Comparing H281DRAFT_02800 H281DRAFT_02800 6-phosphogluconate dehydrogenase (decarboxylating) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6vpbB A novel membrane-bound 6-phosphogluconate dehydrogenase from the acetic acid bacteria gluconacetobacter diazotrophicus (gd6pgd) (see paper)
52% identity, 95% coverage: 1:329/345 of query aligns to 1:324/324 of 6vpbB
2w90B Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase with bound 6- phosphogluconate (see paper)
35% identity, 93% coverage: 2:323/345 of query aligns to 7:306/471 of 2w90B
Sites not aligning to the query:
2iyoA Structural characterization of a bacterial 6pdh reveals aspects of specificity, mechanism and mode of inhibition (see paper)
31% identity, 97% coverage: 2:335/345 of query aligns to 5:318/470 of 2iyoA
Sites not aligning to the query:
2iypA Product rup (see paper)
31% identity, 97% coverage: 2:335/345 of query aligns to 5:318/469 of 2iypA
2iypB Product rup (see paper)
31% identity, 97% coverage: 2:335/345 of query aligns to 6:319/470 of 2iypB
Sites not aligning to the query:
2iz1B 6pdh complexed with pex inhibitor synchrotron data (see paper)
32% identity, 96% coverage: 2:331/345 of query aligns to 7:316/471 of 2iz1B
Sites not aligning to the query:
P96789 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
31% identity, 97% coverage: 2:335/345 of query aligns to 5:318/472 of P96789
Sites not aligning to the query:
8i4qA Crystal structure of 6-phosphogluconate dehydrogenase from corynebacterium glutamicum (see paper)
32% identity, 89% coverage: 2:308/345 of query aligns to 4:287/479 of 8i4qA
7cb2A The 6-phosphogluconate dehydrogenase (NADP-bound) from staphylococcus aureus
30% identity, 96% coverage: 2:331/345 of query aligns to 4:311/466 of 7cb2A
7cb5B The 6-phosphogluconate dehydrogenase from staphylococcus aureus (6- phosphogluconate bound) (see paper)
30% identity, 96% coverage: 2:331/345 of query aligns to 4:311/467 of 7cb5B
Sites not aligning to the query:
2p4qA Crystal structure analysis of gnd1 in saccharomyces cerevisiae (see paper)
33% identity, 93% coverage: 3:322/345 of query aligns to 5:302/476 of 2p4qA
Sites not aligning to the query:
P00350 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Escherichia coli (strain K12) (see paper)
30% identity, 93% coverage: 2:323/345 of query aligns to 5:304/468 of P00350
3fwnB Dimeric 6-phosphogluconate dehydrogenase complexed with 6- phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate (see paper)
30% identity, 93% coverage: 2:323/345 of query aligns to 4:303/467 of 3fwnB
Sites not aligning to the query:
3fwnA Dimeric 6-phosphogluconate dehydrogenase complexed with 6- phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate (see paper)
30% identity, 93% coverage: 2:323/345 of query aligns to 4:303/467 of 3fwnA
Sites not aligning to the query:
2zydA Dimeric 6-phosphogluconate dehydrogenase complexed with glucose (see paper)
30% identity, 93% coverage: 2:323/345 of query aligns to 3:302/464 of 2zydA
Sites not aligning to the query:
6fqzA Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate (see paper)
29% identity, 91% coverage: 3:317/345 of query aligns to 4:303/468 of 6fqzA
Sites not aligning to the query:
6fqyA Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate (see paper)
29% identity, 91% coverage: 3:317/345 of query aligns to 4:303/468 of 6fqyA
P78812 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 97% coverage: 3:335/345 of query aligns to 9:320/492 of P78812
P52209 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Homo sapiens (Human)
34% identity, 89% coverage: 3:308/345 of query aligns to 6:288/483 of P52209
Sites not aligning to the query:
2jkvA Structure of human phosphogluconate dehydrogenase in complex with NADPH at 2.53a
34% identity, 89% coverage: 3:308/345 of query aligns to 5:287/482 of 2jkvA
Sites not aligning to the query:
>H281DRAFT_02800 H281DRAFT_02800 6-phosphogluconate dehydrogenase (decarboxylating)
MQLGMIGLGRMGADMVRRLTKGGQQCIAYDVQPAAVERLGQEGVLGASSLEDLVAKLEKP
RAVWLMVPAAVVDGTLDKLLPLLEPGDIVIDGGNSYYHDDIRRGAQLAERKLHYVDVGTS
GGVAGRERGYCLMIGGEAEVVQRLEPIFSTLAPGAAAAPATPGRTEGSSTAEQGFLHCGP
IGAGHFVKMVHNGIEYGLMAAYAEGLNILRHADAGKHARDADAETSPLRRPELYQYDLNL
ADIAEVWRRGSVIGSWLLDLIAGSLVGDADLKNYAGRVSDSGEGRWTMAAAVDEGVPAPV
LSAALFGRFSSRGEADFANRVLSAMRHDFGGHAEKPPAPSGSQQG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory