Comparing Ga0059261_3125 FitnessBrowser__Korea:Ga0059261_3125 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P60664 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Escherichia coli (strain K12) (see paper)
35% identity, 88% coverage: 1:230/260 of query aligns to 1:234/258 of P60664
1gpwC Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. (see paper)
35% identity, 80% coverage: 1:209/260 of query aligns to 1:207/253 of 1gpwC
Sites not aligning to the query:
7ac8A Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. (see paper)
35% identity, 80% coverage: 1:209/260 of query aligns to 1:207/252 of 7ac8A
Sites not aligning to the query:
Q9X0C6 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
35% identity, 80% coverage: 1:209/260 of query aligns to 1:207/253 of Q9X0C6
3zr4E Structural evidence for ammonia tunneling across the (beta-alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex (see paper)
34% identity, 80% coverage: 1:209/260 of query aligns to 1:198/244 of 3zr4E
Sites not aligning to the query:
1h5yB Hisf protein from pyrobaculum aerophilum (see paper)
38% identity, 78% coverage: 5:207/260 of query aligns to 6:208/253 of 1h5yB
Sites not aligning to the query:
7qc8A Imidazole glycerol phosphate synthase subunit HisF (see paper)
34% identity, 80% coverage: 2:209/260 of query aligns to 2:207/250 of 7qc8A
2wjzE Crystal structure of (hish) k181a y138a mutant of imidazoleglycerolphosphate synthase (hish hisf) which displays constitutive glutaminase activity (see paper)
33% identity, 80% coverage: 1:209/260 of query aligns to 1:193/237 of 2wjzE
5d2tA Directed evolutionary changes in kemp eliminase ke07 - crystal 3 wild type
32% identity, 88% coverage: 5:233/260 of query aligns to 3:228/251 of 5d2tA
4ewnD Structure of hisf-d130v+d176v with bound rcdrp (see paper)
33% identity, 80% coverage: 2:209/260 of query aligns to 1:200/243 of 4ewnD
Sites not aligning to the query:
6dnjA Directed evolutionary changes in kemp eliminase ke07 - crystal 28 round 5 (see paper)
32% identity, 89% coverage: 2:233/260 of query aligns to 1:229/250 of 6dnjA
3iivB Evolutionary optimization of computationally designed enzymes: kemp eliminases of the ke07 series (see paper)
32% identity, 88% coverage: 2:230/260 of query aligns to 2:226/262 of 3iivB
1ox5A Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
27% identity, 83% coverage: 2:218/260 of query aligns to 239:496/532 of 1ox5A
Sites not aligning to the query:
1ox4B Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
28% identity, 83% coverage: 2:218/260 of query aligns to 239:502/538 of 1ox4B
Sites not aligning to the query:
3tdmA Computationally designed tim-barrel protein, halfflr (see paper)
39% identity, 37% coverage: 123:217/260 of query aligns to 1:94/120 of 3tdmA
Sites not aligning to the query:
5ab3A S.Enterica hisa mutant d7n, d10g, dup13-15, q24l, g102a (see paper)
25% identity, 89% coverage: 6:236/260 of query aligns to 2:230/241 of 5ab3A
P33734 Imidazole glycerol phosphate synthase hisHF; IGP synthase; IGPS; ImGP synthase; EC 4.3.2.10; EC 3.5.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
27% identity, 83% coverage: 2:218/260 of query aligns to 236:514/552 of P33734
5dn1A Crystal structure of phosphoribosyl isomerase a from streptomyces coelicolor (see paper)
25% identity, 83% coverage: 1:215/260 of query aligns to 1:208/240 of 5dn1A
P16250 Phosphoribosyl isomerase A; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; EC 5.3.1.16; EC 5.3.1.24 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
25% identity, 83% coverage: 1:215/260 of query aligns to 1:208/240 of P16250
5abtA S.Enterica hisa mutant d7n, g102a, v106m, d176a
26% identity, 89% coverage: 6:236/260 of query aligns to 2:233/246 of 5abtA
>Ga0059261_3125 FitnessBrowser__Korea:Ga0059261_3125
MLRPRIIPCLLIKDGGLVKTVKFGDAKYVGDPINAVRIFNEKQVDELIVANIDATVHGRE
PDYAVIANLAAECRMPLCYSGGVRTAEQVDRIISLGVEKVGISSGAIERPEMISEAARRV
GAQSIVAVMDVKRTGLLKGYELVTHNGTRRTGLKPADWARKAQELGAGEILVNSVDRDGG
MQGYDLDLAQQVRSAVGVPITVLGGAGSLADIEAVLRRFGVIGVSAGSLFVFKGKYRAVL
INYPGGAEKDALFANAMRAT
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Lawrence Berkeley National Laboratory