L

T

T

A

V

H

K

E

E

N

N

V

I

A

L

V

L

P

P

L

L

E

S

L

I

A

T

G

K

-

L

-

S

-

K

-

K

-

E

A

A

P

N

D

R

A

K

F

F

A

E

R

E

A

V

G

A

A

K

E

E

L

L

D

-

A

-

V

-

G

G

L

I

G

Y

H

E

R

L

L

R

T

D

H

K

Y

Y

P

P

V

N

Q

E

L

I

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

V

F

A

I

G

H

R

D

P

P

E

S

I

I

L

I

F

F

A

A

D
|
D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

K

T

S

S

A

G

S

A

D

I

L

V

L

D

N

L

K

L

L

F

S

D

Q

R

L

Q

N

R

Q

A

K

A

R

D

N

A

A

T

T

L

I

L

I

I

M

I

V

T

T

H

H

D

D

P

P

A

V

L

A

A

A

E

S

R

Y

C

C

D

G

R

R

V

V

L

I

T

F

M

I

R

K

D

D

G

G

binding phosphothiophosphoric acid-adenylate ester: Y13 (≠ L20), S42 (= S49), S44 (= S51), T47 (≠ S54), D168 (= D173)

7tchB Bceab e169q variant atp-bound conformation (see paper)
34% identity, 93% coverage: 9:224/232 of query aligns to 1:218/245 of 7tchB

query
sites
7tchB

I

V

A

I

I

L

R

E

A

A

R

N

N

K

V

I

T

R

L

K

T

S

L
x
Y

G

G

T

N

R

K

E

L

A

N

P

K

T
x
Q

E

E

I
x
V

L

L

K

K

G

G

I

I

D

D

V

I

D

H

I

I

A

E

R

K

G

G

S

E

S

F

V

V

A

S

I

I

L

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

S
x
T

S

T

L

L

M

L

A

N

I

V

L

L

S

S

G

S

L

I

E

D

R

Q

A

V

S

S

G

H

G

G

E

T

V

I

S

H

V

I

A

N

G

G

I

N

A

D

Y

M

G

T

T

A

L

M

D

K

E

E

D

K

G

Q

L

L

A

A

R

E

A

F

R

R

R

K

G

Q

R

H

V

L

G

G

I

F

V

I

L

F

Q

Q

A

D

F

Y

H

N

L

L

L

L

P

D

T

T

M

L

T

T

A

V

H

K

E

E

N

N

V

I

A

L

V

L

P

P

L

L

E

S

L

I

A

T

G

K

-

L

-

S

-

K

-

K

-

E

A

A

P

N

D

R

A

K

F

F

A

E

R

E

A

V

G

A

A

K

E

E

L

L

D

-

A

-

V

-

G

G

L

I

G

Y

H

E

R

L

L

R

T

D

H

K

Y

Y

P

P

V

N

Q
x
E

L

I

S

S

G
|
G

G
|
G

E

Q

Q

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

V

F

A

I

G

H

R

D

P

P

E

S

I

I

L

I

F

F

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

K

T

S

S

A

G

S

A

D

I

L

V

L

D

N

L

K

L

L

F

S

D

Q

R

L

Q

N

R

Q

A

K

A

R

D

N

A

A

T

T

L

I

L

I

I

M

I

V

T

T

H

H

D

D

P

P

A

V

L

A

A

A

E

S

R

Y

C

C

D

G

R

R

V

V

L

I

T

F

M

I

R

K

D

D

G

G

binding adenosine-5'-triphosphate: Y12 (≠ L20), Q19 (≠ T27), V21 (≠ I29), S41 (= S49), G42 (= G50), S43 (= S51), K45 (= K53), T46 (≠ S54), E142 (≠ Q148), G145 (= G151), G146 (= G152)

P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see paper)
42% identity, 92% coverage: 11:224/232 of query aligns to 2:213/222 of P0A9R7

query
sites
P0A9R7

I

I

R

R

A

F

R

E

N

H

V

V

T

S

L

K

-

A

T

Y

L

L

G

G

T

G

R

R

E

Q

A

A

P

-

T

-

E

-

I

-

L

L

K

Q

G

G

I

V

D

T

V

F

D

H

I

M

A

Q

R

P

G

G

S

E

S

M

V

A

A

F

I

L

L

T

G

G

P

H

S

S

G

G

S

A

G

G

K
|
K

S

S

S

T

L

L

M

L

A

K

I

L

L

I

S
x
C

G

G

L

I

E

E

R

R

A

P

S

S

G

A

G

G

E

K

V

I

S

W

V

F

A

S

G

G

I

H

A

D

Y

I

G

T

T

R

L

L

D

K

E

N

D

R

G

E

L

V

A

P

R

F

A

L

R

R

R

R

G

-

R

Q

V

I

G

G

I

M

V

I

L

F

Q

Q

A

D

F

H

H

H

L

L

L

L

P

M

T

D

M

R

T

T

A

V

H

Y

E

D

N

N

V

V

A

A

V

I

P

P

L

L

E

I

L

I

A

A

G

G

A

A

P

S

-

G

-

D

D

D

A

I

F

R

A

R

R

R

A

V

G

S

A

A

E

A

L

L

D

D

A

K

V

V

G

G

L

L

G

L

H

D

R

K

L

A

T

K

H

N

Y

F

P

P

V

I

Q

Q

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

V

A

G

I

I

A

A

R

R

A

A

V

V

A

V

G

N

R

K

P

P

E

A

I

V

L

L

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

D

A

A

T

L

S

S

G

E

A

G

I

I

V

L

D

R

L

L

L

F

F

E

D

E

R

F

Q

N

R

R

A

V

A

G

D

-

A

V

T

T

L

V

L

L

I

M

I

A

T

T

H

H

D

D

P

I

A

N

L

L

-

I

A

S

E

R

R

R

C

S

D

Y

R

R

V

M

L

L

T

T

M

L

R

S

D

D

G

G

K41 (= K53) mutation to R: Does not bind ATP.
C49 (≠ S61) mutation to A: Prevents dimer formation. Does not alter ATP-binding.

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
40% identity, 96% coverage: 11:232/232 of query aligns to 2:226/343 of P30750

query
sites
P30750

I

I

R

K

A

L

R

S

N

N

V

I

T

T

L

K

T

V

L

F

G

H

T

Q

R

G

E

T

A

R

P

T

T

I

E

Q

I

A

L

L

K

N

G

N

I

V

D

S

V

L

D

H

I

V

A

P

R

A

G

G

S

Q

S

I

V

Y

A

G

I

V

L

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

M

I

A

R

I

C

L

V

S

N

G

L

L

L

E

E

R

R

A

P

S

T

G

E

G

G

E

S

V

V

S

L

V

V

A

D

G

G

I

Q

A

E

Y

L

G

T

T

T

L

L

D

S

E

E

D

S

G

E

L

L

A

T

R

K

A

A

R

R

R

R

G

-

R

Q

V

I

G

G

I

M

V

I

L

F

Q

Q

A

H

F

F

H

N

L

L

L

L

P

S

T

S

M

R

T

T

A

V

H

F

E

G

N

N

V

V

A

A

V

L

P

P

L

L

E

E

L

L

A

D

G

N

A

T

P

P

-

K

D

D

A

E

F

V

A

K

R

R

A

R

G

V

A

T

E

E

L

L

-

L

D

S

A

L

V

V

G

G

L

L

G

G

H

D

R

K

L

H

T

D

H

S

Y

Y

P

P

V

S

Q

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

A

A

G

S

R

N

P

P

E

K

I

V

L

L

F

L

A

C

D

D

E
|
E

P

A

T

T

G

S

N

A

L

L

D

D

G

P

A

A

T

T

S

T

G

R

A

S

I

I

V

L

D

E

L

L

L

L

F

K

D

D

R

I

Q

N

R

R

A

R

A

L

D

G

A

L

T

T

L

I

L

L

I

L

I

I

T

T

H

H

D

E

P

M

A

D

L

V

A

V

E

K

R

R

-

I

C

C

D

D

R

C

V

V

L

A

T

V

M

I

R

S

D

N

G

G

-

E

L

L

I

I

V

E

A

Q

D

D

S

T

A

V

A

S

40:46 (vs. 49:55, 71% identical) binding
E166 (= E174) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
41% identity, 94% coverage: 11:229/232 of query aligns to 3:217/241 of 4u00A

query
sites
4u00A

I

I

R

R

A

I

R

R

N

N

V

L

T

H

L

K

T

W

L
x
F

G

G

T

-

R

-

E

-

A

-

P

P

T

L

E

H

I
x
V

L

L

K

K

G

G

I

I

D

H

V

L

D

E

I

V

A

A

R

P

G

G

S

E

S

K

V

L

A

V

I

I

L

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

M

I

A

R

I

T

L

I

S

N

G

R

L

L

E

E

R

D

A

F

S

Q

G

E

G

G

E

E

V

V

S

V

V

V

A

D

G

G

I

L

A

-

Y

-

G

-

T

S

L

V

D

K

E

D

D

D

G

R

L

A

A

L

R

R

A

E

R

I

R

R

G

R

R

E

V

V

G

G

I

M

V

V

L

F

Q

Q

A

Q

F

F

H

N

L

L

L

F

P

P

T

H

M

M

T

T

A

V

H

L

E

E

N

N

V

V

A

T

V

L

-

A

P

P

L

M

E

R

L

V

A

R

G

R

A

W

P

P

-

R

-

E

D

K

A

A

F

E

A

K

R

K

A

A

G

L

A

E

E

L

L

L

D

E

A

R

V

V

G

G

L

I

G

L

H

D

R

Q

L

A

T

R

H

K

Y

Y

P

P

V

A

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

A

A

G

M

R

E

P

P

E

K

I

I

L

M

F

L

A

F

D

D

E

E

P

P

T

T

G

S

N

A

L

L

D

D

G

P

A

E

T

M

S

V

G

G

A

E

I

V

V

L

D

D

L

V

L

M

F

R

D

D

R

L

Q

A

R

Q

A

G

A

G

D

-

A

M

T

T

L

M

L

V

I

V

I

V

T

T

H

H

D

E

P

M

A

G

L

F

A

A

-

R

E

E

R

V

C

A

D

D

R

R

V

V

L

V

T

F

M

M

R

D

D

G

G

G

L

Q

I

I

V

V

A

E

D

E

binding adenosine-5'-diphosphate: F12 (≠ L20), V17 (≠ I29), S37 (= S49), G38 (= G50), S39 (= S51), G40 (= G52), K41 (= K53), S42 (= S54), T43 (≠ S55)

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
42% identity, 92% coverage: 11:224/232 of query aligns to 2:213/218 of 8hd0A

query
sites
8hd0A

I

I

R

R

A

F

R

E

N

H

V

V

T

S

L

K

-

A

T
x
Y

L

L

G

G

T

G

R
|
R

E

Q

A
|
A

P

-

T

-

E

-

I

-

L

L

K

Q

G

G

I

V

D

T

V

F

D

H

I

M

A

Q

R

P

G

G

S

E

S

M

V

A

A

F

I

L

L

T

G

G

P

H

S

S

G

G

S

A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

M

L

A

K

I

L

L

I

S

C

G

G

L

I

E

E

R

R

A

P

S

S

G

A

G

G

E

K

V

I

S

W

V

F

A

S

G

G

I

H

A

D

Y

I

G

T

T

R

L

L

D

K

E

N

D

R

G

E

L

V

A

P

R

F

A

L

R

R

R

R

G

-

R

Q

V

I

G

G

I

M

V

I

L

F

Q

Q

A

D

F

H

H

H

L

L

L

L

P

M

T

D

M

R

T

T

A

V

H

Y

E

D

N

N

V

V

A

A

V

I

P

P

L

L

E

I

L

I

A

A

G

G

A

A

P

S

-

G

-

D

D

D

A

I

F

R

A

R

R

R

A

V

G

S

A

A

E

A

L

L

D

D

A

K

V

V

G

G

L

L

G

L

H

D

R

K

L

A

T

K

H

N

Y

F

P

P

V

I

Q

Q

L

L

S
|
S

G

G

G
|
G

E

E

Q

Q

Q

Q

R

R

V

V

A

G

I

I

A

A

R

R

A

A

V

V

A

V

G

N

R

K

P

P

E

A

I

V

L

L

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

N

L

L

D

D

G

D

A

A

T

L

S

S

G

E

A

G

I

I

V

L

D

R

L

L

L

F

F

E

D

E

R

F

Q

N

R

R

A

V

A

G

D

-

A

V

T

T

L

V

L

L

I

M

I

A

T

T

H

H

D

D

P

I

A

N

L

L

-

I

A

S

E

R

R

R

C

S

D

Y

R

R

V

M

L

L

T

T

M

L

R

S

D

D

G

G

binding adenosine-5'-triphosphate: Y11 (≠ T19), R15 (= R23), A17 (= A25), G40 (= G52), K41 (= K53), S42 (= S54), T43 (≠ S55), S139 (= S150), G141 (= G152)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
39% identity, 96% coverage: 11:232/232 of query aligns to 3:227/344 of 3tuzC

query
sites
3tuzC

I

I

R

K

A

L

R

S

N

N

V

I

T

T

L

K

T

V

L
x
F

G

H

T
x
Q

R

G

E

T

A

R

P

T

T

I

E

Q

I

A

L

L

K

N

G

N

I

V

D

S

V

L

D

H

I

V

A

P

R

A

G

G

S

Q

S

I

V

Y

A

G

I

V

L

I

G

G

P

A

S

S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

M

I

A

R

I

C

L

V

S

N

G

L

L

L

E

E

R

R

A

P

S

T

G

E

G

G

E

S

V

V

S

L

V

V

A

D

G

G

I

Q

A

E

Y

L

G

T

T

T

L

L

D

S

E

E

D

S

G

E

L

L

A

T

R

K

A

A

R

R

R

R

G

-

R

Q

V

I

G

G

I

M

V

I

L

F

Q

Q

A

H

F

F

H

N

L

L

L

L

P

S

T

S

M

R

T

T

A

V

H

F

E

G

N

N

V

V

A

A

V

L

P

P

L

L

E

E

L

L

A

D

G

N

A

T

P

P

-

K

D

D

A

E

F

V

A

K

R

R

A

R

G

V

A

T

E

E

L

L

-

L

D

S

A

L

V

V

G

G

L

L

G

G

H

D

R

K

L

H

T

D

H

S

Y

Y

P

P

V

S

Q

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

A

A

G

S

R

N

P

P

E

K

I

V

L

L

F

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

G

P

A

A

T

T

S

T

G

R

A

S

I

I

V

L

D

E

L

L

L

L

F

K

D

D

R

I

Q

N

R

R

A

R

A

L

D

G

A

L

T

T

L

I

L

L

I

L

I

I

T

T

H

H

D

E

P

M

A

D

L

V

A

V

E

K

R

R

-

I

C

C

D

D

R

C

V

V

L

A

T

V

M

I

R

S

D

N

G

G

-

E

L

L

I

I

V

E

A

Q

D

D

S

T

A

V

A

S

binding adenosine-5'-diphosphate: F12 (≠ L20), Q14 (≠ T22), G42 (= G50), G44 (= G52), K45 (= K53), S46 (= S54), T47 (≠ S55)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
39% identity, 96% coverage: 11:232/232 of query aligns to 3:227/344 of 3tuiC

query
sites
3tuiC

I

I

R

K

A

L

R

S

N

N

V

I

T

T

L

K

T

V

L
x
F

G

H

T

Q

R

G

E

T

A

R

P

T

T

I

E

Q

I

A

L

L

K

N

G

N

I

V

D

S

V

L

D

H

I

V

A

P

R

A

G

G

S

Q

S

I

V

Y

A

G

I

V

L

I

G

G

P

A

S

S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

M

I

A

R

I

C

L

V

S

N

G

L

L

L

E

E

R

R

A

P

S

T

G

E

G

G

E

S

V

V

S

L

V

V

A

D

G

G

I

Q

A

E

Y

L

G

T

T

T

L

L

D

S

E

E

D

S

G

E

L

L

A

T

R

K

A

A

R

R

R

R

G

-

R

Q

V

I

G

G

I

M

V

I

L

F

Q

Q

A

H

F

F

H

N

L

L

L

L

P

S

T

S

M

R

T

T

A

V

H

F

E

G

N

N

V

V

A

A

V

L

P

P

L

L

E

E

L

L

A

D

G

N

A

T

P

P

-

K

D

D

A

E

F

V

A

K

R

R

A

R

G

V

A

T

E

E

L

L

-

L

D

S

A

L

V

V

G

G

L

L

G

G

H

D

R

K

L

H

T

D

H

S

Y

Y

P

P

V

S

Q

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

A

A

G

S

R

N

P

P

E

K

I

V

L

L

F

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

G

P

A

A

T

T

S

T

G

R

A

S

I

I

V

L

D

E

L

L

L

L

F

K

D

D

R

I

Q

N

R

R

A

R

A

L

D

G

A

L

T

T

L

I

L

L

I

L

I

I

T

T

H

H

D

E

P

M

A

D

L

V

A

V

E

K

R

R

-

I

C

C

D

D

R

C

V

V

L

A

T

V

M

I

R

S

D

N

G

G

-

E

L

L

I

I

V

E

A

Q

D

D

S

T

A

V

A

S

binding adenosine-5'-diphosphate: F12 (≠ L20), G42 (= G50), A43 (≠ S51), G44 (= G52), K45 (= K53), S46 (= S54), T47 (≠ S55)

Query Sequence

>Ga0059261_0562 FitnessBrowser__Korea:Ga0059261_0562
MSIDPAADIAIRARNVTLTLGTREAPTEILKGIDVDIARGSSVAILGPSGSGKSSLMAIL
SGLERASGGEVSVAGIAYGTLDEDGLARARRGRVGIVLQAFHLLPTMTAHENVAVPLELA
GAPDAFARAGAELDAVGLGHRLTHYPVQLSGGEQQRVAIARAVAGRPEILFADEPTGNLD
GATSGAIVDLLFDRQRAADATLLIITHDPALAERCDRVLTMRDGLIVADSAA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory