SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ga0059261_2556 Ga0059261_2556 ABC-type multidrug transport system, ATPase component to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
41% identity, 39% coverage: 333:559/587 of query aligns to 2:230/285 of 4yerA

query
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4yerA

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binding adenosine-5'-diphosphate: F14 (= F345), F17 (= F348), A19 (= A350), P38 (= P369), N39 (= N370), G40 (= G371), A41 (= A372), G42 (= G373), K43 (= K374), T44 (≠ S375), T45 (= T376), T135 (≠ A466), F136 (≠ L467), S137 (≠ P468)

Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see paper)
33% identity, 40% coverage: 350:585/587 of query aligns to 1398:1645/1704 of Q8R420

query
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Q8R420

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Sites not aligning to the query:

292 E→V: Knockin new born mice are healthy and survive into adulthood without overt signs of respiratory distress. Knockin mice show a severe lung phenotype that begins with alveolar inflammatory cell infiltration at the early stage of the mouse life followed by aberrant lung remodeling with characteristics of diffuse parenchymal lung disease (DPLD)- and emphysema-like alveolar disruption in older mice.

Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see paper)
38% identity, 35% coverage: 21:224/587 of query aligns to 3821:4025/5034 of Q5SSE9

query
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Q5SSE9

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K3849 (= K49) mutation to M: Does not affect intracellular vesicle localization. Affects cholesterol internalization.
T3999 (= T198) mutation to A: Does not affect protein expression. Affects intracellular vesicles localization. Impairs intracellular cholesterol accumulation in the vesicle.

Sites not aligning to the query:

3577 H→P: Does not affect protein expression. Decreases intracellular cholesterol accumulation in the vesicle.
4735 K→M: Does not affect intracellular vesicle localization.Affects cholesterol internalization.
4818 R→C: Does not affect protein expression. Decreases intracellular cholesterol accumulation in the vesicle.

7e7oA Cryo-em structure of human abca4 in nrpe-bound state (see paper)
40% identity, 35% coverage: 19:224/587 of query aligns to 818:1023/2003 of 7e7oA

query
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7e7oA

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Sites not aligning to the query:

binding [(2S)-3-[2-[(E)-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenylidene]amino]ethoxy-oxidanyl-phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxy-propyl] (Z)-octadec-9-enoate: 285, 290, 526, 527, 588, 589, 592, 593, 1327, 1454

8ee6A Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
35% identity, 38% coverage: 335:557/587 of query aligns to 1497:1722/1808 of 8ee6A

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8ee6A

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binding phosphothiophosphoric acid-adenylate ester: Y1507 (vs. gap), A1514 (= A350), G1535 (= G371), A1536 (= A372), G1537 (= G373), K1538 (= K374), T1539 (≠ S375), S1540 (≠ T376), Q1579 (= Q415)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 607, 608, 633, 636, 640, 660, 661, 662, 663, 664, 665, 666

E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
37% identity, 39% coverage: 3:229/587 of query aligns to 1341:1566/2595 of E9Q876

query
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E9Q876

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E

1388:1461 (vs. 53:124, 27% identical) mutation to M: In a mouse model for harlequin ichthyosis (HI), smooth skin (smsk) mutant mice show a pronounced perinatal lethal skin phenotype in 25% of the offspring and newborn mutant pups die within a few hours after birth, and appear severely dehydrated with dry cracking skin. Smsk homozygous mutants embryos show a normal appearance at 14.5 dpc, but at 16.5 dpc develop a partial absence of normal skin folds around the trunk and limbs, and by 18.5 dpc develop a taut, thick skin and limb contractures.

Sites not aligning to the query:

1996 G→D: In a mouse model for harlequin ichthyosis (HI), homozygous mice are embryonic lethal but occasionally pups are found in the first few hours after birth but die and are severely dehydrated and fail to suckle normally. Homozygous pups show hallmarks of HI desease including hyperkeratosis, abnormal extracellular lipid lamellae and defects in cornified envelope processing. At 14.5 dpc and 15.5 dpc homozygous embryos appear normal; however from 16.5 dpc onwards they are characterized by an absence of normal skin folds around the trunk and limbs. As development progressed, embryos develop a taut, thick epidermis and multiple contractures affecting the limbs. Late stage embryos are smaller.

7lkpA Structure of atp-free human abca4 (see paper)
34% identity, 43% coverage: 22:276/587 of query aligns to 745:1002/1941 of 7lkpA

query
sites
7lkpA

E

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binding Digitonin: H819 (≠ E96), Q863 (≠ G140)

Sites not aligning to the query:

binding Digitonin: 518, 519, 522, 526, 530, 533, 534, 612, 613, 616, 617, 1493, 1496
binding cholesterol: 9, 10, 13, 21, 29, 560, 617, 621, 1066, 1070, 1072, 1073, 1074, 1076, 1402, 1433, 1433, 1436, 1436, 1483, 1486, 1487, 1491, 1492, 1493, 1495, 1496, 1496, 1499, 1500, 1595, 1599, 1603

8eopA Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
34% identity, 37% coverage: 335:553/587 of query aligns to 1451:1672/1687 of 8eopA

query
sites
8eopA

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binding adenosine-5'-triphosphate: Y1461 (vs. gap), A1468 (= A350), N1488 (= N370), G1489 (= G371), G1491 (= G373), K1492 (= K374), T1493 (≠ S375), S1494 (≠ T376), Q1533 (= Q415), Y1577 (= Y459), T1584 (≠ A466), S1586 (≠ P468), Q1610 (≠ E492)
binding magnesium ion: T1493 (≠ S375), Q1533 (= Q415)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 659, 662, 666, 686, 687, 689, 690, 691, 692, 731, 782, 784, 787, 839

P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 41 papers)
40% identity, 34% coverage: 25:224/587 of query aligns to 945:1144/2273 of P78363

query
sites
P78363

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