SitesBLAST
Comparing H281DRAFT_02333 FitnessBrowser__Burk376:H281DRAFT_02333 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
39% identity, 97% coverage: 9:477/482 of query aligns to 22:500/515 of 2d4eC
- active site: N173 (≠ S159), K196 (= K182), E271 (= E257), C305 (≠ S291), E409 (= E389), E486 (vs. gap)
- binding nicotinamide-adenine-dinucleotide: I169 (= I155), T170 (≠ A156), P171 (= P157), W172 (= W158), K196 (= K182), A198 (= A184), G229 (= G215), G233 (= G219), A234 (= A220), T248 (≠ S234), G249 (= G235), E250 (≠ S236), T253 (= T239), E271 (= E257), L272 (≠ M258), C305 (≠ S291), E409 (= E389), F411 (= F391), F475 (≠ G456)
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
36% identity, 93% coverage: 18:465/482 of query aligns to 14:460/481 of 3jz4A
- active site: N156 (≠ S159), K179 (= K182), E254 (= E257), C288 (≠ S291), E385 (= E389)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (= P157), W155 (= W158), K179 (= K182), A181 (= A184), S182 (≠ E185), A212 (≠ G215), G216 (= G219), G232 (= G235), S233 (= S236), I236 (≠ T239), C288 (≠ S291), K338 (≠ R341), E385 (= E389), F387 (= F391)
Sites not aligning to the query:
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
36% identity, 93% coverage: 18:465/482 of query aligns to 15:461/482 of P25526
Q8VWZ1 Aminoaldehyde dehydrogenase 1, peroxisomal; PsAMADH1; Aminobutyraldehyde dehydrogenase AMADH1; Gamma-guanidinobutyraldehyde dehydrogenase AMADH1; EC 1.2.1.-; EC 1.2.1.19; EC 1.2.1.54 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
34% identity, 95% coverage: 9:465/482 of query aligns to 3:468/503 of Q8VWZ1
- N27 (≠ S31) binding
- I28 (≠ L32) binding
- D99 (≠ E99) binding
- L189 (≠ S186) binding
- 238:245 (vs. 235:242, 50% identical) binding
- C294 (≠ S291) binding
- E393 (= E389) binding
3iwkH Crystal structure of aminoaldehyde dehydrogenase 1 from pisum sativum (psamadh1) (see paper)
35% identity, 93% coverage: 17:465/482 of query aligns to 6:463/497 of 3iwkH
- active site: N157 (≠ S159), K180 (= K182), E255 (= E257), C289 (≠ S291), E388 (= E389)
- binding nicotinamide-adenine-dinucleotide: W156 (= W158), G213 (= G215), G217 (= G219), A218 (= A220), G233 (= G235), S234 (= S236), T237 (= T239), K240 (≠ R242), C289 (≠ S291), Q336 (= Q338), E388 (= E389), F390 (= F391)
Sites not aligning to the query:
P17202 Aminoaldehyde dehydrogenase BADH; 4-trimethylammoniobutyraldehyde dehydrogenase BADH; Aminobutyraldehyde dehydrogenase BADH; Betaine aldehyde dehydrogenase; SoBADH; EC 1.2.1.-; EC 1.2.1.47; EC 1.2.1.19; EC 1.2.1.8 from Spinacia oleracea (Spinach) (see 3 papers)
33% identity, 93% coverage: 17:465/482 of query aligns to 11:465/497 of P17202
- I28 (≠ L32) binding
- D96 (≠ E99) binding
- SPW 156:158 (≠ APW 156:158) binding
- Y160 (≠ A160) mutation to A: Decreases binding affinity for betaine aldehyde; increases binding affinity for 4-(trimethylamino)butanal.
- W167 (≠ G167) mutation to A: Decreases binding affinity for betaine aldehyde; increases binding affinity for 4-aminobutanal.
- KPSE 182:185 (≠ KPAE 182:185) binding
- L186 (≠ S186) binding
- SSAT 236:239 (≠ SAET 236:239) binding
- V251 (≠ Q251) binding in other chain
- L258 (≠ M258) binding
- W285 (≠ G285) mutation to A: Decreases binding affinity for betaine aldehyde.
- E390 (= E389) binding
- A441 (≠ L440) mutation to I: Decreases binding affinity for betaine aldehyde; increases binding affinity for 4-aminobutanal.
- C450 (≠ V450) mutation to S: Loss of partial inactivation by betaine aldehyde in the absence of NAD(+).
- W456 (≠ G456) binding ; mutation to A: Decreases binding affinity for betaine aldehyde.
- K460 (= K460) binding
4v37A Crystal structure of betaine aldehyde dehydrogenase from spinach showing a thiohemiacetal with 3-aminopropionaldehyde
33% identity, 93% coverage: 17:465/482 of query aligns to 9:463/495 of 4v37A
- active site: N157 (≠ S159), K180 (= K182), E255 (= E257), A289 (≠ S291), E388 (= E389)
- binding 3-aminopropan-1-ol: C448 (≠ V450), W454 (≠ G456)
- binding nicotinamide-adenine-dinucleotide: I153 (= I155), S154 (≠ A156), P155 (= P157), W156 (= W158), N157 (≠ S159), M162 (≠ I164), K180 (= K182), S182 (≠ A184), E183 (= E185), G213 (= G215), G217 (= G219), A218 (= A220), T232 (≠ S234), G233 (= G235), S234 (= S236), T237 (= T239), E255 (= E257), L256 (≠ M258), A289 (≠ S291), E388 (= E389), F390 (= F391)
Sites not aligning to the query:
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
34% identity, 95% coverage: 12:471/482 of query aligns to 1:468/483 of 4npiA
- active site: N152 (≠ S159), K175 (= K182), E251 (= E257), C285 (≠ S291), E387 (= E389), E464 (≠ T467)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (≠ E106), L157 (≠ I164), W160 (≠ G167), E251 (= E257), C285 (≠ S291), Y445 (≠ S448), R447 (≠ V450), F453 (≠ G456)
- binding nicotinamide-adenine-dinucleotide: I148 (= I155), S149 (≠ A156), P150 (= P157), W151 (= W158), K175 (= K182), E178 (= E185), G208 (= G215), G213 (= G219), E214 (≠ A220), F227 (= F233), G229 (= G235), E230 (≠ S236), T233 (= T239), G253 (= G259), C285 (≠ S291), K335 (≠ R341), E387 (= E389), F389 (= F391)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
34% identity, 95% coverage: 12:471/482 of query aligns to 1:468/483 of 4i2rA
- active site: N152 (≠ S159), K175 (= K182), E251 (= E257), C285 (≠ S291), E387 (= E389), E464 (≠ T467)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (≠ E106), L157 (≠ I164), C285 (≠ S291), Y445 (≠ S448), R447 (≠ V450), F453 (≠ G456)
- binding nicotinamide-adenine-dinucleotide: I148 (= I155), S149 (≠ A156), W151 (= W158), N152 (≠ S159), K175 (= K182), E178 (= E185), G208 (= G215), F227 (= F233), T228 (≠ S234), G229 (= G235), E230 (≠ S236), T233 (= T239), E251 (= E257), L252 (≠ M258), G253 (= G259), C285 (≠ S291), E387 (= E389), F389 (= F391)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
34% identity, 95% coverage: 12:471/482 of query aligns to 1:468/483 of 4i25A
- active site: N152 (≠ S159), K175 (= K182), E251 (= E257), C285 (≠ S291), E387 (= E389), E464 (≠ T467)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (≠ E106), L157 (≠ I164), C285 (≠ S291), Y445 (≠ S448), R447 (≠ V450), F453 (≠ G456)
- binding nicotinamide-adenine-dinucleotide: I148 (= I155), S149 (≠ A156), P150 (= P157), W151 (= W158), N152 (≠ S159), K175 (= K182), E178 (= E185), G208 (= G215), G213 (= G219), F227 (= F233), T228 (≠ S234), G229 (= G235), E230 (≠ S236), T233 (= T239), E251 (= E257), L252 (≠ M258), C285 (≠ S291), E387 (= E389), F389 (= F391)
5kj5B Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
34% identity, 95% coverage: 12:471/482 of query aligns to 2:469/484 of 5kj5B
- active site: D153 (≠ S159), K176 (= K182), E252 (= E257), C286 (≠ S291), E388 (= E389), E465 (≠ T467)
- binding nicotinamide-adenine-dinucleotide: I149 (= I155), S150 (≠ A156), P151 (= P157), W152 (= W158), D153 (≠ S159), L158 (≠ I164), K176 (= K182), G209 (= G215), K210 (≠ R216), G214 (= G219), F228 (= F233), T229 (≠ S234), G230 (= G235), E231 (≠ S236), T234 (= T239), E252 (= E257), L253 (≠ M258), C286 (≠ S291), E388 (= E389), F390 (= F391), F454 (≠ G456)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d (see paper)
34% identity, 95% coverage: 12:471/482 of query aligns to 1:468/483 of 5kllA
- active site: D152 (≠ S159), K175 (= K182), E251 (= E257), C285 (≠ S291), E387 (= E389), E464 (≠ T467)
- binding (3~{E},5~{E})-6-oxidanyl-2-oxidanylidene-hexa-3,5-dienoic acid: R103 (≠ E106), D152 (≠ S159), L157 (≠ I164), W160 (≠ G167), C285 (≠ S291), Y445 (≠ S448), R447 (≠ V450), F453 (≠ G456)
5ek6A Thermostable aldehyde dehydrogenase from pyrobaculum sp. 1860 complexed with NADP and isobutyraldehyde (see paper)
34% identity, 96% coverage: 16:479/482 of query aligns to 3:463/482 of 5ek6A
- active site: N147 (≠ S159), K170 (= K182), E245 (= E257), C279 (≠ S291), E374 (= E389), E452 (≠ D468)
- binding 2-methylpropanal: I152 (= I164), K155 (≠ G167), T222 (≠ S234), E245 (= E257), F441 (≠ G456)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I143 (= I155), T144 (≠ A156), W146 (= W158), N147 (≠ S159), I152 (= I164), K170 (= K182), A172 (= A184), S173 (≠ E185), P202 (≠ S214), G203 (= G215), G207 (= G219), F221 (= F233), T222 (≠ S234), G223 (= G235), E224 (≠ S236), T227 (= T239), I231 (≠ V243), E245 (= E257), L246 (≠ M258), C279 (≠ S291), E374 (= E389)
4h73A Thermostable aldehyde dehydrogenase from pyrobaculum sp. Complexed with NADP+
34% identity, 96% coverage: 16:479/482 of query aligns to 3:463/482 of 4h73A
- active site: N147 (≠ S159), K170 (= K182), E245 (= E257), C279 (≠ S291), E374 (= E389), E452 (≠ D468)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I143 (= I155), T144 (≠ A156), P145 (= P157), W146 (= W158), K170 (= K182), A172 (= A184), S173 (≠ E185), G203 (= G215), G207 (= G219), F221 (= F233), G223 (= G235), E224 (≠ S236), T227 (= T239)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens (see paper)
34% identity, 95% coverage: 12:471/482 of query aligns to 1:468/483 of 4ou2A
- active site: N152 (≠ S159), K175 (= K182), A251 (≠ E257), C285 (≠ S291), E387 (= E389), E464 (≠ T467)
- binding (2Z,4E)-2,6-dihydroxyhexa-2,4-dienoic acid: R103 (≠ E106), L157 (≠ I164), C285 (≠ S291), Y445 (≠ S448), R447 (≠ V450), F453 (≠ G456)
- binding nicotinamide-adenine-dinucleotide: I148 (= I155), S149 (≠ A156), P150 (= P157), W151 (= W158), N152 (≠ S159), K175 (= K182), G208 (= G215), G213 (= G219), E214 (≠ A220), F227 (= F233), T228 (≠ S234), G229 (= G235), E230 (≠ S236), T233 (= T239), A251 (≠ E257), L252 (≠ M258), G253 (= G259), C285 (≠ S291), E387 (= E389), F389 (= F391)
5ekcE Thermostable aldehyde dehydrogenase from pyrobaculum sp.1860 complexed with NADP+
34% identity, 96% coverage: 16:479/482 of query aligns to 10:470/490 of 5ekcE
- active site: N154 (≠ S159), K177 (= K182), E252 (= E257), C286 (≠ S291), E381 (= E389), E459 (≠ D468)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I150 (= I155), T151 (≠ A156), P152 (= P157), W153 (= W158), K177 (= K182), S180 (≠ E185), G210 (= G215), G214 (= G219), F228 (= F233), G230 (= G235), E231 (≠ S236), T234 (= T239), N331 (= N335), R333 (≠ A337), Q334 (= Q338)
7yjjC Human cytosolic 10-formyltetrahydrofolate dehydrogenase and gossypol complex
36% identity, 95% coverage: 10:466/482 of query aligns to 14:478/498 of 7yjjC
Sites not aligning to the query:
Q93YB2 Aminoaldehyde dehydrogenase 2, peroxisomal; PsAMADH2; Aminobutyraldehyde dehydrogenase AMADH2; Gamma-guanidinobutyraldehyde dehydrogenase AMADH2; EC 1.2.1.-; EC 1.2.1.19; EC 1.2.1.54 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
33% identity, 95% coverage: 10:465/482 of query aligns to 3:468/503 of Q93YB2
- I28 (≠ L32) binding
- D99 (≠ E99) binding
- W161 (= W158) binding
- K185 (= K182) binding
- L189 (≠ S186) binding
- S239 (= S236) binding
6j76A Structure of 3,6-anhydro-l-galactose dehydrogenase in complex with nap (see paper)
33% identity, 97% coverage: 15:480/482 of query aligns to 3:475/477 of 6j76A
- active site: N148 (≠ S159), E246 (= E257), C280 (≠ S291), E458 (≠ T467)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I144 (= I155), T145 (≠ A156), A146 (≠ P157), W147 (= W158), N148 (≠ S159), K171 (= K182), T173 (≠ A184), S174 (≠ E185), G204 (= G215), G208 (= G219), T223 (≠ S234), G224 (= G235), S225 (= S236), A228 (≠ T239), S231 (≠ R242), I232 (≠ V243), E246 (= E257), L247 (≠ M258), C280 (≠ S291), E381 (= E389), F383 (= F391), H447 (≠ G456)
3iwjA Crystal structure of aminoaldehyde dehydrogenase 2 from pisum sativum (psamadh2) (see paper)
33% identity, 94% coverage: 13:465/482 of query aligns to 3:465/500 of 3iwjA
- active site: N159 (≠ S159), K182 (= K182), E257 (= E257), C291 (≠ S291), E390 (= E389)
- binding glycerol: D110 (≠ R113), Y160 (≠ A160), W167 (≠ G167), I290 (≠ R290), C291 (≠ S291), C450 (≠ V450), W456 (≠ G456)
- binding nicotinamide-adenine-dinucleotide: I155 (= I155), T156 (≠ A156), W158 (= W158), K182 (= K182), S184 (≠ A184), E185 (= E185), G215 (= G215), A220 (= A220), F233 (= F233), G235 (= G235), S236 (= S236), T239 (= T239), I243 (≠ V243)
Sites not aligning to the query:
Query Sequence
>H281DRAFT_02333 FitnessBrowser__Burk376:H281DRAFT_02333
MNRDPLVPLVASPLRHYINGGWETGATTGVSLNPSDLDEPVGEYVRADVRQTDSAIEAAS
AAFREWALSSAQRRADALDAIGSEMLARRDELGRLLAREVGKTLPEALAEATRAGQTFKL
LAADAQRAYAEPLASARAGVEIDMTREPLGVVGIIAPWSAPLAIAAGKIGAALAHGNCVV
YKPAESTPACAAALASIVSRAGLPAGVFNLVMGSGRQVGARIVAHPLVAAISFSGSAETG
TRVLQAAAARQARVQLEMGGKNPFVVLADADLDSAVDAALTGAYGSTGQRSTAAARLIVE
RSIFEPFVDALQTKLARLNVDHALKHGADMGPVANAAQLERDLDYVEIGKQEGAQLLHGG
RQLERATRGYFFEPALFVGEPEHRIAREEIFGPLAVVLRADDYDHALHLANDTAYGLCAG
ICTRSLSRARHFRRHVHSGLVTINLPTSAVEHHAPGGGRKASAYGSTDAAFWTAVKTAYV
AS
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory