SitesBLAST
Comparing Ga0059261_3793 FitnessBrowser__Korea:Ga0059261_3793 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
39% identity, 99% coverage: 1:378/381 of query aligns to 1:378/378 of 5ol2F
- active site: L124 (= L124), T125 (= T125), G241 (= G241), G374 (≠ R374)
- binding calcium ion: E29 (= E29), E33 (≠ A33), R35 (≠ A35)
- binding coenzyme a persulfide: L238 (= L238), R242 (= R242), E362 (= E362), G363 (= G363)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), T125 (= T125), P127 (= P127), T131 (≠ S131), F155 (= F155), I156 (= I156), T157 (= T157), E198 (= E198), R267 (= R267), F270 (= F270), L274 (≠ I274), F277 (≠ H277), Q335 (= Q335), L336 (≠ I336), G338 (= G338), G339 (= G339), Y361 (= Y361), T364 (= T364), E366 (≠ Q366)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
41% identity, 95% coverage: 13:375/381 of query aligns to 15:377/378 of 4n5fA
- active site: L126 (= L124), T127 (= T125), G243 (= G241), E364 (= E362), R376 (= R374)
- binding dihydroflavine-adenine dinucleotide: L126 (= L124), T127 (= T125), G132 (= G130), S133 (= S131), F157 (= F155), T159 (= T157), T210 (≠ V208), Y363 (= Y361), T366 (= T364), E368 (≠ Q366), M372 (≠ L370)
7w0jE Acyl-coa dehydrogenase, tfu_1647
41% identity, 98% coverage: 6:378/381 of query aligns to 9:382/382 of 7w0jE
- binding [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: S127 (≠ T125), W157 (≠ F155), R270 (= R267), Q272 (= Q269), F273 (= F270), I277 (= I274), F280 (≠ H277), I283 (= I280), Q339 (= Q335), L340 (≠ I336), G343 (= G339), Y365 (= Y361), E366 (= E362), T368 (= T364), Q370 (= Q366), I371 (= I367)
8i4rA Crystal structure of acyl-coa dehydrogenase complexed with acetyl-coa from thermobifida fusca
41% identity, 98% coverage: 6:378/381 of query aligns to 8:381/381 of 8i4rA
- binding acetyl coenzyme *a: S132 (= S131), T134 (≠ S133), R180 (= R178), R234 (≠ K232), L237 (≠ M235), R238 (= R236), L240 (= L238), D241 (= D239), R244 (= R242), E365 (= E362), G366 (= G363), R377 (= R374)
- binding flavin-adenine dinucleotide: Y123 (≠ F122), L125 (= L124), S126 (≠ T125), G131 (= G130), S132 (= S131), W156 (≠ F155), I157 (= I156), T158 (= T157), I360 (≠ L357), T367 (= T364), Q369 (= Q366)
8i4pA Crystal structure of acyl-coa dehydrogenase from thermobifida fusca
41% identity, 98% coverage: 6:378/381 of query aligns to 8:381/381 of 8i4pA
- binding flavin-adenine dinucleotide: Y123 (≠ F122), L125 (= L124), S126 (≠ T125), G131 (= G130), S132 (= S131), W156 (≠ F155), I157 (= I156), T158 (= T157), I360 (≠ L357), Y364 (= Y361), T367 (= T364), Q369 (= Q366)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
40% identity, 98% coverage: 5:378/381 of query aligns to 8:381/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ A340), T347 (≠ E344), E348 (≠ D345)
- binding flavin-adenine dinucleotide: F125 (= F122), L127 (= L124), S128 (≠ T125), G133 (= G130), S134 (= S131), W158 (≠ F155), T160 (= T157), R270 (= R267), F273 (= F270), L280 (≠ H277), V282 (≠ L279), Q338 (= Q335), I339 (= I336), G342 (= G339), I360 (≠ L357), Y364 (= Y361), T367 (= T364), E369 (≠ Q366), I370 (= I367), L373 (= L370)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
40% identity, 98% coverage: 5:378/381 of query aligns to 35:408/412 of P16219
- G90 (= G60) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E74) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 122:131, 70% identical) binding in other chain
- R171 (≠ V141) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (≠ FIT 155:157) binding in other chain
- A192 (= A162) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G179) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R267) binding
- Q308 (= Q278) binding in other chain
- R325 (= R295) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (≠ T323) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (= QILGG 335:339) binding
- R380 (= R350) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ TSQ 364:366) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial (see paper)
40% identity, 98% coverage: 5:378/381 of query aligns to 5:378/381 of 8sgsA
- binding coenzyme a: S131 (= S131), A133 (≠ S133), N177 (≠ A177), F231 (= F231), M235 (= M235), L238 (= L238), I312 (≠ V312), E362 (= E362), G363 (= G363)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), T157 (= T157), R267 (= R267), F270 (= F270), L274 (≠ I274), L277 (≠ H277), Q335 (= Q335), I336 (= I336), G338 (= G338), G339 (= G339), I357 (≠ L357), I360 (= I360), Y361 (= Y361), T364 (= T364), E366 (≠ Q366)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
40% identity, 98% coverage: 5:378/381 of query aligns to 11:384/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (= F122), L130 (= L124), S131 (≠ T125), G136 (= G130), S137 (= S131), W161 (≠ F155), T163 (= T157), T214 (≠ V208), R273 (= R267), F276 (= F270), L280 (≠ I274), L283 (≠ H277), V285 (≠ L279), Q341 (= Q335), I342 (= I336), G345 (= G339), I363 (≠ L357), Y367 (= Y361), T370 (= T364), E372 (≠ Q366), L376 (= L370)
6fahD Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
41% identity, 92% coverage: 29:379/381 of query aligns to 29:379/379 of 6fahD
- active site: L124 (= L124), T125 (= T125), G241 (= G241), G374 (≠ R374)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), T125 (= T125), R152 (≠ T152), F155 (= F155), T157 (= T157), E198 (= E198), R267 (= R267), Q269 (= Q269), F270 (= F270), I274 (= I274), F277 (≠ H277), Q335 (= Q335), I336 (= I336), G339 (= G339), Y361 (= Y361), T364 (= T364), Q366 (= Q366)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
39% identity, 95% coverage: 15:377/381 of query aligns to 13:373/374 of 5lnxD
- active site: L122 (= L124), T123 (= T125), G239 (= G241), E358 (= E362), K370 (≠ R374)
- binding flavin-adenine dinucleotide: L122 (= L124), T123 (= T125), G128 (= G130), S129 (= S131), F153 (= F155), T155 (= T157), R265 (= R267), Q267 (= Q269), F268 (= F270), I272 (= I274), N275 (≠ H277), I278 (= I280), Q331 (= Q335), I332 (= I336), G335 (= G339), Y357 (= Y361), T360 (= T364), E362 (≠ Q366)
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
40% identity, 95% coverage: 16:377/381 of query aligns to 17:377/379 of 1ukwB
- active site: L124 (= L124), S125 (≠ T125), T241 (≠ G241), E362 (= E362), R374 (= R374)
- binding cobalt (ii) ion: D145 (= D145), H146 (≠ V146)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), S157 (≠ T157), K200 (= K200), L357 (= L357), Y361 (= Y361), E362 (= E362), T364 (= T364), E366 (≠ Q366), L370 (= L370)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
40% identity, 95% coverage: 16:377/381 of query aligns to 17:377/379 of 1ukwA
- active site: L124 (= L124), S125 (≠ T125), T241 (≠ G241), E362 (= E362), R374 (= R374)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), S157 (≠ T157), L357 (= L357), Y361 (= Y361), E362 (= E362), T364 (= T364), E366 (≠ Q366), L370 (= L370)
4iv6B X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
39% identity, 98% coverage: 9:381/381 of query aligns to 7:380/383 of 4iv6B
- active site: L121 (= L124), T122 (= T125), G240 (= G241), E361 (= E362), K373 (≠ R374)
- binding dihydroflavine-adenine dinucleotide: L121 (= L124), T122 (= T125), G126 (≠ V129), G127 (= G130), S128 (= S131), W152 (≠ F155), I153 (= I156), S154 (≠ T157), R266 (= R267), S268 (≠ Q269), F269 (= F270), I273 (= I274), H276 (= H277), V279 (≠ I280), R334 (≠ Q335), V335 (≠ I336), G338 (= G339), L356 (= L357), G360 (≠ Y361), T363 (= T364), E365 (≠ Q366), I366 (= I367)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
39% identity, 96% coverage: 13:378/381 of query aligns to 14:379/380 of 4l1fA
- active site: L125 (= L124), T126 (= T125), G242 (= G241), E363 (= E362), R375 (= R374)
- binding coenzyme a persulfide: T132 (≠ S131), H179 (≠ R178), F232 (= F231), M236 (= M235), E237 (≠ R236), L239 (= L238), D240 (= D239), R243 (= R242), Y362 (= Y361), E363 (= E362), G364 (= G363), R375 (= R374)
- binding flavin-adenine dinucleotide: F123 (= F122), L125 (= L124), T126 (= T125), G131 (= G130), T132 (≠ S131), F156 (= F155), I157 (= I156), T158 (= T157), R268 (= R267), Q270 (= Q269), F271 (= F270), I275 (= I274), F278 (≠ H277), L281 (≠ I280), Q336 (= Q335), I337 (= I336), G340 (= G339), I358 (≠ L357), Y362 (= Y361), T365 (= T364), Q367 (= Q366)
Sites not aligning to the query:
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
40% identity, 98% coverage: 5:378/381 of query aligns to 2:368/371 of 2vigB
- active site: L121 (= L124), S122 (≠ T125), G231 (= G241), E352 (= E362), G364 (≠ R374)
- binding coenzyme a persulfide: S128 (= S131), F221 (= F231), M225 (= M235), Q226 (≠ R236), L228 (= L238), D229 (= D239), R232 (= R242), E352 (= E362), G353 (= G363), I357 (= I367)
- binding flavin-adenine dinucleotide: L121 (= L124), S122 (≠ T125), G127 (= G130), S128 (= S131), W152 (≠ F155), T154 (= T157), R257 (= R267), F260 (= F270), L264 (≠ I274), L267 (≠ H277), Q325 (= Q335), I326 (= I336), G329 (= G339), I347 (≠ L357), Y351 (= Y361), T354 (= T364), E356 (≠ Q366)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
39% identity, 98% coverage: 5:378/381 of query aligns to 8:381/384 of 1jqiA
- active site: G377 (≠ R374)
- binding acetoacetyl-coenzyme a: L95 (≠ I92), F125 (= F122), S134 (= S131), F234 (= F231), M238 (= M235), Q239 (≠ R236), L241 (= L238), D242 (= D239), R245 (= R242), Y364 (= Y361), E365 (= E362), G366 (= G363)
- binding flavin-adenine dinucleotide: F125 (= F122), L127 (= L124), S128 (≠ T125), G133 (= G130), S134 (= S131), W158 (≠ F155), T160 (= T157), R270 (= R267), F273 (= F270), L280 (≠ H277), Q338 (= Q335), I339 (= I336), G342 (= G339), I360 (≠ L357), T367 (= T364), E369 (≠ Q366), I370 (= I367)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
39% identity, 98% coverage: 5:378/381 of query aligns to 35:408/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
8phfA Cryo-em structure of human acad9-s191a (see paper)
38% identity, 99% coverage: 5:381/381 of query aligns to 20:408/547 of 8phfA
- binding flavin-adenine dinucleotide: T144 (= T125), W176 (≠ F155), K225 (= K200), R292 (= R267), Q294 (= Q269), F295 (= F270), F302 (≠ H277), L304 (= L279), I305 (= I280), I363 (= I336), G365 (= G338), G366 (= G339), F388 (≠ Y361), E393 (≠ Q366), M397 (≠ L370)
Sites not aligning to the query:
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
39% identity, 96% coverage: 11:375/381 of query aligns to 11:375/376 of 4m9aB
- active site: L124 (= L124), T125 (= T125), G241 (= G241), E362 (= E362), R374 (= R374)
- binding dihydroflavine-adenine dinucleotide: F122 (= F122), T125 (= T125), G130 (= G130), S131 (= S131), F155 (= F155), T157 (= T157), T208 (≠ V208), Y361 (= Y361), T364 (= T364), E366 (≠ Q366), M370 (≠ L370)
Query Sequence
>Ga0059261_3793 FitnessBrowser__Korea:Ga0059261_3793
MALDPETFDALIDTVRRFVAQRLRPLESEVEAADAIPDTIVEEMKALGLFGLSIAEEFGG
LGLTMLEECRVAIEMGRTTPAFRSTFGTNVGIGSQGLVMAGTSEQKAAWLPRIASGEIIT
SFALTEPDVGSDSGAVKARAVRDGDVYRLSGTKRFITNADKASLFTVMARTGDEPGARGV
SAFLVPRDLPGISIGEPEKKMGQKGAKVADVIFDDVPVPAANRLGEEGEGFKIAMRVLDR
GRLHISAVSVGVAERLIADCVAYASERKQFGKPIAEHQLIQAMLADSKTECLAARALVLE
TAAAKDAGKDVVMESAAAKLFATEMVGRVADRAVQILGGAGYIEDYGIERLYRDVRLFRI
YEGTSQIQQLIIARETLKRGG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory