SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ga0059261_3874 FitnessBrowser__Korea:Ga0059261_3874 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
46% identity, 88% coverage: 13:226/243 of query aligns to 10:223/233 of P75957

query
sites
P75957

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G42 (= G45) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
46% identity, 88% coverage: 13:226/243 of query aligns to 7:220/226 of 7mdyC

query
sites
7mdyC

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binding adp orthovanadate: Y12 (= Y18), T19 (= T25), V21 (≠ I27), S40 (≠ P46), S41 (= S47), G42 (= G48), S43 (≠ C49), G44 (= G50), K45 (= K51), S46 (= S52), T47 (= T53), Q91 (= Q97), R135 (= R141), H138 (≠ L144), E142 (= E148), S144 (= S150), G145 (= G151), G146 (= G152), E147 (= E153), E168 (= E174), N172 (≠ A178), H201 (= H207)
binding magnesium ion: S46 (= S52), Q91 (= Q97)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
46% identity, 88% coverage: 13:226/243 of query aligns to 7:220/222 of 7arlD

query
sites
7arlD

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binding adenosine-5'-diphosphate: Y12 (= Y18), G42 (= G48), G44 (= G50), K45 (= K51), S46 (= S52), T47 (= T53)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs
45% identity, 88% coverage: 13:226/243 of query aligns to 9:222/229 of 7v8iD

query
sites
7v8iD

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binding phosphoaminophosphonic acid-adenylate ester: V23 (≠ I27), S43 (= S47), G44 (= G48), S45 (≠ C49), G46 (= G50), K47 (= K51), S48 (= S52), T49 (= T53), Q93 (= Q97), R137 (= R141), H140 (≠ L144), E144 (= E148), L145 (= L149), S146 (= S150), G147 (= G151), G148 (= G152), E149 (= E153), N174 (≠ A178), H203 (= H207)
binding magnesium ion: S48 (= S52), Q93 (= Q97)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
39% identity, 93% coverage: 7:233/243 of query aligns to 3:227/650 of 5ws4A

query
sites
5ws4A

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binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F14 (≠ Y18), I23 (= I27), S43 (= S47), G44 (= G48), S45 (≠ C49), G46 (= G50), K47 (= K51), S48 (= S52), T49 (= T53)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
37% identity, 91% coverage: 9:229/243 of query aligns to 5:224/648 of P75831

query
sites
P75831

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A

E

Y

V

V

P

L

A

Q

V

C

Y

M

A

K

G

V

L

K

E

P

R

A

K

E

Q

A

R

R

L

Q

L

R

R

A

A

R

Q

A

E

A

L

L

L

E

Q

A

R

V

L

G

G

L

L

G

E

P

D

R

R

M

T

R

E

L

Y

R

Y

P

P

F

A

E

Q

L

L

S

S

G

G

E

Q

K

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

A

M

K

N

Q

G

P

G

R

Q

I

V

L

I

F

L

A

A

D
|
D

E

E

P

P

T

T

S

G

A

A

L

L

D

D

S

S

H

H

N

S

G

G

H

E

A

E

V

V

I

M

A

A

L

I

L

L

R

H

D

Q

I

L

A

-

H

R

N

D

Q

R

G

G

A

H

A

T

V

V

L

I

C

I

V

V

T

T

H

H

D

D

P

P

R

Q

L

V

L

A

S

A

F

Q

A

A

D

E

R

R

I

V

I

I

H

E

M

I

E

R

D

D

G

G

R

E

I

I

I

V

R

R

D

N

K47 (= K51) mutation to L: Lack of activity.
D169 (= D173) mutation to N: Lack of activity.

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
36% identity, 95% coverage: 9:240/243 of query aligns to 4:235/592 of 5lj7A

query
sites
5lj7A

I

I

D

E

A

I

R

K

E

Q

V

L

S

N

K

R

S

Y

Y
x
F

T

G

V

E

G

G

Q

E

V

N

R

R

T

V

Q

H

I
x
V

L

L

F

K

G

D

V

I

S

S

V

L

S

S

V

I

M

E

P

R

G

G

E

D

L

F

T

V

L

A

V

I

V

M

G

G

P

Q

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

A

N

I

I

L

I

S

G

G

C

L

L

T

D

L

T

P

A

D

T

Q

G

G

G

E

S

V

S

D

K

A

I

L

D

G

G

N

K

P

E

I

T

C

I

R

E

M

L

K

T

A

N

G

D

A

Q

R

L

D

S

A

D

F

L

R

R

L

S

A

Q

N

K

T

F

G

G

F

F

V

I

F

F

Q
|
Q

G

R

F

Y

N

N

L

L

F

L

N

S

A

S

L

L

T

T

A

A

E

A

E

E

Q

N

V

V

A

A

Y

L

V

P

L

A

Q

I

C

Y

M

A

K

G

V

M

K

P

P

Q

A

S

E

Q

A

R

R

L

Q

E

R

R

A

A

R

K

A

Q

A

L

L

L

E

E

A

K

V

L

G

G

L

L

G

G

P

D

R
x
K

M

W

R

Q

L

N

R

K

P

P

F
x
N

E
x
Q

L
|
L

S
|
S

G
|
G

E
x
Q

K

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

A

M

K

N

Q

G

P

G

R

E

I

I

L

I

F

L

A

A

D
|
D

E
x
Q

P

P

T

T

S

G

A
|
A

L

L

D

D

S

S

H

H

N

S

G

G

H

E

A

N

V

V

I

M

A

E

L

I

L

L

R

R

D

Q

I

L

A

-

H

H

N

E

Q

E

G

G

A

H

A

T

V

I

L

I

C

M

V

V

T

T

H
|
H

D

D

P

K

R

H

L

I

L

A

S

A

F

S

A

A

D

N

R

R

I

I

H

E

M

I

E

K

D

D

G

G

R

E

I

I

R

S

D

D

-

T

E

Q

R

K

P

R

D

Q

P

V

T

K

S

S

A

A

V

V

Q

K

R

N

binding adenosine-5'-triphosphate: F13 (≠ Y18), V22 (≠ I27), S42 (= S47), G43 (= G48), S44 (≠ C49), G45 (= G50), K46 (= K51), S47 (= S52), T48 (= T53), Q92 (= Q97), K136 (≠ R141), N142 (≠ F147), Q143 (≠ E148), L144 (= L149), S145 (= S150), G146 (= G151), G147 (= G152), Q148 (≠ E153), Q169 (≠ E174), A173 (= A178), H201 (= H207)
binding magnesium ion: S47 (= S52), Q92 (= Q97), D168 (= D173)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
36% identity, 95% coverage: 9:240/243 of query aligns to 4:235/615 of 5lilA

query
sites
5lilA

I

I

D

E

A

I

R

K

E

Q

V

L

S

N

K

R

S

Y

Y
x
F

T

G

V

E

G

G

Q

E

V

N

R

R

T

V

Q

H

I
x
V

L

L

F

K

G

D

V

I

S

S

V

L

S

S

V

I

M

E

P

R

G

G

E

D

L

F

T

V

L

A

V

I

V

M

G

G

P

Q

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

A

N

I

I

L

I

S

G

G

C

L

L

T

D

L

T

P

A

D

T

Q

G

G

G

E

S

V

S

D

K

A

I

L

D

G

G

N

K

P

E

I

T

C

I

R

E

M

L

K

T

A

N

G

D

A

Q

R

L

D

S

A

D

F

L

R

R

L

S

A

Q

N

K

T

F

G

G

F

F

V

I

F

F

Q
|
Q

G

R

F

Y

N

N

L

L

F

L

N

S

A

S

L

L

T

T

A

A

E

A

E

E

Q

N

V

V

A

A

Y

L

V

P

L

A

Q

I

C

Y

M

A

K

G

V

M

K

P

P

Q

A

S

E

Q

A

R

R

L

Q

E

R

R

A

A

R

K

A

Q

A

L

L

L

E

E

A

K

V

L

G

G

L

L

G

G

P

D

R
x
K

M

W

R

Q

L
x
N

R

K

P

P

F

N

E
x
Q

L
|
L

S
|
S

G
|
G

E
x
Q

K

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

A

M

K

N

Q

G

P

G

R

E

I

I

L

I

F

L

A

A

D
|
D

E
x
Q

P

P

T

T

S

G

A
|
A

L

L

D

D

S

S

H

H

N

S

G

G

H

E

A

N

V

V

I

M

A

E

L

I

L

L

R

R

D

Q

I

L

A

-

H

H

N

E

Q

E

G

G

A

H

A

T

V

I

L

I

C

M

V

V

T

T

H
|
H

D

D

P

K

R

H

L

I

L

A

S

A

F

S

A

A

D

N

R

R

I

I

H

E

M

I

E

K

D

D

G

G

R

E

I

I

R

S

D

D

-

T

E

Q

R

K

P

R

D

Q

P

V

T

K

S

S

A

A

V

V

Q

K

R

N

binding adenosine-5'-triphosphate: F13 (≠ Y18), V22 (≠ I27), S42 (= S47), G43 (= G48), S44 (≠ C49), G45 (= G50), K46 (= K51), S47 (= S52), T48 (= T53), Q92 (= Q97), K136 (≠ R141), N139 (≠ L144), Q143 (≠ E148), L144 (= L149), S145 (= S150), G146 (= G151), G147 (= G152), Q148 (≠ E153), Q169 (≠ E174), A173 (= A178), H201 (= H207)
binding magnesium ion: S47 (= S52), Q92 (= Q97), D168 (= D173)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
40% identity, 92% coverage: 9:231/243 of query aligns to 2:228/232 of 1f3oA

query
sites
1f3oA

I

I

D

K

A

L

R

K

E

N

V

V

S

T

K

K

S

T

Y
|
Y

T

K

V

M

G

G

Q

E

V

E

R

I

T

I

Q

Y

I
x
A

L

L

F

K

G

N

V

V

S

N

V

L

S

N

V

I

M

K

P

E

G

G

E

E

L

F

T

V

L

S

V

I

V

M

G

G

P

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

A

N

I

I

L

I

S

G

G

C

L

L

T

D

L

K

P

P

D

T

Q

E

G

G

E

E

V

V

D

Y

A

I

L

D

G

N

N

I

P

K

I

T

C

N

R

D

M

L

K

D

A

D

G

D

A

E

R

L

D

T

A

K

F

I

R

R

L

R

A

D

N

K

T

I

G

G

F

F

V

V

F

F

Q

Q

G

Q

F

F

N

N

L

L

F

I

N

P

A

L

L

L

T

T

A

A

E

L

E

E

Q

N

V

V

A

E

Y

L

V

P

L

L

Q

-

C

I

M

F

K

K

V

Y

K

R

P

G

A

A

-

M

-

S

-

G

-

E

E

E

A

R

R

R

Q

K

R

R

A

A

R

L

A

E

A

C

L

L

E

K

A

M

V

A

G

E

L

L

G

E

P

E

R

R

M

F

-

A

R

N

L

H

R

K

P

P

F

N

E

Q

L

L

S

S

G

G

E

Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

K

N

Q

N

P

P

R

P

I

I

L

I

F

L

A

A

D

D

E

E

P

P

T

T

S

G

A

A

L

L

D

D

S

S

H

K

N

T

G

G

H

E

A

K

V

I

I

M

A

Q

L

L

R

K

D

K

I

L

A

N

H

E

N

E

Q

D

G

G

A

K

A

T

V

V

L

V

C

V

V

V

T

T

H

H

D

D

P

I

R

N

L

V

L

A

S

R

F

F

A

G

D

E

R

R

I

I

H

Y

M

L

E

K

D

D

G

G

R

E

I

V

I

E

R

R

D

E

E

E

R

K

binding adenosine-5'-diphosphate: Y11 (= Y18), A20 (≠ I27), S40 (= S47), G41 (= G48), S42 (≠ C49), G43 (= G50), K44 (= K51), S45 (= S52), T46 (= T53)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
39% identity, 92% coverage: 9:231/243 of query aligns to 2:228/230 of 1l2tA

query
sites
1l2tA

I

I

D

K

A

L

R

K

E

N

V

V

S

T

K

K

S

T

Y
|
Y

T

K

V
x
M

G

G

Q

E

V

E

R

I

T
x
I

Q

Y

I
x
A

L

L

F

K

G

N

V

V

S

N

V

L

S

N

V

I

M

K

P

E

G

G

E

E

L

F

T

V

L

S

V

I

V

M

G

G

P
|
P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

A

N

I

I

L

I

S

G

G

C

L

L

T

D

L

K

P

P

D

T

Q

E

G

G

E

E

V

V

D

Y

A

I

L

D

G

N

N

I

P

K

I

T

C

N

R

D

M

L

K

D

A

D

G

D

A

E

R

L

D

T

A

K

F

I

R

R

L

R

A

D

N

K

T

I

G

G

F

F

V

V

F

F

Q

Q

G

Q

F

F

N

N

L

L

F

I

N

P

A

L

L

L

T

T

A

A

E

L

E

E

Q

N

V

V

A

E

Y

L

V

P

L

L

Q

-

C

I

M

F

K

K

V

Y

K

R

P

G

A

A

-

M

-

S

-

G

-

E

E

E

A

R

R

R

Q

K

R

R

A

A

R

L

A

E

A

C

L

L

E

K

A

M

V

A

G

E

L

L

G

E

P

E

R

R

M
x
F

-

A

R

N

L
x
H

R

K

P

P

F

N

E
x
Q

L

L

S
|
S

G
|
G

E
x
Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

K

N

Q

N

P

P

R

P

I

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

S

G

A
|
A

L

L

D

D

S

S

H

K

N

T

G

G

H

E

A

K

V

I

I

M

A

Q

L

L

R

K

D

K

I

L

A

N

H

E

N

E

Q

D

G

G

A

K

A

T

V

V

L

V

C

V

V

V

T

T

H
|
H

D

D

P

I

R

N

L

V

L

A

S

R

F

F

A

G

D

E

R

R

I

I

H

Y

M

L

E

K

D

D

G

G

R

E

I

V

I

E

R

R

D

E

E

E

R

K

binding adenosine-5'-triphosphate: Y11 (= Y18), M13 (≠ V20), I18 (≠ T25), A20 (≠ I27), P39 (= P46), S40 (= S47), G41 (= G48), S42 (≠ C49), G43 (= G50), K44 (= K51), S45 (= S52), T46 (= T53), F138 (≠ M142), H141 (≠ L144), Q145 (≠ E148), S147 (= S150), G148 (= G151), G149 (= G152), Q150 (≠ E153), A175 (= A178), H204 (= H207)

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
39% identity, 92% coverage: 7:230/243 of query aligns to 2:221/230 of 6z4wA

query
sites
6z4wA

A

S

A

I

I

I

D

E

A

M

R

R

E

D

V

V

S

V

K

K

S

K

Y
|
Y

T

D

V
x
N

G

G

Q

-

V

-

R

-

T
|
T

Q

T

I
x
A

L

L

F

R

G

G

V

V

S

S

V

V

S

S

V

V

M

Q

P

P

G

G

E

E

L

F

T

A

L

Y

V

I

V

V

G

G

P

P

S
|
S

G
|
G

C
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

I

A

R

I

S

L

L

S

Y

G

R

L

E

T

V

L

K

P

I

D

D

Q

K

G

G

E

S

V

L

D

S

A

V

L

A

G

G

N

F

P

N

I

L

C

V

R

K

M

I

K

K

A

K

G

K

A

D

R

V

D

P

A

L

F

L

R

R

L

R

A

S

N

-

T

V

G

G

F

V

V

V

F

F

Q

Q

G

D

F

Y

N

K

L

L

F

L

N

P

A

K

L

K

T

T

A

V

E

Y

E

E

Q

N

V

I

A

A

Y

Y

V

A

L

M

Q

E

C

V

M

I

K

G

V

E

K

N

P

R

A

R

E

N

A

I

R

K

Q

R

R

R

A

V

R

M

A

E

A

V

L

L

E

D

A

L

V

V

G

G

L

L

G

K

P

H

R

K

M

V

R

R

L

S

R

F

P

P

F

N

E

E

L

L

S

S

G

G

E

E

K

Q

Q

Q

R

R

V

I

A

A

I

I

A

A

R

R

A

A

L

I

A

V

K

N

Q

N

P

P

R

K

I

V

L

L

F

I

A

A

D

D

E

E

P

P

T

T

S

G

A

N

L

L

D

D

S

P

H

D

N

N

G

S

H

W

A

E

V

I

I

M

A

N

L

L

R

E

D

R

I

I

A

-

H

N

N

L

Q

Q

G

G

A

T

V

I

L

L

C

M

V

A

T

T

H

H

D

N

P

S

R

Q

L

I

L

V

-

N

S

T

F

L

A

R

D

H

R

R

I

V

I

I

H

A

M

I

E

E

D

N

G

G

R

R

I

V

R

R

D

D

E

E

binding adenosine-5'-diphosphate: Y13 (= Y18), N15 (≠ V20), T17 (= T25), A19 (≠ I27), S39 (= S47), G40 (= G48), A41 (≠ C49), G42 (= G50), K43 (= K51), S44 (= S52), T45 (= T53)

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
39% identity, 92% coverage: 7:230/243 of query aligns to 2:221/229 of 6z67B

query
sites
6z67B

A

S

A

I

I

I

D

E

A

M

R

R

E

D

V

V

S

V

K

K

S

K

Y
|
Y

T

D

V

N

G
|
G

Q

-

V

-

R

-

T
|
T

Q

T

I
x
A

L

L

F

R

G

G

V

V

S

S

V

V

S

S

V

V

M

Q

P

P

G

G

E

E

L

F

T

A

L

Y

V

I

V

V

G

G

P

P

S
|
S

G
|
G

C
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

I

A

R

I

S

L

L

S

Y

G

R

L

E

T

V

L

K

P

I

D

D

Q

K

G

G

E

S

V

L

D

S

A

V

L

A

G

G

N

F

P

N

I

L

C

V

R

K

M

I

K

K

A

K

G

K

A

D

R

V

D

P

A

L

F

L

R

R

L

R

A

S

N

-

T

V

G

G

F

V

V

V

F

F

Q

Q

G

D

F

Y

N

K

L

L

F

L

N

P

A

K

L

K

T

T

A

V

E

Y

E

E

Q

N

V

I

A

A

Y

Y

V

A

L

M

Q

E

C

V

M

I

K

G

V

E

K

N

P

R

A

R

E

N

A

I

R

K

Q

R

R

R

A

V

R

M

A

E

A

V

L

L

E

D

A

L

V

V

G

G

L

L

G

K

P

H

R

K

M

V

R

R

L

S

R

F

P

P

F

N

E

E

L

L

S

S

G

G

E

E

K

Q

Q

Q

R

R

V

I

A

A

I

I

A

A

R

R

A

A

L

I

A

V

K

N

Q

N

P

P

R

K

I

V

L

L

F

I

A

A

D

D

E

E

P

P

T

T

S

G

A

N

L

L

D

D

S

P

H

D

N

N

G

S

H

W

A

E

V

I

I

M

A

N

L

L

R

E

D

R

I

I

A

-

H

N

N

L

Q

Q

G

G

A

T

V

I

L

L

C

M

V

A

T

T

H
|
H

D

N

P

S

R

Q

L

I

L

V

-

N

S

T

F

L

A

R

D

H

R

R

I

V

I

I

H

A

M

I

E

E

D

N

G

G

R

R

I

V

R

R

D

D

E

E

binding phosphoaminophosphonic acid-adenylate ester: Y13 (= Y18), G16 (= G21), T17 (= T25), A19 (≠ I27), S39 (= S47), G40 (= G48), A41 (≠ C49), G42 (= G50), K43 (= K51), S44 (= S52), T45 (= T53), H197 (= H207)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
42% identity, 83% coverage: 26:227/243 of query aligns to 17:217/223 of 2pclA

query
sites
2pclA

Q

E

I

I

L

L

F

K

G

G

V

I

S

S

V

L

S

S

V

V

M

K

P

K

G

G

E

E

L

F

T

V

L

S

V

I

G

G

P

A

S

S

G

G

C

S

G

G

K

K

S

S

T

T

L

L

A

Y

I

I

L

L

S

G

G

L

L

L

T

D

L

A

P

P

D

T

Q

E

G

G

E

K

V

V

D

F

A

L

L

E

G

G

N

K

P

E

I

V

C

D

R

Y

M

T

K

N

A

E

G

K

A

E

R

L

D

S

A

L

F

L

R

R

L

N

A

R

N

K

T

L

G

G

F

F

V

V

F

F

Q

Q

G

F

F

H

N

Y

L

L

F

I

N

P

A

E

L

L

T

T

A

A

E

L

E

E

Q

N

V

V

A

I

Y

V

V

P

L

M

Q

L

C

K

M

M

K

G

V

K

K

P

P

K

A

K

E

E

A

A

R

K

Q

E

R

R

A

G

R

E

A

Y

A

L

L

L

E

S

A

E

V

L

G

G

L

L

G

G

P

D

R

K

M

L

R

S

L

R

R

K

P

P

F

Y

E

E

L

L

S

S

G

G

E

E

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

K

N

Q

E

P

P

R

I

I

L

L

L

F

F

A

A

D

D

E
|
E

P
|
P

T
|
T

S

G

A

N

L

L

D

D

S

S

H

A

N

N

G

T

H

K

A

R

V

V

I

M

A

D

L

I

L

F

R

L

D

K

I

I

A

-

H

N

N

E

Q

G

G

G

A

T

A

S

V

I

L

V

C

M

V

V

T
|
T

H

H

D

E

P

R

R

E

L

L

L

A

S

E

F

L

A

T

D

H

R

R

I

T

I

L

H

E

M

M

E

K

D

D

G

G

R

K

I

V

binding magnesium ion: E165 (= E174), P166 (= P175), T167 (= T176), T196 (= T206)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
38% identity, 91% coverage: 9:229/243 of query aligns to 4:223/226 of 5xu1B

query
sites
5xu1B

I

I

D

S

A

L

R

K

E

N

V

I

S

F

K

R

S

S

Y

Y

T

R

V

N

G

G

Q

D

V

Q

R

E

T

L

Q

Q

I

V

L

L

F

K

G

N

V

I

S

N

V

L

S

E

V

V

M

N

P

E

G

G

E

E

L

F

T

V

L

A

V

I

V

M

G

G

P

P

S

S

G

G

C

S

G
|
G

K
|
K

S
|
S

T

T

L

L

L

M

A

N

I

T

L

I

S

G

G

M

L

L

T

D

L

T

P

P

D

T

Q

S

G

G

E

E

V

Y

D

Y

A

L

L

E

G

G

N

Q

P

E

I

V

C

A

R

G

M

L

K

G

A

E

G

K

A

Q

R

L

D

A

A

K

F

V

R

R

L

N

A

Q

N

Q

T

I

G

G

F

F

V

V

F

F

Q

Q

G

Q

F

F

N

F

L

L

F

L

N

S

A

K

L

L

T

N

A

A

E

L

E

Q

Q

N

V

V

A

E

Y

L

V

P

L

L

Q

I

C

Y

M

A

K

G

V

V

K

S

P

S

A

S

E

K

A

R

R

R

Q

K

R

L

A

A

R

E

A

E

A

Y

L

L

E

D

A

K

V

V

G

E

L

L

G

T

P

E

R

R

M

S

R

H

L

H

R

L

P

P

F

S

E

E

L

L

S

S

G

G

E

Q

K

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

V

K

N

Q

N

P

P

R

S

I

I

L

I

F

L

A

A

D

D

E

E

P

P

T

T

S

G

A

A

L

L

D

D

S

T

H

K

N

T

G

G

H

N

A

Q

V

I

I

M

A

Q

L

L

R

V

D

D

I

L

A

-

H

N

N

K

Q

E

G

G

A

K

A

T

V

I

L

I

C

M

V

V

T

T

H

H

D

E

P

P

R

E

L

I

L

A

S

A

F

Y

A

A

D

K

R

R

I

Q

I

I

H

V

M

I

E

R

D

D

G

G

R

V

I

I

I

S

R

S

D

D

binding magnesium ion: G45 (= G50), K46 (= K51), S47 (= S52)

8g4cB Bacitracin export ATP-binding protein BceA (see paper)
33% identity, 90% coverage: 9:226/243 of query aligns to 4:221/248 of 8g4cB

query
sites
8g4cB

I

L

D

E

A

A

R

N

E

K

V

I

S

R

K

K

S

S

Y
|
Y

T

G

V

N

G

K

Q

L

V

N

R

K

T
x
Q

Q

E

I

V

L

L

F

K

G

G

V

I

S

D

V

I

S

H

V

I

M

E

P

K

G

G

E

E

L

F

T

V

L

S

V

I

V

M

G

G

P

A

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
x
T

T
|
T

L

L

A

N

I

V

L

L

S

S

G

S

L

I

T

D

L

Q

P

V

D

S

Q

H

G

G

E

T

V

I

D

H

A

I

L

N

G

G

N

N

P

D

I

M

C

T

R

A

M

M

K

K

A

E

G

K

A

Q

R

L

D

A

A

E

F

F

R

R

L

K

A

Q

N

H

T

L

G

G

F

F

V

I

F

F

Q

Q

G

D

F

Y

N

N

L

L

F

L

N

D

A

T

L

L

T

T

A

V

E

K

E

E

Q

N

V

I

A

L

Y

L

V

P

L

L

Q

S

C

I

M

T

K

K

V

L

K

S

P

K

A

K

E

E

A

A

R

N

Q

R

R

K

A

F

R

E

A

E

A

V

L

A

E

K

A

E

V

L

G

G

L

I

G

Y

P

E

R

L

M

R

R

D

L

K

R

Y

P

P

F

N

E

E

L

I

S

S

G

G

E

Q

K

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

L

F

A

I

K

H

Q

D

P

P

R

S

I

I

L

I

F

F

A

A

D
|
D

E

E

P

P

T

T

S

G

A

A

L

L

D

D

S

S

H

K

N

S

G

A

H

S

A

D

V

L

I

L

A

N

L

K

L

L

R

S

D

Q

I

L

A

N

H

Q

N

K

Q

R

G

N

A

A

A

T

V

I

L

I

C

M

V

V

T

T

H

H

D

D

P

P

R

V

L

A

S

S

F

Y

A

C

D

G

R

R

I

V

I

I

H

F

M

I

E

K

D

D

G

G

R

Q

I

M

binding phosphothiophosphoric acid-adenylate ester: Y13 (= Y18), Q20 (≠ T25), S42 (= S47), G43 (= G48), S44 (≠ C49), G45 (= G50), K46 (= K51), T47 (≠ S52), T48 (= T53), D168 (= D173)

7tchB Bceab e169q variant atp-bound conformation (see paper)
33% identity, 90% coverage: 9:226/243 of query aligns to 3:220/245 of 7tchB

query
sites
7tchB

I

L

D

E

A

A

R

N

E

K

V

I

S

R

K

K

S

S

Y
|
Y

T

G

V

N

G

K

Q

L

V

N

R

K

T
x
Q

Q

E

I
x
V

L

L

F

K

G

G

V

I

S

D

V

I

S

H

V

I

M

E

P

K

G

G

E

E

L

F

T

V

L

S

V

I

V

M

G

G

P

A

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
x
T

T
|
T

L

L

A

N

I

V

L

L

S

S

G

S

L

I

T

D

L

Q

P

V

D

S

Q

H

G

G

E

T

V

I

D

H

A

I

L

N

G

G

N

N

P

D

I

M

C

T

R

A

M

M

K

K

A

E

G

K

A

Q

R

L

D

A

A

E

F

F

R

R

L

K

A

Q

N

H

T

L

G

G

F

F

V

I

F

F

Q
|
Q

G

D

F

Y

N

N

L

L

F

L

N

D

A

T

L

L

T

T

A

V

E

K

E

E

Q

N

V

I

A

L

Y

L

V

P

L

L

Q

S

C

I

M

T

K

K

V

L

K

S

P

K

A

K

E

E

A

A

R

N

Q

R

R

K

A

F

R

E

A

E

A

V

L

A

E

K

A

E

V

L

G

G

L

I

G

Y

P

E

R

L

M

R

R

D

L

K

R

Y

P

P

F

N

E
|
E

L

I

S
|
S

G
|
G

E

Q

K

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

L

F

A

I

K

H

Q

D

P

P

R

S

I

I

L

I

F

F

A

A

D

D

E

Q

P

P

T

T

S

G

A

A

L

L

D

D

S

S

H

K

N

S

G

A

H

S

A

D

V

L

I

L

A

N

L

K

L

L

R

S

D

Q

I

L

A

N

H

Q

N

K

Q

R

G

N

A

A

A

T

V

I

L

I

C

M

V

V

T

T

H
|
H

D

D

P

P

R

V

L

A

S

S

F

Y

A

C

D

G

R

R

I

V

I

I

H

F

M

I

E

K

D

D

G

G

R

Q

I

M

binding adenosine-5'-triphosphate: Y12 (= Y18), Q19 (≠ T25), V21 (≠ I27), S41 (= S47), G42 (= G48), S43 (≠ C49), G44 (= G50), K45 (= K51), T46 (≠ S52), T47 (= T53), Q91 (= Q97), E142 (= E148), S144 (= S150), G145 (= G151), G146 (= G152), H201 (= H207)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
40% identity, 86% coverage: 26:233/243 of query aligns to 15:221/240 of 4ymuJ

query
sites
4ymuJ

Q

E

I
x
V

L

L

F

K

G

G

V

V

S

T

V

L

S

K

V

V

M

N

P

K

G

G

E

E

L

V

T

V

L

V

V

I

G

G

P

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

A

R

I

C

L

I

S

N

G

L

L

L

T
x
E

L

E

P

P

D

T

Q

K

G

G

E

E

V

V

D

F

A

I

L

D

G

G

N

V

P

K

I

I

C

N

R

N

M

G

K

K

A

V

G

N

A

I

R

N

D

K

A

V

F

R

R

Q

L

-

A

-

N

K

T

V

G

G

F

M

V

V

F

F

Q

Q

G

H

F

F

N

N

L

L

F

F

N

P

A

H

L

L

T

T

A

A

E

I

E

E

Q

N

V

I

A

T

Y

L

V

A

-

P

L

V

Q

K

C

V

M

K

K

K

V

M

K

N

P

K

A

K

E

E

A

A

R

E

Q

E

R

L

A

A

R

V

A

D

A

L

L

L

E

A

A

K

V

V

G

G

L

L

G

L

P

D

R

K

M

K

R

D

L

Q

R

Y

P

P

F

I

E

K

L

L

S

S

G

G

E

Q

K

K

Q

Q

R

R

V

L

A

A

I

I

A

A

R

R

A

A

L

L

A

A

K

M

Q

Q

P

P

R

E

I

V

L

M

F

L

A

F

D

D

E
|
E

P

P

T

T

S

S

A

A

L

L

D

D

S

P

H

E

N

M

G

V

H

K

A

E

V

V

I

L

A

N

L

V

L

M

R

K

D

Q

I

L

A

A

H

-

N

N

Q

E

G

G

A

M

A

T

V

M

L

V

C

V

V

V

T

T

H
|
H

D

E

P

-

R

-

L

-

L

M

S

G

F

F

A

A

-

R

-

E

-

V

-

G

D

D

R

R

I

V

I

I

H

F

M

M

E

D

D

D

G

G

R

V

I

I

I

V

R

E

D

E

E

G

R

T

P

P

D

E

binding adenosine-5'-triphosphate: V16 (≠ I27), S36 (= S47), G37 (= G48), S38 (≠ C49), G39 (= G50), K40 (= K51), S41 (= S52), T42 (= T53), E51 (≠ T62), E162 (= E174), H194 (= H207)
binding magnesium ion: S41 (= S52), E162 (= E174)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 11, 14

7w78A Heme exporter hrtba in complex with mg-amppnp (see paper)
42% identity, 81% coverage: 32:228/243 of query aligns to 28:217/218 of 7w78A

query
sites
7w78A

S

N

V

V

S

E

V

I

M

F

P

P

G

G

E

E

L

L

T

V

L

A

V

I

V

V

G

G

P
x
E

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

A

S

I

I

L

A

S

G

G

F

L

L

T

Q

L

E

P

P

D

T

Q

S

G

G

E

T

V

V

D

T

A

L

L

H

G

G

N

A

P

E

I

G

C

L

R

D

M

A

K

T

A

S

G

T

A

R

R

R

D

E

A

-

F

-

R

-

L

-

A

-

N

H

T

I

G

G

F

F

V

V

F

F

Q
|
Q

G

Q

F

P

N

N

L

L

F

L

N

G

A

S

L

L

T

T

A

A

E

R

E

E

Q

Q

V

L

A

L

Y

I

V

T

L

D

Q

H

C

L

M

R

K

G

V

I

K

K

P

P

A

R

E

-

A

-

R

K

Q

D

R

R

A

A

R

D

A

E

A

L

L

L

E

A

A

R

V

V

G

G

L

L

G

K

P

G

R

L

M

G

R

G

L

R

R

R

P

V

F

A

E

Q

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

N

I

I

A

A

R

R

A

A

L

L

A

M

K

G

Q

N

P

P

R

Q

I

L

L

L

F

L

A

A

D

D

E
|
E

P

P

T

T

S

S

A

A

L

L

D

D

S

A

H

R

N

L

G

S

H

K

A

E

V

I

I

V

A

E

L

L

R

R

D

D

I

V

A

T

H

K

N

E

Q

F

G

A

A

L

A

A

V

T

L

L

C

M

V

V

T

T

H
|
H

D

D

P

R

R

S

L

Q

L

L

S

A

F

Y

A

A

D

D

R

R

I

F

I

V

H

E

M

M

E

A

D

D

G

G

R

K

I

A

I

L

R

Q

binding phosphoaminophosphonic acid-adenylate ester: E42 (≠ P46), S43 (= S47), G44 (= G48), S45 (≠ C49), G46 (= G50), K47 (= K51), S48 (= S52), T49 (= T53), Q88 (= Q97), E163 (= E174), H196 (= H207)
binding magnesium ion: S48 (= S52), Q88 (= Q97)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 14, 21, 23

7w79A Heme exporter hrtba in complex with mn-amppnp (see paper)
43% identity, 81% coverage: 32:227/243 of query aligns to 28:216/216 of 7w79A

query
sites
7w79A

S

N

V

V

S
x
E

V

I

M

F

P

P

G

G

E

E

L

L

T

V

L

A

V

I

V

V

G

G

P
x
E

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

A

S

I

I

L

A

S

G

G

F

L

L

T

Q

L

E

P

P

D

T

Q

S

G

G

E

T

V

V

D

T

A

L

L

H

G

G

N

A

P

E

I

G

C

L

R

D

M

A

K

T

A

S

G

T

A

R

R

R

D

E

A

-

F

-

R

-

L

-

A

-

N

H

T

I

G

G

F

F

V

V

F

F

Q
|
Q

G

Q

F

P

N

N

L

L

F

L

N

G

A

S

L

L

T

T

A

A

E

R

E

E

Q

Q

V

L

A

L

Y

I

V

T

L

D

Q

H

C

L

M

R

K

G

V

I

K

K

P

P

A

R

E

K

A

D

R

R

Q

A

R

D

-

E

-

L

A

A

R

R

A

V

A

G

L

L

E

K

A

-

V

-

G

G

L

L

G

G

P

G

R

R

M

-

R

-

L

-

R

R

P

V

F

A

E

Q

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

N

I

I

A

A

R

R

A

A

L

L

A

M

K

G

Q

N

P

P

R

Q

I

L

L

L

F

L

A

A

D

D

E
|
E

P

P

T

T

S

S

A

A

L

L

D

D

S

A

H

R

N

L

G

S

H

K

A

E

V

I

I

V

A

E

L

L

R

R

D

D

I

V

A

T

H

K

N

E

Q

F

G

A

A

L

A

A

V

T

L

L

C

M

V

V

T

T

H
|
H

D

D

P

R

R

S

L

Q

L

L

S

A

F

Y

A

A

D

D

R

R

I

F

I

V

H

E

M

M

E

A

D

D

G

G

R

K

I

A

I

L

binding adenosine-5'-triphosphate: E42 (≠ P46), S43 (= S47), G44 (= G48), S45 (≠ C49), G46 (= G50), K47 (= K51), S48 (= S52), T49 (= T53), Q88 (= Q97), E163 (= E174), H196 (= H207)
binding manganese (ii) ion: E30 (≠ S34), S48 (= S52), Q88 (= Q97), E163 (= E174), H196 (= H207)

Sites not aligning to the query:

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
40% identity, 86% coverage: 26:233/243 of query aligns to 16:221/241 of 4u00A

query
sites
4u00A

Q

H

I
x
V

L

L

F

K

G

G

V

I

S

H

V

L

S

E

V

V

M

A

P

P

G

G

E

E

L

K

T

L

L

V

V

I

G

G

P

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

A

R

I

T

L

I

S

N

G

R

L

L

T

E

L

D

P

F

D

Q

Q

E

G

G

E

E

V

V

D

V

A

V

L

D

G

G

N

L

P

S

I

V

C

K

R

D

M

D

K

R

A

A

G

-

A

L

R

R

D

E

A

I

F

R

R

R

L

-

A

-

N

E

T

V

G

G

F

M

V

V

F

F

Q

Q

G

Q

F

F

N

N

L

L

F

F

N

P

A

H

L

M

T

T

A

V

E

L

E

E

Q

N

V

V

A

T

Y

L

V

A

L

P

Q

M

C

R

M

V

K

R

V

R

K

W

P

P

A

R

E

E

-

K

A

A

R

E

Q

K

R

K

A

A

R

L

A

E