SitesBLAST – Find functional sites

 

SitesBLAST

Comparing H281DRAFT_02531 FitnessBrowser__Burk376:H281DRAFT_02531 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 10 hits to proteins with known functional sites (download)

P77455 Bifunctional protein PaaZ; EC 3.3.2.12; EC 1.2.1.91 from Escherichia coli (strain K12) (see paper)
35% identity, 76% coverage: 20:142/161 of query aligns to 531:658/681 of P77455

query
sites
P77455
L
 
F
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P
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G
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A
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A
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E
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I
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F
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G
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E
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Y
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A
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A
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V
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I
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A
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N
-
 
Y
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G
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-
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I
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E
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-
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R
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A
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E
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E
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K
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P
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E
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A
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V
K
 
E
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V
L
 
F
N
 
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Q

Sites not aligning to the query:

6jqoA Structure of paaz, a bifunctional enzyme in complex with NADP+ and ccoa (see paper)
35% identity, 76% coverage: 20:142/161 of query aligns to 530:657/678 of 6jqoA

query
sites
6jqoA
L
 
F
N
 
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E
I
 
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E
 
Q
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P
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G
D
 
D
Y
 
S
Y
 
L
L
 
L
T
 
T
A
 
P
G
 
R
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R
T
 
T
V
 
M
T
 
T
E
 
E
T
 
A
H
 
D
V
 
I
V
 
V
N
 
N
F
 
F
A
 
A
G
 
C
V
 
L
S
 
S
G
 
G
D
 
D
Y
 
H
Y
 
F
D
 
Y
I
 
A
H
 
H
V
 
M
D
 
D
D
 
K
V
 
I
A
 
A
A
 
A
Q
 
A
E
 
E
A
 
S
G
 
I
F
 
F
P
 
G
G
 
E
R
 
R
I
 
V
A
 
V
H
 
H
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G
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Y
L
 
F
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L
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S
L
 
A
A
 
A
D
 
A
G
 
G
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L
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F
T
 
V
R
 
D
C
 
A
-
 
G
-
 
V
-
 
G
P
 
P
V
 
V
L
 
I
L
 
A
K
 
N
-
 
Y
G
 
G
L
 
L
A
 
E
T
 
S
L
 
L
G
 
-
W
 
-
N
 
-
W
 
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S
 
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F
 
F
R
 
I
A
 
E
P
 
P
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R
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L
E
 
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C
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-
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-
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K
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T
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R
 
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P
 
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D
 
Q
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|
R
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S
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A
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E
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E
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K
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G
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V
A
 
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T
 
E
L
 
W
R
 
A
L
 
V
K
 
E
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V
L
 
F
N
 
N
Q
 
Q

Sites not aligning to the query:

6jqnA Structure of paaz, a bifunctional enzyme in complex with NADP+ and ocoa (see paper)
35% identity, 76% coverage: 20:142/161 of query aligns to 530:657/678 of 6jqnA

query
sites
6jqnA
L
 
F
N
 
E
D
 
E
I
 
L
E
 
Q
A
 
P
G
 
G
D
 
D
Y
 
S
Y
 
L
L
 
L
T
 
T
A
 
P
G
 
R
V
 
R
T
 
T
V
 
M
T
 
T
E
 
E
T
 
A
H
 
D
V
 
I
V
 
V
N
 
N
F
 
F
A
 
A
G
 
C
V
 
L
S
 
S
G
 
G
D
 
D
Y
 
H
Y
x
F
D
 
Y
I
 
A
H
|
H
V
 
M
D
 
D
D
 
K
V
 
I
A
 
A
A
 
A
Q
 
A
E
 
E
A
 
S
G
 
I
F
|
F
P
 
G
G
 
E
R
 
R
I
 
V
A
 
V
H
 
H
G
|
G
L
 
Y
L
 
F
G
 
V
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L
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S
L
 
A
A
 
A
D
 
A
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G
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L
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F
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x
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R
 
D
C
 
A
-
 
G
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V
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G
P
 
P
V
 
V
L
 
I
L
x
A
K
x
N
-
x
Y
G
 
G
L
 
L
A
 
E
T
 
S
L
 
L
G
 
-
W
 
-
N
 
-
W
 
-
S
 
R
F
|
F
R
x
I
A
 
E
P
 
P
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V
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K
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P
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R
 
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R
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A
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E
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E
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E
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W
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A
L
 
V
K
 
E
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F
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Q

Sites not aligning to the query:

6jqmA Structure of paaz with NADPH (see paper)
35% identity, 76% coverage: 20:142/161 of query aligns to 530:657/678 of 6jqmA

query
sites
6jqmA
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M
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T
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E
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A
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D
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N
 
N
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F
A
 
A
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C
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D
Y
 
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A
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M
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D
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K
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I
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A
A
 
A
Q
 
A
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E
A
 
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I
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F
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Y
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A
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E
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E
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A
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E
V
 
V
L
 
F
N
 
N
Q
 
Q

Sites not aligning to the query:

O32472 (R)-specific enoyl-CoA hydratase; EC 4.2.1.119 from Aeromonas caviae (Aeromonas punctata) (see 2 papers)
33% identity, 69% coverage: 47:157/161 of query aligns to 29:134/134 of O32472

query
sites
O32472
V
 
L
S
 
S
G
 
E
D
|
D
Y
 
F
Y
 
N
D
 
P
I
 
L
H
|
H
V
 
L
D
 
D
D
 
P
V
 
A
A
 
F
A
 
A
Q
 
A
E
 
T
A
 
T
G
 
A
F
 
F
P
 
E
G
 
R
R
 
P
I
 
I
A
 
V
H
 
H
G
 
G
L
 
M
L
 
L
G
 
L
L
 
A
S
 
S
L
 
L
A
 
F
D
x
S
G
 
G
-
 
L
L
 
L
K
 
G
T
 
Q
R
 
Q
C
 
L
P
 
P
V
 
G
L
 
-
L
 
-
K
 
K
G
 
G
L
 
S
A
 
I
T
 
Y
L
 
L
G
 
G
W
 
Q
N
 
S
W
 
L
S
 
S
F
 
F
R
 
K
A
 
L
P
 
P
L
 
V
M
 
F
I
 
V
G
 
G
D
 
D
R
 
E
I
 
V
H
 
T
V
 
A
D
 
E
I
 
V
E
 
E
V
 
V
I
 
T
G
 
A
K
 
-
R
 
-
P
 
-
T
 
-
K
 
L
R
 
R
P
 
E
D
 
D
R
 
K
G
 
P
I
 
I
A
 
A
T
 
T
L
 
L
R
 
T
L
 
T
K
 
R
V
 
I
L
 
F
N
 
T
Q
 
Q
R
 
G
G
 
G
E
 
A
V
 
L
V
 
A
Q
 
V
E
 
T
G
 
G
E
 
E
T
 
A
L
 
V
M
 
V
M
 
K
M
 
L
P
 
P

Sites not aligning to the query:

A0A3Q7HWE4 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FERN, mitochondrial; 3-hydroxyl-ACP dehydratase FERN; Protein FERN-LIKE; SlFERN; EC 4.2.1.59 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
26% identity, 80% coverage: 30:158/161 of query aligns to 29:152/165 of A0A3Q7HWE4

query
sites
A0A3Q7HWE4
L
 
L
T
 
K
A
 
Q
G
 
A
V
 
R
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T
V
 
F
T
 
A
E
 
D
T
 
D
H
 
D
V
 
V
V
 
L
N
 
G
F
 
Y
A
 
S
G
 
K
V
 
L
S
 
T
G
 
H
D
 
D
Y
 
A
Y
 
N
D
 
P
I
 
L
H
 
H
V
 
F
D
 
D
D
 
A
V
 
E
A
 
C
A
 
A
Q
 
K
E
 
N
A
 
A
G
 
G
F
 
F
P
 
T
G
 
D
R
 
C
I
 
L
A
 
V
H
 
P
G
 
G
L
 
M
L
 
L
G
 
V
L
 
A
S
 
S
L
 
L
A
 
F
D
 
P
G
 
R
L
 
I
K
 
I
T
 
A
R
 
-
C
 
-
P
 
-
V
 
A
L
 
H
L
 
F
K
 
P
G
 
G
L
 
A
A
 
I
T
 
Y
L
 
V
G
 
S
W
 
Q
N
 
T
W
 
L
S
 
H
F
 
F
R
 
K
A
 
L
P
 
P
L
 
V
M
 
Y
I
 
I
G
 
G
D
 
D
R
 
E
I
 
I
H
 
I
V
 
A
D
 
E
I
 
V
E
 
Q
V
 
A
I
 
V
G
 
S
K
 
I
R
 
R
P
 
Q
T
 
I
K
 
K
R
 
-
P
 
-
D
 
N
R
 
K
G
 
Y
I
 
I
A
 
A
T
 
K
L
 
L
R
 
S
L
 
T
K
 
K
V
x
C
L
 
I
N
 
K
Q
 
R
R
 
D
G
 
G
E
 
P
V
 
L
V
 
V
Q
 
I
E
 
D
G
 
G
E
 
E
T
 
A
L
 
T
M
 
A
M
 
M
M
 
L
P
 
P
T
 
S

7svtB Mycobacterium tuberculosis 3-hydroxyl-acp dehydratase hadab in complex with 1,3-diarylpyrazolyl-acylsulfonamide inhibitor (see paper)
36% identity, 41% coverage: 20:85/161 of query aligns to 5:70/141 of 7svtB

query
sites
7svtB
L
 
F
N
 
S
D
 
S
I
 
V
E
 
K
A
 
V
G
 
G
D
 
D
Y
 
Q
Y
 
L
L
 
P
T
 
E
A
 
K
G
 
T
V
 
Y
T
 
P
V
 
L
T
 
T
E
 
R
T
 
Q
H
 
D
V
 
L
V
 
V
N
 
N
F
 
Y
A
 
A
G
 
G
V
 
V
S
 
S
G
 
G
D
 
D
Y
 
L
Y
 
N
D
 
P
I
 
I
H
|
H
V
 
W
D
 
D
D
 
D
V
 
E
A
 
I
A
 
A
Q
 
K
E
 
V
A
 
V
G
 
G
F
 
L
P
 
D
G
 
T
R
 
A
I
 
I
A
 
A
H
|
H
G
 
G
L
 
M
L
 
L
G
 
T
L
 
M
S
 
G
L
 
I
A
 
G
D
 
G
G
 
G
L
 
Y
K
 
V
T
 
T

P86397 Hydroxyacyl-thioester dehydratase type 2, mitochondrial; HsHTD2; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; EC 4.2.1.59 from Homo sapiens (Human) (see paper)
30% identity, 75% coverage: 37:157/161 of query aligns to 49:163/168 of P86397

query
sites
P86397
T
 
T
E
 
Q
T
 
T
H
 
D
V
 
V
V
 
A
N
 
T
F
 
F
A
 
S
G
 
E
V
 
L
S
 
T
G
 
G
D
|
D
Y
 
V
Y
 
N
D
 
P
I
 
L
H
|
H
V
 
L
D
 
N
D
 
E
V
 
D
A
 
F
A
 
A
Q
 
K
E
 
H
A
 
T
G
 
K
F
 
F
P
 
G
G
 
N
R
 
T
I
 
I
A
 
V
H
 
H
G
 
G
L
 
V
L
 
L
G
 
I
L
 
N
S
 
G
L
 
L
A
 
I
D
 
S
G
 
A
-
 
L
L
 
L
K
 
G
T
 
T
R
 
K
C
 
M
P
 
P
V
 
G
L
 
-
L
 
-
K
 
P
G
 
G
L
 
C
A
 
V
T
 
F
L
 
L
G
 
S
W
 
Q
N
 
E
W
 
I
S
 
S
F
 
F
R
 
P
A
 
A
P
 
P
L
 
L
M
 
Y
I
 
I
G
 
G
D
 
E
R
 
V
I
 
V
H
 
L
V
 
A
D
 
S
I
 
A
E
 
E
V
 
V
I
 
-
G
 
-
K
 
-
R
 
-
P
 
-
T
 
-
K
 
K
R
 
K
P
 
L
D
 
K
R
 
R
G
 
F
I
 
I
A
 
A
T
 
I
L
 
I
R
 
A
L
 
V
K
 
S
V
 
C
-
 
S
L
 
V
N
 
I
Q
 
E
R
 
S
G
 
K
E
 
K
V
 
T
V
 
V
Q
 
M
E
 
E
G
 
G
E
 
W
T
 
V
L
 
K
M
 
V
M
 
M
M
 
V
P
 
P

Sites not aligning to the query:

4v12A Crystal structure of the msmeg_6754 dehydratase from mycobacterium smegmatis (see paper)
33% identity, 43% coverage: 15:83/161 of query aligns to 198:266/337 of 4v12A

query
sites
4v12A
P
 
P
G
 
T
L
 
S
Y
 
L
G
 
N
L
 
F
N
 
D
D
 
D
I
 
L
E
 
K
A
 
V
G
 
G
D
 
E
Y
 
E
Y
 
L
L
 
P
T
 
V
A
 
H
G
 
T
V
 
A
T
 
R
V
 
L
T
 
S
E
 
R
T
 
G
H
 
D
V
 
L
V
 
V
N
 
N
F
 
Y
A
 
A
G
 
G
V
 
V
S
 
A
G
 
G
D
 
D
Y
 
A
Y
 
N
D
 
P
I
 
L
H
 
H
V
 
W
D
 
D
D
 
E
V
 
N
A
 
I
A
 
A
Q
 
K
E
 
L
A
 
A
G
 
G
F
 
Q
P
 
P
G
 
D
R
 
V
I
 
I
A
 
A
H
 
H
G
 
G
L
x
M
L
 
L
G
 
T
L
 
M
S
 
G
L
 
L
A
 
G
D
 
A
G
 
G
L
 
F

Sites not aligning to the query:

P9WNP3 3-hydroxyacyl-thioester dehydratase Z; 3-hydroxybutyryl-CoA dehydratase; Enoyl-CoA hydratase 2; N-related protein; Nodulation protein; EC 4.2.1.-; EC 4.2.1.55; EC 4.2.1.119 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
33% identity, 55% coverage: 34:121/161 of query aligns to 24:114/151 of P9WNP3

query
sites
P9WNP3
V
 
V
T
 
T
V
 
I
T
 
T
E
 
Q
T
 
E
H
 
E
V
 
V
V
 
N
N
 
L
F
 
F
A
 
A
G
 
D
V
 
A
S
 
T
G
 
G
D
|
D
Y
 
H
Y
 
Q
D
 
W
I
 
I
H
|
H
V
 
V
D
 
D
D
 
P
V
 
E
A
 
R
A
 
A
Q
 
A
E
 
A
A
 
G
G
 
P
F
 
F
P
 
G
G
 
T
R
 
T
I
 
I
A
 
A
H
 
H
G
 
G
L
 
F
L
 
M
G
 
T
L
 
L
S
 
A
L
 
L
A
 
L
D
 
P
G
 
R
L
 
L
K
 
Q
T
 
H
R
 
Q
C
 
M
P
 
-
V
 
Y
L
 
T
L
 
V
K
 
K
G
 
G
L
 
V
A
 
-
T
 
K
L
 
L
G
 
A
W
 
I
N
 
N
W
 
Y
S
 
G
-
 
L
-
 
N
-
 
K
-
 
V
-
 
R
F
 
F
R
 
P
A
 
A
P
 
P
L
 
V
M
 
P
I
 
V
G
 
G
D
 
S
R
 
R
I
 
V
H
 
R
V
 
A
D
 
T
I
 
S
E
 
S
V
 
L
I
 
V
G
 
G

Query Sequence

>H281DRAFT_02531 FitnessBrowser__Burk376:H281DRAFT_02531
MSDSVANDTRRLLKPGLYGLNDIEAGDYYLTAGVTVTETHVVNFAGVSGDYYDIHVDDVA
AQEAGFPGRIAHGLLGLSLADGLKTRCPVLLKGLATLGWNWSFRAPLMIGDRIHVDIEVI
GKRPTKRPDRGIATLRLKVLNQRGEVVQEGETLMMMPTTLA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory