Comparing H281DRAFT_01493 H281DRAFT_01493 aspartate carbamoyltransferase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1ml4A The pala-liganded aspartate transcarbamoylase catalytic subunit from pyrococcus abyssi (see paper)
41% identity, 73% coverage: 85:400/430 of query aligns to 2:306/307 of 1ml4A
P20054 Multifunctional protein pyr1-3; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Dictyostelium discoideum (Social amoeba)
40% identity, 83% coverage: 44:399/430 of query aligns to 1885:2222/2225 of P20054
Sites not aligning to the query:
6ys6B Arabidopsis aspartate transcarbamoylase complex with pala (see paper)
44% identity, 70% coverage: 96:398/430 of query aligns to 14:309/312 of 6ys6B
6ypoA Arabidopsis aspartate transcarbamoylase bound to ump (see paper)
44% identity, 70% coverage: 96:398/430 of query aligns to 14:309/312 of 6ypoA
6yvbC Arabidopsis aspartate transcarbamoylase complex with carbamoyl phosphate (see paper)
44% identity, 70% coverage: 96:398/430 of query aligns to 26:321/324 of 6yvbC
P49077 Aspartate carbamoyltransferase, chloroplastic; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
43% identity, 70% coverage: 96:398/430 of query aligns to 92:387/390 of P49077
5g1nE Aspartate transcarbamoylase domain of human cad bound to pala (see paper)
41% identity, 72% coverage: 90:399/430 of query aligns to 7:305/307 of 5g1nE
P08955 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Mesocricetus auratus (Golden hamster) (see paper)
41% identity, 72% coverage: 90:399/430 of query aligns to 1925:2223/2225 of P08955
Sites not aligning to the query:
P27708 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Homo sapiens (Human) (see 7 papers)
41% identity, 72% coverage: 90:399/430 of query aligns to 1925:2223/2225 of P27708
Sites not aligning to the query:
4eknB Structure of the catalytic chain of methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form (see paper)
41% identity, 72% coverage: 90:398/430 of query aligns to 3:300/304 of 4eknB
5g1pA Aspartate transcarbamoylase domain of human cad bound to carbamoyl phosphate (see paper)
41% identity, 72% coverage: 90:399/430 of query aligns to 4:290/292 of 5g1pA
Q18990 Multifunctional protein pyr-1; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Caenorhabditis elegans (see 3 papers)
42% identity, 72% coverage: 90:399/430 of query aligns to 1878:2194/2198 of Q18990
Sites not aligning to the query:
P05990 Multifunctional protein r; Protein rudimentary; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Drosophila melanogaster (Fruit fly) (see 2 papers)
38% identity, 76% coverage: 72:399/430 of query aligns to 1904:2218/2224 of P05990
Sites not aligning to the query:
P07259 Multifunctional protein URA2; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
36% identity, 91% coverage: 12:401/430 of query aligns to 1852:2213/2214 of P07259
Q09794 Multifunctional protein ura1; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
40% identity, 74% coverage: 88:405/430 of query aligns to 1936:2244/2244 of Q09794
Sites not aligning to the query:
8bplA Aspartate transcarbamoylase mutant (n2045c, r2238c) from chaetomium thermophilum cad-like bound to carbamoyl phosphate (see paper)
40% identity, 73% coverage: 88:399/430 of query aligns to 15:316/316 of 8bplA
6jktA Crystal structure of aspartate transcarbamoylase from trypanosoma cruzi in complex with n-(phosphonacetyl)-l-aspartic acid (pala).
41% identity, 73% coverage: 86:399/430 of query aligns to 13:310/310 of 6jktA
6jksD Crystal structure of aspartate transcarbamoylase from trypanosoma cruzi in complex with carbamoyl phosphate (cp) and aspartate (asp)
41% identity, 73% coverage: 86:399/430 of query aligns to 13:328/328 of 6jksD
7zeaB Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum with bound inhibitor o-benzylhydroxylamine (see paper)
33% identity, 80% coverage: 74:418/430 of query aligns to 9:346/346 of 7zeaB
7zidB Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum in complex with bda-14 (see paper)
35% identity, 72% coverage: 91:399/430 of query aligns to 14:326/331 of 7zidB
>H281DRAFT_01493 H281DRAFT_01493 aspartate carbamoyltransferase
MSVPQQAFLRDAMRRLNMTRETFAGRIGVSRRALDTWLLPDDSQESRAMPEIVERFVSEI
VVHGEPGDRYTQSVDSQSLASQMLWEGKPQLLSVDQFSRDSVEALFRVADIMQPIARRRK
ISRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVCDTTGFTFSSMAKGESIYDTSRVM
SGYVDALVIRHPEQGSVAEFARATNVPVINGGDGPGEHPSQALLDLYTIQREFSRLGKIV
DGAHIALVGDLKYGRTVHSLVKLLALYRGIKFTLISPPMLEMPGYIIEQISRNGHVIEQT
HDLPTGLRGADVVYATRIQKERFTDESFEGYTPDFQINQALVDSVCGSDTLIMHPLPRDS
RPGANDLSVDLNHDSRLAIFRQTDNGIPVRMAIFAVLLGVEKLVQHSMRDAAWRPPAYLG
PDDAVFHGID
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory