SitesBLAST
Comparing Ga0059261_1495 Ga0059261_1495 succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3ju8A Crystal structure of succinylglutamic semialdehyde dehydrogenase from pseudomonas aeruginosa.
52% identity, 95% coverage: 12:466/480 of query aligns to 16:473/486 of 3ju8A
- active site: N147 (= N141), K170 (= K164), E245 (= E239), C279 (= C273), E377 (= E370), P455 (= P448)
- binding nicotinamide-adenine-dinucleotide: G144 (= G138), Y146 (= Y140), N147 (= N141), L152 (= L146), K170 (= K164), S172 (= S166), F220 (= F214), T221 (= T215), G222 (= G216), S223 (= S217), T226 (= T220), E245 (= E239), M246 (= M240), G247 (= G241), C279 (= C273), E377 (= E370), F379 (= F372), F444 (= F437)
5u0mA Fatty aldehyde dehydrogenase from marinobacter aquaeolei vt8 and cofactor complex (see paper)
49% identity, 96% coverage: 12:471/480 of query aligns to 17:478/488 of 5u0mA
- active site: N148 (= N141), K171 (= K164), E246 (= E239), C280 (= C273), E377 (= E370), P455 (= P448)
- binding nicotinamide-adenine-dinucleotide: F144 (≠ L137), Y147 (= Y140), N148 (= N141), K171 (= K164), S173 (= S166), E174 (= E167), G207 (= G200), T222 (= T215), G223 (= G216), S224 (= S217), V227 (≠ T220), E246 (= E239), M247 (= M240), G248 (= G241), C280 (= C273), E377 (= E370), F379 (= F372)
5u0lA X-ray crystal structure of fatty aldehyde dehydrogenase enzymes from marinobacter aquaeolei vt8 complexed with a substrate (see paper)
49% identity, 96% coverage: 12:471/480 of query aligns to 17:478/488 of 5u0lA
- active site: N148 (= N141), K171 (= K164), E246 (= E239), C280 (= C273), E377 (= E370), P455 (= P448)
- binding decanal: K107 (= K99), H152 (= H145), L153 (= L146), G156 (= G149), H157 (= H150), S456 (= S449), A457 (= A450)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
31% identity, 93% coverage: 8:455/480 of query aligns to 21:476/494 of 4pz2B
- active site: N159 (= N141), K182 (= K164), E258 (= E239), C292 (= C273), E392 (= E370), D469 (≠ P448)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ L137), I156 (≠ G138), P157 (= P139), W158 (≠ Y140), N159 (= N141), M164 (≠ L146), K182 (= K164), A184 (≠ S166), E185 (= E167), G215 (= G196), G219 (= G200), F233 (= F214), T234 (= T215), G235 (= G216), S236 (= S217), V239 (≠ T220), E258 (= E239), L259 (≠ M240), C292 (= C273), E392 (= E370), F394 (= F372)
1bpwA Betaine aldehyde dehydrogenase from cod liver (see paper)
30% identity, 91% coverage: 19:456/480 of query aligns to 42:485/503 of 1bpwA
- active site: N166 (= N141), K189 (= K164), E263 (= E239), C297 (= C273), E400 (= E370), E477 (≠ P448)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ L137), L163 (≠ G138), W165 (≠ Y140), N166 (= N141), K189 (= K164), G221 (= G196), G225 (= G200), T240 (= T215), G241 (= G216), S242 (= S217), T245 (= T220), E263 (= E239), L264 (≠ M240), C297 (= C273), E400 (= E370), F402 (= F372), F466 (= F437)
P56533 4-trimethylaminobutyraldehyde dehydrogenase; TMABA-DH; TMABADH; Aldehyde dehydrogenase family 9 member A1; Betaine aldehyde dehydrogenase; BADH; EC 1.2.1.47; EC 1.2.1.3 from Gadus morhua subsp. callarias (Baltic cod) (Gadus callarias) (see paper)
30% identity, 91% coverage: 19:456/480 of query aligns to 42:485/503 of P56533
5izdA Wild-type glyceraldehyde dehydrogenase from thermoplasma acidophilum in complex with NADP
29% identity, 89% coverage: 11:438/480 of query aligns to 16:449/494 of 5izdA
- active site: N149 (= N141), K172 (= K164), E247 (= E239), C281 (= C273), E381 (= E370)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: L145 (= L137), T146 (≠ G138), W148 (≠ Y140), K172 (= K164), P173 (= P165), S174 (= S166), S175 (≠ E167), R204 (vs. gap), G205 (= G196), G209 (= G200), D210 (≠ K201), G225 (= G216), S226 (= S217), T229 (= T220)
Sites not aligning to the query:
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
31% identity, 93% coverage: 11:455/480 of query aligns to 33:483/501 of Q56YU0
- G152 (vs. gap) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A387) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
6wsbA Crystal structure of a betaine aldehyde dehydrogenase from burkholderia pseudomallei bound to cofactor NAD (see paper)
31% identity, 91% coverage: 11:447/480 of query aligns to 19:461/489 of 6wsbA
- active site: N152 (= N141), E250 (= E239), C284 (= C273)
- binding nicotinamide-adenine-dinucleotide: I148 (≠ L137), G149 (= G138), A150 (≠ P139), W151 (≠ Y140), N152 (= N141), K175 (= K164), E178 (= E167), G208 (≠ P197), G211 (= G200), A212 (≠ K201), F225 (= F214), T226 (= T215), G227 (= G216), G228 (≠ S217), T231 (= T220), V235 (≠ L224), E250 (= E239), L251 (≠ M240), G252 (= G241), C284 (= C273), E385 (= E370), F387 (= F372)
Sites not aligning to the query:
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
29% identity, 93% coverage: 8:455/480 of query aligns to 16:468/486 of 4pxlA
- active site: N154 (= N141), K177 (= K164), E253 (= E239), C287 (= C273), E384 (= E370), D461 (≠ P448)
- binding nicotinamide-adenine-dinucleotide: I150 (≠ L137), V151 (≠ G138), P152 (= P139), W153 (≠ Y140), K177 (= K164), E180 (= E167), G210 (= G196), G214 (= G200), A215 (≠ K201), F228 (= F214), G230 (= G216), S231 (= S217), V234 (≠ T220), E253 (= E239), G255 (= G241), C287 (= C273), Q334 (≠ T321), K337 (≠ L324), E384 (= E370), F386 (= F372)
7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
30% identity, 96% coverage: 3:463/480 of query aligns to 19:486/489 of 7a6qB
- active site: N163 (= N141), E262 (= E239), C296 (= C273), E470 (≠ P448)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ L137), W162 (≠ Y140), K186 (= K164), E189 (= E167), G219 (= G196), G223 (= G200), S240 (= S217), V243 (≠ T220), K342 (≠ D320)
- binding (3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium: A32 (≠ I16), T33 (≠ S17), C34 (≠ T18), P36 (= P20), D103 (≠ E81), E189 (= E167), Q190 (≠ K168), F218 (vs. gap), I339 (= I317), D340 (= D318)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (≠ T95), D141 (≠ P119), N143 (= N121), N451 (= N429), L453 (≠ A431), A455 (≠ S433)
7a6qA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
30% identity, 96% coverage: 3:463/480 of query aligns to 19:486/489 of 7a6qA
- active site: N163 (= N141), E262 (= E239), C296 (= C273), E470 (≠ P448)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ L137), T160 (≠ G138), W162 (≠ Y140), K186 (= K164), A188 (≠ S166), E189 (= E167), G219 (= G196), G223 (= G200), S240 (= S217), V243 (≠ T220), K342 (≠ D320), K346 (≠ L324)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (≠ T95), D141 (≠ P119), N143 (= N121), N451 (= N429), L453 (≠ A431), Y454 (≠ S432)
5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid (see paper)
30% identity, 96% coverage: 3:463/480 of query aligns to 19:486/489 of 5fhzA
- active site: N163 (= N141), K186 (= K164), E262 (= E239), C296 (= C273), E393 (= E370), E470 (≠ P448)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ L137), T160 (≠ G138), W162 (≠ Y140), K186 (= K164), E189 (= E167), G219 (= G196), G223 (= G200), F237 (= F214), G239 (= G216), S240 (= S217), T241 (≠ A218), V243 (≠ T220), G264 (= G241), Q343 (≠ T321), E393 (= E370)
- binding retinoic acid: G118 (≠ T95), R121 (≠ A98), F164 (= F142), M168 (≠ L146), W171 (≠ G149), C295 (≠ R272), C296 (= C273), L453 (≠ A431)
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
29% identity, 96% coverage: 3:463/480 of query aligns to 18:485/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (≠ L137), T159 (≠ G138), P160 (= P139), W161 (≠ Y140), K185 (= K164), E188 (= E167), G218 (= G196), G222 (= G200), F236 (= F214), S239 (= S217), V242 (≠ T220)
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
29% identity, 96% coverage: 3:463/480 of query aligns to 37:504/512 of P47895
- R89 (≠ A49) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K164) binding
- E207 (= E167) binding
- GSTEVG 257:262 (≠ GSARTG 216:221) binding
- Q361 (≠ T321) binding
- E411 (= E370) binding
- A493 (= A453) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
6tryA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with mf13 inhibitor compound (see paper)
30% identity, 96% coverage: 3:463/480 of query aligns to 12:474/478 of 6tryA
- active site: N156 (= N141), E255 (= E239), C289 (= C273), E458 (≠ P448)
- binding nicotinamide-adenine-dinucleotide: I152 (≠ L137), T153 (≠ G138), W155 (≠ Y140), K179 (= K164), A181 (≠ S166), E182 (= E167), G212 (= G196), G216 (= G200), A217 (≠ K201), F230 (= F214), G232 (= G216), S233 (= S217), V236 (≠ T220), K335 (≠ D320)
- binding 8-(4-chlorophenyl)-2-phenyl-imidazo[1,2-a]pyridine: I107 (≠ T91), G111 (≠ T95), T115 (≠ K99), L160 (≠ H145), C288 (≠ R272), L441 (≠ A431), A443 (≠ S433)
Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
31% identity, 86% coverage: 33:447/480 of query aligns to 76:493/518 of Q63639
6te5B Crystal structure of human aldehyde dehydrogenase 1a3 in complex with lq43 inhibitor compound (see paper)
30% identity, 96% coverage: 3:463/480 of query aligns to 13:475/479 of 6te5B
- active site: N157 (= N141), E256 (= E239), C290 (= C273), E459 (≠ P448)
- binding 6-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine: E111 (= E94), G112 (≠ T95), T116 (≠ K99), L442 (≠ A431), A444 (≠ S433)
- binding nicotinamide-adenine-dinucleotide: I153 (≠ L137), T154 (≠ G138), W156 (≠ Y140), K180 (= K164), E183 (= E167), G213 (= G196), F231 (= F214), S234 (= S217), V237 (≠ T220), Q337 (≠ T321), K340 (≠ S328)
6tgwA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with a selective inhibitor (see paper)
29% identity, 96% coverage: 3:463/480 of query aligns to 11:475/478 of 6tgwA
- active site: N155 (= N141), E254 (= E239), C288 (= C273), E459 (≠ P448)
- binding methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate: I106 (≠ T91), G110 (≠ T95), F156 (= F142), Q278 (= Q263), F282 (≠ T267), L442 (≠ A431), A444 (≠ S433)
- binding nicotinamide-adenine-dinucleotide: I151 (≠ L137), T152 (≠ G138), P153 (= P139), W154 (≠ Y140), K178 (= K164), G211 (= G196), G215 (= G200), F229 (= F214), G231 (= G216), S232 (= S217), V235 (≠ T220)
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
30% identity, 86% coverage: 33:447/480 of query aligns to 50:467/492 of 6b5hA
- active site: N161 (= N141), E260 (= E239), C294 (= C273)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (≠ T91), G116 (≠ T95), F162 (= F142), W169 (≠ G149), Q284 (= Q263), F288 (≠ T267), T295 (= T274), N449 (= N429), L451 (≠ A431), N452 (≠ S432), F457 (= F437)
- binding nicotinamide-adenine-dinucleotide: I157 (≠ L137), I158 (≠ G138), W160 (≠ Y140), N161 (= N141), K184 (= K164), G217 (= G196), G221 (= G200), F235 (= F214), T236 (= T215), G237 (= G216), S238 (= S217), V241 (≠ T220), E260 (= E239), L261 (≠ M240), C294 (= C273), F393 (= F372)
Sites not aligning to the query:
Query Sequence
>Ga0059261_1495 Ga0059261_1495 succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71)
LGSNPKKEQMSGSEIISTEPATGAVLWRRPIGDVDAEVAAARASWADWAARPLTYRIEAL
RRFANVVRQKSEAFTDLIARETGKPLWEARTEVETVIAKVDISVTAFSERTGQRRIEAPM
NTRLALRHKPHGVLAVLGPYNFPAHLPNGHIVPALLAGNAVVFKPSEKTPATGAFLVECY
HAAGIPEGCIRLLIGGPDEGKALAGHDGIDGLLFTGSARTGIALNRAFAAKPEKILALEM
GGNNPILVWSTPDIYSAAVLVIQSAFTSAGQRCTAARRLIVDEKLYDPLLEEVNKLIGRL
IVGEPHADPAPFMGPVIDNDTADLLTESFLELSFMGGRPLRHMERPVDGRPFLTPAMIDM
TDAKEKPDVELFGPILQVIRARTFEEAIAEANNTRYGLSASLVSQDPKLYDQFWANIRAG
IVNWNRPTNGASSAAPFGGIGWSGNHRPSAFYAADYCAYPVVSSEAEQARVSMGVGIRDA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory