SitesBLAST
Comparing Ga0059261_1951 FitnessBrowser__Korea:Ga0059261_1951 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4dnaA Crystal structure of putative glutathione reductase from sinorhizobium meliloti 1021
51% identity, 99% coverage: 4:447/448 of query aligns to 2:447/461 of 4dnaA
- active site: Y37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y178 (= Y178), E182 (= E182), A435 (= A435), H437 (= H437), E442 (= E442)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G11 (≠ A13), G12 (= G14), G14 (= G16), E33 (= E35), E34 (= E36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), R112 (= R114), A113 (= A115), V139 (= V140), G140 (= G141), Y178 (= Y178), R264 (= R264), G303 (= G303), D304 (= D304), Q310 (= Q310), L311 (= L311), T312 (= T312)
Sites not aligning to the query:
3o0hB Crystal structure of glutathione reductase from bartonella henselae
46% identity, 99% coverage: 4:447/448 of query aligns to 2:445/459 of 3o0hB
- active site: S13 (= S15), I37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), D74 (= D76), P75 (≠ C77), Y177 (= Y178), E181 (= E182), I314 (= I316), A433 (= A435), H435 (= H437), E440 (= E442)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), A32 (= A34), E33 (= E35), E34 (= E36), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), R112 (= R114), A113 (= A115), T139 (≠ V140), G140 (= G141), Y177 (= Y178), R262 (= R264), N265 (= N267), G301 (= G303), D302 (= D304), Q308 (= Q310), L309 (= L311), T310 (= T312)
Sites not aligning to the query:
6n7fA 1.90 angstrom resolution crystal structure of glutathione reductase from streptococcus pyogenes in complex with fad.
41% identity, 99% coverage: 6:448/448 of query aligns to 6:451/451 of 6n7fA
- active site: C43 (= C43), C48 (= C48), K51 (= K51), Y178 (= Y178), E182 (= E182), H440 (= H437), E445 (= E442)
- binding flavin-adenine dinucleotide: I11 (= I11), G12 (= G12), G14 (= G14), S15 (= S15), A16 (≠ G16), A34 (= A34), E35 (= E35), G36 (≠ E36), K37 (≠ Y37), G41 (= G41), T42 (= T42), C43 (= C43), G47 (= G47), C48 (= C48), K51 (= K51), Y115 (≠ R114), A116 (= A115), T140 (≠ V140), G141 (= G141), Y178 (= Y178), I179 (= I179), R264 (= R264), G303 (= G303), D304 (= D304), L311 (= L311), T312 (= T312)
- binding riboflavin: G36 (≠ E36), K37 (≠ Y37), Y115 (≠ R114), G270 (= G270)
5grtA Human glutathione reductase a34e, r37w mutant, glutathionylspermidine complex (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 5grtA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding flavin-adenine dinucleotide: I9 (= I11), G12 (= G14), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ E36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), Y180 (= Y178), G313 (= G303), D314 (= D304), L320 (≠ Q310), L321 (= L311), T322 (= T312)
- binding glutathionylspermidine disulfide: S13 (= S15), E17 (≠ R19), C41 (= C43), V42 (= V44), Y89 (≠ E91), L93 (= L95), I96 (≠ A98), Y97 (= Y99), T322 (= T312), I326 (= I316)
4grtA Human glutathione reductase a34e, r37w mutant, mixed disulfide between trypanothione and the enzyme (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 4grtA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G11 (≠ A13), G12 (= G14), S13 (= S15), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ E36), H35 (≠ Y37), G39 (= G41), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), Y180 (= Y178), G313 (= G303), D314 (= D304), L320 (≠ Q310), L321 (= L311), T322 (= T312), A325 (= A315)
- binding bis(gamma-glutamyl-cysteinyl-glycinyl)spermidine: S13 (= S15), L16 (≠ V18), E17 (≠ R19), C41 (= C43), V42 (= V44), V47 (= V49), L93 (= L95), Y97 (= Y99), I326 (= I316)
3grtA Human glutathione reductase a34e, r37w mutant, oxidized trypanothione complex (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 3grtA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ E36), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), Y180 (= Y178), G313 (= G303), D314 (= D304), L321 (= L311), T322 (= T312)
- binding 2-amino-4-[4-(4-amino-4-carboxy-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyric acid: S13 (= S15), E17 (≠ R19), W20 (≠ R22), V42 (= V44), L93 (= L95), Y97 (= Y99), T322 (= T312), I326 (= I316)
2grtA Human glutathione reductase a34e, r37w mutant, oxidized glutathione complex (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 2grtA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding flavin-adenine dinucleotide: I9 (= I11), G12 (= G14), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ E36), G39 (= G41), T40 (= T42), C41 (= C43), V44 (≠ R46), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), Y180 (= Y178), G313 (= G303), D314 (= D304), L321 (= L311), T322 (= T312)
- binding oxidized glutathione disulfide: E17 (≠ R19), W20 (≠ R22), V42 (= V44), L93 (= L95), I96 (≠ A98), Y97 (= Y99)
5vdnA 1.55 angstrom resolution crystal structure of glutathione reductase from yersinia pestis in complex with fad
43% identity, 95% coverage: 24:448/448 of query aligns to 22:449/449 of 5vdnA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y176 (= Y178), E180 (= E182), A436 (= A435), H438 (= H437), E443 (= E442)
- binding beta-D-fructopyranose: K35 (≠ Y37), T40 (= T42), G140 (≠ A142), D157 (≠ N159)
- binding flavin-adenine dinucleotide: E33 (= E35), A34 (≠ E36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), F113 (≠ R114), A114 (= A115), T138 (≠ V140), G139 (= G141), Y176 (= Y178), I177 (= I179), R262 (= R264), G301 (= G303), D302 (= D304), E308 (≠ Q310), L309 (= L311), T310 (= T312)
Sites not aligning to the query:
4gr1A The binding of the retro-analogue of glutathione disulfide to glutathione reductase (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 4gr1A
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding flavin-adenine dinucleotide: G12 (= G14), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ E36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), Y180 (= Y178), G313 (= G303), D314 (= D304), L321 (= L311), T322 (= T312)
- binding 4n-malonyl-cysteinyl-2,4-diaminobutyrate disulfide: L93 (= L95), Y97 (= Y99), R330 (≠ Q320)
3sqpA Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 3sqpA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding 5-methylphenazin-1(5H)-one: V57 (≠ H59), V57 (≠ H59), H58 (≠ F60), F61 (≠ D63), F61 (≠ D63)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ E36), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), Y180 (= Y178), R274 (= R264), G313 (= G303), D314 (= D304), L320 (≠ Q310), L321 (= L311), T322 (= T312), P323 (= P313)
2gh5A Crystal structure of human glutathione reductase complexed with a fluoro-analogue of the menadione derivative m5 (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 2gh5A
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding 6-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hexanoic acid: S13 (= S15), A17 (≠ R19), R20 (= R22), C41 (= C43), V42 (= V44), L93 (= L95), Y97 (= Y99)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ E36), G39 (= G41), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), Y180 (= Y178), I181 (= I179), R274 (= R264), G313 (= G303), D314 (= D304), L320 (≠ Q310), L321 (= L311), T322 (= T312)
2aaqA Crystal structure analysis of the human glutahione reductase, complexed with gopi (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 2aaqA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding gold ion: C41 (= C43), C46 (= C48), T322 (= T312)
- binding 2-(2-phenyl-3-pyridin-2-yl-4,5,6,7-tetrahydro-2h-isophosphindol-1-yl)pyridine: L156 (≠ H154), I158 (= I156), G162 (≠ E160), L244 (= L243), D266 (= D256), C267 (≠ L257)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ E36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), S160 (= S158), R274 (= R264), D314 (= D304), L321 (= L311), T322 (= T312)
1xanA Human glutathione reductase in complex with a xanthene inhibitor (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 1xanA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ E36), H35 (≠ Y37), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), Y180 (= Y178), R274 (= R264), G313 (= G303), D314 (= D304), L320 (≠ Q310), L321 (= L311), T322 (= T312)
- binding 3,6-dihydroxy-xanthene-9-propionic acid: V57 (≠ H59), F61 (≠ D63), H65 (≠ A67), Y390 (≠ K377)
1grbA Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 angstroms resolution (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 1grbA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding flavin-adenine dinucleotide: G12 (= G14), G14 (= G16), E33 (= E35), S34 (≠ E36), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), G313 (= G303), D314 (= D304), L320 (≠ Q310), L321 (= L311), T322 (= T312)
- binding nicotinamide-adenine-dinucleotide: K49 (= K51), A178 (= A176), G179 (= G177), Y180 (= Y178), I181 (= I179), E184 (= E182), R201 (= R199), A271 (= A261), I272 (≠ T262), G273 (= G263), L320 (≠ Q310), V353 (≠ A342)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: K49 (= K51), A178 (= A176), G179 (= G177), Y180 (= Y178), I181 (= I179), E184 (= E182), R201 (= R199), R207 (= R205), I272 (≠ T262), G273 (= G263), L320 (≠ Q310), V353 (≠ A342)
- binding phosphate ion: R201 (= R199), H202 (≠ S200), R207 (= R205)
1dncA Human glutathione reductase modified by diglutathione-dinitroso-iron (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 1dncA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding flavin-adenine dinucleotide: G12 (= G14), E33 (= E35), S34 (≠ E36), G39 (= G41), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), Y180 (= Y178), R274 (= R264), G313 (= G303), D314 (= D304), L320 (≠ Q310), L321 (= L311), T322 (= T312)
- binding glutathione: S13 (= S15), R20 (= R22), C41 (= C43), V42 (= V44), Y97 (= Y99), I326 (= I316), R330 (≠ Q320)
1bwcA Structure of human glutathione reductase complexed with ajoene inhibitor and subversive substrate (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 4:461/461 of 1bwcA
- active site: L37 (≠ V39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (= A435), H450 (= H437), E455 (= E442)
- binding 3-(prop-2-ene-1-sulfinyl)-propene-1-thiol: S13 (= S15), C41 (= C43), V42 (= V44), Y97 (= Y99), R330 (≠ Q320)
- binding flavin-adenine dinucleotide: G10 (= G12), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ E36), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ R114), A113 (= A115), T139 (≠ V140), G140 (= G141), Y180 (= Y178), R274 (= R264), D314 (= D304), L320 (≠ Q310), L321 (= L311), T322 (= T312)
3djjA Catalytic cycle of human glutathione reductase near 1 a resolution (see paper)
42% identity, 99% coverage: 6:448/448 of query aligns to 5:462/462 of 3djjA
- active site: L38 (≠ V39), C42 (= C43), C47 (= C48), K50 (= K51), Y181 (= Y178), E185 (= E182), A449 (= A435), H451 (= H437), E456 (= E442)
- binding flavin-adenine dinucleotide: G13 (= G14), E34 (= E35), S35 (≠ E36), G40 (= G41), T41 (= T42), G46 (= G47), C47 (= C48), K50 (= K51), H113 (≠ R114), A114 (= A115), T140 (≠ V140), G141 (= G141), R275 (= R264), G314 (= G303), D315 (= D304), L321 (≠ Q310), L322 (= L311), T323 (= T312)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: A179 (= A176), G180 (= G177), Y181 (= Y178), I182 (= I179), E185 (= E182), R202 (= R199), R208 (= R205), I273 (≠ T262), G274 (= G263), L321 (≠ Q310), V354 (≠ A342)
P00390 Glutathione reductase, mitochondrial; GR; GRase; EC 1.8.1.7 from Homo sapiens (Human) (see 2 papers)
42% identity, 99% coverage: 5:448/448 of query aligns to 64:522/522 of P00390
- C102 (= C43) modified: Disulfide link with 107, Redox-active
- C107 (= C48) modified: Disulfide link with 102, Redox-active
- C134 (= C77) modified: Interchain
- R153 (= R94) to C: in dbSNP:rs8190955
- G232 (≠ K169) to S: in dbSNP:rs8190976
- I261 (≠ N198) to V: in dbSNP:rs8190997
- E297 (≠ G234) to D: in dbSNP:rs8191004
- G374 (= G303) to A: in HAGRD; decreased glutathione reductase activity; decreased enzyme stability; dbSNP:rs1586033745
6du7A Glutathione reductase from streptococcus pneumoniae (see paper)
41% identity, 95% coverage: 24:448/448 of query aligns to 22:448/448 of 6du7A
- active site: C41 (= C43), C46 (= C48), K49 (= K51), Y176 (= Y178), E180 (= E182), H437 (= H437), E442 (= E442)
- binding flavin-adenine dinucleotide: I32 (≠ A34), E33 (= E35), E34 (= E36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H113 (≠ R114), A114 (= A115), T138 (≠ V140), Y176 (= Y178), R261 (= R264), G300 (= G303), D301 (= D304), L308 (= L311), T309 (= T312)
Sites not aligning to the query:
5u1oB 2.3 angstrom resolution crystal structure of glutathione reductase from vibrio parahaemolyticus in complex with fad.
41% identity, 95% coverage: 24:448/448 of query aligns to 23:451/451 of 5u1oB
- active site: L38 (≠ V39), C42 (= C43), C47 (= C48), K50 (= K51), Y177 (= Y178), E181 (= E182), A438 (= A435), H440 (= H437), E445 (= E442)
- binding flavin-adenine dinucleotide: E34 (= E35), A35 (≠ E36), T41 (= T42), C42 (= C43), G46 (= G47), C47 (= C48), K50 (= K51), F114 (≠ R114), A115 (= A115), V139 (= V140), Y177 (= Y178), I178 (= I179), R263 (= R264), G302 (= G303), D303 (= D304), E310 (≠ Q310), L311 (= L311), T312 (= T312)
Sites not aligning to the query:
Query Sequence
>Ga0059261_1951 FitnessBrowser__Korea:Ga0059261_1951
MADYDYDLFVIGAGSGGVRASRVAAAHGAKVAIAEEYRVGGTCVIRGCVPKKLLVYGAHF
AEDLKDARRFGWNVPDCDFDWAVLRDNVLAEVDRLNGAYTHTLDNHGVEIVHERATVSGP
HEVTLASGKTITAGKILIAVGARPAVPNCPGSEHGITSNEVFHLDALPKRVLIAGAGYIA
NEFAGIFNEFGSKVTLINRSDVILRGYDEQIRDRLLQISMTKGIDFRFHAEFRGIEKQAD
GSLKVSMTNHEPLEVDLVLFATGRVPNTEGLGLAEAGVELDAKGAIVVGADNRSSVDSIY
AVGDVTNRVQLTPVAIREGQAFADTVFGNKPTIVDYSCIPAAVFSHPPIAGVGLTEGQAK
QKYGSVRVYTSDFRAMKNVLANRNERALYKMVCEADSGKVLGLHMIGPDAPEILQAAAIA
VKAGLTKADFDQTVALHPSMAEELVLMK
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory