SitesBLAST
Comparing Ga0059261_4131 Ga0059261_4131 Ornithine/acetylornithine aminotransferase to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2eh6A Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
41% identity, 96% coverage: 3:384/398 of query aligns to 1:371/375 of 2eh6A
- active site: F127 (= F130), E179 (= E183), D212 (= D216), Q215 (= Q219), K241 (= K246), T270 (= T275), R352 (= R365)
- binding pyridoxal-5'-phosphate: S94 (= S96), G95 (= G97), T96 (= T98), F127 (= F130), H128 (= H131), G129 (= G132), E179 (= E183), D212 (= D216), V214 (= V218), Q215 (= Q219), K241 (= K246), S269 (≠ T274), T270 (= T275), F271 (≠ A276)
O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
41% identity, 96% coverage: 3:384/398 of query aligns to 2:372/376 of O66442
- GT 96:97 (= GT 97:98) binding
- K242 (= K246) modified: N6-(pyridoxal phosphate)lysine
- T271 (= T275) binding
P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
44% identity, 96% coverage: 5:387/398 of query aligns to 17:399/405 of P40732
- GT 108:109 (= GT 97:98) binding
- K255 (= K246) modified: N6-(pyridoxal phosphate)lysine
- T284 (= T275) binding
4jevB N-acetylornithine aminotransferase from s. Typhimurium complexed with gabaculine
43% identity, 96% coverage: 5:387/398 of query aligns to 12:394/402 of 4jevB
- active site: F136 (= F130), E188 (= E183), D221 (= D216), Q224 (= Q219), K250 (= K246), T279 (= T275), R372 (= R365)
- binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: I46 (≠ V40), S102 (= S96), G103 (= G97), T104 (= T98), N107 (≠ V101), F136 (= F130), H137 (= H131), G138 (= G132), E188 (= E183), E193 (= E188), D221 (= D216), V223 (= V218), Q224 (= Q219), K250 (= K246), S278 (≠ T274), T279 (= T275), R372 (= R365)
2pb0A Structure of biosynthetic n-acetylornithine aminotransferase from salmonella typhimurium: studies on substrate specificity and inhibitor binding (see paper)
43% identity, 96% coverage: 5:387/398 of query aligns to 6:383/389 of 2pb0A
- active site: F130 (= F130), E182 (= E183), D215 (= D216), Q218 (= Q219), K244 (= K246), T268 (= T275), R361 (= R365)
- binding pyridoxal-5'-phosphate: S96 (= S96), G97 (= G97), T98 (= T98), N101 (≠ V101), F130 (= F130), H131 (= H131), G132 (= G132), E182 (= E183), D215 (= D216), V217 (= V218), Q218 (= Q219), K244 (= K246)
2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
40% identity, 97% coverage: 5:391/398 of query aligns to 11:393/393 of 2ordA
- active site: F134 (= F130), E186 (= E183), D219 (= D216), Q222 (= Q219), K248 (= K246), T276 (= T275), R367 (= R365)
- binding pyridoxal-5'-phosphate: T101 (≠ S96), G102 (= G97), T103 (= T98), N106 (≠ V101), F134 (= F130), H135 (= H131), G136 (= G132), E186 (= E183), E191 (= E188), D219 (= D216), V221 (= V218), Q222 (= Q219), K248 (= K246), T275 (= T274), T276 (= T275)
Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
40% identity, 97% coverage: 5:391/398 of query aligns to 3:385/385 of Q9X2A5
4jewA N-acetylornithine aminotransferase from s. Typhimurium complexed with l-canaline
43% identity, 96% coverage: 5:387/398 of query aligns to 12:389/397 of 4jewA
- active site: F136 (= F130), E188 (= E183), D221 (= D216), Q224 (= Q219), K250 (= K246), T274 (= T275), R367 (= R365)
- binding (2S)-2-azanyl-4-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxy-butanoic acid: I46 (≠ V40), S102 (= S96), G103 (= G97), T104 (= T98), N107 (≠ V101), F136 (= F130), H137 (= H131), G138 (= G132), R139 (= R133), E188 (= E183), E193 (= E188), D221 (= D216), V223 (= V218), Q224 (= Q219), K250 (= K246)
- binding picric acid: K25 (≠ R18), K27 (≠ E20), W32 (≠ Y25), G36 (= G29), E38 (= E31)
4addA Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
44% identity, 96% coverage: 5:388/398 of query aligns to 12:395/400 of 4addA
- active site: F136 (= F130), E188 (= E183), D221 (= D216), Q224 (= Q219), K250 (= K246), T279 (= T275), R372 (= R365)
- binding pyridoxal-5'-phosphate: S102 (= S96), G103 (= G97), A104 (≠ T98), N107 (≠ V101), F136 (= F130), H137 (= H131), G138 (= G132), E188 (= E183), D221 (= D216), V223 (= V218), Q224 (= Q219), K250 (= K246), T278 (= T274), T279 (= T275)
- binding n~2~-(3-carboxypropanoyl)-l-ornithine: Y16 (= Y9), I46 (≠ V40), G75 (≠ M69), F136 (= F130), R139 (= R133), E193 (= E188), K250 (= K246), G277 (= G273), T278 (= T274), T279 (= T275)
4adbB Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
44% identity, 96% coverage: 5:388/398 of query aligns to 12:395/401 of 4adbB
- active site: F136 (= F130), E188 (= E183), D221 (= D216), Q224 (= Q219), K250 (= K246), T279 (= T275), R372 (= R365)
- binding pyridoxal-5'-phosphate: S102 (= S96), G103 (= G97), A104 (≠ T98), N107 (≠ V101), F136 (= F130), H137 (= H131), G138 (= G132), E188 (= E183), D221 (= D216), V223 (= V218), Q224 (= Q219), K250 (= K246), T278 (= T274), T279 (= T275)
Q9M8M7 Acetylornithine aminotransferase, chloroplastic/mitochondrial; ACOAT; Acetylornithine transaminase; AOTA; Protein HOPW1-1-INTERACTING 1; EC 2.6.1.11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
39% identity, 97% coverage: 5:391/398 of query aligns to 69:456/457 of Q9M8M7
Sites not aligning to the query:
- 1:41 modified: transit peptide, Chloroplast and mitochondrion
- 42 modified: N-acetylvaline; in Acetylornithine aminotransferase, chloroplastic
A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
39% identity, 95% coverage: 5:384/398 of query aligns to 11:379/390 of A0QYS9