SitesBLAST
Comparing Ga0059261_1674 FitnessBrowser__Korea:Ga0059261_1674 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 9:554/595 of 1t9bB
- active site: Y29 (≠ V38), G31 (= G40), G32 (≠ V41), A33 (≠ Q42), I34 (≠ L43), E55 (= E65), T78 (≠ V88), F117 (≠ L129), Q118 (≠ H130), E119 (= E131), K167 (≠ P180), R226 (= R234), M262 (vs. gap), V289 (vs. gap), V405 (= V392), L430 (≠ Q414), G431 (= G415), M433 (≠ L417), D458 (= D442), N485 (≠ D469), E487 (≠ N471), Q488 (≠ F472), M490 (≠ N474), V491 (= V475), W494 (≠ I478), L516 (= L500), G521 (= G505), L522 (≠ V506)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V117), P108 (≠ N118), D287 (vs. gap), R288 (vs. gap), M490 (≠ N474), W494 (≠ I478)
- binding flavin-adenine dinucleotide: R157 (= R170), G215 (= G226), A216 (≠ S227), G217 (= G228), N220 (vs. gap), T242 (≠ R250), L243 (≠ H251), Q244 (≠ M252), M259 (vs. gap), L260 (vs. gap), M262 (vs. gap), H263 (vs. gap), G282 (= G284), A283 (≠ S285), R284 (= R286), D286 (vs. gap), R288 (vs. gap), V289 (vs. gap), E315 (≠ D305), V316 (≠ L306), N320 (≠ E310), G333 (≠ A323), D334 (= D324), A335 (= A325), Q409 (≠ S396), M410 (≠ R397), G428 (≠ S412), G429 (≠ Y413)
- binding magnesium ion: D458 (= D442), N485 (≠ D469), E487 (≠ N471)
Sites not aligning to the query:
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 9:550/591 of 5wkcA
- active site: Y29 (≠ V38), G31 (= G40), G32 (≠ V41), A33 (≠ Q42), I34 (≠ L43), E55 (= E65), T78 (≠ V88), F117 (≠ L129), Q118 (≠ H130), E119 (= E131), K167 (≠ P180), R222 (= R234), M258 (vs. gap), V285 (vs. gap), V401 (= V392), L426 (≠ Q414), G427 (= G415), M429 (≠ L417), D454 (= D442), N481 (≠ D469), E483 (≠ N471), Q484 (≠ F472), M486 (≠ N474), V487 (= V475), W490 (≠ I478), L512 (= L500), G517 (= G505), L518 (≠ V506)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V392), G402 (= G393), Q403 (≠ Y394), H404 (≠ A395), G427 (= G415), M429 (≠ L417), G453 (= G441), D454 (= D442), A455 (≠ G443), S456 (≠ G444), M459 (≠ Y447), N481 (≠ D469), E483 (≠ N471), Q484 (≠ F472), G485 (= G473), M486 (≠ N474), V487 (= V475)
- binding ethaneperoxoic acid: G32 (≠ V41), Q118 (≠ H130)
- binding flavin-adenine dinucleotide: R157 (= R170), G211 (= G226), A212 (≠ S227), G213 (= G228), N216 (vs. gap), T238 (≠ R250), L239 (≠ H251), Q240 (≠ M252), L256 (vs. gap), M258 (vs. gap), G278 (= G284), A279 (≠ S285), R280 (= R286), R284 (vs. gap), V285 (vs. gap), E311 (≠ D305), V312 (≠ L306), N316 (≠ E310), D330 (= D324), A331 (= A325), M406 (≠ R397), G424 (≠ S412)
- binding magnesium ion: D454 (= D442), N481 (≠ D469), E483 (≠ N471)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ V41), A33 (≠ Q42), V107 (= V117), F117 (≠ L129), K167 (≠ P180), M258 (vs. gap), R284 (vs. gap), M486 (≠ N474), W490 (≠ I478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P39), E55 (= E65)
Sites not aligning to the query:
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 13:566/607 of 6u9dB
- active site: Y33 (≠ V38), G35 (= G40), G36 (≠ V41), A37 (≠ Q42), I38 (≠ L43), E59 (= E65), T82 (≠ V88), F121 (≠ L129), Q122 (≠ H130), E123 (= E131), K171 (≠ P180), M274 (vs. gap), V301 (vs. gap), V417 (= V392), G443 (= G415), M445 (≠ L417), D470 (= D442), N497 (≠ D469), E499 (≠ N471), Q500 (≠ F472), M502 (≠ N474), V503 (= V475), W506 (≠ I478)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ V41), V111 (= V117), P112 (≠ N118), F121 (≠ L129), K171 (≠ P180), D299 (vs. gap), R300 (vs. gap), M502 (≠ N474), W506 (≠ I478)
- binding flavin-adenine dinucleotide: R161 (= R170), A228 (≠ S227), G229 (= G228), N232 (vs. gap), T254 (≠ R250), L255 (≠ H251), Q256 (≠ M252), L272 (vs. gap), M274 (vs. gap), G294 (= G284), R296 (= R286), D298 (vs. gap), R300 (vs. gap), V301 (vs. gap), E327 (≠ D305), V328 (≠ L306), N332 (≠ E310), D346 (= D324), A347 (= A325), M422 (≠ R397), G440 (≠ S412), G441 (≠ Y413)
- binding magnesium ion: D470 (= D442), N497 (≠ D469)
- binding thiamine diphosphate: E59 (= E65), P85 (= P91), V417 (= V392), G418 (= G393), Q419 (≠ Y394), H420 (≠ A395), G443 (= G415), M445 (≠ L417), A471 (≠ G443), S472 (≠ G444), N497 (≠ D469), E499 (≠ N471), Q500 (≠ F472), G501 (= G473), M502 (≠ N474), V503 (= V475)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 8:541/582 of 1t9dB
- active site: Y28 (≠ V38), G30 (= G40), G31 (≠ V41), A32 (≠ Q42), I33 (≠ L43), E54 (= E65), T77 (≠ V88), F116 (≠ L129), Q117 (≠ H130), E118 (= E131), K166 (≠ P180), R213 (= R234), M249 (vs. gap), V276 (vs. gap), V392 (= V392), L417 (≠ Q414), G418 (= G415), M420 (≠ L417), D445 (= D442), N472 (≠ D469), E474 (≠ N471), Q475 (≠ F472), M477 (≠ N474), V478 (= V475), W481 (≠ I478), L503 (= L500), G508 (= G505), L509 (≠ V506)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (≠ V41), A32 (≠ Q42), V106 (= V117), P107 (≠ N118), F116 (≠ L129), K166 (≠ P180), M249 (vs. gap), D274 (vs. gap), R275 (vs. gap), W481 (≠ I478)
- binding flavin-adenine dinucleotide: R156 (= R170), G202 (= G226), A203 (≠ S227), G204 (= G228), N207 (vs. gap), T229 (≠ R250), L230 (≠ H251), Q231 (≠ M252), L247 (vs. gap), M249 (vs. gap), H250 (vs. gap), G269 (= G284), A270 (≠ S285), R271 (= R286), D273 (vs. gap), R275 (vs. gap), V276 (vs. gap), E302 (≠ D305), V303 (≠ L306), N307 (≠ E310), G320 (≠ A323), D321 (= D324), A322 (= A325), Q396 (≠ S396), M397 (≠ R397), G415 (≠ S412), G416 (≠ Y413)
- binding magnesium ion: D445 (= D442), N472 (≠ D469), E474 (≠ N471)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E65), P80 (= P91), G418 (= G415), M420 (≠ L417), M450 (≠ Y447)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 9:542/583 of 1t9bA
- active site: Y29 (≠ V38), G31 (= G40), G32 (≠ V41), A33 (≠ Q42), I34 (≠ L43), E55 (= E65), T78 (≠ V88), F117 (≠ L129), Q118 (≠ H130), E119 (= E131), K167 (≠ P180), R214 (= R234), M250 (vs. gap), V277 (vs. gap), V393 (= V392), L418 (≠ Q414), G419 (= G415), M421 (≠ L417), D446 (= D442), N473 (≠ D469), E475 (≠ N471), Q476 (≠ F472), M478 (≠ N474), V479 (= V475), W482 (≠ I478), L504 (= L500), G509 (= G505), L510 (≠ V506)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V117), P108 (≠ N118), F117 (≠ L129), D275 (vs. gap), R276 (vs. gap), M478 (≠ N474), W482 (≠ I478)
- binding flavin-adenine dinucleotide: R157 (= R170), G203 (= G226), A204 (≠ S227), G205 (= G228), N208 (vs. gap), T230 (≠ R250), L231 (≠ H251), Q232 (≠ M252), M247 (vs. gap), L248 (vs. gap), M250 (vs. gap), H251 (vs. gap), G270 (= G284), A271 (≠ S285), R272 (= R286), D274 (vs. gap), R276 (vs. gap), V277 (vs. gap), E303 (≠ D305), V304 (≠ L306), N308 (≠ E310), D322 (= D324), A323 (= A325), Q397 (≠ S396), M398 (≠ R397), G416 (≠ S412), G417 (≠ Y413)
- binding magnesium ion: D446 (= D442), N473 (≠ D469), E475 (≠ N471)
Sites not aligning to the query:
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 93:646/687 of P07342
- R241 (= R170) binding
- 355:376 (vs. 267:286, 27% identical) binding
- 407:426 (vs. 305:324, 15% identical) binding
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 11:558/599 of 1n0hA
- active site: Y31 (≠ V38), G33 (= G40), G34 (≠ V41), A35 (≠ Q42), I36 (≠ L43), E57 (= E65), T80 (≠ V88), F119 (≠ L129), Q120 (≠ H130), E121 (= E131), K169 (≠ P180), R230 (= R234), M266 (vs. gap), V293 (vs. gap), V409 (= V392), L434 (≠ Q414), G435 (= G415), M437 (≠ L417), D462 (= D442), N489 (≠ D469), E491 (≠ N471), Q492 (≠ F472), M494 (≠ N474), V495 (= V475), W498 (≠ I478), L520 (= L500), G525 (= G505), L526 (≠ V506)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V392), G410 (= G393), Q411 (≠ Y394), H412 (≠ A395), G435 (= G415), M437 (≠ L417), G461 (= G441), D462 (= D442), A463 (≠ G443), S464 (≠ G444), M467 (≠ Y447), N489 (≠ D469), E491 (≠ N471), Q492 (≠ F472), G493 (= G473), V495 (= V475)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ V41), A35 (≠ Q42), V109 (= V117), P110 (≠ N118), F119 (≠ L129), K169 (≠ P180), M266 (vs. gap), D291 (vs. gap), R292 (vs. gap), V495 (= V475), W498 (≠ I478)
- binding flavin-adenine dinucleotide: R159 (= R170), G219 (= G226), A220 (≠ S227), G221 (= G228), N224 (vs. gap), T246 (≠ R250), L247 (≠ H251), Q248 (≠ M252), L264 (vs. gap), G265 (vs. gap), M266 (vs. gap), H267 (vs. gap), G286 (= G284), A287 (≠ S285), R288 (= R286), D290 (vs. gap), R292 (vs. gap), V293 (vs. gap), E319 (≠ D305), V320 (≠ L306), N324 (≠ E310), G337 (≠ A323), D338 (= D324), A339 (= A325), M414 (≠ R397), G432 (≠ S412), G433 (≠ Y413)
- binding magnesium ion: D462 (= D442), N489 (≠ D469), E491 (≠ N471)
- binding thiamine diphosphate: Y31 (≠ V38), E57 (= E65), P83 (= P91)
Sites not aligning to the query:
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 10:556/597 of 1t9aA
- active site: Y30 (≠ V38), G32 (= G40), G33 (≠ V41), A34 (≠ Q42), I35 (≠ L43), E56 (= E65), T79 (≠ V88), F118 (≠ L129), Q119 (≠ H130), E120 (= E131), K168 (≠ P180), R228 (= R234), M264 (vs. gap), V291 (vs. gap), V407 (= V392), L432 (≠ Q414), G433 (= G415), M435 (≠ L417), D460 (= D442), N487 (≠ D469), E489 (≠ N471), Q490 (≠ F472), M492 (≠ N474), V493 (= V475), W496 (≠ I478), L518 (= L500), G523 (= G505), L524 (≠ V506)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ V41), V108 (= V117), P109 (≠ N118), F118 (≠ L129), K168 (≠ P180), M264 (vs. gap), D289 (vs. gap), R290 (vs. gap), M492 (≠ N474), V493 (= V475), W496 (≠ I478)
- binding flavin-adenine dinucleotide: R158 (= R170), G217 (= G226), A218 (≠ S227), G219 (= G228), N222 (vs. gap), T244 (≠ R250), L245 (≠ H251), Q246 (≠ M252), L262 (vs. gap), M264 (vs. gap), H265 (vs. gap), G284 (= G284), A285 (≠ S285), R286 (= R286), D288 (vs. gap), R290 (vs. gap), V291 (vs. gap), E317 (≠ D305), V318 (≠ L306), N322 (≠ E310), G335 (≠ A323), D336 (= D324), A337 (= A325), Q411 (≠ S396), M412 (≠ R397), G430 (≠ S412), G431 (≠ Y413)
- binding magnesium ion: D460 (= D442), N487 (≠ D469), E489 (≠ N471)
- binding propyl trihydrogen diphosphate: V407 (= V392), G408 (= G393), Q409 (≠ Y394), H410 (≠ A395), M435 (≠ L417), G459 (= G441), D460 (= D442), A461 (≠ G443), S462 (≠ G444), N487 (≠ D469), E489 (≠ N471), Q490 (≠ F472), G491 (= G473), M492 (≠ N474)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G415), M435 (≠ L417), M465 (≠ Y447)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 9:555/596 of 1t9dA
- active site: Y29 (≠ V38), G31 (= G40), G32 (≠ V41), A33 (≠ Q42), I34 (≠ L43), E55 (= E65), T78 (≠ V88), F117 (≠ L129), Q118 (≠ H130), E119 (= E131), K167 (≠ P180), R227 (= R234), M263 (vs. gap), V290 (vs. gap), V406 (= V392), L431 (≠ Q414), G432 (= G415), M434 (≠ L417), D459 (= D442), N486 (≠ D469), E488 (≠ N471), Q489 (≠ F472), M491 (≠ N474), V492 (= V475), W495 (≠ I478), L517 (= L500), G522 (= G505), L523 (≠ V506)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ V41), A33 (≠ Q42), V107 (= V117), P108 (≠ N118), F117 (≠ L129), K167 (≠ P180), M263 (vs. gap), D288 (vs. gap), R289 (vs. gap), W495 (≠ I478)
- binding flavin-adenine dinucleotide: R157 (= R170), G216 (= G226), A217 (≠ S227), G218 (= G228), N221 (vs. gap), T243 (≠ R250), L244 (≠ H251), Q245 (≠ M252), M260 (vs. gap), L261 (vs. gap), H264 (vs. gap), G283 (= G284), A284 (≠ S285), R285 (= R286), D287 (vs. gap), R289 (vs. gap), V290 (vs. gap), E316 (≠ D305), V317 (≠ L306), N321 (≠ E310), G334 (≠ A323), D335 (= D324), A336 (= A325), Q410 (≠ S396), M411 (≠ R397), G429 (≠ S412), G430 (≠ Y413)
- binding magnesium ion: D459 (= D442), N486 (≠ D469), E488 (≠ N471)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E65), P81 (= P91), Q118 (≠ H130), G432 (= G415), M434 (≠ L417), M464 (≠ Y447)
Sites not aligning to the query:
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 9:555/596 of 1t9cA
- active site: Y29 (≠ V38), G31 (= G40), G32 (≠ V41), A33 (≠ Q42), I34 (≠ L43), E55 (= E65), T78 (≠ V88), F117 (≠ L129), Q118 (≠ H130), E119 (= E131), K167 (≠ P180), R227 (= R234), M263 (vs. gap), V290 (vs. gap), V406 (= V392), L431 (≠ Q414), G432 (= G415), M434 (≠ L417), D459 (= D442), N486 (≠ D469), E488 (≠ N471), Q489 (≠ F472), M491 (≠ N474), V492 (= V475), W495 (≠ I478), L517 (= L500), G522 (= G505), L523 (≠ V506)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ V41), V107 (= V117), P108 (≠ N118), F117 (≠ L129), K167 (≠ P180), D288 (vs. gap), R289 (vs. gap), W495 (≠ I478)
- binding flavin-adenine dinucleotide: R157 (= R170), G216 (= G226), A217 (≠ S227), G218 (= G228), N221 (vs. gap), T243 (≠ R250), L244 (≠ H251), Q245 (≠ M252), L261 (vs. gap), M263 (vs. gap), H264 (vs. gap), G283 (= G284), A284 (≠ S285), R285 (= R286), D287 (vs. gap), R289 (vs. gap), V290 (vs. gap), E316 (≠ D305), V317 (≠ L306), N321 (≠ E310), G334 (≠ A323), D335 (= D324), A336 (= A325), M411 (≠ R397), G429 (≠ S412), G430 (≠ Y413)
- binding magnesium ion: D459 (= D442), N486 (≠ D469), E488 (≠ N471)
Sites not aligning to the query:
4rjiC Acetolactate synthase from bacillus subtilis bound to thdp - crystal form i (see paper)
30% identity, 94% coverage: 16:538/555 of query aligns to 1:533/555 of 4rjiC
- binding magnesium ion: D438 (= D442), D465 (= D469), T467 (≠ N471)
- binding thiamine diphosphate: P24 (= P39), E48 (= E65), P74 (= P91), S387 (vs. gap), H388 (vs. gap), Q411 (≠ G415), G437 (= G441), D438 (= D442), G439 (= G443), G440 (= G444), T467 (≠ N471), Y468 (≠ F472), D469 (≠ G473), M470 (≠ N474), V471 (= V475)
Sites not aligning to the query:
4rjkF Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii (see paper)
30% identity, 94% coverage: 19:538/555 of query aligns to 3:532/552 of 4rjkF
- binding magnesium ion: D437 (= D442), D464 (= D469), T466 (≠ N471)
- binding pyruvic acid: A25 (≠ V41), K26 (≠ Q42)
- binding thiamine diphosphate: P23 (= P39), E47 (= E65), P73 (= P91), G385 (= G393), S386 (vs. gap), H387 (vs. gap), Q410 (≠ G415), L412 (= L417), G436 (= G441), D437 (= D442), G438 (= G443), G439 (= G444), T466 (≠ N471), Y467 (≠ F472), D468 (≠ G473), M469 (≠ N474), V470 (= V475)
Sites not aligning to the query:
4rjkG Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii (see paper)
30% identity, 94% coverage: 19:538/555 of query aligns to 3:532/553 of 4rjkG
- binding magnesium ion: D437 (= D442), D464 (= D469), T466 (≠ N471)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: E47 (= E65), Q110 (≠ E131)
- binding thiamine diphosphate: I384 (≠ V392), G385 (= G393), S386 (vs. gap), H387 (vs. gap), Q410 (≠ G415), L412 (= L417), G436 (= G441), D437 (= D442), G438 (= G443), G439 (= G444), T466 (≠ N471), Y467 (≠ F472), D468 (≠ G473), M469 (≠ N474), V470 (= V475)
Sites not aligning to the query:
6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
29% identity, 94% coverage: 18:538/555 of query aligns to 11:540/542 of 6bd9A
- active site: Y31 (≠ V38), G33 (= G40), G34 (≠ V41), A35 (≠ Q42), I36 (≠ L43), E57 (= E65), T80 (≠ V88), F119 (≠ L129), Q120 (≠ H130), E121 (= E131), K169 (≠ P180), R228 (= R234), M264 (vs. gap), V291 (vs. gap), V407 (= V392), L432 (≠ Q414), G433 (= G415), M435 (≠ L417), D460 (= D442), N487 (≠ D469), E489 (≠ N471), L502 (= L500), G507 (= G505), L508 (≠ V506)
- binding flavin-adenine dinucleotide: R159 (= R170), G217 (= G226), A218 (≠ S227), G219 (= G228), N222 (vs. gap), T244 (≠ R250), L245 (≠ H251), L262 (vs. gap), G263 (vs. gap), H265 (vs. gap), G284 (= G284), A285 (≠ S285), R286 (= R286), D288 (≠ T288), R290 (vs. gap), V291 (vs. gap), E317 (≠ D305), V318 (≠ L306), N322 (≠ E310), G335 (≠ A323), D336 (= D324), A337 (= A325)
- binding magnesium ion: D460 (= D442), N487 (≠ D469)
- binding oxygen molecule: G34 (≠ V41), T80 (≠ V88), Q120 (≠ H130), A461 (≠ G443), Q494 (vs. gap)
- binding pyruvic acid: G33 (= G40), G34 (≠ V41), G34 (≠ V41), A35 (≠ Q42), Q120 (≠ H130)
- binding thiamine diphosphate: P32 (= P39), E57 (= E65), V407 (= V392), G408 (= G393), Q409 (≠ Y394), H410 (≠ A395), G433 (= G415), M435 (≠ L417), G459 (= G441), D460 (= D442), A461 (≠ G443), S462 (≠ G444), M465 (≠ Y447), N487 (≠ D469)
Sites not aligning to the query:
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
29% identity, 93% coverage: 21:535/555 of query aligns to 9:554/594 of 8i07D
- binding 2-oxidanylethanal: R285 (= R291), I480 (≠ V475)
- binding flavin-adenine dinucleotide: R155 (= R170), P156 (= P171), G212 (= G226), G213 (≠ S227), G214 (= G228), N217 (vs. gap), T238 (≠ R250), L239 (≠ H251), M240 (= M252), V256 (≠ A270), G257 (≠ L271), Q259 (≠ H273), T260 (≠ W274), G279 (= G284), N280 (≠ S285), R281 (= R286), R285 (= R291), H286 (≠ E292), D303 (= D305), I304 (≠ L306), Q308 (≠ E310), D322 (= D324), A323 (= A325), I399 (≠ Y394), G417 (≠ S412)
- binding magnesium ion: D447 (= D442), F452 (≠ Y447), L453 (≠ T448), E455 (≠ P450), N474 (≠ D469), Y476 (≠ N471)
- binding thiamine diphosphate: V52 (≠ E65), T76 (≠ V88), G395 (≠ T390), L396 (≠ Q391), S397 (≠ V392), L422 (= L417), G446 (= G441), D447 (= D442), F448 (≠ G443), D449 (≠ G444), N474 (≠ D469), Y476 (≠ N471), L477 (≠ F472), G478 (= G473), L479 (≠ N474), I480 (≠ V475)
- binding ubiquinone-1: Q354 (vs. gap), R358 (vs. gap), C492 (≠ G484), Q494 (≠ R486)
Sites not aligning to the query:
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
29% identity, 93% coverage: 21:535/555 of query aligns to 9:554/594 of 8i07A
- binding flavin-adenine dinucleotide: R155 (= R170), P156 (= P171), G212 (= G226), G213 (≠ S227), G214 (= G228), N217 (vs. gap), T238 (≠ R250), L239 (≠ H251), M240 (= M252), V256 (≠ A270), G257 (≠ L271), Q259 (≠ H273), T260 (≠ W274), G279 (= G284), N280 (≠ S285), R281 (= R286), R285 (= R291), H286 (≠ E292), D303 (= D305), I304 (≠ L306), Q308 (≠ E310), D322 (= D324), A323 (= A325), I394 (≠ M389), I399 (≠ Y394), G417 (≠ S412)
- binding magnesium ion: D447 (= D442), F452 (≠ Y447), L453 (≠ T448), E455 (≠ P450), N474 (≠ D469), Y476 (≠ N471)
- binding thiamine diphosphate: I394 (≠ M389), G395 (≠ T390), L396 (≠ Q391), S397 (≠ V392), L422 (= L417), G446 (= G441), D447 (= D442), F448 (≠ G443), D449 (≠ G444), N474 (≠ D469), Y476 (≠ N471), L477 (≠ F472), G478 (= G473), L479 (≠ N474), I480 (≠ V475)
- binding ubiquinone-1: Q354 (vs. gap), C492 (≠ G484), Q494 (≠ R486)
Sites not aligning to the query:
1jscA Crystal structure of the catalytic subunit of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors (see paper)
29% identity, 94% coverage: 18:538/555 of query aligns to 11:539/541 of 1jscA
- active site: Y31 (≠ V38), G33 (= G40), G34 (≠ V41), A35 (≠ Q42), I36 (≠ L43), E57 (= E65), T80 (≠ V88), F119 (≠ L129), Q120 (≠ H130), E121 (= E131), K169 (≠ P180), M263 (vs. gap), V290 (vs. gap), V406 (= V392), G432 (= G415), M434 (≠ L417), D459 (= D442), N486 (≠ D469), E488 (≠ N471)
- binding dihydrogenphosphate ion: G33 (= G40), G34 (≠ V41), Q120 (≠ H130)
- binding flavin-adenine dinucleotide: R159 (= R170), G216 (= G226), A217 (≠ S227), G218 (= G228), N221 (vs. gap), T243 (≠ R250), L244 (≠ H251), L261 (vs. gap), G262 (vs. gap), H264 (vs. gap), G283 (= G284), A284 (≠ S285), R285 (= R286), D287 (≠ T288), R289 (vs. gap), V290 (vs. gap), E316 (≠ D305), V317 (≠ L306), N321 (≠ E310), G334 (≠ A323), D335 (= D324), A336 (= A325)
- binding magnesium ion: D459 (= D442), N486 (≠ D469)
- binding thiamine diphosphate: Y31 (≠ V38), P32 (= P39), E57 (= E65), P83 (= P91), V406 (= V392), G407 (= G393), Q408 (≠ Y394), H409 (≠ A395), M434 (≠ L417), D459 (= D442), A460 (≠ G443), S461 (≠ G444), N486 (≠ D469)
Sites not aligning to the query:
6lpiB Crystal structure of ahas holo-enzyme (see paper)
28% identity, 95% coverage: 16:545/555 of query aligns to 5:527/539 of 6lpiB
- active site: I27 (≠ V38), G29 (= G40), G30 (≠ V41), S31 (≠ Q42), I32 (≠ L43), E53 (= E65), C76 (≠ V88), F115 (≠ L129), Q116 (≠ H130), E117 (= E131), K165 (≠ P180), M256 (vs. gap), A283 (vs. gap), V375 (≠ M389), G401 (= G415), M403 (≠ L417), D428 (= D442), N455 (≠ D469), A457 (≠ N471), L458 (≠ F472), L460 (≠ N474), V461 (= V475), Q464 (≠ I478)
- binding flavin-adenine dinucleotide: R155 (= R170), G212 (= G226), G213 (≠ S227), G214 (= G228), T236 (≠ R250), L237 (≠ H251), M238 (= M252), L254 (vs. gap), M256 (vs. gap), H257 (vs. gap), G276 (= G284), A277 (≠ S285), R278 (= R286), D280 (≠ T288), R282 (≠ L290), A283 (vs. gap), D300 (= D305), I301 (≠ L306), D319 (= D324), V320 (≠ A325), M380 (≠ Y394), G398 (≠ S412)
- binding magnesium ion: D428 (= D442), N455 (≠ D469)
- binding thiamine diphosphate: E53 (= E65), C76 (≠ V88), P79 (= P91), G376 (≠ T390), Q377 (= Q391), H378 (≠ V392), G401 (= G415), M403 (≠ L417), G427 (= G441), D428 (= D442), G429 (= G443), S430 (≠ G444), M433 (≠ Y447), N455 (≠ D469), A457 (≠ N471), L458 (≠ F472), G459 (= G473), L460 (≠ N474), V461 (= V475)
6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
28% identity, 94% coverage: 18:538/555 of query aligns to 11:536/538 of 6bd3A
- active site: Y31 (≠ V38), G33 (= G40), G34 (≠ V41), A35 (≠ Q42), I36 (≠ L43), E57 (= E65), T80 (≠ V88), F119 (≠ L129), Q120 (≠ H130), E121 (= E131), K169 (≠ P180), R225 (= R234), M261 (vs. gap), V288 (vs. gap), V404 (= V392), L429 (≠ Q414), G430 (= G415), M432 (≠ L417), D457 (= D442), N484 (≠ D469), L498 (= L500), G503 (= G505), L504 (≠ V506)
- binding flavin-adenine dinucleotide: R159 (= R170), G214 (= G226), A215 (≠ S227), G216 (= G228), N219 (vs. gap), T241 (≠ R250), L242 (≠ H251), Q243 (≠ M252), L259 (vs. gap), G260 (vs. gap), H262 (vs. gap), G281 (= G284), A282 (≠ S285), R283 (= R286), D285 (≠ T288), R287 (vs. gap), V288 (vs. gap), E314 (≠ D305), V315 (≠ L306), D333 (= D324), A334 (= A325)
- binding 2-acetyl-thiamine diphosphate: P32 (= P39), E57 (= E65), P83 (= P91)
- binding magnesium ion: D457 (= D442), N484 (≠ D469)
- binding oxygen molecule: A35 (≠ Q42), T80 (≠ V88), S81 (≠ P89), Q120 (≠ H130)
- binding thiamine diphosphate: V404 (= V392), G405 (= G393), Q406 (≠ Y394), H407 (≠ A395), G430 (= G415), M432 (≠ L417), D457 (= D442), A458 (≠ G443), S459 (≠ G444), M462 (≠ Y447), N484 (≠ D469)
Sites not aligning to the query:
8i01A Crystal structure of escherichia coli glyoxylate carboligase
29% identity, 93% coverage: 21:535/555 of query aligns to 9:554/594 of 8i01A
- binding flavin-adenine dinucleotide: R155 (= R170), G212 (= G226), G213 (≠ S227), G214 (= G228), N217 (vs. gap), T238 (≠ R250), L239 (≠ H251), M240 (= M252), V256 (≠ A270), G257 (≠ L271), Q259 (≠ H273), T260 (≠ W274), G279 (= G284), N280 (≠ S285), R281 (= R286), A283 (≠ T288), R285 (= R291), H286 (≠ E292), D303 (= D305), I304 (≠ L306), Q308 (≠ E310), D322 (= D324), A323 (= A325), G417 (≠ S412)
- binding magnesium ion: D447 (= D442), F452 (≠ Y447), E455 (≠ P450), N474 (≠ D469), Y476 (≠ N471)
- binding thiamine diphosphate: G395 (≠ T390), L396 (≠ Q391), S397 (≠ V392), L422 (= L417), G446 (= G441), D447 (= D442), F448 (≠ G443), D449 (≠ G444), N474 (≠ D469), Y476 (≠ N471), L477 (≠ F472), G478 (= G473), L479 (≠ N474), I480 (≠ V475)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q354 (vs. gap), C492 (≠ G484), Q494 (≠ R486)
Sites not aligning to the query:
Query Sequence
>Ga0059261_1674 FitnessBrowser__Korea:Ga0059261_1674
VSLDQRTKAENVSATRGTGGDALVAGLHRWGVDTFFGVPGVQLDELFDGLQRGGGDIRVV
HSRHEQGAAYMALGYAMVTGKPGVCAVVPGPGLLNAGAALSTAYACNARVLCLTSTVNSA
LIDRRYGALHEINDQDGLLRSLTKWSARATHASEIPGLLDEAFRQLLTGRPRPVALEIPP
DILAQTGFFTYPDALPSLANPLADPAAIEQAATLIAGARNPMIVVGSGAQEAGREVRALA
ELIQAPIVSRHMGRGVVRSDDDYALPAAAALPHWPDVDVVIGIGSRLTQLREWGMGGGLK
VVHIDLDQSEINRIAPPAVGIVADAAEATAKLVDALAEKNLSPAPRTAEFAAIRAAFREE
VATEIQPQVGYLDVIRAAMAEDDVFVDEMTQVGYASRYALPVYTPRTYVNSSYQGTLGYG
FATALGAQVGAGKRRVISVNGDGGFMYTMPELATAVLHRIPLIAIVFNDGNFGNVRRIQA
NKYGGRLIASNLHNPDFVALAHSFGVAGLKAEGPEGLATALETARGLEGPVLIEVPMNLE
ATPSPWKHVHGRKVR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory