SitesBLAST

F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 2 papers)
29% identity, 39% coverage: 24:226/517 of query aligns to 942:1137/2281 of F1MWM0

query
sites
F1MWM0

G

G

V

R

K

P

S

A

L

V

D

D

Q

R

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L

S

N

L

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Y

A

E

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E

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I

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T

A

A

L

F

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L

G

G

E

H

N

N

G

G

A

A

G

G

K

K

S

T

T

T

L

T

T

L

K

S

I

I

M

M

A

T

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Y

L

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P

P

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S

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G

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P

D

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W

-

K

-

S

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A

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A

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D

A

A

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R

H

Q

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S

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M

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C

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P

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Q

E

H

L

N

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L

L

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F

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A

A

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E

N

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Y

A

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T

G

R

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I

-

G

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V

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L

-

D

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K

M

A

N

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M

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A

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M

L

L

G

E

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L

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N

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N

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M

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A

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M

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L

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D

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T

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-

D

-

P

-

Y

A

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L

D

L

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L

A

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Y

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L

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R

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A

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K

-

G

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M

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Sites not aligning to the query:

415 modified: carbohydrate, N-linked (Hex...) asparagine
504 modified: carbohydrate, N-linked (Hex...) asparagine
901 modified: Phosphothreonine; T→A: Decreases expression level. Affects subcellular location.
1185 modified: Phosphoserine; S→A: Does not affect subcellular location. Does not affect expression level. Does not affect ATPase activity. Reduces the stimulating effect of all-trans-retinal on ATP hydrolysis.
1309 Cleavage; by trypsin
1313 modified: Phosphothreonine; T→A: Does not affect subcellular location. Does not affect expression level. Does not affect ATPase activity. Reduces the stimulating effect of all-trans-retinal on ATP hydrolysis.
1317 modified: Phosphoserine; S→A: Does not affect subcellular location. Does not affect expression level. Affects both the basal and stimulated ATPase activity.
1319 modified: Phosphoserine
1455 modified: carbohydrate, N-linked (Hex...) asparagine
1527 modified: carbohydrate, N-linked (Hex...) asparagine
1660 modified: carbohydrate, N-linked (Hex...) asparagine

7mdyC Lolcde nucleotide-bound
33% identity, 40% coverage: 28:233/517 of query aligns to 22:226/226 of 7mdyC

query
sites
7mdyC

L

L

D

H

Q

N

V

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L

F

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G

A

E

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G

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M

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E

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N

S

G
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G

A
x
S

G
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G

K
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K

S
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S

T
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T

L

L

T

L

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H

I

L

M

L

A

G

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G

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L

Y

D

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N

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G

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Q

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P

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M

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A

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K

A

A

-

E

-

L

K

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Q

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T

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A

L

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E

N

N

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G

-

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A

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M

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-

T

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S

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M

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E

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N

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H

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M

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M

binding adp orthovanadate: G42 (= G48), S43 (≠ A49), G44 (= G50), K45 (= K51), S46 (= S52), T47 (= T53), Q91 (= Q94), H138 (≠ E145), E142 (≠ N149), S144 (= S151), G145 (≠ V152), G146 (≠ A153), E168 (= E175), N172 (≠ V179), H201 (= H207)
binding magnesium ion: S46 (= S52), Q91 (= Q94)

Sites not aligning to the query:

binding adp orthovanadate: 12

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
28% identity, 42% coverage: 8:226/517 of query aligns to 13:225/378 of P69874

query
sites
P69874

S

S

A

L

G

S

D

P

L

L

L

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x
C

F
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F

P

D

G

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K

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S

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Q

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N

A

N

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G

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x
F

H

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A

T

L

L

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L

G

G

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P

N

S

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G

A
x
C

G

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K

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T

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x
L

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M

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A

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x
L

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N

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N

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E

N

N

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G

A

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P

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x
V

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D

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K

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L

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C26 (≠ E21) mutation to A: Lower ATPase activity and transport efficiency.
F27 (= F22) mutation to L: Lower ATPase activity and transport efficiency.
F45 (≠ I40) mutation to L: Lower ATPase activity and transport efficiency.
C54 (≠ A49) mutation to T: Loss of ATPase activity and transport.
L60 (≠ T55) mutation to F: Lower ATPase activity and transport efficiency.
L76 (≠ F71) mutation to P: Lower ATPase activity and transport efficiency.
V135 (≠ L137) mutation to M: Loss of ATPase activity and transport.
D172 (= D174) mutation to N: Loss of ATPase activity and transport.

Sites not aligning to the query:

276 C→A: Lower ATPase activity and transport efficiency.
297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.

7arlD Lolcde in complex with lipoprotein and adp (see paper)
33% identity, 39% coverage: 28:229/517 of query aligns to 22:222/222 of 7arlD

query
sites
7arlD

L

L

D

H

Q

N

V

V

S

S

L

F

G

S

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V

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G

A

E

G

G

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M

H

M

A

A

L

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V

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G

G

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N

S

G
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G

A

S

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G

K
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K

S
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S

T

T

L

L

T

L

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M

L

A

G

G

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D

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F

F

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N

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G

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Q

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P

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M

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L

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P

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A

L

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N

N

I

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F

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A

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G

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M

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L

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L

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P

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M

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N

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L

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L

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M

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N

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N

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L

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F

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L

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N

R

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H

H

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D

L

L

D

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Q

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C

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M

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D

G

G

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L

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T

A

A

binding adenosine-5'-diphosphate: G42 (= G48), G44 (= G50), K45 (= K51), S46 (= S52)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
32% identity, 40% coverage: 28:233/517 of query aligns to 24:228/229 of 7v8iD

query
sites
7v8iD

L

L

D

H

Q

N

V

V

S

S

L

F

G

S

V

V

R

G

A

E

G

G

E

E

I

M

H

M

A

A

L

I

V

V

G

G

E

S

N
x
S

G
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G

A

S

G
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G

K
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K

S
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S

T
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T

L

L

T

L

K

H

I

L

M

L

A

G

G

G

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L

Y

D

A

T

P

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F

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N

G

G

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Q

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P

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M

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W

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D

K

A

A

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E

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L

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Q

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L

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A

L

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E

N

N

I

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G

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M

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D
x
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x
H

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S

N
x
E

L

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S

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A
x
G

D
x
E

Q

R

Q

Q

M

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A

I

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A

A

K

R

A

A

M

L

A

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G

N

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N

T

P

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L

L

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L

L

A

D

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Q

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P

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L

L

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N

R

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Q

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A

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H
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H

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D

L

L

D

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E

Q

I

L

F

A

E

K

L

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C

M

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L

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M

M

K

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D

D

G

G

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T

A

A

T

E

Q

L

S

S

V

L

binding phosphoaminophosphonic acid-adenylate ester: S43 (≠ N47), G44 (= G48), G46 (= G50), K47 (= K51), S48 (= S52), T49 (= T53), Q93 (= Q94), R137 (≠ D142), H140 (≠ E145), E144 (≠ N149), S146 (= S151), G148 (≠ A153), E149 (≠ D154), H203 (= H207)
binding magnesium ion: S48 (= S52), Q93 (= Q94)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 23

8f5bA Human abca4 structure in complex with amp-pnp
29% identity, 39% coverage: 24:226/517 of query aligns to 734:929/1924 of 8f5bA

query
sites
8f5bA

G

G

V

R

K

P

S

A

L

V

D

D

Q

R

V

L

S

N

L

I

G

T

V

F

R

Y

A

E

G

N

E

Q

I

I

H

T

A

A

L

F

V

L

G

G

E

H

N
|
N

G
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G

A

A

G
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G

K
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K

S
x
T

T
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T

L

T

T

L

K

S

I

I

M

L

A

T

G

G

V

L

Y

L

A

P

P

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K

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D

A

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binding phosphoaminophosphonic acid-adenylate ester: N757 (= N47), G758 (= G48), G760 (= G50), K761 (= K51), T762 (≠ S52), T763 (= T53), Q802 (= Q94), D853 (≠ N149)
binding magnesium ion: T762 (≠ S52), Q802 (= Q94)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 1652, 1653, 1654, 1655, 1656, 1657, 1697, 1748, 1750
binding magnesium ion: 1657, 1697

P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 43 papers)
29% identity, 39% coverage: 24:226/517 of query aligns to 942:1137/2273 of P78363

query
sites
P78363

G
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G

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R943 (≠ V25) to Q: risk factor for STGD1; risk factor for ARMD2; decreases 11-cis-Retinal binding affinity by 100-fold; dbSNP:rs1801581; to W: in STGD1 and FFM; dbSNP:rs61749446
Y954 (≠ R36) to D: in STGD1; uncertain significance; dbSNP:rs61749447
T959 (≠ H41) to I: in STGD1; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs61752409
963:970 (vs. 45:52, 75% identical) binding
N965 (= N47) to S: in STGD1; reduced retinal-stimulated ATP hydrolysis; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; decreases about 60% the N-retinylidene-phosphatidylethanolamine transfer activity; stimulates modestly the retinal-stimulated ATPase activity; does not affect ATP-independent N-retinylidene-phosphatidylethanolamine binding; does not affect ATP-dependent release of N-retinylidene-phosphatidylethanolamine; significantly reduces phosphatidylethanolamine flippase activity; dbSNP:rs201471607; to Y: in STGD1; uncertain significance
G966 (= G48) mutation to D: Abolishes basal and retinal-stimulated ATP hydrolysis.
K969 (= K51) mutation to M: Abolishes basal and retinal-stimulated ATP hydrolysis.; mutation to M: Inhibits ATPase activity; when associated with M-1978. Decreases translocase activity; when associated with M-1978. Does not affect protein subcellular localization in endoplasmic reticulum; when associated with M-1978. Loss of ATP-dependent all-trans-retinal transport; when associated with M-1978. Loss in N-retinylidene-PE transfer activity. Inhibits ATPase activity with increasing retinal concentration. Does not affect N-retinylidene-PE binding. Impairs ATP-dependent release of N-retinylidene-PE. Significantly reduces PE flippase activity.
T970 (≠ S52) to P: in STGD1; uncertain significance; dbSNP:rs1570377849
T971 (= T53) to N: in STGD1; highly reduced ATP-binding capacity; abolishes retinal-stimulated ATP hydrolysis; dbSNP:rs61749450
T972 (≠ L54) to N: in STGD1; uncertain significance; dbSNP:rs61749451
L973 (≠ T55) to S: in STGD1; uncertain significance
T977 (≠ A59) to P: in STGD1; uncertain significance
G978 (= G60) to D: in STGD1; uncertain significance; dbSNP:rs61749453
G991 (= G73) to R: in FFM and STGD1; dbSNP:rs61749455
E1022 (= E106) to G: in STGD1; uncertain significance; to K: in STGD1; uncertain significance; dbSNP:rs61749459
A1038 (= A130) to V: in STGD1, FFM and CORD3; frequent mutation; reduced ATP-binding and retinal-stimulated ATP hydrolysis; decreases solubility at 70%; does not affect intracellular vesicle localization; significantly reduces substrate binding in the absence of ATP; reduces basal ATPase activity; dbSNP:rs61751374
G1050 (= G138) to D: in STGD1; uncertain significance; dbSNP:rs61750062
K1054 (≠ D142) binding
S1071 (≠ E159) to L: in STGD1; reduced ATP-binding capacity; dbSNP:rs61750065
I1074 (≠ K162) to L: in STGD1; uncertain significance
G1078 (= G166) to E: in STGD1; uncertain significance
E1087 (= E175) mutation to Q: Does not affect protein folding; when associated with Q-2096. Loss of ATPase activity; when associated with Q-2096.
G1091 (≠ V179) to E: in FFM and STGD1; decreases solubilized at 70%; does not affect intracellular vesicle localization; does not affect substrate binding; drastically reduces basal ATPase activity with little or no substrate stimulation; dbSNP:rs61752417
P1094 (vs. gap) to T: in STGD1; uncertain significance
R1097 (≠ G182) to S: in STGD1; uncertain significance
R1098 (≠ K183) to C: in STGD1; uncertain significance; dbSNP:rs756840095
S1099 (≠ E184) to P: in STGD1; uncertain significance; dbSNP:rs61750119
D1102 (≠ L187) to Y: in dbSNP:rs138641544
R1108 (= R193) to C: in STGD1 and FFM; reduced ATP-binding capacity; dbSNP:rs61750120
E1122 (= E211) to K: in STGD1 and CORD3; dbSNP:rs61751399
R1129 (= R218) to C: in STGD1; may predispose to develop retinal toxicity after treatment with chloroquine and hydroxychloroquine; dbSNP:rs779426136; to L: in ARMD2 and STGD1; also found in patients with fundus flavimaculatus; reduced ATP-binding capacity; dbSNP:rs1801269
I1130 (≠ V219) to T: in STGD1; uncertain significance; dbSNP:rs1064793010

Sites not aligning to the query:

14 N → K: in STGD1; uncertain significance
18 R → P: in STGD1; uncertain significance
21:2273 natural variant: Missing (in STGD1; uncertain significance)
24 R → H: in STGD1; uncertain significance; dbSNP:rs62645958
53:2273 natural variant: Missing (in CORD3; uncertain significance; dbSNP:rs764744217)
54 modified: Disulfide link with 81
55 H → R: in CORD3; uncertain significance
63 S → P: in CORD3; uncertain significance
65 G → E: in STGD1 and CORD3; dbSNP:rs62654395
72 G → R: in STGD1; does not affect intracellular vesicle localization; does not affect solubility; significantly reduces N-Ret-PE binding; drastically reduces basal ATPase activity with little or no all trans retinal stimulation; dbSNP:rs61751412; G → V: in STGD1; uncertain significance
75 modified: Disulfide link with 324
81 modified: Disulfide link with 54
89:2273 natural variant: Missing (in STGD1; uncertain significance)
96 N → H: in STGD1; uncertain significance; dbSNP:rs61748529; N → K: in STGD1; uncertain significance; dbSNP:rs886039297
97 Y → C: in STGD1; uncertain significance; dbSNP:rs755691060
98 modified: carbohydrate, N-linked (GlcNAc...) asparagine
100 S → P: in STGD1; highly decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs61748530
107:2273 natural variant: Missing (in CORD3; uncertain significance; dbSNP:rs765429911)
108 D → V: in STGD1; uncertain significance
143 P → L: in STGD1; uncertain significance; dbSNP:rs62646860
172 G → S: in STGD1; uncertain significance; dbSNP:rs61748532
184 S → F: in STGD1; uncertain significance; S → R: in STGD1; uncertain significance
185:2273 natural variant: Missing (in STGD1; uncertain significance)
206 S → R: in STGD1; reduced basal and retinal-stimulated ATP-hydrolysis; dbSNP:rs61748536
212 R → C: in STGD1 and CORD3; common mutation in southern Europe; reduced ATP-binding capacity; dbSNP:rs61750200; R → H: in dbSNP:rs6657239
218:2273 natural variant: Missing (in CORD3; uncertain significance)
219:2273 natural variant: Missing (found in a patient with chorioretinal atrophy; uncertain significance)
223 K → Q: in STGD1; uncertain significance; dbSNP:rs147619585
224 T → M: in a breast cancer sample; somatic mutation; dbSNP:rs373540612
240 I → R: in STGD1; uncertain significance; dbSNP:rs1553195472
241 E → D: in STGD1; uncertain significance
245:2273 natural variant: Missing (in STGD1; uncertain significance)
246 A → T: in STGD1; uncertain significance
290 R → W: in STGD1; uncertain significance; dbSNP:rs781716640
291 P → L: in STGD1; uncertain significance; dbSNP:rs190540405
320 S → C: in CORD3; uncertain significance
324 modified: Disulfide link with 75
326:2273 natural variant: Missing (in STGD1; uncertain significance; dbSNP:rs747540967)
339:2273 natural variant: Missing (in CORD3; uncertain significance)
345 Y → S: in STGD1; uncertain significance
370 modified: Disulfide link with 519
407 A → V: in STGD1 and CORD3; dbSNP:rs61751264
410 I → T: in STGD1; uncertain significance
415 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N → K: in STGD1; uncertain significance
418 F → S: in STGD1; uncertain significance; dbSNP:rs794726979
423 H → R: in dbSNP:rs3112831
424 V → A: in STGD1 and RP19; uncertain significance
431:2273 natural variant: Missing (in STGD1; uncertain significance)
440 Y → C: in CORD3; uncertain significance; dbSNP:rs770439859
444 modified: carbohydrate, N-linked (GlcNAc...) asparagine
455 L → M: in RP19; uncertain significance; dbSNP:rs764170051
471 E → K: in ARMD2 and STGD1; uncertain significance; ATP-binding capacity and retinal stimulation as in wild-type; dbSNP:rs1800548
498 D → E: in STGD1; uncertain significance
504 modified: carbohydrate, N-linked (GlcNAc...) asparagine
508 R → C: in STGD1; uncertain significance; dbSNP:rs138157885
511 R → C: in STGD1; uncertain significance; dbSNP:rs752786160
519 modified: Disulfide link with 370; C → R: in STGD1; uncertain significance; dbSNP:rs1224959251
533:2273 natural variant: Missing (in STGD1; uncertain significance)
541 L → P: in STGD1, FFM and CORD3; reduced ATP-binding capacity; abolishes retinal-stimulated ATP hydrolysis; does not affect solubility; does not affect intracellular vesicle localization; significantly reduces substrate binding; drastically reduces basal ATPase activity with little or no substrate stimulation; dbSNP:rs61751392
548 W → R: in STGD1; uncertain significance
552 V → I: in RP19; uncertain significance; dbSNP:rs145525174
572:2273 natural variant: Missing (in STGD1; uncertain significance)
576 D → H: found in a patient with pattern dystrophy; uncertain significance; dbSNP:rs374224955
593 P → L: in STGD1; uncertain significance
603 Y → C: in STGD1; uncertain significance
605:2273 natural variant: Missing (in CORD3; uncertain significance)
608 F → I: in STGD1; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs61752398
616 E → K: in STGD1; uncertain significance; dbSNP:rs1557787473
636 Q → K: in CORD3; uncertain significance
639:2273 natural variant: Missing (in STGD1; uncertain significance)
640 P → L: in STGD1; uncertain significance; dbSNP:rs760790294
641 modified: Disulfide link with 1490, Interchain; C → S: in STGD1; uncertain significance; dbSNP:rs61749416
643 V → G: in CORD3; uncertain significance; dbSNP:rs61754024
653 R → C: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; very low substrate binding; dbSNP:rs61749420; R → H: in STGD1; uncertain significance; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; very low substrate binding; dbSNP:rs141823837
661 L → R: in CORD3; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding
681:2273 natural variant: Missing (found in a patient with macular dystrophy; uncertain significance)
686 L → S: in STGD1; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61752402
690 G → V: in STGD1; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization; very low substrate binding
700:2273 natural variant: Missing (in STGD1; uncertain significance)
716 T → M: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; decreases N-Ret-PE binding in the range of 40-70%; dbSNP:rs61749426
754 F → S: in STGD1; uncertain significance
764 C → Y: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; decreases N-Ret-PE binding in the range of 40-70%; dbSNP:rs61749428
765 S → N: in STGD1; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61749429; S → R: in STGD1; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61752404
767 V → D: in STGD1; also found in a patient with macular dystrophy; severely decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; severely decreases N-Ret-PE-stimulated ATPase activity; very low substrate binding; dbSNP:rs61751395
779:2273 natural variant: Missing (in STGD1; uncertain significance)
782:2273 natural variant: Missing (in STGD1; uncertain significance)
797 L → P: in STGD1; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61749432
808:2273 natural variant: Missing (in STGD1; uncertain significance)
816 G → V: in STGD1; uncertain significance
818 G → E: in STGD1; reduced ATP-binding capacity; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; very low substrate binding; dbSNP:rs61750202
821 W → R: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; very low substrate binding; dbSNP:rs61749433
824 I → T: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; very low substrate binding
840 M → R: in STGD1; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding
846 D → H: severely decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; severely decreases N-Ret-PE-stimulated ATPase activity; very low substrate binding; dbSNP:rs61754027
849 V → A: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; decreases N-Ret-PE binding in the range of 40-70%; dbSNP:rs61749435
851 G → D: in STGD1; highly reduced ATP-binding capacity; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61749436
854 A → T: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; decreases N-Ret-PE binding in the range of 40-70%; dbSNP:rs61749437
863 G → A: in STGD1, FFM and CORD3; also found in a patient with bull's eye maculopathy; mild alteration probably leading to disease phenotype only in combination with a more severe allele; frequent mutation in northern Europe in linkage disequilibrium with the polymorphic variant Q-943; reduced ATP-binding capacity and retinal-stimulated ATP hydrolysis; significantly attenuates 11-cis-retinal binding; decreases about 80% the N-retinylidene-phosphatidylethanolamine transport activity; stimulates modestely the retinal-stimulated ATPase activity; does not affect ATP-independent N-retinylidene-phosphatidylethanolamine binding. Does not affect ATP-dependent release of N-retinylidene-phosphatidylethanolamine; significantly reduces phosphatidylethanolamine flippase activity; dbSNP:rs76157638; natural variant: Missing (in STGD1 and CORD3; reduced ATP-binding capacity and retinal-stimulated ATP hydrolysis)
876:2273 natural variant: Missing (in STGD1; uncertain significance)
901 T → A: in dbSNP:rs61754030
914 natural variant: H -> R
940 P→R: Decreases 11-cis-Retinal binding affinity by 50%.
1029:2273 natural variant: Missing (in STGD1; uncertain significance)
1099:2273 natural variant: Missing (in STGD1; uncertain significance)
1140 C → W: in STGD1; uncertain significance
1145 L → H: in CORD3; uncertain significance
1148 natural variant: K -> T
1159 L → S: in STGD1; uncertain significance; dbSNP:rs1340749727
1161 R → H: in STGD1; uncertain significance; dbSNP:rs768278935
1177:2273 natural variant: Missing (in STGD1; uncertain significance)
1183 G → C: in CORD3; uncertain significance; dbSNP:rs75267647
1201 L → R: in STGD1; may predispose to develop retinal toxicity after treatment with chloroquine and hydroxychloroquine; dbSNP:rs61750126
1203 G → E: in CORD3; uncertain significance; dbSNP:rs146786552; G → R: in STGD1; uncertain significance
1204 D → N: in STGD1; uncertain significance; dbSNP:rs61750127
1209 M → T: in dbSNP:rs76258939
1253 T → M: in FFM; uncertain significance; dbSNP:rs61752424
1300 R → Q: in STGD1; uncertain significance; dbSNP:rs61750129
1300:2273 natural variant: Missing (in STGD1; uncertain significance; dbSNP:rs61752427)
1314 P → T: in dbSNP:rs61754041
1332:2273 natural variant: Missing (in STGD1; uncertain significance)
1357 A→T: Decreases solubility at 50%. Loss of intracellular vesicle localization. Does not affect substrate binding. Reduces basal ATPase activity.
1368 R → C: in CORD3; uncertain significance; dbSNP:rs1183074086
1371 K → N: in STGD1; uncertain significance
1380 P → L: in STGD1; also found in a patient with chorioretinal atrophy; reduced ATP-binding capacity; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs61750130
1399 E → K: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; increases N-Ret-PE binding; dbSNP:rs62642573
1408 W → L: in STGD1; does not affect secondary structure; decreases structural flexibility; significantly decreases all-trans-retinal binding; dbSNP:rs61750134; W → R: in STGD1; reduced retinal-stimulated ATP hydrolysis; dbSNP:rs61750135
1408:2273 natural variant: Missing (in STGD1; uncertain significance)
1416 natural variant: Missing (in STGD1; uncertain significance)
1428 T → M: in dbSNP:rs1800549
1442 N → K: in STGD1; uncertain significance; dbSNP:rs762150575
1443 R → H: in STGD1; loss of the majority of alpha-helical secondary structure; does not bind all-trans-retinal; does not affect conformational change; dbSNP:rs61750142
1444 modified: Disulfide link with 1455
1453:2273 natural variant: Missing (in STGD1; uncertain significance)
1455 modified: Disulfide link with 1444
1461:2273 natural variant: Missing (in STGD1; uncertain significance)
1469 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1479:2273 natural variant: Missing (in STGD1 and CORD3; uncertain significance; dbSNP:rs61752434)
1484 P → S: in STGD1; uncertain significance
1488 modified: Disulfide link with 1502; C → R: in STGD1 and FFM; also found in a patient with chorioretinal atrophy; reduced retinal-stimulated ATP hydrolysis; does not affect secondary structure; oss of structural flexibility; significantly decreases all-trans-retinal binding; dbSNP:rs61750146
1490 modified: Disulfide link with 641, Interchain; C → Y: in STGD1 and CORD3; reduced retinal-stimulated ATP hydrolysis; dbSNP:rs61751402
1502 modified: Disulfide link with 1488; C→R: Moderately decreased protein abundance. Moderately decreased ATPase activity. Moderately decreased phospholipid translocase activity.
1503 P → L: in STGD1; uncertain significance
1511 P → H: in STGD1; uncertain significance; dbSNP:rs886046564
1512 P → R: in STGD1; uncertain significance; dbSNP:rs61750150
1526 T → M: in STGD1; also found in a patient with chorioretinal atrophy; reduced retinal-stimulated ATP hydrolysis; dbSNP:rs61750152
1529 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1537 T → M: in STGD1; moderately decreased protein abundance; moderately decreased ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs62642575
1551 natural variant: Missing (in STGD1; uncertain significance)
1556 R → T: in STGD1; uncertain significance
1557 Y → C: found in a patient with chorioretinal atrophy; uncertain significance; dbSNP:rs1401716074
1562 I → T: in STGD1, FFM, ARMD2 and CORD3; uncertain significance; dbSNP:rs1762111
1572 T → M: in dbSNP:rs185093512
1588 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1591 G → R: in STGD1; uncertain significance; also found in a patient with macular dystrophy; uncertain significance; dbSNP:rs113106943
1598 A → D: in CORD3 and STGD1; uncertain significance; dbSNP:rs61750155
1618:2273 natural variant: Missing
1623 G → V: in dbSNP:rs1571257969
1637 A → T: in dbSNP:rs61754056
1640 R → Q: in STGD1, FFM and CORD3; dbSNP:rs61751403; R → W: in STGD1 and CORD3; dbSNP:rs61751404
1650:2273 natural variant: Missing (in CORD3; uncertain significance)
1652:2273 natural variant: Missing (in STGD1 and FFM; uncertain significance)
1662 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1681:1685 natural variant: Missing (in STGD1; highly reduced ATP-binding capacity)
1696 S → N: in STGD1; uncertain significance; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; increases N-Ret-PE binding; dbSNP:rs61750564
1703 Q → E: in STGD1; uncertain significance; does not affect solubility; does not affect location in cytoplasmic vesicle;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; dbSNP:rs61750565; Q → K: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity
1705 R → L: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs61753021; R → Q: in STGD1; uncertain significance; dbSNP:rs61753021
1724:2273 natural variant: Missing (in STGD1; uncertain significance)
1754 Y → D: in STGD1; uncertain significance
1761:1763 natural variant: Missing (in STGD1; highly reduced ATP-binding capacity)
1762 A → D: in STGD1; uncertain significance; dbSNP:rs121909206
1773 A → E: found in a patient with chorioretinal atrophy; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; A → V: in STGD1; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; dbSNP:rs760549861
1775 I → N: in STGD1; uncertain significance; dbSNP:rs771742619
1779 Y → H: in STGD1; uncertain significance
1779:2273 natural variant: Missing (in STGD1; uncertain significance)
1794 A → D: in STGD1; also found in a patient with bull's eye maculopathy; uncertain significance; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; severely decreases N-Ret-PE-stimulated ATPase activity; dbSNP:rs61751406; A → P: in STGD1; uncertain significance; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; decreases solubility below 50%; significantly reduces N-Ret-PE binding in the absence of ATP; dbSNP:rs1571252997
1805 N → D: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs61753029
1817 natural variant: E -> D
1838 H → D: in STGD1; uncertain significance; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs62642562; H → N: in STGD1; uncertain significance; does not affect solubility; does not affect location in cytoplasmic vesicle; decreases basal ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs62642562; H → Y: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; severely decreases N-Ret-PE-stimulated ATPase activity; dbSNP:rs62642562; H→R: Severely decreases solubility. Loss of cytoplasmic vesicle localization. Decreases basal ATPase activity below 50%. Loss of N-Ret-PE-induced stimulation in ATPase activity.
1843 R → W: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; does not affect N-Ret-PE binding; dbSNP:rs62642576
1868 N → I: risk factor for STGD1; slightly reduced retinal-stimulated ATP hydrolysis; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; does not affect N-Ret-PE binding; dbSNP:rs1801466
1882 M → I: in CORD3; uncertain significance; dbSNP:rs752160946
1886 G → E: in STGD1; highly reduced ATP-binding capacity; dbSNP:rs62642579
1898 R → C: does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; dbSNP:rs201357151; R → H: in STGD1 and ARMD2; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; Increases N-Ret-PE binding; dbSNP:rs1800552
1921 V → G: in STGD1; uncertain significance
1940 L → P: in STGD1 and FFM; dbSNP:rs61753033
1942 E → Q: in STGD1; uncertain significance; dbSNP:rs760353830
1948 P → L: in dbSNP:rs56142141; natural variant: P -> S
1961 G → E: in STGD1, FFM and CORD3; risk factor for ARMD2; also found in patients with cone dystrophy and with macular dystrophy; inhibition of ATP hydrolysis by retinal; dbSNP:rs1800553; G → R: in STGD1; uncertain significance; dbSNP:rs142253670
1970 L → F: in ARMD2, FFM and STGD1; also found in a patient with cone dystrophy; dbSNP:rs28938473
1971 L → R: in FFM; highly reduced ATP-binding capacity; abolishes basal and retinal-stimulated ATP hydrolysis; dbSNP:rs61753034
1972:1980 binding
1975 G→D: Inhibition of retinal-stimulated ATP hydrolysis.
1977 G → S: in STGD1 and ARMD2; highly reduced ATP-binding capacity; inhibition of ATP hydrolysis by retinal; dbSNP:rs61750639
1978 K→M: Inhibits ATPase activity; when associated with M-969. Decreases translocase activity; when associated with M-969. Does not affect protein subcellular localization in endoplasmic reticulum; when associated with M-969. Loss of ATP-dependent all-trans-retinal transport; when associated with M-1978. Loss in N-retinylidene-PE transfer activity. Inhibits ATPase activity with increasing retinal concentration. Does not affect ATP-independent N-retinylidene-PE binding. Does not affect ATP-dependent of N-retinylidene-PE release. Significantly reduces PE flippase activity. Inhibition of retinal-stimulated ATP hydrolysis.
2017 C → Y: in STGD1; uncertain significance
2023 I → T: in STGD1; uncertain significance; dbSNP:rs150633517
2027 L → F: in STGD1 and FFM; also found in a patient with chorioretinal atrophy; highly reduced ATP-binding capacity; dbSNP:rs61751408
2030 R → Q: in STGD1 and FFM; dbSNP:rs61750641
2030:2273 natural variant: Missing (in STGD1 and CORD3; uncertain significance; dbSNP:rs61751383)
2032 H → R: in STGD1; uncertain significance; dbSNP:rs1242866408
2033 L → R: in STGD1; uncertain significance; dbSNP:rs1553186896
2038 R → W: in STGD1; highly reduced ATP-binding capacity; dbSNP:rs61750643
2040 R → Q: in STGD1; uncertain significance; dbSNP:rs148460146
2040:2273 natural variant: Missing (in STGD1; uncertain significance; also found in a patient with chorioretinal atrophy; uncertain significance; dbSNP:rs61753038)
2042 V → G: in STGD1; uncertain significance
2043 P → S: in CORD3; uncertain significance; dbSNP:rs763230559
2050 V → L: in STGD1 and CORD3; may act as a modifier of macular dystrophy in patients who also have a Trp-172 mutation in PRPH2; dbSNP:rs41292677
2059 natural variant: G -> A
2064 A → T: in STGD1; uncertain significance; dbSNP:rs61753040
2073:2074 binding
2074 G → V: in STGD1; uncertain significance; dbSNP:rs367839100
2077 R → W: in STGD1; highly reduced ATP-binding capacity; decreases solubility at 50 %; loss of intracellular vesicle localization; drastically reduced basal activity with little or no substrate stimulation; dbSNP:rs61750645
2078 K → E: in STGD1; uncertain significance
2096 E → K: in STGD1; inhibition of ATP hydrolysis by retinal; dbSNP:rs61750646; E→Q: Does not affect protein folding; when associated with Q-1087. Loss of ATPase activity; when associated with Q-1087.
2097 P → S: in STGD1; uncertain significance; dbSNP:rs1166357291
2106 R → C: in STGD1 and FFM; reduced ATP-binding capacity; dbSNP:rs61750648
2107 R → C: in STGD1; uncertain significance; dbSNP:rs2297669; R → H: in STGD1 and CORD3; may predispose to develop retinal toxicity after treatment with chloroquine and hydroxychloroquine; dbSNP:rs62642564; R→P: Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
2131 E → K: in STGD1; uncertain significance; dbSNP:rs61750652
2140 L → Q: in STGD1; uncertain significance; dbSNP:rs774475956
2150 C → Y: in STGD1 and CORD3; dbSNP:rs61751384
2177 D → N: in CORD3, ARMD2 and STGD1; uncertain significance; increased retinal-stimulated ATP hydrolysis; dbSNP:rs1800555
2180 P→L: Does not affect protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity.
2188 F → S: in STGD1; uncertain significance; dbSNP:rs61750658
2216 A → V: in dbSNP:rs886044763
2221 L → P: in STGD1; uncertain significance
2237 T → P: in STGD1; uncertain significance
2244:2249 Essential for ATP binding and ATPase activity
2255 S → I: in dbSNP:rs6666652

7lkpA Structure of atp-free human abca4 (see paper)
29% identity, 40% coverage: 20:226/517 of query aligns to 732:940/1941 of 7lkpA

query
sites
7lkpA

K

R

E

E

F

H

P

P

G

G

-

W

-

V

-

P

-

G

-

V

-

C

V

V

K

K

S

N

L

L

-

V

-

K

-

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D

Q

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V

L

S

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L

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A

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A

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F

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L

G

G

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N

N

G

G

A

A

G

G

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T

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H

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F

P
x
H

Q

H

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L

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T

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V

A

A

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x
Q

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A

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R

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binding Digitonin: H819 (≠ P100), Q863 (≠ G148)

Sites not aligning to the query:

binding Digitonin: 522, 526, 530, 533, 616
binding cholesterol: 9, 10, 13, 617, 1073, 1074, 1076, 1402, 1436, 1487, 1492, 1495, 1496, 1499, 1603

P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 2 papers)
29% identity, 45% coverage: 18:250/517 of query aligns to 17:249/265 of P07821

query
sites
P07821

I

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K

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K50 (= K51) mutation to Q: Lack of activity.
D172 (= D174) mutation to E: Lack of activity.
E173 (= E175) mutation to A: Lack of activity.

7e7oA Cryo-em structure of human abca4 in nrpe-bound state (see paper)
29% identity, 39% coverage: 27:226/517 of query aligns to 824:1016/2003 of 7e7oA

query
sites
7e7oA

S

A

L

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D

Q

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A

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G

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A

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M

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R

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D

R

R

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A

V

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M

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K

A

D

Q

G

G

R

R

Sites not aligning to the query:

binding [(2S)-3-[2-[(E)-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenylidene]amino]ethoxy-oxidanyl-phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxy-propyl] (Z)-octadec-9-enoate: 285, 290, 526, 527, 589, 592, 1454

3fvqB Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
32% identity, 43% coverage: 13:232/517 of query aligns to 4:221/350 of 3fvqB

query
sites
3fvqB

L

L

E

H

V

I

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R

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F
|
F

P
x
Q

G

N

V
x
T

K

P

S
x
V

L

L

D

N

Q

D

V

I

S

S

L

L

G

S

V

L

R

D

A

P

G

G

E

E

I

I

H

L

A

F

L

I

V

I

G

G

E

A

N
x
S

G
|
G

A
x
C

G
|
G

K
|
K

S
x
T

T
|
T

L

L

T

L

K

R

I

C

M

L

A

A

G

G

V

F

Y

E

A

Q

P

P

D

D

S

S

G

G

E

E

I

I

R

S

F

L

A

S

G

G

Q

K

P

T

L

I

Q

F

W

S

K

K

S

N

A

T

A

N

-

L

D

P

A

V

K

R

R

E

H

R

G

R

I

L

H

G

V

Y

I

L

H

V

Q
|
Q

E

E

L

G

V

V

L

L

F

F

P

P

Q

H

S

L

T

T

V

V

A

Y

E

R

N

N

I

I

F

A

A

Y

G

G

-

L

-

G

-

N

-

G

-

K

-

G

-

R

-

T

A

A

E

Q

P

E

R

R

T

Q

R

R

I

I

G

-

V

-

L

-

D

-

H

-

G

-

R

-

M

-

N

-

R

-

D

-

A

-

Q

E

A

A

L

M

L

L

G

E

E

L

L

T

G

G

V

I

R

S

L

E

D

L

S

A

R

G

E
x
R

R

Y

V

P

G

H

N
x
E

L

L

S
|
S

V

G

A
x
G

D
x
Q

Q

Q

M

R

V

A

E

A

I

L

A

A

K

R

A

A

M

L

A

A

G

P

E

D

T

P

R

E

V

L

L

I

I

L

L

L

D

D

E

E

P

P

T

F

A

S

V

A

I

L

A

D

G

E

K

Q

-

L

E

R

V

R

Q

Q

L

I

L

R

F

E

A

D

R

M

V

I

R

A

A

A

L

L

R

R

A

A

K

N

G

G

V

K

A

S

I

A

V

V

Y

F

I

V

S

S

H

H

R

D

L

R

D

E

E

E

I

A

F

L

E

Q

L

Y

C

A

D

D

R

R

V

I

T

A

V

V

M

M

K

K

D

Q

G

G

R

R

K

I

V

L

A

Q

T

T

Q

A

S

S

binding adenosine-5'-triphosphate: F13 (= F22), Q14 (≠ P23), T16 (≠ V25), V18 (≠ S27), S38 (≠ N47), G39 (= G48), C40 (≠ A49), G41 (= G50), K42 (= K51), T43 (≠ S52), T44 (= T53), R133 (≠ E145), E137 (≠ N149), S139 (= S151), G141 (≠ A153), Q142 (≠ D154)
binding calcium ion: T43 (≠ S52), Q86 (= Q94)

7lkzA Structure of atp-bound human abca4 (see paper)
28% identity, 39% coverage: 24:226/517 of query aligns to 722:917/1920 of 7lkzA

query
sites
7lkzA

G

G

V

R

K

P

S
x
A

L

V

D

D

Q

R

V

L

S

N

L

I

G

T

V

F

R

Y

A

E

G

N

E

Q

I

I

H

T

A

A

L

F

V

L

G

G

E

H

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T

T

L

T

T

L

K

S

I

I

M

L

A

T

G

G

V

L

Y

L

A

P

P

P

D

T

S

S

G

G

E

T

I

V

R

L

F

V

A

G

G

G

Q

R

P

D

L

I

Q

E

W

-

K

-

S

T

A

S

A

L

D

D

A

A

K

V

R

R

H

Q

G

S

I

L

H

G

V

M

I

C

H

P

Q
|
Q

E

H

L

N

V

I

L

L

F

F

P

H

Q

H

S

L

T

T

V

V

A

A

E

E

N

H

I

M

F

L

A

F

G

Y

A

A

E

Q

P

L

R

K

T

-

R

-

I

-

G

-

V

-

L

-

D

-

H

-

G

G

R

K

M

S

N

Q

R

E

D

E

A

A

Q

Q

-

L

-

E

-

M

-

E

A

A

L

M

L

L

G

E

E

D

L

T

G

G

V

L

R

H

L

H

D
x
K

S

R

R

N

E

E

R

E

V

A

G

Q

N
x
D

L

L

S
|
S

V

G

A

G

D

M

Q

Q

Q

R

M

K

V

L

E

S

I

V

A

A

K

I

A

A

M

F

A

V

G

G

E

D

T

A

R

K

V

V

L

V

I

I

L

L

D

D

E

Q

P

P

T

T

A

S

V

G

I

V

-

D

-

P

-

Y

A

S

G

R

K

R

E

S

V

I

Q

W

L

D

L

L

F

L

A

L

R

K

V

Y

R

R

A

S

L

-

R

-

A

-

K

-

G

G

V

R

A

T

I

I

V

I

Y

M

I

S

S

T

H

H

R

H

L

M

D

D

E

E

I

A

F

D

E

L

L

L

C

G

D

D

R

R

V

I

T

A

V

I

M

I

K

A

D

Q

G

G

R

R

binding adenosine-5'-triphosphate: A725 (≠ S27), N745 (= N47), G746 (= G48), G748 (= G50), K749 (= K51), T750 (≠ S52), K834 (≠ D142), D841 (≠ N149), S843 (= S151)
binding magnesium ion: T750 (≠ S52), Q790 (= Q94)

Sites not aligning to the query:

binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: 22, 465, 566, 567, 568, 572, 592, 593, 595, 1076, 1355, 1362, 1470, 1471
binding adenosine-5'-triphosphate: 718, 1619, 1646, 1647, 1649, 1650, 1651, 1652, 1742, 1744, 1745

7e7qA Cryo-em structure of human abca4 in atp-bound state (see paper)
28% identity, 39% coverage: 24:226/517 of query aligns to 805:1000/1958 of 7e7qA

query
sites
7e7qA

G

G

V

R

K

P

S
x
A

L

V

D

D

Q

R

V

L

S

N

L

I

G

T

V

F

R

Y

A

E

G

N

E

Q

I

I

H

T

A

A

L

F

V

L

G

G

E

H

N
|
N

G

G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

T

L

K

S

I

I

M

L

A

T

G

G

V

L

Y

L

A

P

P

P

D

T

S

S

G

G

E

T

I

V

R

L

F

V

A

G

G

G

Q

R

P

D

L

I

Q

E

W

-

K

-

S

T

A

S

A

L

D

D

A

A

K

V

R

R

H

Q

G

S

I

L

H

G

V

M

I

C

H

P

Q
|
Q

E

H

L

N

V

I

L

L

F

F

P

H

Q

H

S

L

T

T

V

V

A

A

E

E

N

H

I

M

F

L

A

F

G

Y

A

A

E

Q

P

L

R

K

T

-

R

-

I

-

G

-

V

-

L

-

D

-

H

-

G

G

R

K

M

S

N

Q

R

E

D

E

A

A

Q

Q

-

L

-

E

-

M

-

E

A

A

L

M

L

L

G

E

E

D

L

T

G

G

V

L

R

H

L

H

D

K

S

R

R

N

E

E

R

E

V

A

G

Q

N

D

L

L

S
|
S

V

G

A
x
G

D

M

Q

Q

Q

R

M

K

V

L

E

S

I

V

A

A

K

I

A

A

M

F

A

V

G

G

E

D

T

A

R

K

V

V

L

V

I

I

L

L

D

D

E

Q

P

P

T

T

A

S

V

G

I

V

-

D

-

P

-

Y

A

S

G

R

K

R

E

S

V

I

Q

W

L

D

L

L

F

L

A

L

R

K

V

Y

R

R

A

S

L

-

R

-

A

-

K

-

G

G

V

R

A

T

I

I

V

I

Y

M

I

S

S

T

H

H

R

H

L

M

D

D

E

E

I

A

F

D

E

L

L

L

C

G

D

D

R

R

V

I

T

A

V

I

M

I

K

A

D

Q

G

G

R

R

binding adenosine-5'-triphosphate: A808 (≠ S27), N828 (= N47), G831 (= G50), K832 (= K51), T833 (≠ S52), T834 (= T53), Q873 (= Q94), S926 (= S151), G928 (≠ A153)
binding magnesium ion: T833 (≠ S52), Q873 (= Q94)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 801, 804, 1671, 1698, 1701, 1702, 1703, 1704, 1743, 1794, 1796
binding magnesium ion: 1703, 1743

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
27% identity, 46% coverage: 12:251/517 of query aligns to 2:239/240 of 6mjpA

query
sites
6mjpA

L

I

L

L

E

K

V

A

I

Q

R

H

I

L

T

A

K

K

E

S

F

Y

P

K

G

K

V

R

K

K

S

V

L

V

D

S

Q

D

V

V

S

S

L

L

G

Q

V

V

R

E

A

S

G

G

E

Q

I

I

H

V

A

G

L

L

V

L

G

G

E

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

L

S

T

F

K

Y

I

M

M

I

A

V

G

G

V

L

Y

V

A

A

P

R

D

D

S

E

G

G

E

T

I

I

R

T

F

I

A

D

G

D

Q

N

P

D

L

I

Q

S

W

I

K

L

S

P

A

M

A

H

D

S

A

R

K

S

R

R

H

M

G

G

I

I

H

G

V

Y

I

L

H

P

Q

Q

E

E

L

A

V

S

L

I

F

F

P

R

Q

K

S

L

T

S

V

V

A

E

E

D

N

N

I

I

F

M

A

A

G

V

A

L

E

Q

P

T

R

R

T

E

R

E

I

-

G

-

V

-

L

L

D

T

H

H

G
x
E

R

E

M

R

N

Q

R
x
D

D

K

A

L

Q

E

A

D

L

L

G

E

E

E

L

F

G

H

V

I

R

Q

L

H

D

I

S

R

R

K

E

S

R

A

V

G

G

M

N

A

L

L

S

S

V

G

A

G

D

E

Q

R

M

R

V

V

E

E

I

I

A

A

K

R

A

A

M

L

A

A

G

A

E

N

T

P

R

Q

V

F

L

I

I

L

L

L

D

D

E

Q

P

P

T

F

A

A

V

G

I

V

A

D

G

P

K

I

E

S

V

V

Q

I

L

D

L

I

F

K

A

K

R

I

V

I

R

E

A

H

L

L

R

R

A

D

K

R

G

G

V

L

A

G

I

V

V

L

Y

I

I

T

S

D

H

H

R

N

L

V

D

R

E

E

I

T

F

L

E

D

L

V

C

C

D

E

R

K

V

A

T

Y

V

I

M

V

K

S

D

Q

G

G

R

R

K

L

V

I

A

A

-

E

-

G

-

T

T

P

Q

Q

S

D

V

V

A

L

N

N

T

N

T

-

R

-

D

E

Q

Q

L

V

V

K

R

Q

L

V

M

Y

V

L

G

G

R

E

E

Q

M

F

K

R

binding calcium ion: E111 (≠ G124), D115 (≠ R128)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
28% identity, 45% coverage: 12:243/517 of query aligns to 6:233/240 of 1ji0A

query
sites
1ji0A

L

V

L

L

E

E

V

V

I

Q

R

S

I

L

T

H

K

V

E

Y

F
x
Y

P

G

G

A

V

I

K

H

S

A

L

I

D

K

Q

G

V

I

S

D

L

L

G

K

V

V

R

P

A

R

G

G

E

Q

I

I

H

V

A

T

L

L

V

I

G

G

E

A

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

T

L

K

S

I

A

M

I

A

A

G

G

V

L

Y

V

A

R

P

A

D

Q

S

K

G

G

E

K

I

I

R

I

F

F

A

N

G

G

Q

Q

P

D

L

I

Q

T

W

N

K

K

S

P

A

A

A

H

D

V

A

I

K

N

R

R

H

M

G

G

I

I

H

A

V

L

I

V

H

P

Q
x
E

E

G

L

R

V

R

L

I

F

F

P

P

Q

E

S

L

T

T

V

V

A

Y

E

E

N

N

I

L

F

M

A

M

G

G

A

A

E

Y

P

N

R

R

T

K

R

-

I

-

G

-

V

-

L

-

D

D

H

K

G

E

R

G

M

I

N

K

R

R

D

D

A

L

Q

E

A

W

L

I

L

F

G

-

E

S

L

L

G

F

V

P

R

R

L

L

D

K

S

E

R

R

E

L

R

K

V

Q

-

L

-

G

G

G

N

T

L

L

S

S

V

G

A

G

D

E

Q

Q

M

M

V

L

E

A

I

I

A

G

K

R

A

A

M

L

A

M

G

S

E

R

T

P

R

K

V

L

L

L

I

M

L

M

D

D

E
|
E

P

P

T

S

A

L

V

G

I

L

A

A

G

P

K

I

E

L

V

V

Q

S

L

E

L

V

F

F

A

E

R

V

V

I

R

Q

A

K

L

I

R

N

A

Q

K

E

G

G

V

T

A

T

I

I

V

L

Y

L

I

V

S

E

H

Q

R

N

L

A

D

L

E

G

I

A

F

L

E

K

L

V

C

A

D

H

R

Y

V

G

T

Y

V

V

M

L

K

E

D

T

G

G

R

Q

K

I

V

V

A

L

T

E

Q

G

S

K

V

A

A

S

N

E

T

L

R

D

D

N

Q

E

L

M

V

V

R

R

binding adenosine-5'-triphosphate: Y16 (≠ F22), G42 (= G48), G44 (= G50), K45 (= K51), T46 (≠ S52), T47 (= T53), E88 (≠ Q94), E165 (= E175)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
31% identity, 42% coverage: 12:229/517 of query aligns to 4:223/650 of 5ws4A

query
sites
5ws4A

L

L

E

E

V

V

I

S

R

N

I

L

T

V

K

R

E

E

F

F

P

P

G

A

-

G

-

E

-

S

-

T

V

I

K

Q

S

I

L

L

D

K

Q

G

V

I

S

D

L

L

G

T

V

I

R

Y

A

E

G

G

E

E

I

L

H

V

A

A

L

I

V

V

G

G

E

Q

N
x
S

G
|
G

A

S

G

G

K

K

S
|
S

T

T

L

L

T

M

K

N

I

I

M

L

A

G

G

C

V

L

Y

D

A

R

P

P

D

T

S

S

G

G

E

S

I

Y

R

K

F

V

A

N

G

G

Q

Q

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S

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (≠ N47), G44 (= G48), S48 (= S52)

Query Sequence

>H281DRAFT_01057 FitnessBrowser__Burk376:H281DRAFT_01057
MNGHADISAGDLLEVIRITKEFPGVKSLDQVSLGVRAGEIHALVGENGAGKSTLTKIMAG
VYAPDSGEIRFAGQPLQWKSAADAKRHGIHVIHQELVLFPQSTVAENIFAGAEPRTRIGV
LDHGRMNRDAQALLGELGVRLDSRERVGNLSVADQQMVEIAKAMAGETRVLILDEPTAVI
AGKEVQLLFARVRALRAKGVAIVYISHRLDEIFELCDRVTVMKDGRKVATQSVANTTRDQ
LVRLMVGREMKDIYPDKPILAPGVPNVLEVNGLCVGNRVVDASLTVRAGEIVGIAGMVGS
GRTELAAGIFGALRAHRGTVDIGGTRRTRMTPRTAIRLGLGFVTEDRKSQGLLMLLDVAQ
NVTATTLAQVSRFGLMRPALERAAAQAAINEYRIAGAHPAGGVATLSGGNQQKVLISRWV
RVCKRVLILDEPTRGVDVGAKAEIYRVMRELTSRGLGILMISSELQEVIGMSDRVLVMRE
GRINGEVSGEQMTEHDIMRLATTETSQTTGDAHEHAY

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory