SitesBLAST
Comparing H281DRAFT_02427 FitnessBrowser__Burk376:H281DRAFT_02427 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 9 hits to proteins with known functional sites (download)
7w2jD Cryo-em structure of membrane-bound fructose dehydrogenase from gluconobacter japonicus
27% identity, 98% coverage: 5:529/534 of query aligns to 3:536/537 of 7w2jD
- binding fe3-s4 cluster: R200 (≠ I187), C211 (= C198), G213 (≠ N200), N214 (≠ L201), N215 (≠ G202), C217 (= C204), C221 (= C208), I223 (≠ Q210), A225 (= A212), S338 (≠ C330)
- binding flavin-adenine dinucleotide: G9 (= G11), G11 (= G13), D32 (≠ E35), A33 (≠ Q36), Y59 (= Y45), K97 (≠ N88), G101 (= G92), T102 (≠ S93), T103 (= T94), H105 (≠ L96), W106 (≠ Y97), S109 (≠ H100), V249 (≠ A237), A284 (≠ C272), N285 (≠ S273), E288 (≠ G276), K291 (≠ R279), L292 (= L280), N472 (≠ W465), N516 (= N509), S517 (≠ P510), T518 (≠ V511)
- binding heme c: P209 (≠ G196), I223 (≠ Q210)
8jejA Cryo-em structure of na-dithionite reduced membrane-bound fructose dehydrogenase from gluconobacter japonicus
27% identity, 98% coverage: 5:529/534 of query aligns to 6:539/540 of 8jejA
- binding fe3-s4 cluster: R203 (≠ I187), C214 (= C198), C215 (≠ V199), G216 (≠ N200), N217 (≠ L201), N218 (≠ G202), N219 (≠ P203), C220 (= C204), C224 (= C208), I226 (≠ Q210), M229 (≠ K213), S341 (≠ C330)
- binding flavin-adenine dinucleotide: I11 (= I10), G12 (= G11), G14 (= G13), I15 (≠ A14), C16 (≠ S15), D35 (≠ E35), A36 (≠ Q36), G97 (≠ S83), K100 (≠ N88), G101 (= G89), G104 (= G92), T105 (≠ S93), T106 (= T94), H108 (≠ L96), W109 (≠ Y97), A110 (≠ S98), S112 (≠ H100), M221 (≠ N205), A250 (≠ C235), V252 (≠ A237), A287 (≠ C272), N288 (≠ S273), E291 (≠ G276), N475 (≠ W465), H476 (= H466), N519 (= N509), T521 (≠ V511), M524 (≠ A514)
8grjB Crystal structure of gamma-alpha subunit complex from burkholderia cepacia fad glucose dehydrogenase in complex with gluconolactone
27% identity, 86% coverage: 72:529/534 of query aligns to 73:531/531 of 8grjB
- binding fe3-s4 cluster: C204 (= C198), C205 (≠ V199), G206 (≠ N200), N207 (≠ L201), N209 (≠ P203), C210 (= C204), C214 (= C208), P331 (≠ D317)
- binding flavin-adenine dinucleotide: Q86 (≠ A85), R89 (≠ N88), T94 (≠ S93), H97 (≠ L96), W98 (≠ Y97), A99 (≠ S98), S101 (≠ H100), M211 (≠ N205), V242 (≠ A237), A277 (≠ C272), N278 (≠ S273), E281 (≠ G276), I285 (≠ L280), N467 (vs. gap), N511 (= N509), T513 (≠ V511)
- binding D-glucono-1,5-lactone: M211 (≠ N205), E333 (≠ D319), H355 (≠ Y337), N466 (vs. gap), N467 (vs. gap), H468 (= H466), N511 (= N509)
Sites not aligning to the query:
B5WWZ8 Long-chain-alcohol oxidase FAO1; Long-chain fatty alcohol oxidase 1; EC 1.1.3.20 from Lotus japonicus (Lotus corniculatus var. japonicus) (see paper)
24% identity, 61% coverage: 202:528/534 of query aligns to 397:747/749 of B5WWZ8
Sites not aligning to the query:
- 396 C→G: Loss of activity.
4ha6A Crystal structure of pyridoxine 4-oxidase - pyridoxamine complex (see paper)
24% identity, 96% coverage: 6:519/534 of query aligns to 3:500/508 of 4ha6A
- active site: F360 (≠ L374), G361 (= G375), H444 (≠ G464), H446 (= H466), G487 (= G506), P488 (≠ A507)
- binding flavin-adenine dinucleotide: G8 (= G11), G10 (= G13), S11 (≠ A14), A12 (≠ S15), E32 (= E35), A33 (≠ Q36), W58 (= W52), R77 (vs. gap), G78 (vs. gap), G83 (= G92), S84 (= S93), L87 (= L96), H88 (≠ Y97), A89 (≠ S98), M90 (≠ A99), G91 (≠ H100), V218 (≠ A237), A251 (≠ S273), G252 (= G274), E255 (≠ G276), H445 (≠ W465), A478 (≠ S499), P488 (≠ A507), I489 (≠ V508), H490 (≠ N509)
- binding 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol: A89 (≠ S98), S314 (= S323), H444 (≠ G464), H446 (= H466)
3t37A Crystal structure of pyridoxine 4-oxidase from mesorbium loti
24% identity, 96% coverage: 6:519/534 of query aligns to 3:500/509 of 3t37A
- active site: F360 (≠ L374), G361 (= G375), H444 (≠ G464), H446 (= H466), G487 (= G506), P488 (≠ A507)
- binding flavin-adenine dinucleotide: G8 (= G11), G10 (= G13), S11 (≠ A14), A12 (≠ S15), E32 (= E35), A33 (≠ Q36), W58 (= W52), R77 (vs. gap), G78 (vs. gap), R79 (vs. gap), G83 (= G92), S84 (= S93), H88 (≠ Y97), A89 (≠ S98), G91 (≠ H100), R217 (= R236), V218 (≠ A237), A251 (≠ S273), E255 (≠ G276), H445 (≠ W465), A478 (≠ S499), P488 (≠ A507), I489 (≠ V508), H490 (≠ N509)
7qfdA Crystal structure of a bacterial pyranose 2-oxidase complex with d- glucose (see paper)
26% identity, 29% coverage: 376:529/534 of query aligns to 299:453/458 of 7qfdA
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 11, 14, 15, 16, 36, 37, 38, 101, 106, 107, 111, 112, 114, 210, 211, 246, 250
- binding alpha-D-glucopyranose: 77, 112
7qvaA Crystal structure of a bacterial pyranose 2-oxidase in complex with mangiferin (see paper)
28% identity, 24% coverage: 403:529/534 of query aligns to 324:452/457 of 7qvaA
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 11, 12, 14, 15, 16, 36, 37, 38, 97, 102, 103, 106, 107, 108, 110, 206, 207, 241, 242, 243, 246
- binding Mangiferin: 51, 73, 108, 299
7qf8A Crystal structure of a bacterial pyranose 2-oxidase from pseudoarthrobacter siccitolerans (see paper)
28% identity, 24% coverage: 403:529/534 of query aligns to 359:487/494 of 7qf8A
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 11, 12, 14, 15, 16, 37, 38, 114, 119, 120, 124, 125, 127, 227, 261, 262, 263, 266, 331
Query Sequence
>H281DRAFT_02427 FitnessBrowser__Burk376:H281DRAFT_02427
MKEVADIVIIGSGASGAAAAWSLSRDRSLRIVCLEQGSVTKPSDYPSTSVDWELSRSGAY
SSNPSVRRSAADYPIDDSASPISIANFNGFGGSTILYSAHFPRFHPSDFRTRTLDGVGDD
WPLSFEELKPFFTENERMMGVAGLVGDPANPDYESLLPPIPLGPMGRTMAAAFNELGWHW
WPSYSAINTHRHGNRGACVNLGPCNTGCAQGAKASVDVTYWPVARQQGVEVRTQCRAREI
TLDARGQADGVLYMDADGVEHRLNARVVVVACSGVGTPRLLLNSRSSAFPDGLLNDNGLV
GRNLMLHPLAYTEAVFDHDVQSSIGPHGCCILSQQFYESAAERDFVRGYTMQVLRGAPPV
ETAVSGYFMRQVPLGAEHHAKFNRLFNRTAGIAIITEDLPEPENRVELDPDRCDSSGMPG
VKVFYKLGDNTSRMLKHGIEMSKQVFAAAGAKVMSSFAPVKNTGWHLMGTARMGDDPATS
VVNKFGQAHAVKNLFIVDSSIFVTAGAVNPVATAQALTLMACDHLQRNLHTLVA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory