SitesBLAST
Comparing Ga0059261_3126 FitnessBrowser__Korea:Ga0059261_3126 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1lluA The ternary complex of pseudomonas aeruginosa alcohol dehydrogenase with its coenzyme and weak substrate (see paper)
34% identity, 29% coverage: 66:268/707 of query aligns to 32:267/341 of 1lluA
- active site: C43 (≠ K77), H44 (≠ P78), T45 (= T79), H48 (≠ E81), H66 (≠ Y95), E67 (≠ C96), C97 (vs. gap), C100 (vs. gap), C103 (vs. gap), C111 (vs. gap), Q115 (vs. gap), C153 (≠ V150), T157 (≠ I154)
- binding 1,2-ethanediol: H44 (≠ P78), T45 (= T79), L47 (≠ I80), D53 (≠ K86), W92 (vs. gap), C153 (≠ V150)
- binding nicotinamide-adenine-dinucleotide: C43 (≠ K77), H44 (≠ P78), T45 (= T79), H48 (≠ E81), C153 (≠ V150), T157 (≠ I154), G179 (= G176), G180 (≠ L177), L181 (≠ I178), D200 (= D197), I201 (≠ F198), K205 (= K202), A243 (= A242), V244 (≠ A243), S245 (≠ T244), A248 (≠ S247), V265 (= V266), L267 (≠ V268)
- binding zinc ion: C43 (≠ K77), H66 (≠ Y95), C100 (vs. gap), C103 (vs. gap), C111 (vs. gap), C153 (≠ V150)
Sites not aligning to the query:
3s2fE Crystal structure of furx nadh:furfural
29% identity, 36% coverage: 14:268/707 of query aligns to 16:264/340 of 3s2fE
- active site: C40 (≠ E42), H41 (≠ R43), T42 (≠ M44), H45 (≠ D47), H63 (≠ Y95), E64 (≠ C96), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), Q112 (vs. gap), C150 (≠ V150), T154 (≠ I154)
- binding furfural: T42 (≠ M44), W51 (= W53), H63 (≠ Y95), W89 (vs. gap), C150 (≠ V150)
- binding nicotinamide-adenine-dinucleotide: C40 (≠ E42), H41 (≠ R43), T42 (≠ M44), C150 (≠ V150), T154 (≠ I154), G174 (= G174), G176 (= G176), G177 (≠ L177), L178 (≠ I178), D197 (= D197), I198 (≠ F198), K202 (= K202), T239 (= T241), A240 (= A242), V241 (≠ A243), N262 (≠ V266), G263 (= G267), L264 (≠ V268)
- binding zinc ion: C40 (≠ E42), H63 (≠ Y95), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), C150 (≠ V150)
Sites not aligning to the query:
3s2fA Crystal structure of furx nadh:furfural
29% identity, 36% coverage: 14:268/707 of query aligns to 16:264/340 of 3s2fA
- active site: C40 (≠ E42), H41 (≠ R43), T42 (≠ M44), H45 (≠ D47), H63 (≠ Y95), E64 (≠ C96), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), Q112 (vs. gap), C150 (≠ V150), T154 (≠ I154)
- binding phosphorylisopropane: T42 (≠ M44), H63 (≠ Y95), W89 (vs. gap)
- binding zinc ion: C40 (≠ E42), H63 (≠ Y95), E64 (≠ C96), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), C150 (≠ V150)
Sites not aligning to the query:
3s2eE Crystal structure of furx nadh complex 1
29% identity, 36% coverage: 14:268/707 of query aligns to 16:264/340 of 3s2eE
- active site: C40 (≠ E42), H41 (≠ R43), T42 (≠ M44), H45 (≠ D47), H63 (≠ Y95), E64 (≠ C96), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), Q112 (vs. gap), C150 (≠ V150), T154 (≠ I154)
- binding nicotinamide-adenine-dinucleotide: C40 (≠ E42), H41 (≠ R43), T42 (≠ M44), C150 (≠ V150), T154 (≠ I154), G176 (= G176), G177 (≠ L177), L178 (≠ I178), D197 (= D197), I198 (≠ F198), K202 (= K202), T239 (= T241), A240 (= A242), V241 (≠ A243), S242 (= S246), A245 (≠ P249), N262 (≠ V266), G263 (= G267), L264 (≠ V268)
- binding zinc ion: C40 (≠ E42), H63 (≠ Y95), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), C150 (≠ V150)
Sites not aligning to the query:
3s2eA Crystal structure of furx nadh complex 1
29% identity, 36% coverage: 14:268/707 of query aligns to 16:264/340 of 3s2eA
- active site: C40 (≠ E42), H41 (≠ R43), T42 (≠ M44), H45 (≠ D47), H63 (≠ Y95), E64 (≠ C96), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), Q112 (vs. gap), C150 (≠ V150), T154 (≠ I154)
- binding zinc ion: C40 (≠ E42), H63 (≠ Y95), E64 (≠ C96), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), C150 (≠ V150)
Sites not aligning to the query:
P12311 Alcohol dehydrogenase; ADH-T; EC 1.1.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
29% identity, 26% coverage: 90:273/707 of query aligns to 56:267/337 of P12311
Sites not aligning to the query:
- 38 C→S: No activity.
- 40 T→A: No activity.; T→S: Little decrease in activity.
- 43 H→A: No activity.; H→R: Higher level of activity at pH 9.
1rjwA Crystal structure of NAD(+)-dependent alcohol dehydrogenase from bacillus stearothermophilus strain lld-r (see paper)
29% identity, 27% coverage: 90:278/707 of query aligns to 56:272/339 of 1rjwA
- active site: H61 (≠ Y95), E62 (≠ C96), C92 (vs. gap), C95 (vs. gap), C98 (vs. gap), C106 (vs. gap), K110 (vs. gap), C148 (≠ V150), T152 (≠ I154)
- binding trifluoroethanol: C148 (≠ V150)
- binding zinc ion: H61 (≠ Y95), C92 (vs. gap), C95 (vs. gap), C98 (vs. gap), C106 (vs. gap)
Sites not aligning to the query:
4z6kA Alcohol dehydrogenase from the antarctic psychrophile moraxella sp. Tae 123
28% identity, 32% coverage: 44:268/707 of query aligns to 5:262/345 of 4z6kA
- active site: C38 (≠ K77), H39 (≠ P78), T40 (= T79), H43 (≠ E81), H61 (≠ Y95), E62 (≠ C96), C92 (vs. gap), C95 (vs. gap), C98 (vs. gap), C106 (vs. gap), Q110 (vs. gap), C148 (≠ V150), T152 (≠ I154)
- binding zinc ion: C38 (≠ K77), H61 (≠ Y95), C92 (vs. gap), C95 (vs. gap), C98 (vs. gap), C106 (vs. gap), C148 (≠ V150)
Sites not aligning to the query:
5vm2A Crystal structure of eck1772, an oxidoreductase/dehydrogenase of unknown specificity involved in membrane biogenesis from escherichia coli
26% identity, 33% coverage: 121:351/707 of query aligns to 123:328/347 of 5vm2A
Sites not aligning to the query:
- active site: 39, 40, 41, 44, 65, 66, 95, 98, 101, 109, 113, 340
- binding magnesium ion: 65, 66
- binding zinc ion: 95, 98, 101, 109
Q8GIX7 Alcohol dehydrogenase; ADH; EC 1.1.1.1 from Moraxella sp. (strain TAE123) (see paper)
28% identity, 32% coverage: 44:268/707 of query aligns to 5:262/338 of Q8GIX7
- C38 (≠ K77) binding
- H61 (≠ Y95) binding
- E62 (≠ C96) binding
- C92 (vs. gap) binding
- C95 (vs. gap) binding
- C98 (vs. gap) binding
- C106 (vs. gap) binding
- C148 (≠ V150) binding
3piiA Crystal structure of mutant of ht- alcohol dehydrogenase with substrate analogue butyramide
29% identity, 27% coverage: 90:278/707 of query aligns to 56:272/337 of 3piiA
- active site: H61 (≠ Y95), E62 (≠ C96), C92 (vs. gap), C95 (vs. gap), C98 (vs. gap), C106 (vs. gap), K110 (vs. gap), C148 (≠ V150), T152 (≠ I154)
- binding butyramide: H61 (≠ Y95), W87 (vs. gap), C148 (≠ V150)
- binding zinc ion: H61 (≠ Y95), E62 (≠ C96), C92 (vs. gap), C95 (vs. gap), C98 (vs. gap), C106 (vs. gap), C148 (≠ V150)
Sites not aligning to the query:
Q00796 Sorbitol dehydrogenase; SDH; (R,R)-butanediol dehydrogenase; L-iditol 2-dehydrogenase; Polyol dehydrogenase; Ribitol dehydrogenase; RDH; Xylitol dehydrogenase; XDH; EC 1.1.1.-; EC 1.1.1.4; EC 1.1.1.14; EC 1.1.1.56; EC 1.1.1.9 from Homo sapiens (Human) (see 10 papers)
22% identity, 49% coverage: 11:357/707 of query aligns to 18:341/357 of Q00796
- C45 (≠ A39) binding
- H70 (≠ Y95) binding
- E71 (≠ C96) binding
- R110 (≠ E125) to P: in SORDD; results in protein aggregation
- H135 (vs. gap) to R: in SORDD; results in protein aggregation
- A153 (≠ S147) to D: in SORDD; uncertain significance; results in protein aggregation; dbSNP:rs145813597
- I184 (= I178) binding
- D204 (= D197) binding
- R209 (≠ K202) binding
- Q239 (≠ G232) to L: in dbSNP:rs1042079
- N269 (≠ R262) to T: in dbSNP:rs930337
- VGL 273:275 (≠ VGV 266:268) binding
- VFR 297:299 (≠ PGR 293:295) binding
- V322 (≠ I338) to I: in SORDD; uncertain significance; dbSNP:rs149975952
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
1pl6A Human sdh/nadh/inhibitor complex (see paper)
22% identity, 49% coverage: 11:357/707 of query aligns to 17:340/356 of 1pl6A
- active site: C44 (≠ A39), G45 (= G40), S46 (≠ T41), H49 (≠ M44), H69 (≠ Y95), E70 (≠ C96), R99 (vs. gap), D102 (vs. gap), C105 (≠ G121), S113 (≠ V129), F117 (vs. gap), P156 (≠ L151), G160 (≠ A155)
- binding 4-[2-(hydroxymethyl)pyrimidin-4-yl]-n,n-dimethylpiperazine-1-sulfonamide: C44 (≠ A39), S46 (≠ T41), I56 (vs. gap), F59 (≠ W53), H69 (≠ Y95), E155 (≠ V150), L274 (≠ V268), F297 (≠ G294)
- binding nicotinamide-adenine-dinucleotide: G181 (= G176), P182 (≠ L177), I183 (= I178), D203 (= D197), L204 (≠ F198), R208 (≠ K202), C249 (≠ A243), T250 (= T244), V272 (= V266), G273 (= G267), L274 (≠ V268), F297 (≠ G294), R298 (= R295)
- binding zinc ion: C44 (≠ A39), H69 (≠ Y95)
Sites not aligning to the query:
3meqA Crystal structure of alcohol dehydrogenase from brucella melitensis
30% identity, 26% coverage: 86:268/707 of query aligns to 54:266/341 of 3meqA
- active site: H63 (≠ Y95), E64 (≠ C96), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), L112 (vs. gap), C150 (≠ V150), T154 (≠ I154)
- binding 1,4-dihydronicotinamide adenine dinucleotide: C150 (≠ V150), T154 (≠ I154), G176 (= G176), G177 (≠ L177), L178 (≠ I178), D197 (= D197), I198 (≠ F198), K202 (= K202), T241 (= T241), A242 (= A242), V243 (≠ A243), S244 (= S246), A247 (≠ P249), N264 (≠ V266), G265 (= G267), L266 (≠ V268)
- binding zinc ion: H63 (≠ Y95), C94 (vs. gap), C97 (vs. gap), C100 (vs. gap), C108 (vs. gap), C150 (≠ V150)
Sites not aligning to the query:
- active site: 40, 41, 42, 45, 335
- binding 1,4-dihydronicotinamide adenine dinucleotide: 40, 41, 42, 45, 289, 290
- binding zinc ion: 40
6z42A The low resolution structure of a zinc-dependent alcohol dehydrogenase from halomonas elongata.
26% identity, 36% coverage: 17:268/707 of query aligns to 20:262/336 of 6z42A
- active site: C41 (≠ E42), T43 (≠ M44), H46 (≠ D47), H64 (≠ Y95), C148 (≠ V150)
- binding zinc ion: C41 (≠ E42), H64 (≠ Y95), E65 (≠ C96), C95 (≠ A118), C98 (≠ G121), C101 (≠ A124), C109 (vs. gap), C148 (≠ V150)
6iqdA Crystal structure of alcohol dehydrogenase from geobacillus stearothermophilus (see paper)
26% identity, 32% coverage: 47:273/707 of query aligns to 8:267/336 of 6iqdA
- active site: C38 (≠ K77), T40 (= T79), H43 (≠ E81), H61 (≠ Y95), C148 (≠ V150)
- binding zinc ion: C38 (≠ K77), H61 (≠ Y95), E62 (≠ C96), C92 (vs. gap), C95 (vs. gap), C98 (vs. gap), C106 (vs. gap), C148 (≠ V150)
2eerB Structural study of project id st2577 from sulfolobus tokodaii strain7
26% identity, 33% coverage: 45:274/707 of query aligns to 6:278/347 of 2eerB
- active site: C38 (≠ K77), H39 (≠ P78), S40 (≠ T79), H43 (vs. gap), H68 (≠ Y95), E69 (≠ C96), E98 (vs. gap), C101 (vs. gap), C104 (vs. gap), C112 (vs. gap), R116 (vs. gap), C154 (≠ V150), T158 (≠ I154)
- binding nicotinamide-adenine-dinucleotide: C38 (≠ K77), H39 (≠ P78), S40 (≠ T79), H43 (vs. gap), C154 (≠ V150), T158 (≠ I154), G178 (= G174), G181 (≠ L177), G182 (vs. gap), L183 (≠ I178), D203 (= D197), V204 (≠ F198), R205 (≠ D199), L247 (≠ T241), N248 (≠ A242), V270 (= V266), G271 (= G267), L272 (≠ V268), F273 (≠ T269)
- binding zinc ion: E98 (vs. gap), C101 (vs. gap), C104 (vs. gap), C112 (vs. gap)
Sites not aligning to the query:
2dfvA Hyperthermophilic threonine dehydrogenase from pyrococcus horikoshii (see paper)
23% identity, 49% coverage: 14:358/707 of query aligns to 16:337/346 of 2dfvA
- active site: C40 (≠ A39), G41 (= G40), T42 (= T41), H45 (≠ G49), H65 (≠ Y95), E66 (≠ C96), C95 (vs. gap), C98 (vs. gap), C101 (vs. gap), C109 (vs. gap), K113 (vs. gap), P151 (≠ L151), A155 (= A155)
- binding nicotinamide-adenine-dinucleotide: G175 (= G176), P176 (≠ L177), L177 (≠ I178), E197 (≠ D199), P198 (= P200), R202 (vs. gap), F241 (≠ A243), S242 (≠ T244), A244 (≠ S246), L264 (≠ V266), G265 (= G267), L266 (≠ V268), I289 (vs. gap), T290 (≠ P293)
- binding zinc ion: C95 (vs. gap), C101 (vs. gap), C109 (vs. gap)
Sites not aligning to the query:
O58389 L-threonine 3-dehydrogenase; L-ThrDH; TDH; L-threonine dehydrogenase; EC 1.1.1.103 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 2 papers)
23% identity, 49% coverage: 14:358/707 of query aligns to 18:339/348 of O58389
- C42 (≠ A39) binding
- T44 (= T41) mutation to A: Total loss of enzymatic activity.
- H67 (≠ Y95) binding
- E68 (≠ C96) binding
- C97 (vs. gap) binding
- C100 (vs. gap) binding
- C103 (vs. gap) binding
- C111 (vs. gap) binding
- E152 (≠ V150) mutation E->A,Q: Almost complete loss of enzymatic activity.; mutation to C: 120-fold decrease in catalytic efficiency.; mutation to D: Shows 3-fold higher turnover rate and reduced affinities toward L-threonine and NAD(+), compared to wild-type.; mutation to K: Total loss of enzymatic activity.
- L179 (≠ I178) binding
- E199 (≠ D199) binding ; mutation to A: Large decrease in affinity for NAD(+).
- R204 (vs. gap) binding ; mutation to A: Large decrease in affinity for NAD(+).
- LGL 266:268 (≠ VGV 266:268) binding
- IT 291:292 (≠ -P 293) binding
- R294 (= R295) mutation to A: 4000-fold decrease in catalytic efficiency.
7y9pA Xylitol dehydrogenase s96c/s99c/y102c mutant(thermostabilized form) from pichia stipitis (see paper)
25% identity, 40% coverage: 87:368/707 of query aligns to 57:357/357 of 7y9pA
Sites not aligning to the query:
Query Sequence
>Ga0059261_3126 FitnessBrowser__Korea:Ga0059261_3126
VKQVLQNLRSGKTSVVDVPVPQAGRGQLLIRTSHTLISAGTERMLVDFGKANWIDKARQQ
PDKARQVLDKIRTDGLKPTIEAVFNKLDQPLPMGYCNVGRVAEVGAGVTGYAVGDRVASN
GKHAEYALVPLNLSARVPDAVSDEEASFTVLGAIALQGIRLVQPTLGEAIVVSGLGLIGL
ITVQLLRAQGCRVLGIDFDPAKLAMARSMGAEVVDLSAGQDPVAAGIAFSRGRGIDGVIV
TAATKSSEPIHQAAKMSRKRGRIVLVGVTGLELSRADFFEKELTFQVSCSYGPGRYDPNY
EQGGNDYPVGFVRWTEQRNFEAVLDMMASGALDVKPLISHRFAIDDAEGAYGLISGGEPS
LGVLLDYPQDAEAARATTIALKDGAGPGVSGAPSVSFIGSGNYATGMLIPVFKKAGATLD
TIASKEGVTGVHAGRKFGFAATTTDSDSLLAGTSDAVVITTRHNSHGAMVAAALKAGKSV
FVEKPLCLTLAEQAEIETAYAAAGGAARLMVGYNRRFAPQVQKMKVLLAGVTGPKAFVMT
VNAGAIPAEHWTQNSEIGGGRIIGEACHFVDLLRFLAGAPLTGWSRIGMESATADTVSLS
LTFADGSIGTVHYFANGSKAFSKERLEVFAAGRILQLDNFRKLTGFGWPGFSTMKLSRQD
KGQAACAQAFLASLAGGPAPIPVDQIFEINRVCIDLANADTPGGENA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory