SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ga0059261_3619 FitnessBrowser__Korea:Ga0059261_3619 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8a9vA Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with a linear di-adenosine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 8a9vA

query
sites
8a9vA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

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E

M

I

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V

I

A

S

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I

G

G

G

G

D
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D

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G

F

T

M

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Q

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L

F

H

H

M

Q

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Y

L

E

E

E

K

R

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N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I
x
L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
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N

E
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E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
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A

Y
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Y

N

N

L

K

S
|
S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

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E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A
x
H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

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R

I

Y

E

E

I

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D

S

P

A

K

K

R

K

binding ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[8-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy]prop-1-ynyl]-6-azanyl-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-2-azanyl-ethanesulfonamide: D45 (= D44), L49 (= L48), L72 (≠ I71), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162), H220 (≠ A215)

7zzjA Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with a linear di-adenosine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 7zzjA

query
sites
7zzjA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
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D

G
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G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I
x
L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

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V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

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V

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E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
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N

E
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E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

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L

C

V

M

A

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T

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P

P

A

S

G

G

S

T

T
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T

A
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A

Y
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Y

N

N

L

K

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S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

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A

L

M

A

Q

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E

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A

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F

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P

N

R

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W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

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Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A
x
H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

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Y

E

E

I

V

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S

P

A

K

K

R

K

binding (1~{R},23~{R},24~{S},25~{R})-14-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-7-azanyl-24,25-bis(oxidanyl)-26-oxa-2,4,6,9,14,17,21-heptazatetracyclo[21.2.1.0^{2,10}.0^{3,8}]hexacosa-3(8),4,6,9-tetraen-11-yne-16,20-dione: D45 (= D44), G46 (= G45), L72 (≠ I71), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162), H220 (≠ A215)

7zzgA Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with a linear di-adenosine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 7zzgA

query
sites
7zzgA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
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D

G
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G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
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F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

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R

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S

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Y

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P

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M

L

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K

A

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K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
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N

E
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E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

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E

D

V

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T

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N

N

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D

R

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I

I

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E

E

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L

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R

C

G

D

D

G

G

I

L

L

C

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M

A

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P

A

S

G

G

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T
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T

A
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A

Y
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Y

N

N

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S

A

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H

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G

G

P

A

I

L

L

M

P

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L

M

A

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L

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E

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A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A
x
H

D

L

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S

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I

E

L

V

H

R

R

D

D

V

V

A

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Y

E

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A

K

K

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K

binding (1~{R},24~{R},25~{S},26~{R})-14-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-7-azanyl-25,26-bis(oxidanyl)-27-oxa-2,4,6,9,14,17,20,22-octazatetracyclo[22.2.1.0^{2,10}.0^{3,8}]heptacosa-3(8),4,6,9-tetraen-11-yne-16,21-dione: D45 (= D44), G46 (= G45), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162), H220 (≠ A215)

7zzeA Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with a linear di-adenosine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 7zzeA

query
sites
7zzeA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
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N

E
|
E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A
x
S

G

G

S

T

T
|
T

A
|
A

Y
|
Y

N

N

L

K

S
|
S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A
x
H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding (1~{R},25~{R},26~{S},27~{R})-14-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-7-azanyl-26,27-bis(oxidanyl)-28-oxa-2,4,6,9,14,17,21,23-octazatetracyclo[23.2.1.0^{2,10}.0^{3,8}]octacosa-3(8),4,6,9-tetraen-11-yne-16,22-dione: D45 (= D44), G46 (= G45), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), S155 (≠ A154), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162), H220 (≠ A215)

7zzcA Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with a linear di-adenosine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 7zzcA

query
sites
7zzcA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L
|
L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E
|
E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

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E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

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L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

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M

A

S

T

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P

P

A

S

G

G

S

T

T
|
T

A
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A

Y
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Y

N

N

L

K

S
|
S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-[(2-azanylethylsulfonylamino)methyl]-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynyl]amino]ethanoic acid: D45 (= D44), G46 (= G45), L49 (= L48), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162)

7zzaA Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with a linear di-adenosine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 7zzaA

query
sites
7zzaA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L
|
L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E
|
E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y
|
Y

N

N

L

K

S
|
S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-[(3-azanylpropylcarbamoylamino)methyl]-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynyl]amino]ethanoic acid: D45 (= D44), G46 (= G45), L49 (= L48), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162)

6z61A Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with a di-adenosine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6z61A

query
sites
6z61A

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G

G

F

T

M

F

L
|
L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E
|
E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y
|
Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding (2~{R},3~{R},4~{S},5~{R})-2-[6-azanyl-8-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-[6-(2-azanylethylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy]prop-1-ynyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol: D45 (= D44), L49 (= L48), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159)

6rr2A Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rr2A

query
sites
6rr2A

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D

D

G

G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E
|
E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y
|
Y

N

N

L

K

S
|
S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 9-[(2~{S})-oxan-2-yl]purin-6-amine: F74 (= F73), Y75 (≠ L74), N119 (= N116), T158 (= T157), A159 (= A158)
binding 5'-deoxy-5'-methylthioadenosine: N119 (= N116), E120 (= E117), Y160 (= Y159), S163 (= S162)

6rgfA Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with an inhibitor
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rgfA

query
sites
6rgfA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L
|
L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T
x
H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E
|
E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y
|
Y

N

N

L

K

S
|
S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding [(2~{R},3~{R},4~{R},5~{R})-2-[8-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-methyl-amino]prop-1-ynyl]-6-azanyl-purin-9-yl]-5-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl] dihydrogen phosphate: D45 (= D44), G46 (= G45), L49 (= L48), H71 (≠ T70), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162)

6rgbA Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an inhibitor (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rgbA

query
sites
6rgbA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L
|
L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E
|
E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y
|
Y

N

N

L

K

S
|
S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynylamino]methyl]oxolane-3,4-diol: D45 (= D44), G46 (= G45), L49 (= L48), F74 (= F73), Y75 (≠ L74), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162)

6rc5A Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rc5A

query
sites
6rc5A

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L
|
L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L

Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y

Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 9-ethyl-8-ethynyl-purin-6-amine: D45 (= D44), G46 (= G45), L49 (= L48), F74 (= F73), N119 (= N116), T158 (= T157), A159 (= A158)

6rc4A Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rc4A

query
sites
6rc4A

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G

G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y

Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 2-(6-azanyl-8-methyl-purin-9-yl)ethanol: D45 (= D44), F74 (= F73), Y75 (≠ L74), N119 (= N116), T158 (= T157), A159 (= A158)

6rc2A Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rc2A

query
sites
6rc2A

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G

G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y

Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 8-methyl-9-pent-4-ynyl-purin-6-amine: D45 (= D44), F74 (= F73), Y75 (≠ L74), N119 (= N116), T158 (= T157), A159 (= A158)

6rbxA Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rbxA

query
sites
6rbxA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y

Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 3-(6-azanyl-8-bromanyl-purin-9-yl)propan-1-ol: D45 (= D44), G46 (= G45), F74 (= F73), Y75 (≠ L74), N119 (= N116), T158 (= T157), A159 (= A158)

6rbwA Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rbwA

query
sites
6rbwA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y

Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 9-(4-azidobutyl)-8-bromanyl-purin-6-amine: D45 (= D44), G46 (= G45), F74 (= F73), Y75 (≠ L74), N119 (= N116), T158 (= T157), A159 (= A158)

6rbuA Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rbuA

query
sites
6rbuA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G

G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y

Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 9-(2-azidoethyl)-8-bromanyl-purin-6-amine: D45 (= D44), F74 (= F73), Y75 (≠ L74), N119 (= N116), T158 (= T157), A159 (= A158)

6rbtA Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rbtA

query
sites
6rbtA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G
|
G

D
|
D

G
|
G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L

Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y

Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 8-bromanyl-9-(4-bromanylbutyl)purin-6-amine: G44 (= G43), D45 (= D44), G46 (= G45), F74 (= F73), N119 (= N116), T158 (= T157), A159 (= A158)

6rbsA Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rbsA

query
sites
6rbsA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G

G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y

Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 8-bromanyl-9-pent-4-ynyl-purin-6-amine: D45 (= D44), F74 (= F73), Y75 (≠ L74), N119 (= N116), T158 (= T157), A159 (= A158)

6rbqA Crystal structure of NAD kinase 1 from listeria monocytogenes in complexe with an adenine derivative (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 6rbqA

query
sites
6rbqA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G

G

F

T

M

F

L

L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L

Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E

E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y
|
Y

N

N

L

K

S

S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding ~{S}-[4-(6-aminopurin-9-yl)butyl] ethanethioate: D45 (= D44), F74 (= F73), N119 (= N116), T158 (= T157), A159 (= A158), Y160 (= Y159)

3v7uA Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with mta (see paper)
27% identity, 82% coverage: 24:234/257 of query aligns to 24:239/261 of 3v7uA

query
sites
3v7uA

L

F

A

G

A

E

H

Y

D

D

W

M

V

E

H

Y

P

D

D

D

-

V

E

E

A

P

E

E

M

I

I

V

V

I

A

S

L

I

G

G

G

G

D
|
D

G
|
G

F

T

M

F

L
|
L

Q

S

T

A

L

F

H

H

M

Q

L

Y

L

E

E

E

K

R

H

L

R

D

N

E

L

I

P

A

V

F

F

I

G

G

M

I

N

H

L

T

G

G

T

H

I

L

G

G

F
|
F

L
x
Y

M

A

N

D

E

-

W

W

R

R

P

P

-

A

-

E

-

A

D

D

G

K

L

L

D

V

A

K

R

L

L

L

A

A

R

K

A

G

R

E

P

Y

F

Q

R

K

V

V

T

S

P

Y

L

P

V

L

M

L

T

K

A

T

T

T

T

V

V

K

E

Y

G

G

D

K

T

E

H

A

V

T

L

Y

P

L

A

A

I

L

N
|
N

E
|
E

V

-

S

S

L

T

L

V

R

K

E

S

T

S

R

G

Q

G

T

P

A

F

K

V

L

V

E

D

V

V

T

V

V

I

N

N

D

D

R

-

I

I

V

H

L

F

P

E

E

R

L

F

V

R

C

G

D

D

G

G

I

L

L

C

V

M

A

S

T

T

P

P

A

S

G

G

S

T

T
|
T

A
|
A

Y
|
Y

N

N

L

K

S
|
S

A

L

H

G

G

G

P

A

I

L

L

M

P

H

L

P

G

S

S

I

Q

E

M

A

L

M

A

Q

L

L

T

T

P

E

I

M

S

A

P

S

F

I

R

N

P

N

R

R

R

V

W

Y

R

R

-

T

-

I

G

G

A

S

-

P

-

L

I

V

L

F

P

P

E

K

K

H

T

H

R

V

I

V

S

S

L

L

Q

Q

V

P

L

V

D

N

P

D

G

K

K

D

R

F

P

Q

V

I

S

S

A

V

V

D

A

H

D

L

Q

S

R

I

E

L

V

H

R

R

D

D

V

V

A

Q

R

E

V

I

D

R

I

Y

E

E

I

V

D

S

P

A

K

K

R

K

binding 5'-deoxy-5'-methylthioadenosine: D45 (= D44), G46 (= G45), L49 (= L48), F74 (= F73), Y75 (≠ L74), N119 (= N116), N119 (= N116), E120 (= E117), T158 (= T157), A159 (= A158), Y160 (= Y159), S163 (= S162)

Query Sequence

>Ga0059261_3619 FitnessBrowser__Korea:Ga0059261_3619
MSGIRRALVASPTNPAEVAAHELLAAHDWVHPDEAEMIVALGGDGFMLQTLHMLLEKHRN
LPVFGMNLGTIGFLMNEWRPDGLDARLARARPFRVTPLVMTATTVEGDTHVLPAINEVSL
LRETRQTAKLEVTVNDRIVLPELVCDGILVATPAGSTAYNLSAHGPILPLGSQMLALTPI
SPFRPRRWRGAILPEKTRISLQVLDPGKRPVSAVADQREVRDVARVDIEIDPKRDLTLLF
DPEHALDDRITMEQFVA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory