SitesBLAST

P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
22% identity, 59% coverage: 1:213/364 of query aligns to 71:282/496 of P39976

query
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P39976

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Sites not aligning to the query:

17 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
31% identity, 35% coverage: 45:173/364 of query aligns to 93:213/459 of P9WIT1

query
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P9WIT1

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Sites not aligning to the query:

354 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
25% identity, 48% coverage: 1:176/364 of query aligns to 103:277/521 of Q8N465

query
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Q8N465

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S109 (≠ I7) to W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
N127 (vs. gap) to K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
G131 (= G26) to V: in D2HGA1; uncertain significance; complete loss of catalytic activity
I147 (≠ V39) to S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
M153 (≠ F45) to T: in D2HGA1; uncertain significance; significant loss of catalytic activity; to V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
C172 (≠ T64) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
P189 (≠ A81) to L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
A205 (= A104) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
A231 (≠ G130) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
G233 (= G132) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734

Sites not aligning to the query:

15 R → G: in dbSNP:rs4675887
169:521 natural variant: Missing (in D2HGA1; uncertain significance)
375 D → Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
386 binding ; binding ; binding ; R→A: Loss of catalytic activity.
390 binding ; binding ; T→A: Significantly reduced catalytic activity.
399 V → M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
401 binding ; binding ; K→A: Loss of catalytic activity.
419 R → H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
426 A → T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
434 binding ; H→A: Loss of catalytic activity.
436 G → V: slight reduction in catalytic activity
439 N → D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
441 binding ; H→A: Loss of catalytic activity.
443 binding ; N→A: Significantly reduced catalytic activity.
444 V → A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
446 A → V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
475 binding ; E→A: Loss of catalytic activity.
476 binding ; binding ; binding ; H→A: Loss of catalytic activity.
477 G → R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640

6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
25% identity, 48% coverage: 1:176/364 of query aligns to 51:225/467 of 6lpnB

query
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6lpnB

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binding flavin-adenine dinucleotide: P76 (vs. gap), G78 (= G25), G79 (= G26), N80 (≠ S27), T81 (≠ K28), G82 (≠ D29), M83 (≠ A30), G86 (≠ A33), S87 (≠ P34), L140 (= L91), A142 (≠ N93), C146 (≠ A97), H147 (≠ T98), G150 (= G101), N151 (≠ V102), A153 (= A104), T154 (≠ A105), G208 (= G159), I212 (≠ A163), I213 (≠ L164)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 40, 423, 460

6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
25% identity, 48% coverage: 1:176/364 of query aligns to 50:224/466 of 6lpxA

query
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binding flavin-adenine dinucleotide: P75 (vs. gap), Q76 (≠ G24), G77 (= G25), G78 (= G26), N79 (≠ S27), T80 (≠ K28), G81 (≠ D29), M82 (≠ A30), G85 (≠ A33), S86 (≠ P34), L139 (= L91), G140 (= G92), A141 (≠ N93), C145 (≠ A97), G149 (= G101), N150 (≠ V102), A152 (= A104), T153 (≠ A105), G157 (= G109), G207 (= G159), I212 (≠ L164)

Sites not aligning to the query:

binding 2-oxoglutaric acid: 333, 337, 348, 379, 381, 388, 423
binding flavin-adenine dinucleotide: 39, 422, 459
binding zinc ion: 381, 388, 422

6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
25% identity, 48% coverage: 1:176/364 of query aligns to 50:224/466 of 6lpuA

query
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6lpuA

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F

M

I

L

M

A

P

F

L

D

D

P

-

F

-

D

-

H

-

G

-

A

-

M

-

L
|
L

G
|
G

N
x
A

D

K

G

G

G

S

A
x
C

T
x
H

I

I

G
|
G

V
x
N

V

V

A
|
A

A
x
T

G

N

V
x
A

A

G

G

G

P

L

A

R

R

F

L

L

S

R

R

Y

G

G

G

S

A

L

R

H

D

G

H

T

L

V

L

L

G

G

F

L

T

E

A

V

V

V

S

L

G

A

R

D

G

G

E

T

R

V

F

L

V

D

A

C

G

L

A

T

K

S

V

L

V

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

P

K

K

Q

L

L

M

F

A

I

G

G

S

S

W
x
E

G
|
G

R

T

L

L

A

G

A
x
I

L
x
I

T

T

E

T

V

V

T

S

L

I

K

L

V

C

L

P

P

P

A

K

P

P

R

R

binding flavin-adenine dinucleotide: P75 (vs. gap), G77 (= G25), G78 (= G26), N79 (≠ S27), T80 (≠ K28), G81 (≠ D29), G85 (≠ A33), S86 (≠ P34), L139 (= L91), G140 (= G92), A141 (≠ N93), C145 (≠ A97), H146 (≠ T98), G148 (= G100), G149 (= G101), N150 (≠ V102), A152 (= A104), T153 (≠ A105), A155 (≠ V107), E206 (≠ W158), G207 (= G159), I211 (≠ A163), I212 (≠ L164)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 422, 459
binding (2s)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 423
binding zinc ion: 381, 388, 422

6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal) (see paper)
25% identity, 48% coverage: 1:176/364 of query aligns to 50:224/466 of 6lpqA

query
sites
6lpqA

M

L

L

L

R

R

P

P

A

R

N

T

I

S

G

E

E

E

L

V

C

S

E

H

V

I

I

L

A

R

T

H

G

C

G

H

K

E

L

R

R

N

L

L

R

A

-

V

-

N

-
x
P

G

Q

G
|
G

S
x
N

K
x
T

D
x
G

A
x
M

I

V

G

G

A
x
G

P
x
S

C

V

-

P

-

V

-

F

D

D

A

E

Q

I

V

I

V

L

D

S

M

T

R

A

G

R

F

M

S

N

G

R

I

V

V

L

D

S

Y

F

D

H

P

S

P

V

E

S

L

G

V

I

L

L

T

V

V

C

G

Q

A

A

G

G

T

C

P

V

L

L

A

E

Q

E

I

L

E

S

A

R

L

Y

V

V

V

E

G

E

E

R

G

D

Q

F

M

I

L

M

A

P

F

L

D

D

P

-

F

-

D

-

H

-

G

-

A

-

M

-

L
|
L

G
|
G

N
x
A

D

K

G

G

G

S

A
x
C

T
x
H

I

I

G

G

G
|
G

V
x
N

V

V

A
|
A

A
x
T

G

N

V
x
A

A

G

G
|
G

P

L

A

R

R

F

L

L

S

R

R

Y

G

G

G

S

A

L

R

H

D

G

H

T

L

V

L

L

G

G

F

L

T

E

A

V

V

V

S

L

G

A

R

D

G

G

E

T

R

V

F

L

V

D

A

C

G

L

A

T

K

S

V

L

V

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

P

K

K

Q

L

L

M

F

A

I

G

G

S

S

W
x
E

G
|
G

R

T

L

L

A

G

A
x
I

L
x
I

T

T

E

T

V

V

T

S

L

I

K

L

V

C

L

P

P

P

A

K

P

P

R

R

binding flavin-adenine dinucleotide: P75 (vs. gap), G77 (= G25), G78 (= G26), N79 (≠ S27), T80 (≠ K28), G81 (≠ D29), G85 (≠ A33), S86 (≠ P34), L139 (= L91), G140 (= G92), A141 (≠ N93), C145 (≠ A97), H146 (≠ T98), G149 (= G101), N150 (≠ V102), A152 (= A104), T153 (≠ A105), A155 (≠ V107), G157 (= G109), E206 (≠ W158), G207 (= G159), I211 (≠ A163), I212 (≠ L164)
binding d-malate: M82 (≠ A30)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 422, 459
binding d-malate: 333, 337, 348, 379, 381, 388, 422, 423
binding zinc ion: 381, 388, 422

6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg) (see paper)
25% identity, 48% coverage: 1:176/364 of query aligns to 50:224/466 of 6lppA

query
sites
6lppA

M

L

L

L

R

R

P

P

A

R

N

T

I

S

G

E

E

E

L

V

C

S

E

H

V

I

I

L

A

R

T

H

G

C

G

H

K

E

L

R

R

N

L

L

R

A

-

V

-

N

-
x
P

G

Q

G
|
G

S
x
N

K
x
T

D
x
G

A
x
M

I

V

G

G

A
x
G

P
x
S

C

V

-

P

-

V

-

F

D

D

A

E

Q

I

V

I

V

L

D

S

M

T

R

A

G

R

F

M

S

N

G

R

I

V

V

L

D

S

Y

F

D

H

P

S

P

V

E

S

L

G

V

I

L

L

T

V

V

C

G

Q

A

A

G

G

T

C

P

V

L

L

A

E

Q

E

I

L

E

S

A

R

L

Y

V

V

V

E

G

E

E

R

G

D

Q

F

M

I

L

M

A

P

F

L

D

D

P

-

F

-

D

-

H

-

G

-

A

-

M

-

L
|
L

G
|
G

N
x
A

D

K

G

G

G

S

A
x
C

T

H

I

I

G

G

G
|
G

V
x
N

V

V

A
|
A

A
x
T

G

N

V
x
A

A

G

G
|
G

P

L

A

R

R

F

L

L

S

R

R

Y

G

G

G

S

A

L

R

H

D

G

H

T

L

V

L

L

G

G

F

L

T

E

A

V

V

V

S

L

G

A

R

D

G

G

E

T

R

V

F

L

V

D

A

C

G

L

A

T

K

S

V

L

V

R

K

K

N

D

V

N

T

T

G

G

Y

Y

D

D

L

L

P

K

K

Q

L

L

M

F

A

I

G

G

S

S

W

E

G
|
G

R

T

L

L

A

G

A

I

L
x
I

T

T

E

T

V

V

T

S

L

I

K

L

V

C

L

P

P

P

A

K

P

P

R

R

binding flavin-adenine dinucleotide: P75 (vs. gap), G77 (= G25), G78 (= G26), N79 (≠ S27), T80 (≠ K28), G81 (≠ D29), M82 (≠ A30), G85 (≠ A33), S86 (≠ P34), L139 (= L91), G140 (= G92), A141 (≠ N93), C145 (≠ A97), G149 (= G101), N150 (≠ V102), A152 (= A104), T153 (≠ A105), A155 (≠ V107), G157 (= G109), G207 (= G159), I212 (≠ L164)

Sites not aligning to the query:

binding (2R)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 390, 423
binding flavin-adenine dinucleotide: 39, 422, 423
binding zinc ion: 381, 388, 422

4bc7B Mammalian alkyldihydroxyacetonephosphate synthase: arg419his mutant (see paper)
25% identity, 60% coverage: 24:242/364 of query aligns to 142:358/543 of 4bc7B

query
sites
4bc7B

G
|
G

S
x
T

K
x
S

D
x
V

A

S

I

Y

G
|
G

A
x
L

P

M

C

C

D

P

A

A

Q

D

V

E

V

T

D

-

M

-

R

-

G

-

F

-

S

R

G

T

I

I

V

I

D

S

Y

L

D

D

P

T

P

S

E

Q

L

M

-

N

-

R

V

I

L

L

T

W

V

V

G

D

A

E

G

N

T

N

P

L

L

T

A

A

Q

H

I

V

E

E

A

A

L

G

V

I

V

T

G

G

E

-

G

-

Q

Q

M

E

L

L

A

E

F

R

D

Q

P

L

F

K

D

E

H

S

G

G

A

Y

M

C

L

T

G

G

N

H

D

E

-
x
P

-
x
D

-
x
S

-

L

G

E

G

F

A
x
S

T
|
T

I

V

G

G

G
|
G

V

W

V

I

A
x
S

A
x
T

G

R

V
x
A

A
x
S

G

G

P

M

A

K

R

K

L

N

S

I

R

Y

G

G

G

N

A

I

R

E

D

D

H

L

L

V

G

H

F

M

T

K

A

V

V

V

S

T

G

P

R

R

G

G

-

V

-

I

E

E

R

K

F

S

V

C

A

Q

G

G

A

P

K

R

V

M

V

S

K

-

N

-

V

-

T

T

G

G

Y

P

D

D

L

I

P

H

K

H

L

F

M

I

A

M

G

G

S

S

W
x
E

G
|
G

R

T

L

L

A

G

A

V

L
x
I

T

T

E

E

V

A

T

T

L

I

K

K

V

I

L

R

P

P

A

T

P

P

R

E

T

Y

R

Q

L

K

T

Y

L

G

A

S

M

V

R

A

G

F

L

P

D

N

A

F

A

E

G

Q

A

G

V

V

A

A

A

C

M

L

A

-

R

R

A

E

L

I

G

A

S

K

A

Q

A

R

E

C

V

A

T

P

A

A

A

S

A

I

H

H

L

L

P

M

D

D

W

N

R

Q

G

Q

E

F

A

Q

V

F

-

G

T

H

A

A

L

L

R

K

L

P

D

Q

G

G

F

F

A

D

E

P

S

N

V

Q

A

L

A

S

R

V

A

A

A

T

M

L

L

L

P

F

E

E

F

G

D

D

binding flavin-adenine dinucleotide: G142 (= G24), G143 (= G25), G144 (= G26), T145 (≠ S27), S146 (≠ K28), V147 (≠ D29), G150 (= G32), L151 (≠ A33), P208 (vs. gap), D209 (vs. gap), S210 (vs. gap), S214 (≠ A97), T215 (= T98), G218 (= G101), S221 (≠ A104), T222 (≠ A105), A224 (≠ V107), S225 (≠ A108), E274 (≠ W158), G275 (= G159), I280 (≠ L164)

Sites not aligning to the query:

Query Sequence

>Ga0059261_2632 FitnessBrowser__Korea:Ga0059261_2632
MLRPANIGELCEVIATGGKLRLRGGGSKDAIGAPCDAQVVDMRGFSGIVDYDPPELVLTV
GAGTPLAQIEALVVGEGQMLAFDPFDHGAMLGNDGGATIGGVVAAGVAGPARLSRGGARD
HLLGFTAVSGRGERFVAGAKVVKNVTGYDLPKLMAGSWGRLAALTEVTLKVLPAPRTRLT
LAMRGLDAAGAVAAMARALGSAAEVTAAAHLPDWRGEAVTALRLDGFAESVAARAAMLPE
FDAIEDADALWRAVRDASPLPREWPLWRLIVAPGKAPGVIAALPDAQWLLDWAGGLIWLT
SDAGPVAIRTAAEAAGGHATLWRASEAMRRAVPALHPQPGALAAIEARVRRAFDPGGVFE
TGRF

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory