SitesBLAST
Comparing H281DRAFT_02499 FitnessBrowser__Burk376:H281DRAFT_02499 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
44% identity, 95% coverage: 12:488/503 of query aligns to 5:482/489 of 4o6rA
- active site: N150 (= N158), K173 (= K181), E248 (= E256), C282 (= C290), E383 (= E389), E460 (= E466)
- binding adenosine monophosphate: I146 (≠ M154), V147 (≠ T155), K173 (= K181), G206 (= G214), G210 (= G218), Q211 (≠ A219), F224 (= F232), G226 (= G234), S227 (≠ G235), T230 (≠ V238), R233 (≠ S241)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
45% identity, 95% coverage: 12:488/503 of query aligns to 4:480/487 of 4go4A
- active site: N149 (= N158), K172 (= K181), E247 (= E256), C281 (= C290), E381 (= E389), E458 (= E466)
- binding nicotinamide-adenine-dinucleotide: I145 (≠ M154), V146 (≠ T155), W148 (≠ F157), N149 (= N158), F154 (≠ I163), K172 (= K181), G205 (= G214), G209 (= G218), Q210 (≠ A219), F223 (= F232), T224 (= T233), G225 (= G234), S226 (≠ G235), T229 (≠ V238), E247 (= E256), G249 (= G258), C281 (= C290), E381 (= E389), F383 (= F391)
7radA Crystal structure analysis of aldh1b1
43% identity, 95% coverage: 12:489/503 of query aligns to 14:492/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ M154), I159 (≠ T155), P160 (≠ S156), W161 (≠ F157), N162 (= N158), M167 (≠ I163), K185 (= K181), E188 (= E184), G218 (= G214), G222 (= G218), A223 (= A219), T237 (= T233), G238 (= G234), S239 (≠ G235), V242 (= V238), E261 (= E256), L262 (= L257), C295 (= C290), E392 (= E389), F394 (= F391)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (vs. gap), E117 (≠ R113), F163 (≠ H159), E285 (≠ F280), F289 (≠ I284), N450 (≠ H447), V452 (≠ L449)
7mjdA Crystal structure analysis of aldh1b1
43% identity, 95% coverage: 12:489/503 of query aligns to 14:492/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ M154), I159 (≠ T155), P160 (≠ S156), W161 (≠ F157), N162 (= N158), M167 (≠ I163), K185 (= K181), E188 (= E184), G218 (= G214), G222 (= G218), F236 (= F232), T237 (= T233), G238 (= G234), S239 (≠ G235), V242 (= V238), E261 (= E256), L262 (= L257), C295 (= C290), E392 (= E389), F394 (= F391)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ R113), E285 (≠ F280), F289 (≠ I284), N450 (≠ H447), V452 (≠ L449)
7mjcA Crystal structure analysis of aldh1b1
43% identity, 95% coverage: 12:489/503 of query aligns to 14:492/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ M154), I159 (≠ T155), P160 (≠ S156), W161 (≠ F157), N162 (= N158), K185 (= K181), E188 (= E184), G218 (= G214), G222 (= G218), T237 (= T233), G238 (= G234), S239 (≠ G235), V242 (= V238), E261 (= E256), L262 (= L257), C295 (= C290), E392 (= E389), F394 (= F391)
4neaA 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
39% identity, 95% coverage: 15:494/503 of query aligns to 22:504/505 of 4neaA
- active site: N166 (= N158), K189 (= K181), E264 (= E256), C298 (= C290), E399 (= E389), E476 (= E466)
- binding nicotinamide-adenine-dinucleotide: P164 (≠ S156), K189 (= K181), E192 (= E184), G222 (= G214), G226 (= G218), G242 (= G234), G243 (= G235), T246 (≠ V238), H249 (≠ S241), I250 (= I242), C298 (= C290), E399 (= E389), F401 (= F391)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 5l13A
- active site: N163 (= N158), K186 (= K181), E262 (= E256), C296 (= C290), E393 (= E389), E470 (= E466)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ H159), M168 (≠ I163), W171 (≠ K166), F290 (≠ I284), C295 (≠ T289), C296 (= C290), C297 (≠ V291), D451 (≠ H447), F453 (≠ L449)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 4kwgA
- active site: N163 (= N158), K186 (= K181), E262 (= E256), C296 (= C290), E393 (= E389), E470 (= E466)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ H159), M168 (≠ I163), C295 (≠ T289), C296 (= C290), C297 (≠ V291), D451 (≠ H447), F453 (≠ L449)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 4kwfA
- active site: N163 (= N158), K186 (= K181), E262 (= E256), C296 (= C290), E393 (= E389), E470 (= E466)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ H159), M168 (≠ I163), W171 (≠ K166), E262 (= E256), C295 (≠ T289), C296 (= C290), C297 (≠ V291), D451 (≠ H447), F453 (≠ L449), F459 (≠ W455)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 3sz9A
- active site: N163 (= N158), K186 (= K181), E262 (= E256), C296 (= C290), E393 (= E389), E470 (= E466)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ H159), C295 (≠ T289), C296 (= C290), D451 (≠ H447), F453 (≠ L449), F459 (≠ W455)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 3injA
- active site: N163 (= N158), K186 (= K181), E262 (= E256), C296 (= C290), E393 (= E389), E470 (= E466)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ R113), F164 (≠ H159), L167 (≠ M162), F286 (= F280), F290 (≠ I284), D451 (≠ H447), F453 (≠ L449)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 2vleA
- active site: N163 (= N158), K186 (= K181), E262 (= E256), C296 (= C290), E393 (= E389), E470 (= E466)
- binding daidzin: M118 (≠ R113), F164 (≠ H159), M168 (≠ I163), W171 (≠ K166), F286 (= F280), F290 (≠ I284), C295 (≠ T289), C296 (= C290), D451 (≠ H447), V452 (≠ R448), F453 (≠ L449)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 1o01B
- active site: N163 (= N158), K186 (= K181), E262 (= E256), C296 (= C290), E393 (= E389), E470 (= E466)
- binding (2e)-but-2-enal: C296 (= C290), C297 (≠ V291), F453 (≠ L449)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ M154), I160 (≠ T155), P161 (≠ S156), W162 (≠ F157), K186 (= K181), E189 (= E184), G219 (= G214), G223 (= G218), A224 (= A219), F237 (= F232), G239 (= G234), S240 (≠ G235), I243 (≠ V238), L263 (= L257), G264 (= G258), C296 (= C290), Q343 (≠ S337), E393 (= E389), F395 (= F391)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 1cw3A
- active site: N163 (= N158), K186 (= K181), E262 (= E256), C296 (= C290), E393 (= E389), E470 (= E466)
- binding magnesium ion: V34 (= V31), D103 (≠ N99), Q190 (= Q185)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ M154), I160 (≠ T155), P161 (≠ S156), W162 (≠ F157), K186 (= K181), G219 (= G214), G223 (= G218), A224 (= A219), F237 (= F232), G239 (= G234), S240 (≠ G235), I243 (≠ V238), L263 (= L257), G264 (= G258), C296 (= C290), Q343 (≠ S337), K346 (≠ R340), E393 (= E389), F395 (= F391)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 14:492/493 of 4fr8A
- active site: N162 (= N158), K185 (= K181), Q261 (≠ E256), C295 (= C290), E392 (= E389), E469 (= E466)
- binding nicotinamide-adenine-dinucleotide: I158 (≠ M154), I159 (≠ T155), W161 (≠ F157), K185 (= K181), G218 (= G214), G222 (= G218), A223 (= A219), F236 (= F232), G238 (= G234), S239 (≠ G235), I242 (≠ V238), Q342 (≠ S337), K345 (≠ R340), E392 (= E389), F394 (= F391)
- binding propane-1,2,3-triyl trinitrate: F163 (≠ H159), L166 (≠ M162), W170 (≠ K166), F289 (≠ I284), S294 (≠ T289), C295 (= C290), D450 (≠ H447), F452 (≠ L449)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
41% identity, 95% coverage: 12:489/503 of query aligns to 41:519/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 17:495/496 of 4fr8C
- active site: N165 (= N158), K188 (= K181), Q264 (≠ E256), C298 (= C290), E395 (= E389), E472 (= E466)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ M154), I162 (≠ T155), W164 (≠ F157), K188 (= K181), G221 (= G214), G225 (= G218), A226 (= A219), F239 (= F232), G241 (= G234), S242 (≠ G235), I245 (≠ V238), Q345 (≠ S337), E395 (= E389), F397 (= F391)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
38% identity, 94% coverage: 10:484/503 of query aligns to 16:489/491 of 5gtlA
- active site: N165 (= N158), K188 (= K181), E263 (= E256), C297 (= C290), E394 (= E389), E471 (= E466)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ M154), P163 (≠ S156), K188 (= K181), A190 (≠ S183), E191 (= E184), Q192 (= Q185), G221 (= G214), G225 (= G218), G241 (= G234), S242 (≠ G235), T245 (≠ V238), L264 (= L257), C297 (= C290), E394 (= E389), F396 (= F391)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
38% identity, 94% coverage: 10:484/503 of query aligns to 16:489/491 of 5gtkA
- active site: N165 (= N158), K188 (= K181), E263 (= E256), C297 (= C290), E394 (= E389), E471 (= E466)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ M154), I162 (≠ T155), P163 (≠ S156), W164 (≠ F157), K188 (= K181), E191 (= E184), G221 (= G214), G225 (= G218), A226 (= A219), F239 (= F232), G241 (= G234), S242 (≠ G235), T245 (≠ V238), Y248 (≠ S241), L264 (= L257), C297 (= C290), Q344 (≠ S337), R347 (= R340), E394 (= E389), F396 (= F391)
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
41% identity, 95% coverage: 12:489/503 of query aligns to 15:493/494 of 1nzwA
- active site: N163 (= N158), K186 (= K181), E262 (= E256), S296 (≠ C290), E393 (= E389), E470 (= E466)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (≠ M154), I160 (≠ T155), P161 (≠ S156), K186 (= K181), E189 (= E184), G219 (= G214), P220 (≠ R215), G223 (= G218), A224 (= A219), F237 (= F232), G239 (= G234), S240 (≠ G235), I243 (≠ V238), E262 (= E256), G264 (= G258), S296 (≠ C290), Q343 (≠ S337), E393 (= E389), F395 (= F391)
Query Sequence
>H281DRAFT_02499 FitnessBrowser__Burk376:H281DRAFT_02499
MNTGNSQRYDAQLLIGGEWTDAEDGRTLDIVNPATGEVIGALASASARDVDRAVQAGHRA
FEGGAWRDMSIQQRARILNRFADLFEADLEQFYKLETLNNGRPIAETRAQISRLPQFYRY
FAALALTRRSDVIPIEGPYLCYTQRVPLGVVALMTSFNHPLMILSKSLAPALATGNSVVI
KASEQTPLTTVRLVKLLQDAGVPKGVVNVVNGEGRVAGAALAQHPLIRKVVFTGGTEVGR
SIGEAAARNFALTTLELGGKGAVILFDDFDIERAVNGASFAAFIGAGQTCVCGARILVQK
SMYAAFLERFRAKVERIRVGDPTDAKTQLGPVISERSRQRILAMLERAQQAGAKLLTGGR
VPQELTSGYFLEPTVVYDADPHSEIGQDEVFGPVTVVMPFEDEADAIRIANDTSFGLAAS
IWTQDVARAHRVAGRLEFGMVWVNDHHRLDPASPWGGFKNSGVGRETGIESFDQFSEPRA
VTINTSGKTVDWYADDGELKRLN
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory