Comparing H281DRAFT_00095 H281DRAFT_00095 beta-alanine--pyruvate transaminase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9A3Q9 Omega-aminotransferase; Beta-alanine--pyruvate aminotransferase; EC 2.6.1.-; EC 2.6.1.18 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see paper)
65% identity, 99% coverage: 6:443/443 of query aligns to 5:439/439 of Q9A3Q9
Q9I700 Beta-alanine--pyruvate aminotransferase; Beta-A--Py AT; Beta-alanine--pyruvate transaminase; Omega-amino acid aminotransferase; Omega-amino acid AT; Omega-amino acid--pyruvate aminotransferase; Omega-APT; EC 2.6.1.18 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
50% identity, 98% coverage: 7:440/443 of query aligns to 12:445/448 of Q9I700
4b98A The structure of the omega aminotransferase from pseudomonas aeruginosa (see paper)
50% identity, 98% coverage: 7:440/443 of query aligns to 5:438/441 of 4b98A
4uhmA Characterization of a novel transaminase from pseudomonas sp. Strain aac (see paper)
49% identity, 97% coverage: 11:440/443 of query aligns to 3:432/435 of 4uhmA
3a8uX Crystal structure of omega-amino acid:pyruvate aminotransferase
48% identity, 98% coverage: 7:441/443 of query aligns to 4:439/441 of 3a8uX
3i5tA Crystal structure of aminotransferase prk07036 from rhodobacter sphaeroides kd131
41% identity, 94% coverage: 26:442/443 of query aligns to 22:437/444 of 3i5tA
Sites not aligning to the query:
6gwiB The crystal structure of halomonas elongata amino-transferase (see paper)
36% identity, 96% coverage: 18:442/443 of query aligns to 17:445/450 of 6gwiB
5kr5A Directed evolution of transaminases by ancestral reconstruction. Using old proteins for new chemistries
35% identity, 93% coverage: 30:442/443 of query aligns to 31:452/455 of 5kr5A
5lhaA Amine transaminase crystal structure from an uncultivated pseudomonas species in the pmp-bound form
40% identity, 92% coverage: 15:423/443 of query aligns to 10:427/447 of 5lhaA
7ypmA Crystal structure of transaminase cc1012 complexed with plp and l- alanine (see paper)
37% identity, 93% coverage: 30:443/443 of query aligns to 31:448/454 of 7ypmA
5lh9D Amine transaminase crystal structure from an uncultivated pseudomonas species in the plp-bound (internal aldimine) form
40% identity, 92% coverage: 15:423/443 of query aligns to 12:429/449 of 5lh9D
5kr3A Directed evolution of transaminases by ancestral reconstruction. Using old proteins for new chemistries
35% identity, 98% coverage: 11:442/443 of query aligns to 12:453/458 of 5kr3A
6fyqA The crystal structure of a new transaminase from the marine bacterium virgibacillus (see paper)
34% identity, 97% coverage: 11:439/443 of query aligns to 7:435/443 of 6fyqA
7ypnD Crystal structure of transaminase cc1012 mutant m9 complexed with plp (see paper)
36% identity, 93% coverage: 30:443/443 of query aligns to 31:448/455 of 7ypnD
5kr6B Directed evolution of transaminases by ancestral reconstruction. Using old proteins for new chemistries
35% identity, 97% coverage: 1:431/443 of query aligns to 3:445/460 of 5kr6B
7qx3A Structure of the transaminase tr2e2 with eos (see paper)
35% identity, 93% coverage: 30:442/443 of query aligns to 2:417/422 of 7qx3A
6io1B Crystal structure of a novel thermostable (s)-enantioselective omega- transaminase from thermomicrobium roseum (see paper)
34% identity, 98% coverage: 11:442/443 of query aligns to 12:446/448 of 6io1B
5kquC Directed evolution of transaminases by ancestral reconstruction. Using old proteins for new chemistries
34% identity, 100% coverage: 1:442/443 of query aligns to 1:454/459 of 5kquC
7qx0B Transaminase structure of plurienzyme (tr2e2) in complex with plp (see paper)
33% identity, 96% coverage: 18:442/443 of query aligns to 16:438/443 of 7qx0B
6s54A Transaminase from pseudomonas fluorescens (see paper)
36% identity, 92% coverage: 29:435/443 of query aligns to 31:444/453 of 6s54A
Sites not aligning to the query:
>H281DRAFT_00095 H281DRAFT_00095 beta-alanine--pyruvate transaminase
MTESAGANQPDMSAFWMPFTANRQFKSAPRLLASAKGMYYTSHDGRRILDGTAGLWCVNA
GHCRDEIVAAVQAQAAEMDFAPTFQMGHPKAFEAATKIARHTPGDLKHIFFVNSGSEAVD
TALKIALAYHRSRGEGQRTRFIGRERGYHGVGFGGISVGGIAPNRKAFSGALLPSIDHLP
HTLNIKEAAYSKGQPAWGAHLADELERIVALHDASTVAAVIVEPVAGSTGVLIPPQGYLQ
RLREICDKHGILLIFDEVITGWGRLGAPFAAQYFGVTPDLLTMAKGTNNAAAPMGAVAAS
GQIHDSIVNGAPGGIELFHGYTYSGHPIAAAAACATIDLYEREQLFDQAARMAPLFERAI
HKLRGERHVIDVRNLGLVGGVELAPRDGAPGTRAYDVFVRCFQKGVLTRYTGDILAFSPP
LIIEEAQIDEIFATVAEVLRETD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory