SitesBLAST
Comparing H281DRAFT_02676 FitnessBrowser__Burk376:H281DRAFT_02676 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t3qB Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
37% identity, 98% coverage: 13:782/788 of query aligns to 11:784/786 of 1t3qB
- active site: Q224 (= Q229), A259 (≠ L264), E336 (≠ T338), V343 (≠ T345), R371 (= R373), E743 (= E741), S744 (≠ G742)
- binding pterin cytosine dinucleotide: G254 (= G259), F255 (= F260), R371 (= R373), S506 (≠ Q502), G507 (= G503), Q508 (= Q504), H510 (= H506), T513 (= T509), Y545 (≠ F542), S547 (= S544), G549 (≠ V546), A550 (≠ T547), C666 (≠ S664), I670 (= I668), I674 (= I672), V675 (= V673), Q678 (= Q676), K739 (= K737), G740 (= G738), M741 (≠ A739), G742 (= G740)
7dqxD Crystal structure of xanthine dehydrogenase family protein
35% identity, 98% coverage: 13:781/788 of query aligns to 3:767/770 of 7dqxD
- binding pterin cytosine dinucleotide: G247 (= G258), S248 (≠ G259), F249 (= F260), R363 (= R373), V491 (≠ Q502), G492 (= G503), Q493 (= Q504), G494 (= G505), V498 (≠ T509), S530 (≠ T541), W531 (≠ F542), S532 (≠ A543), S533 (= S544), R534 (= R545), S535 (≠ V546), T536 (= T547), T658 (≠ I672), T659 (≠ V673), Q662 (= Q676), G725 (= G738), L726 (≠ A739), G727 (= G740), E728 (= E741)
1ffvB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
33% identity, 97% coverage: 16:782/788 of query aligns to 12:792/797 of 1ffvB
- active site: Q231 (= Q229), V266 (≠ L264), P343 (≠ I341), I349 (≠ T345), R378 (= R373), C379 (≠ G374), E751 (= E741), S752 (≠ G742)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G260 (= G258), G261 (= G259), F262 (= F260), G263 (= G261), A376 (≠ P371), R378 (= R373), C379 (≠ G374), Q516 (= Q502), G517 (= G503), Q518 (= Q504), H520 (= H506), T523 (= T509), Y556 (≠ F542), G557 (≠ A543), S558 (= S544), S560 (≠ V546), T561 (= T547), C674 (≠ S664), I678 (= I668), I683 (≠ V673), Q686 (= Q676), K747 (= K737), G748 (= G738), V749 (≠ A739), A750 (≠ G740), E751 (= E741)
1ffuB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
33% identity, 97% coverage: 16:782/788 of query aligns to 12:792/797 of 1ffuB
- active site: Q231 (= Q229), V266 (≠ L264), P343 (≠ I341), I349 (≠ T345), R378 (= R373), C379 (≠ G374), E751 (= E741), S752 (≠ G742)
- binding cytidine-5'-diphosphate: Q518 (= Q504), H520 (= H506), T523 (= T509), S558 (= S544), S560 (≠ V546), T561 (= T547), C674 (≠ S664), T676 (≠ K666), I678 (= I668), I683 (≠ V673), K747 (= K737), G748 (= G738), V749 (≠ A739), A750 (≠ G740)
P19913 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
33% identity, 97% coverage: 19:782/788 of query aligns to 21:798/803 of P19913
- R384 (= R373) modified: 4-hydroxyarginine
1n60B Crystal structure of the cu,mo-co dehydrogenase (codh); cyanide- inactivated form (see paper)
34% identity, 98% coverage: 16:786/788 of query aligns to 15:802/803 of 1n60B
- active site: Q234 (= Q229), V269 (≠ L264), P346 (≠ I337), I352 (= I343), R381 (= R373), C382 (≠ G374), E757 (= E741), S758 (≠ G742)
- binding pterin cytosine dinucleotide: G264 (= G259), F265 (= F260), R381 (= R373), Q522 (= Q502), G523 (= G503), Q524 (= Q504), H526 (= H506), T529 (= T509), T561 (= T541), Y562 (≠ F542), G563 (≠ A543), S564 (= S544), S566 (≠ V546), T567 (= T547), C680 (≠ S664), I684 (= I668), I688 (= I672), I689 (≠ V673), Q692 (= Q676), K753 (= K737), G754 (= G738), V755 (≠ A739), E757 (= E741)
- binding mo(vi)(=o)(oh)2 cluster: F265 (= F260), G266 (= G261), Y562 (≠ F542), G563 (≠ A543), E757 (= E741)
1n63B Crystal structure of the cu,mo-co dehydrogenase (codh); carbon monoxide reduced state (see paper)
34% identity, 98% coverage: 16:786/788 of query aligns to 17:804/805 of 1n63B
- active site: Q236 (= Q229), V271 (≠ L264), P348 (≠ I337), I354 (= I343), R383 (= R373), C384 (≠ G374), E759 (= E741), S760 (≠ G742)
- binding cu(i)-s-mo(iv)(=o)oh cluster: G268 (= G261), A381 (≠ P371), R383 (= R373), C384 (≠ G374), Y564 (≠ F542), G565 (≠ A543), E759 (= E741)
- binding pterin cytosine dinucleotide: G266 (= G259), F267 (= F260), R383 (= R373), Q524 (= Q502), G525 (= G503), Q526 (= Q504), H528 (= H506), T531 (= T509), T563 (= T541), Y564 (≠ F542), S566 (= S544), S568 (≠ V546), T569 (= T547), C682 (≠ S664), I686 (= I668), I690 (= I672), I691 (≠ V673), Q694 (= Q676), K755 (= K737), G756 (= G738), V757 (≠ A739), E759 (= E741)
1zxiB Reconstituted co dehydrogenase from oligotropha carboxidovorans (see paper)
34% identity, 98% coverage: 16:786/788 of query aligns to 16:803/804 of 1zxiB
- active site: Q235 (= Q229), V270 (≠ L264), P347 (≠ I337), I353 (= I343), R382 (= R373), C383 (≠ G374), E758 (= E741), S759 (≠ G742)
- binding copper (ii) ion: C383 (≠ G374), S384 (≠ A375), E758 (= E741)
- binding cu(i)-s-mo(vi)(=o)oh cluster: F266 (= F260), G267 (= G261), A380 (≠ P371), Y381 (≠ V372), R382 (= R373), C383 (≠ G374), Y563 (≠ F542), G564 (≠ A543), E758 (= E741)
- binding pterin cytosine dinucleotide: G265 (= G259), F266 (= F260), R382 (= R373), Q523 (= Q502), G524 (= G503), Q525 (= Q504), H527 (= H506), T530 (= T509), T562 (= T541), Y563 (≠ F542), S565 (= S544), S567 (≠ V546), T568 (= T547), C681 (≠ S664), I685 (= I668), I689 (= I672), I690 (≠ V673), Q693 (= Q676), K754 (= K737), G755 (= G738), V756 (≠ A739), E758 (= E741)
1n62B Crystal structure of the mo,cu-co dehydrogenase (codh), n- butylisocyanide-bound state (see paper)
34% identity, 98% coverage: 16:786/788 of query aligns to 16:803/804 of 1n62B
- active site: Q235 (= Q229), V270 (≠ L264), P347 (≠ I337), I353 (= I343), R382 (= R373), C383 (≠ G374), E758 (= E741), S759 (≠ G742)
- binding cu(i)-s-mo(iv)(=o)o-nbic cluster: G267 (= G261), V379 (vs. gap), A380 (≠ P371), R382 (= R373), C383 (≠ G374), F385 (≠ G376), Y563 (≠ F542), G564 (≠ A543), E758 (= E741)
- binding pterin cytosine dinucleotide: G265 (= G259), F266 (= F260), R382 (= R373), Q523 (= Q502), G524 (= G503), Q525 (= Q504), H527 (= H506), T530 (= T509), T562 (= T541), Y563 (≠ F542), G564 (≠ A543), S565 (= S544), S567 (≠ V546), T568 (= T547), C681 (≠ S664), I685 (= I668), I689 (= I672), I690 (≠ V673), Q693 (= Q676), K754 (= K737), G755 (= G738), V756 (≠ A739), G757 (= G740), E758 (= E741)
1n5wB Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
34% identity, 98% coverage: 16:786/788 of query aligns to 16:803/804 of 1n5wB
- active site: Q235 (= Q229), V270 (≠ L264), P347 (≠ I337), I353 (= I343), R382 (= R373), C383 (≠ G374), E758 (= E741), S759 (≠ G742)
- binding cu(i)-s-mo(vi)(=o)oh cluster: G267 (= G261), A380 (≠ P371), R382 (= R373), C383 (≠ G374), Y563 (≠ F542), G564 (≠ A543), E758 (= E741)
- binding pterin cytosine dinucleotide: G265 (= G259), F266 (= F260), R382 (= R373), Q523 (= Q502), G524 (= G503), Q525 (= Q504), H527 (= H506), T530 (= T509), T562 (= T541), Y563 (≠ F542), S565 (= S544), S567 (≠ V546), T568 (= T547), C681 (≠ S664), I685 (= I668), I689 (= I672), I690 (≠ V673), Q693 (= Q676), K754 (= K737), G755 (= G738), V756 (≠ A739), E758 (= E741)
P19919 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
34% identity, 98% coverage: 16:786/788 of query aligns to 21:808/809 of P19919
- C388 (≠ G374) binding
- E763 (= E741) binding
4zohA Crystal structure of glyceraldehyde oxidoreductase (see paper)
33% identity, 95% coverage: 15:761/788 of query aligns to 2:688/701 of 4zohA
- active site: Q186 (= Q229), I219 (≠ L264), V298 (≠ I343), S300 (≠ T345), M304 (vs. gap), R332 (= R373), E668 (= E741), A669 (≠ G742)
- binding pterin cytosine dinucleotide: G213 (= G258), A214 (≠ G259), F215 (= F260), R332 (= R373), H442 (≠ Q502), G443 (= G503), Q444 (= Q504), D446 (≠ H506), W482 (≠ F542), S484 (= S544), T486 (≠ V546), V487 (≠ T547), I594 (= I668), N595 (= N669), L598 (≠ I672), Q602 (= Q676), K664 (= K737), G665 (= G738), I666 (≠ A739), G667 (= G740), E668 (= E741)
1rm6A Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
30% identity, 98% coverage: 16:785/788 of query aligns to 3:761/761 of 1rm6A
- active site: Q206 (= Q229), T241 (≠ L264), Y318 (≠ I341), L322 (≠ T345), R350 (= R373), E718 (= E741), G719 (= G742)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G235 (= G258), G236 (= G259), F237 (= F260), G238 (= G261), R350 (= R373), I473 (≠ Q502), G474 (= G503), Q475 (= Q504), G476 (= G505), Y513 (≠ F542), S514 (≠ A543), S515 (= S544), V517 (= V546), T518 (= T547), L646 (≠ I668), N647 (= N669), V651 (= V673), Q654 (= Q676), K714 (= K737), E715 (≠ G738), A716 (= A739), S717 (≠ G740), E718 (= E741)
O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see paper)
30% identity, 98% coverage: 16:785/788 of query aligns to 11:769/769 of O33819
5y6qC Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
27% identity, 94% coverage: 16:755/788 of query aligns to 7:729/748 of 5y6qC
- active site: Q204 (= Q229), P239 (≠ L264), A310 (≠ I341), V316 (vs. gap), R344 (= R373), E715 (= E741), L716 (≠ G742)
- binding pterin cytosine dinucleotide: G233 (= G258), G234 (= G259), F235 (= F260), I461 (≠ Q502), G462 (= G503), T463 (≠ Q504), G464 (= G505), I468 (≠ T509), G500 (≠ T541), S502 (= S544), Q503 (≠ R545), L504 (≠ V546), A505 (≠ T547), R638 (≠ K666), Y640 (≠ I668), N641 (= N669), Q648 (= Q676), K711 (= K737), V713 (≠ A739), G714 (= G740), E715 (= E741)
3hrdE Crystal structure of nicotinate dehydrogenase (see paper)
30% identity, 51% coverage: 12:409/788 of query aligns to 3:386/420 of 3hrdE
- active site: Q207 (= Q229), L242 (= L264), R318 (≠ I341), H322 (≠ T345), R350 (= R373)
- binding calcium ion: T206 (≠ G228), N208 (≠ A230), D212 (≠ E234), K241 (= K263), L242 (= L264), D243 (≠ P265)
- binding pterin cytosine dinucleotide: G237 (= G259), F238 (= F260), R350 (= R373)
- binding selenium atom: F238 (= F260), A348 (≠ P371), F349 (≠ V372), R350 (= R373)
3hrdA Crystal structure of nicotinate dehydrogenase (see paper)
30% identity, 51% coverage: 12:409/788 of query aligns to 3:386/420 of 3hrdA
- active site: Q207 (= Q229), L242 (= L264), R318 (≠ I341), H322 (≠ T345), R350 (= R373)
- binding pterin cytosine dinucleotide: G236 (= G258), G237 (= G259), F238 (= F260), R350 (= R373)
- binding magnesium ion: T206 (≠ G228), N208 (≠ A230), D212 (≠ E234), K241 (= K263), L242 (= L264), D243 (≠ P265), T305 (≠ N328), Y308 (≠ F331), A309 (≠ L332), S346 (≠ T369)
- binding nicotinic acid: A314 (≠ I337), R318 (≠ I341), F352 (≠ A375)
- binding selenium atom: F238 (= F260), G239 (= G261), A348 (≠ P371), F349 (≠ V372), R350 (= R373)
Q0QLF2 Nicotinate dehydrogenase large molybdopterin subunit; NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
30% identity, 51% coverage: 12:409/788 of query aligns to 4:387/425 of Q0QLF2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2:425 modified: mature protein, Nicotinate dehydrogenase large molybdopterin subunit
3hrdB Crystal structure of nicotinate dehydrogenase (see paper)
34% identity, 41% coverage: 458:781/788 of query aligns to 2:326/330 of 3hrdB
- active site: E289 (= E741), P290 (≠ G742)
- binding pterin cytosine dinucleotide: I45 (≠ Q502), G46 (= G503), Q47 (= Q504), G48 (= G505), S49 (≠ H506), S85 (≠ F542), S87 (= S544), Q89 (≠ V546), T90 (= T547), I215 (= I668), N216 (= N669), M219 (≠ I672), V220 (= V673), Q223 (= Q676), K285 (= K737), G286 (= G738), V287 (≠ A739), G288 (= G740), E289 (= E741)
- binding nicotinic acid: N17 (≠ G474), T18 (= T475)
Q0QLF1 Nicotinate dehydrogenase medium molybdopterin subunit; NDH; Nicotinic acid hydroxylase medium molybdopterin subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
34% identity, 41% coverage: 458:781/788 of query aligns to 2:326/330 of Q0QLF1
Query Sequence
>H281DRAFT_02676 FitnessBrowser__Burk376:H281DRAFT_02676
MEISDLKGAPTDQRYIGKRVTRTEDKKLLQGQGSYVDDVHLPNMLQAAVLRSSHAHAKIV
SIDCTAARELKGVHAVYTHADLSGRARGRAPSMLPNPAIRFERTQELLASTEVTFAGEAV
AFVVADNRYIAEDACGLIEVEYDTLPAVADCRDGLRPESPLCHTDAKDNVVAHIEMGFGD
IDAAFNGAPHVVEETYWQNRGSAHPMETRGYLAEFHAANGELTVWSSGQAPHHEKKNLVE
LLEWDAEKLRVLMNDVGGGFGPKLPFYPEEALVAIAAVALKRPVKWIEDRREHFLAVTQE
RDQWWTVKIALENDGKIRGVKLEMVHDNGAFLPWGIITPYISITTTPGPYVIPAMGAKLD
VVYTNKCATSPVRGAGRPQAVFAMERILDKAARALGMDRAELRWRNLIQPEQMPYDAGFI
YRDGSPLRYDSGDYPACQKAALERAKYSSFAQRKAEARREGRFIGIGMASFVEGTGMGPF
EGATVRVQANGRIAVITGASPQGQGHKTTFAQICAEQLNVPLETIDVITGDTGGISMGVG
TFASRVTVNAGNSVYIAAQAVGEKMLTLTAHLWKCKPEELLLVEGHVARRAGIEQRMSYG
QLAKISQGMPGFTMPEGLTAGLEETKYFSPAQSTYCNGTAVVELEVDRETGHITILNYVM
AHDSGKLINPMIVDGQVIGSVAHGIGNATLEWMQYDENAQPITTNFGEYLLPMATDVPNI
DIVHLETPSPLNPLGVKGAGEGGTIPAAAAIVAAIEDALSEYGVEFTEAPLVPQRVFQKL
KEAGAYAR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory