SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ga0059261_1321 Ga0059261_1321 ABC-type antimicrobial peptide transport system, ATPase component to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
50% identity, 94% coverage: 7:230/238 of query aligns to 3:225/226 of 5xu1B

query
sites
5xu1B

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binding magnesium ion: G45 (= G49), K46 (= K50), S47 (= S51)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
49% identity, 95% coverage: 7:233/238 of query aligns to 1:231/232 of 1f3oA

query
sites
1f3oA

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binding adenosine-5'-diphosphate: Y11 (≠ F17), G41 (= G47), G43 (= G49), K44 (= K50), S45 (= S51), T46 (= T52)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
48% identity, 94% coverage: 7:229/238 of query aligns to 1:227/230 of 1l2tA

query
sites
1l2tA

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binding adenosine-5'-triphosphate: Y11 (≠ F17), S40 (= S46), G41 (= G47), S42 (= S48), G43 (= G49), K44 (= K50), S45 (= S51), T46 (= T52), F138 (≠ W140), Q145 (≠ E147), S147 (= S149), G149 (= G151), Q150 (= Q152), H204 (= H206)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
46% identity, 93% coverage: 6:227/238 of query aligns to 3:223/648 of P75831

query
sites
P75831

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K47 (= K50) mutation to L: Lack of activity.
D169 (= D172) mutation to N: Lack of activity.

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
47% identity, 91% coverage: 7:223/238 of query aligns to 3:218/615 of 5lilA

query
sites
5lilA

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G

binding adenosine-5'-triphosphate: F13 (= F17), V22 (≠ A26), S42 (= S46), G43 (= G47), G45 (= G49), K46 (= K50), S47 (= S51), T48 (= T52), Q92 (= Q96), K136 (≠ W140), Q143 (≠ E147), S145 (= S149), G147 (= G151), Q148 (= Q152)
binding magnesium ion: S47 (= S51), Q92 (= Q96)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
47% identity, 91% coverage: 7:223/238 of query aligns to 3:218/592 of 5lj7A

query
sites
5lj7A

I

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Q
|
Q

G

R

F

Y

N

N

L

L

S

S

R

S

T

L

N

T

A

A

L

A

E

E

N

N

V

V

E

A

L

L

P

P

L

A

L

I

Y

Y

R

A

G

G

E

M

D

P

K

Q

K

S

V

Q

R

R

H

L

E

E

L

R

G

A

M

K

A

Q

A

L

L

L

E

E

K

K

V

L

G

G

L

L

A

G

D

D

W
x
K

W

W

D

Q

H

N

T

K

P

P

A

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

P

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

I

L

V

M

T

N

S

G

P

G

A

E

V

I

L

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

S

S

A

H

R

S

S

G

V

E

E

N

I

V

M

M

E

E

L

I

L

L

T

R

S

Q

L

L

N

H

K

E

D

E

S

-

G

G

I

H

T

T

V

I

L

I

M

M

V

V

T

T

H

H

E

D

P

K

D

H

M

I

A

A

F

S

A

A

R

N

T

R

I

I

V

I

H

E

F

I

K

K

D

D

G

G

binding adenosine-5'-triphosphate: V22 (≠ A26), S42 (= S46), G43 (= G47), G45 (= G49), K46 (= K50), S47 (= S51), T48 (= T52), Q92 (= Q96), K136 (≠ W140), Q143 (≠ E147), S145 (= S149), G147 (= G151), Q148 (= Q152)
binding magnesium ion: S47 (= S51), Q92 (= Q96)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
46% identity, 91% coverage: 7:223/238 of query aligns to 4:219/650 of 5ws4A

query
sites
5ws4A

I

L

R

E

L

V

R

S

N

N

I

L

T

V

K

R

V

E

F

F

G

P

E

A

G

G

A

E

T

S

A

T

F

I

Q

Q

A

I

L

L

K

K

G

G

V

I

D

D

L

L

D

T

I

I

A

Y

E

E

R

G

D

E

F

L

V

V

A

A

V

I

M

V

G

G

P

Q

S
|
S

G
|
G

S

S

G

G

K

K

S
|
S

T

T

T

L

M

M

N

N

I

I

L

L

G

G

C

C

L

L

D

D

V

R

P

P

T

T

S

S

G

G

E

S

F

Y

L

K

F

V

K

N

G

G

V

Q

Y

E

I

T

E

G

T

K

L

L

D

E

R

P

D

D

Q

Q

R

L

A

A

L

Q

V

L

R

R

K

E

Y

Y

L

F

G

G

F

F

V

I

F

F

Q

Q

G

R

F

Y

N

H

L

L

S

G

R

D

T

L

N

S

A

A

L

E

E

G

N

N

V

V

E

E

L

V

P

P

L

A

L

V

Y

Y

R

A

G

G

E

V

D

T

K

P

K

A

V

D

R

R

H

K

E

Q

L

R

G

A

M

T

A

A

A

L

L

L

E

T

K

E

V

L

G

G

L

L

A

G

D

T

W

K

W

T

D

Q

H

N

T

R

P

P

A

S

E

Q

L

L

S

S

G

G

Q

Q

P

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

I

L

V

M

T

N

S

G

P

G

A

D

V

V

L

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

S

S

A

H

R

S

S

G

V

V

E

E

I

V

M

M

E

R

L

I

L

L

T

R

S

E

L

L

N

N

K

A

D

-

S

A

G

G

I

H

T

T

V

I

L

I

M

L

V

V

T

T

H

H

E

D

P

M

D

Q

M

V

A

A

A

K

F

N

A

A

R

T

T

R

I

I

V

I

H

E

F

I

K

S

D

D

G

G

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S46), G44 (= G47), S48 (= S51)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
43% identity, 92% coverage: 7:225/238 of query aligns to 3:216/223 of 2pclA

query
sites
2pclA

I

I

I

L

R

R

L

A

R

E

N

N

I

I

T

K

K

K

V

V

F

I

G

-

E

-

G

-

A

-

T

R

A

G

F

Y

Q

E

A

I

L

L

K

K

G

G

V

I

D

S

L

L

D

S

I

V

A

K

E

K

R

G

D

E

F

F

V

V

A

S

V

I

M

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

S

S

T

T

T

L

M

L

N

Y

I

I

L

L

G

G

C

L

L

L

D

D

V

A

P

P

T

T

S

E

G

G

E

K

F

V

L

F

F

L

K

E

G

G

V

K

Y

E

I

V

E

D

T

Y

L

T

D

N

R

E

D

K

Q

E

R

L

A

S

L

L

V

L

R

R

R

N

K

R

Y

K

L

L

G

G

F

F

V

V

F

F

Q

Q

G

F

F

H

N

Y

L

L

L

I

S

P

R

E

T

L

N

T

A

A

L

L

E

E

N

N

V

V

E

I

L

V

P

P

L

M

L

L

Y

K

R

M

G

G

E

K

D

P

K

K

V

E

R

A

H

K

E

E

L

R

G

G

M

E

A

Y

A

L

L

L

E

S

K

E

V

L

G

G

L

L

A

G

D

D

W

K

W

L

D

S

H

R

T

K

P

P

A

Y

E

E

L

L

S

S

G

G

Q

E

P

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

T

N

S

E

P

P

A

I

V

L

L

L

L

F

A

A

D

D

E
|
E

P
|
P

T
|
T

G

G

N

N

L

L

D

D

S

S

A

A

R

N

S

T

V

K

E

R

I

V

M

M

E

D

L

I

L

F

T

L

S

K

L

I

N

N

K

-

D

E

S

G

G

G

I

T

T

S

V

I

L

V

M

M

V

V

T
|
T

H

H

E

E

P

R

D

E

M

L

A

A

A

E

F

L

A

T

R

H

T

R

I

T

V

L

H

E

F

M

K

K

D

D

G

G

L

K

V

V

binding magnesium ion: E165 (= E173), P166 (= P174), T167 (= T175), T196 (= T205)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
40% identity, 91% coverage: 7:223/238 of query aligns to 5:221/233 of P75957

query
sites
P75957

I

L

R

Q

L

C

R

D

N

N

I

L

T

C

K

K

V

R

F

Y

G

Q

E

E

G

G

A

S

T

V

A

Q

F

T

Q

D

A

V

L

L

K

H

G

N

V

V

D

S

L

F

D

S

I

V

A

G

E

E

R

G

D

E

F

M

V

M

A

A

V

I

M

V

G
|
G

P

S

S

S

G

G

S

S

G

G

K

K

S

S

T

T

T

L

M

L

N

H

I

L

L

L

G

G

C

G

L

L

D

D

V

T

P

P

T

T

S

S

G

G

E

D

F

V

L

I

F

F

K

N

G

G

V

Q

Y

P

I

M

E

S

T

K

L

L

D

S

R

S

D

A

Q

A

R

K

A

A

L

E

V

L

R

R

R

N

K

Q

Y

K

L

L

G

G

F

F

V

I

F

Y

Q

Q

G

F

F

H

N

H

L

L

S

P

R

D

T

F

N

T

A

A

L

L

E

E

N

N

V

V

E

A

L

M

P

P

L

L

Y

I

R

G

G

K

E

K

D

K

K

P

K

A

V

E

R

I

H

N

E

S

L

R

G

A

M

L

A

E

A

M

L

L

E

K

K

A

V

V

G

G

L

L

A

D

D

H

W

R

W

A

D

N

H

H

T

R

P

P

A

S

E

E

L

L

S

S

G

G

Q

E

P

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

V

T

N

S

N

P

P

A

R

V

L

L

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

A

A

R

R

N

S

A

V

D

E

S

I

I

M

F

E

Q

L

L

T

G

S

E

L

L

N

N

K

R

D

L

S

Q

G

G

I

T

T

A

V

F

L

L

M

V

V

V

T

T

H

H

E

D

P

L

D

Q

M

L

A

A

A

K

F

R

A

M

R

S

T

R

I

Q

V

L

H

E

F

M

K

R

D

D

G

G

G42 (= G44) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
40% identity, 91% coverage: 7:223/238 of query aligns to 2:218/226 of 7mdyC

query
sites
7mdyC

I

L

R

Q

L

C

R

D

N

N

I

L

T

C

K

K

V

R

F
x
Y

G

Q

E

E

G

G

A

S

T

V

A

Q

F

T

Q

D

A

V

L

L

K

H

G

N

V

V

D

S

L

F

D

S

I

V

A

G

E

E

R

G

D

E

F

M

V

M

A

A

V

I

M

V

G

G

P

S

S

S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

M

L

N

H

I

L

L

L

G

G

C

G

L

L

D

D

V

T

P

P

T

T

S

S

G

G

E

D

F

V

L

I

F

F

K

N

G

G

V

Q

Y

P

I

M

E

S

T

K

L

L

D

S

R

S

D

A

Q

A

R

K

A

A

L

E

V

L

R

R

R

N

K

Q

Y

K

L

L

G

G

F

F

V

I

F

Y

Q
|
Q

G

F

F

H

N

H

L

L

S

P

R

D

T

F

N

T

A

A

L

L

E

E

N

N

V

V

E

A

L

M

P

P

L

L

Y

I

R

G

G

K

E

K

D

K

K

P

K

A

V

E

R

I

H

N

E

S

L

R

G

A

M

L

A

E

A

M

L

L

E

K

K

A

V

V

G

G

L

L

A

D

D

H

W

R

W

A

D

N

H
|
H

T

R

P

P

A

S

E
|
E

L

L

S
|
S

G
|
G

Q

E

P

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

V

T

N

S

N

P

P

A

R

V

L

L

V

L

L

A

A

D

D

E
|
E

P

P

T

T

G

G

N
|
N

L

L

D

D

S

A

A

R

R

N

S

A

V

D

E

S

I

I

M

F

E

Q

L

L

T

G

S

E

L

L

N

N

K

R

D

L

S

Q

G

G

I

T

T

A

V

F

L

L

M

V

V

V

T

T

H
|
H

E

D

P

L

D

Q

M

L

A

A

A

K

F

R

A

M

R

S

T

R

I

Q

V

L

H

E

F

M

K

R

D

D

G

G

binding adp orthovanadate: Y12 (≠ F17), G42 (= G47), S43 (= S48), G44 (= G49), K45 (= K50), S46 (= S51), T47 (= T52), Q91 (= Q96), H138 (= H143), E142 (= E147), S144 (= S149), G145 (= G150), G146 (= G151), E168 (= E173), N172 (= N177), H201 (= H206)
binding magnesium ion: S46 (= S51), Q91 (= Q96)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
40% identity, 91% coverage: 7:223/238 of query aligns to 2:218/222 of 7arlD

query
sites
7arlD

I

L

R

Q

L

C

R

D

N

N

I

L

T

C

K

K

V

R

F

Y

G

Q

E

E

G

G

A

S

T

V

A

Q

F

T

Q

D

A

V

L

L

K

H

G

N

V

V

D

S

L

F

D

S

I

V

A

G

E

E

R

G

D

E

F

M

V

M

A

A

V

I

M

V

G

G

P

S

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T

T

T

L

M

L

N

H

I

L

L

L

G

G

C

G

L

L

D

D

V

T

P

P

T

T

S

S

G

G

E

D

F

V

L

I

F

F

K

N

G

G

V

Q

Y

P

I

M

E

S

T

K

L

L

D

S

R

S

D

A

Q

A

R

K

A

A

L

E

V

L

R

R

R

N

K

Q

Y

K

L

L

G

G

F

F

V

I

F

Y

Q

Q

G

F

F

H

N

H

L

L

S

P

R

D

T

F

N

T

A

A

L

L

E

E

N

N

V

V

E

A

L

M

P

P

L

L

Y

I

R

G

G

K

E

K

D

K

K

P

K

A

V

E

R

I

H

N

E

S

L

R

G

A

M

L

A

E

A

M

L

L

E

K

K

A

V

V

G

G

L

L

A

D

D

H

W

R

W

A

D

N

H

H

T

R

P

P

A

S

E

E

L

L

S

S

G

G

Q

E

P

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

V

T

N

S

N

P

P

A

R

V

L

L

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

A

A

R

R

N

S

A

V

D

E

S

I

I

M

F

E

Q

L

L

T

G

S

E

L

L

N

N

K

R

D

L

S

Q

G

G

I

T

T

A

V

F

L

L

M

V

V

V

T

T

H

H

E

D

P

L

D

Q

M

L

A

A

A

K

F

R

A

M

R

S

T

R

I

Q

V

L

H

E

F

M

K

R

D

D

G

G

binding adenosine-5'-diphosphate: G42 (= G47), G44 (= G49), K45 (= K50), S46 (= S51)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
40% identity, 91% coverage: 7:223/238 of query aligns to 4:220/229 of 7v8iD

query
sites
7v8iD

I

L

R

Q

L

C

R

D

N

N

I

L

T

C

K

K

V

R

F

Y

G

Q

E

E

G

G

A

S

T

V

A

Q

F

T

Q

D

A
x
V

L

L

K

H

G

N

V

V

D

S

L

F

D

S

I

V

A

G

E

E

R

G

D

E

F

M

V

M

A

A

V

I

M

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

M

L

N

H

I

L

L

L

G

G

C

G

L

L

D

D

V

T

P

P

T

T

S

S

G

G

E

D

F

V

L

I

F

F

K

N

G

G

V

Q

Y

P

I

M

E

S

T

K

L

L

D

S

R

S

D

A

Q

A

R

K

A

A

L

E

V

L

R

R

R

N

K

Q

Y

K

L

L

G

G

F

F

V

I

F

Y

Q
|
Q

G

F

F

H

N

H

L

L

S

P

R

D

T

F

N

T

A

A

L

L

E

E

N

N

V

V

E

A

L

M

P

P

L

L

Y

I

R

G

G

K

E

K

D

K

K

P

K

A

V

E

R

I

H

N

E

S

L

R

G

A

M

L

A

E

A

M

L

L

E

K

K

A

V

V

G

G

L

L

A

D

D

H

W
x
R

W

A

D

N

H
|
H

T

R

P

P

A

S

E
|
E

L

L

S
|
S

G

G

G
|
G

Q
x
E

P

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

V

T

N

S

N

P

P

A

R

V

L

L

V

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

N

L

L

D

D

S

A

A

R

R

N

S

A

V

D

E

S

I

I

M

F

E

Q

L

L

T

G

S

E

L

L

N

N

K

R

D

L

S

Q

G

G

I

T

T

A

V

F

L

L

M

V

V

V

T

T

H
|
H

E

D

P

L

D

Q

M

L

A

A

A

K

F

R

A

M

R

S

T

R

I

Q

V

L

H

E

F

M

K

R

D

D

G

G

binding phosphoaminophosphonic acid-adenylate ester: V23 (≠ A26), S43 (= S46), G44 (= G47), G46 (= G49), K47 (= K50), S48 (= S51), T49 (= T52), Q93 (= Q96), R137 (≠ W140), H140 (= H143), E144 (= E147), S146 (= S149), G148 (= G151), E149 (≠ Q152), H203 (= H206)
binding magnesium ion: S48 (= S51), Q93 (= Q96)

8g4cB Bceabs atpgs high res tm (see paper)
35% identity, 91% coverage: 7:223/238 of query aligns to 3:219/248 of 8g4cB

query
sites
8g4cB

I

I

I

L

R

E

L

A

R

N

N

K

I

I

T

R

K

K

V

S

F
x
Y

G

G

E

N

G

K

A

L

T

N

A

K

F

Q

Q

E

A

V

L

L

K

K

G

G

V

I

D

D

L

I

D

H

I

I

A

E

E

K

R

G

D

E

F

F

V

V

A

S

V

I

M

M

G

G

P

A

S
|
S

G

G

S
|
S

G

G

K

K

S
x
T

T

T

T

L

M

L

N

N

I

V

L

L

G

S

C

S

L

I

D

D

V

Q

P

V

T

S

S

H

G

G

E

T

F

I

L

H

F

I

K

N

G

G

V

N

Y

D

I

M

E

T

T

A

L

M

D

K

R

E

D

K

Q

Q

R

L

A

A

L

E

V

F

R

R

R

K

K

Q

Y

H

L

L

G

G

F

F

V

I

F

F

Q

Q

G

D

F

Y

N

N

L

L

S

D

R

T

T

L

N

T

A

V

L

K

E

E

N

N

V

I

E

L

L

L

P

P

L

L

L

S

Y

I

R

T

G

K

E

L

D

S

K

K

V

E

R

A

H

N

E

R

L

K

G

F

M

E

A

E

A

V

L

A

E

K

K

E

V

L

G

G

L

I

A

Y

D

E

W

L

W

R

D

D

H

K

T

Y

P

P

A

N

E

E

L

I

S

S

G

G

Q

Q

P

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

I

F

V

I

T

H

S

D

P

P

A

S

V

I

L

I

L

F

A

A

D
|
D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

S

S

A

K

R

S

S

A

V

S

E

D

I

L

M

L

E

N

L

K

L

L

T

S

S

Q

L

L

N

N

K

Q

D

K

S

R

G

N

I

A

T

T

V

I

L

I

M

M

V

V

T

T

H

H

E

D

P

P

D

V

M

A

A

A

A

S

F

Y

A

C

R

G

T

R

I

V

V

I

H

F

F

I

K

K

D

D

G

G

binding phosphothiophosphoric acid-adenylate ester: Y13 (≠ F17), S42 (= S46), S44 (= S48), T47 (≠ S51), D168 (= D172)

7tchB Bceab e169q variant atp-bound conformation (see paper)
35% identity, 91% coverage: 7:223/238 of query aligns to 2:218/245 of 7tchB

query
sites
7tchB

I

I

I

L

R

E

L

A

R

N

N

K

I

I

T

R

K

K

V

S

F
x
Y

G

G

E

N

G

K

A

L

T

N

A

K

F
x
Q

Q

E

A
x
V

L

L

K

K

G

G

V

I

D

D

L

I

D

H

I

I

A

E

E

K

R

G

D

E

F

F

V

V

A

S

V

I

M

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

S
x
T

T

T

T

L

M

L

N

N

I

V

L

L

G

S

C

S

L

I

D

D

V

Q

P

V

T

S

S

H

G

G

E

T

F

I

L

H

F

I

K

N

G

G

V

N

Y

D

I

M

E

T

T

A

L

M

D

K

R

E

D

K

Q

Q

R

L

A

A

L

E

V

F

R

R

R

K

K

Q

Y

H

L

L

G

G

F

F

V

I

F

F

Q

Q

G

D

F

Y

N

N

L

L

S

D

R

T

T

L

N

T

A

V

L

K

E

E

N

N

V

I

E

L

L

L

P

P

L

L

L

S

Y

I

R

T

G

K

E

L

D

S

K

K

V

E

R

A

H

N

E

R

L

K

G

F

M

E

A

E

A

V

L

A

E

K

K

E

V

L

G

G

L

I

A

Y

D

E

W

L

W

R

D

D

H

K

T

Y

P

P

A

N

E
|
E

L

I

S

S

G
|
G

Q

Q

P

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

I

F

V

I

T

H

S

D

P

P

A

S

V

I

L

I

L

F

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

S

S

A

K

R

S

S

A

V

S

E

D

I

L

M

L

E

N

L

K

L

L

T

S

S

Q

L

L

N

N

K

Q

D

K

S

R

G

N

I

A

T

T

V

I

L

I

M

M

V

V

T

T

H

H

E

D

P

P

D

V

M

A

A

A

A

S

F

Y

A

C

R

G

T

R

I

V

V

I

H

F

F

I

K

K

D

D

G

G

binding adenosine-5'-triphosphate: Y12 (≠ F17), Q19 (≠ F24), V21 (≠ A26), S41 (= S46), G42 (= G47), S43 (= S48), K45 (= K50), T46 (≠ S51), E142 (= E147), G145 (= G150), G146 (= G151)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
43% identity, 86% coverage: 7:210/238 of query aligns to 1:203/343 of P30750

query
sites
P30750

I

M

I

I

R

K

L

L

R

S

N

N

I

I

T

T

K

K

V

V

F

F

G

H

E

Q

G

G

A

T

T

R

A

T

F

I

Q

Q

A

A

L

L

K

N

G

N

V

V

D

S

L

L

D

H

I

V

A

P

E

A

R

G

D

Q

F

I

V

Y

A

G

V

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

T

L

M

I

N

R

I

C

L

V

G

N

C

L

L

L

D

E

V

R

P

P

T

T

S

E

G

G

E

S

F

V

L

L

F

V

K

D

G

G

V

Q

Y

E

I

L

E

T

T

T

L

L

D

S

R

E

D

S

Q

E

R

L

A

T

L

K

V

A

R

R

K

Q

Y

-

L

I

G

G

F

M

V

I

F

F

Q

Q

G

H

F

F

N

N

L

L

S

S

R

S

T

R

N

T

A

V

L

F

E

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

Y

L

R

D

G

N

E

T

D

P

K

K

K

D

V

E

R

V

H

K

E

R

L

R

G

V

M

T

A

E

A

L

L

L

E

S

K

L

V

V

G

G

L

L

A

G

D

D

W

K

W

H

D

D

H

S

T

Y

P

P

A

S

E

N

L

L

S

S

G

G

Q

Q

P

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

T

S

S

N

P

P

A

K

V

V

L

L

A

C

D

D

E
|
E

P

A

T

T

G

S

N

A

L

L

D

D

S

P

A

A

R

T

S

T

V

R

E

S

I

I

M

L

E

E

L

L

T

K

S

D

L

I

N

N

K

R

D

R

S

L

G

G

I

L

T

T

V

I

L

L

M

L

V

I

T

T

H

H

E

E

P

M

D

D

M

V

40:46 (vs. 46:52, 86% identical) binding
E166 (= E173) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
43% identity, 86% coverage: 7:210/238 of query aligns to 2:204/344 of 6cvlD

query
sites
6cvlD

I

M

I

I

R

K

L

L

R

S

N

N

I

I

T

T

K

K

V

V

F
|
F

G

H

E
x
Q

G

G

A

T

T

R

A

T

F
x
I

Q

Q

A

A

L

L

K

N

G

N

V

V

D

S

L

L

D

H

I

V

A

P

E

A

R

G

D

Q

F

I

V

Y

A

G

V

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

T

L

M

I

N

R

I

C

L

V

G

N

C

L

L

L

D

E

V

R

P

P

T

T

S

E

G

G

E

S

F

V

L

L

F

V

K

D

G

G

V

Q

Y

E

I

L

E

T

T

T

L

L

D

S

R

E

D

S

Q

E

R

L

A

T

L

K

V

A

R

R

K

Q

Y

-

L

I

G

G

F

M

V

I

F

F

Q

Q

G

H

F

F

N

N

L

L

S

S

R

S

T

R

N

T

A

V

L

F

E

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

Y

L

R

D

G

N

E

T

D

P

K

K

K

D

V

E

R

V

H

K

E

R

L

R

G

V

M

T

A

E

A

L

L

L

E

S

K

L

V

V

G

G

L

L

A

G

D

D

W

K

W

H

D

D

H

S

T

Y

P

P

A

S

E
x
N

L

L

S
|
S

G

G

Q
|
Q

P

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

T

S

S

N

P

P

A

K

V

V

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

S

P

A

A

R

T

S

T

V

R

E

S

I

I

M

L

E

E

L

L

T

K

S

D

L

I

N

N

K

R

D

R

S

L

G

G

I

L

T

T

V

I

L

L

M

L

V

I

T

T

H
|
H

E

E

P

M

D

D

M

V

binding phosphothiophosphoric acid-adenylate ester: F12 (= F17), Q14 (≠ E19), I19 (≠ F24), S41 (= S46), G42 (= G47), A43 (≠ S48), G44 (= G49), K45 (= K50), S46 (= S51), T47 (= T52), N141 (≠ E147), S143 (= S149), Q146 (= Q152), H200 (= H206)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
43% identity, 86% coverage: 7:210/238 of query aligns to 2:204/344 of 3tuzC

query
sites
3tuzC

I

M

I

I

R

K

L

L

R

S

N

N

I

I

T

T

K

K

V

V

F
|
F

G

H

E
x
Q

G

G

A

T

T

R

A

T

F

I

Q

Q

A

A

L

L

K

N

G

N

V

V

D

S

L

L

D

H

I

V

A

P

E

A

R

G

D

Q

F

I

V

Y

A

G

V

V

M

I

G

G

P

A

S

S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

T
|
T

T

L

M

I

N

R

I

C

L

V

G

N

C

L

L

L

D

E

V

R

P

P

T

T

S

E

G

G

E

S

F

V

L

L

F

V

K

D

G

G

V

Q

Y

E

I

L

E

T

T

T

L

L

D

S

R

E

D

S

Q

E

R

L

A

T

L

K

V

A

R

R

K

Q

Y

-

L

I

G

G

F

M

V

I

F

F

Q

Q

G

H

F

F

N

N

L

L

S

S

R

S

T

R

N

T

A

V

L

F

E

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

Y

L

R

D

G

N

E

T

D

P

K

K

K

D

V

E

R

V

H

K

E

R

L

R

G

V

M

T

A

E

A

L

L

L

E

S

K

L

V

V

G

G

L

L

A

G

D

D

W

K

W

H

D

D

H

S

T

Y

P

P

A

S

E

N

L

L

S

S

G

G

Q

Q

P

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

T

S

S

N

P

P

A

K

V

V

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

S

P

A

A

R

T

S

T

V

R

E

S

I

I

M

L

E

E

L

L

T

K

S

D

L

I

N

N

K

R

D

R

S

L

G

G

I

L

T

T

V

I

L

L

M

L

V

I

T

T

H

H

E

E

P

M

D

D

M

V

binding adenosine-5'-diphosphate: F12 (= F17), Q14 (≠ E19), G42 (= G47), G44 (= G49), K45 (= K50), S46 (= S51), T47 (= T52)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
43% identity, 86% coverage: 7:210/238 of query aligns to 2:204/344 of 3tuiC

query
sites
3tuiC

I

M

I

I

R

K

L

L

R

S

N

N

I

I

T

T

K

K

V

V

F
|
F

G

H

E

Q

G

G

A

T

T

R

A

T

F

I

Q

Q

A

A

L

L

K

N

G

N

V

V

D

S

L

L

D

H

I

V

A

P

E

A

R

G

D

Q

F

I

V

Y

A

G

V

V

M

I

G

G

P

A

S

S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

T

L

M

I

N

R

I

C

L

V

G

N

C

L

L

L

D

E

V

R

P

P

T

T

S

E

G

G

E

S

F

V

L

L

F

V

K

D

G

G

V

Q

Y

E

I

L

E

T

T

T

L

L

D

S

R

E

D

S

Q

E

R

L

A

T

L

K

V

A

R

R

K

Q

Y

-

L

I

G

G

F

M

V

I

F

F

Q

Q

G

H

F

F

N

N

L

L

S

S

R

S

T

R

N

T

A

V

L

F

E

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

Y

L

R

D

G

N

E

T

D

P

K

K

K

D

V

E

R

V

H

K

E

R

L

R

G

V

M

T

A

E

A

L

L

L

E

S

K

L

V

V

G

G

L

L

A

G

D

D

W

K

W

H

D

D

H

S

T

Y

P

P

A

S

E

N

L

L

S

S

G

G

Q

Q

P

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

T

S

S

N

P

P

A

K

V

V

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

S

P

A

A

R

T

S

T

V

R

E

S

I

I

M

L

E

E

L

L

T

K

S

D

L

I

N

N

K

R

D

R

S

L

G

G

I

L

T

T

V

I

L

L

M

L

V

I

T

T

H

H

E

E

P

M

D

D

M

V

binding adenosine-5'-diphosphate: F12 (= F17), G42 (= G47), A43 (≠ S48), G44 (= G49), K45 (= K50), S46 (= S51), T47 (= T52)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
38% identity, 92% coverage: 7:225/238 of query aligns to 1:214/240 of 4ymuJ

query
sites
4ymuJ

I

M

I

I

R

F

L

V

R

N

N

D

I

V

T

Y

K

K

V

N

F
|
F

G

G

E

-

G

-

A

-

T

-

A

S

F

L

Q

E

A
x
V

L

L

K

K

G

G

V

V

D

T

L

L

D

K

I

V

A

N

E

K

R

G

D

E

F

V

V

V

A

V

V

I

M

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

M

L

N

R

I

C

L

I

G

N

C

L

L

L

D

E

V

E

P

P

T

T

S

K

G

G

E

E

F

V

L

F

F

I

K

D

G

G

V

V

Y

K

I

I

E

N

T

N

L

G

D

K

R

V

D

N

Q

I

R

N

A

K

L

V

V

-

R

-

R

R

K

Q

Y

K

L

V

G

G

F

M

V

V

F

F

Q

Q

G

H

F

F

N

N

L

L

L

F

S

P

R

H

T

L

N

T

A

A

L

I

E

E

N

N

V

I

E

T

L

L

-

A

P

P

L

V

L

K

Y

V

R

K

G

K

E

M

D

N

K

K

V

E

R

A

H

E

E

E

L

L

G

A

M

V

A

D

A

L

L

L

E

A

K

K

V

V

G

G

L

L

A

L

D

D

W

K

D

D

H

Q

T

Y

P

P

A

I

E

K

L

L

S

S

G

G

Q

Q

P

K

Q

Q

R

R

V

L

A

A

I

I

A

A

R

R

A

A

I

L

V

A

T

M

S

Q

P

P

A

E

V

V

L

M

L

L

A

F

D

D

E
|
E

P

P

T

T

G

S

N

A

L

L

D

D

S

P

A

E

R

M

S

V

V

K

E

E

I

V

M

L

E

N

L

V

L

M

T

K

S

Q

L

L

N

-

K

A

D

N

S

E

G

G

I

M

T

T

V

M

L

V

M

V

V

V

T

T

H
|
H

E

E

P

-

D

-

M

-

A

M

A

G

F

F

A

A

R

R

T

E

-

V

-

G

-

D

-

R

I

V

V

I

H

F

F

M

K

D

D

D

G

G

L

V

V

I

binding adenosine-5'-triphosphate: F11 (= F17), V16 (≠ A26), S36 (= S46), G37 (= G47), S38 (= S48), G39 (= G49), K40 (= K50), S41 (= S51), T42 (= T52), E162 (= E173), H194 (= H206)
binding magnesium ion: S41 (= S51), E162 (= E173)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
40% identity, 92% coverage: 6:223/238 of query aligns to 1:211/241 of 4u00A

query
sites
4u00A

P

P

I

I

R

R

L

I

R

R

N

N

I

L

T

H

K

K

V

W

F
|
F

G

G

E

-

G

-

A

-

T

-

A

P

F

L

Q

H

A
x
V

L

L

K

K

G

G

V

I

D

H

L

L

D

E

I

V

A

A

E

P

R

G

D

E

F

K

V

L

A

V

V

I

M

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

M

I

N

R

I

T

L

I

G

N

C

R

L

L

D

E

V

D

P

F

T

Q

S

E

G

G

E

E

F

V

L

V

F

V

K

D

G

G

V

L

Y

S

I

V

E

-

T

-

L

-

D

-

R

K

D

D

Q

D

R

R

A

A

L

L

V

R

R

E

-

I

R

R

K

R

Y

E

L

V

G

G

F

M

V

V

F

F

Q

Q

G

Q

F

F

N

N

L

L

L

F

S

P

R

H

T

M

N

T

A

V

L

L

E

E

N

N

V

V

E

T

L

L

-

A

P

P

L

M

L

R

Y

V

R

R

G

R

E

W

D

P

K

R

K

E

V

K

R

A

H

E

E

K

L

K

G

A

M

L

A

E

A

L

L

L

E

E

K

R

V

V

G

G

L

I

A

L

D

D

W

Q

W

A

D

R

H

K

T

Y

P

P

A

A

E

Q

L

L

S

S

G

G

Q

Q

P

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

T

M

S

E

P

P

A

K

V

I

L

M

L

L

A

F

D

D

E

E

P

P

T

T

G

S

N

A

L

L

D

D

S

P

A

E

R

M

S

V

V

G

E

E

I

V

M

L

E

D

L

V

L

M

T

R

S

D

L

L

N

A

K

Q

D

-

S

G

G

G

I

M

T

T

V

M

L

V

M

V

V

V

T

T

H

H

E

E

P

-

D

-

M

-

A

M

A

G

F

F

A

A

R

R

T

E

I

V

-

A

-

D

-

R

V

V

H

V

F

F

K

M

D

D

G

G

binding adenosine-5'-diphosphate: F12 (= F17), V17 (≠ A26), S37 (= S46), G38 (= G47), S39 (= S48), G40 (= G49), K41 (= K50), S42 (= S51), T43 (= T52)

Query Sequence

>Ga0059261_1321 Ga0059261_1321 ABC-type antimicrobial peptide transport system, ATPase component
VADADPIIRLRNITKVFGEGATAFQALKGVDLDIAERDFVAVMGPSGSGKSTTMNILGCL
DVPTSGEFLFKGVYIETLDRDQRALVRRKYLGFVFQGFNLLSRTNALENVELPLLYRGED
KKVRHELGMAALEKVGLADWWDHTPAELSGGQPQRVAIARAIVTSPAVLLADEPTGNLDS
ARSVEIMELLTSLNKDSGITVLMVTHEPDMAAFARTIVHFKDGLVERTEAGNGAGVPA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory