SitesBLAST
Comparing H281DRAFT_03644 FitnessBrowser__Burk376:H281DRAFT_03644 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 94% coverage: 17:487/499 of query aligns to 19:487/491 of 5gtlA
- active site: N165 (= N161), K188 (= K184), E263 (= E259), C297 (= C293), E394 (= E394), E471 (= E471)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I157), P163 (= P159), K188 (= K184), A190 (= A186), E191 (= E187), Q192 (≠ V188), G221 (= G217), G225 (= G221), G241 (= G237), S242 (≠ G238), T245 (≠ V241), L264 (= L260), C297 (= C293), E394 (= E394), F396 (= F396)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 94% coverage: 17:487/499 of query aligns to 19:487/491 of 5gtkA
- active site: N165 (= N161), K188 (= K184), E263 (= E259), C297 (= C293), E394 (= E394), E471 (= E471)
- binding nicotinamide-adenine-dinucleotide: I161 (= I157), I162 (≠ T158), P163 (= P159), W164 (= W160), K188 (= K184), E191 (= E187), G221 (= G217), G225 (= G221), A226 (≠ D222), F239 (= F235), G241 (= G237), S242 (≠ G238), T245 (≠ V241), Y248 (≠ G244), L264 (= L260), C297 (= C293), Q344 (≠ H340), R347 (≠ T343), E394 (= E394), F396 (= F396)
7radA Crystal structure analysis of aldh1b1
41% identity, 95% coverage: 12:486/499 of query aligns to 10:484/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I157), I159 (≠ T158), P160 (= P159), W161 (= W160), N162 (= N161), M167 (≠ S166), K185 (= K184), E188 (= E187), G218 (= G217), G222 (= G221), A223 (≠ D222), T237 (= T236), G238 (= G237), S239 (≠ G238), V242 (= V241), E261 (= E259), L262 (= L260), C295 (= C293), E392 (= E394), F394 (= F396)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (= L113), E117 (≠ S116), F163 (≠ S162), E285 (≠ Y283), F289 (≠ S287), N450 (≠ K452), V452 (≠ F454)
7mjdA Crystal structure analysis of aldh1b1
41% identity, 95% coverage: 12:486/499 of query aligns to 10:484/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I157), I159 (≠ T158), P160 (= P159), W161 (= W160), N162 (= N161), M167 (≠ S166), K185 (= K184), E188 (= E187), G218 (= G217), G222 (= G221), F236 (= F235), T237 (= T236), G238 (= G237), S239 (≠ G238), V242 (= V241), E261 (= E259), L262 (= L260), C295 (= C293), E392 (= E394), F394 (= F396)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ S116), E285 (≠ Y283), F289 (≠ S287), N450 (≠ K452), V452 (≠ F454)
7mjcA Crystal structure analysis of aldh1b1
41% identity, 95% coverage: 12:486/499 of query aligns to 10:484/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I157), I159 (≠ T158), P160 (= P159), W161 (= W160), N162 (= N161), K185 (= K184), E188 (= E187), G218 (= G217), G222 (= G221), T237 (= T236), G238 (= G237), S239 (≠ G238), V242 (= V241), E261 (= E259), L262 (= L260), C295 (= C293), E392 (= E394), F394 (= F396)
4neaA 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
38% identity, 96% coverage: 18:497/499 of query aligns to 21:502/505 of 4neaA
- active site: N166 (= N161), K189 (= K184), E264 (= E259), C298 (= C293), E399 (= E394), E476 (= E471)
- binding nicotinamide-adenine-dinucleotide: P164 (= P159), K189 (= K184), E192 (= E187), G222 (= G217), G226 (= G221), G242 (= G237), G243 (= G238), T246 (≠ V241), H249 (≠ G244), I250 (= I245), C298 (= C293), E399 (= E394), F401 (= F396)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
42% identity, 91% coverage: 34:487/499 of query aligns to 24:476/489 of 4o6rA
- active site: N150 (= N161), K173 (= K184), E248 (= E259), C282 (= C293), E383 (= E394), E460 (= E471)
- binding adenosine monophosphate: I146 (= I157), V147 (≠ T158), K173 (= K184), G206 (= G217), G210 (= G221), Q211 (≠ D222), F224 (= F235), G226 (= G237), S227 (≠ G238), T230 (≠ V241), R233 (≠ G244)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
40% identity, 95% coverage: 17:492/499 of query aligns to 9:485/490 of Q9HTJ1
- GAWN 150:153 (≠ TPWN 158:161) binding
- K162 (= K170) active site, Charge relay system
- KPSE 176:179 (≠ KPAE 184:187) binding
- G209 (= G217) binding
- GTST 230:233 (≠ GTEV 238:241) binding
- E252 (= E259) active site, Proton acceptor
- C286 (= C293) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E394) binding
- E464 (= E471) active site, Charge relay system
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
40% identity, 95% coverage: 17:492/499 of query aligns to 8:484/489 of 4cazA
- active site: N152 (= N161), K175 (= K184), E251 (= E259), C285 (= C293), E386 (= E394), E463 (= E471)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I157), G149 (≠ T158), W151 (= W160), N152 (= N161), K175 (= K184), E178 (= E187), G208 (= G217), G212 (= G221), F226 (= F235), T227 (= T236), G228 (= G237), G229 (= G238), T232 (≠ V241), V236 (≠ I245), E251 (= E259), L252 (= L260), C285 (= C293), E386 (= E394), F388 (= F396)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
40% identity, 95% coverage: 17:492/499 of query aligns to 8:484/489 of 2woxA
- active site: N152 (= N161), K175 (= K184), E251 (= E259), C285 (= C293), E386 (= E394), E463 (= E471)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I157), G149 (≠ T158), W151 (= W160), N152 (= N161), K175 (= K184), S177 (≠ A186), E178 (= E187), G208 (= G217), G212 (= G221), F226 (= F235), T227 (= T236), G228 (= G237), G229 (= G238), T232 (≠ V241), V236 (≠ I245), E251 (= E259), L252 (= L260), C285 (= C293), E386 (= E394), F388 (= F396)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
40% identity, 95% coverage: 17:492/499 of query aligns to 8:484/489 of 2wmeA
- active site: N152 (= N161), K175 (= K184), E251 (= E259), C285 (= C293), E386 (= E394), E463 (= E471)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ T158), W151 (= W160), K175 (= K184), S177 (≠ A186), E178 (= E187), G208 (= G217), G212 (= G221), F226 (= F235), G228 (= G237), G229 (= G238), T232 (≠ V241), V236 (≠ I245)
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
39% identity, 95% coverage: 17:492/499 of query aligns to 34:509/512 of P47895
- R89 (≠ S70) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K184) binding
- E207 (= E187) binding
- GSTEVG 257:262 (≠ GGTEVG 237:242) binding
- Q361 (≠ H340) binding
- E411 (= E394) binding
- A493 (≠ G476) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
39% identity, 94% coverage: 17:486/499 of query aligns to 16:485/489 of 7a6qB
- active site: N163 (= N161), E262 (= E259), C296 (= C293), E470 (= E471)
- binding nicotinamide-adenine-dinucleotide: I159 (= I157), W162 (= W160), K186 (= K184), E189 (= E187), G219 (= G217), G223 (= G221), S240 (≠ G238), V243 (= V241), K342 (≠ A339)
- binding (3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium: A32 (≠ K32), T33 (≠ S33), C34 (≠ L34), P36 (= P36), D103 (= D102), E189 (= E187), Q190 (≠ V188), F218 (≠ K216), I339 (= I336), D340 (≠ T337)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (≠ S116), D141 (≠ R139), N143 (≠ D141), N451 (≠ K452), L453 (≠ F454), A455 (≠ I456)
7a6qA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
39% identity, 94% coverage: 17:486/499 of query aligns to 16:485/489 of 7a6qA
- active site: N163 (= N161), E262 (= E259), C296 (= C293), E470 (= E471)
- binding nicotinamide-adenine-dinucleotide: I159 (= I157), T160 (= T158), W162 (= W160), K186 (= K184), A188 (= A186), E189 (= E187), G219 (= G217), G223 (= G221), S240 (≠ G238), V243 (= V241), K342 (≠ A339), K346 (≠ T343)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (≠ S116), D141 (≠ R139), N143 (≠ D141), N451 (≠ K452), L453 (≠ F454), Y454 (≠ S455)
5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid (see paper)
39% identity, 94% coverage: 17:486/499 of query aligns to 16:485/489 of 5fhzA
- active site: N163 (= N161), K186 (= K184), E262 (= E259), C296 (= C293), E393 (= E394), E470 (= E471)
- binding nicotinamide-adenine-dinucleotide: I159 (= I157), T160 (= T158), W162 (= W160), K186 (= K184), E189 (= E187), G219 (= G217), G223 (= G221), F237 (= F235), G239 (= G237), S240 (≠ G238), T241 (= T239), V243 (= V241), G264 (= G261), Q343 (≠ H340), E393 (= E394)
- binding retinoic acid: G118 (≠ S116), R121 (≠ N119), F164 (≠ S162), M168 (≠ S166), W171 (≠ Q169), C295 (≠ A292), C296 (= C293), L453 (≠ F454)
O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 6 papers)
40% identity, 94% coverage: 17:486/499 of query aligns to 40:509/518 of O94788
- E50 (≠ R27) to G: in dbSNP:rs34266719
- A110 (= A85) to V: in dbSNP:rs35365164
- Q182 (≠ A156) to K: in DIH4; decreased retinoic acid biosynthetic process
- IPW 184:186 (≠ TPW 158:160) binding
- KPAE 210:213 (= KPAE 184:187) binding
- STE 264:266 (≠ GTE 238:240) binding
- C320 (= C293) active site, Nucleophile
- R347 (≠ L320) to H: in DIH4; decreased expression; dbSNP:rs141245344
- V348 (≠ R321) to I: in dbSNP:rs4646626
- KQYNK 366:370 (≠ AHRET 339:343) binding
- A383 (≠ G356) to T: in DIH4; uncertain significance; dbSNP:rs749124508
- E417 (= E394) binding
- E436 (≠ K413) to K: in dbSNP:rs34744827
- S461 (≠ A438) to Y: in DIH4; decreased retinoic acid biosynthetic process
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
39% identity, 94% coverage: 17:486/499 of query aligns to 15:484/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (= I157), T159 (= T158), P160 (= P159), W161 (= W160), K185 (= K184), E188 (= E187), G218 (= G217), G222 (= G221), F236 (= F235), S239 (≠ G238), V242 (= V241)
7rluA Structure of aldh1l1 (10-formyltetrahydrofolate dehydrogenase) in complex with NADP (see paper)
38% identity, 95% coverage: 17:488/499 of query aligns to 105:581/583 of 7rluA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: K278 (= K184), S310 (≠ K216), G311 (= G217), G315 (= G221), G331 (= G237), S332 (≠ G238), V335 (= V241)
- binding 4'-phosphopantetheine: K201 (≠ R111), F382 (≠ S287), N387 (≠ A292), C388 (= C293), N545 (≠ K452)
6tgwA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with a selective inhibitor (see paper)
39% identity, 94% coverage: 17:486/499 of query aligns to 8:474/478 of 6tgwA
- active site: N155 (= N161), E254 (= E259), C288 (= C293), E459 (= E471)
- binding methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate: I106 (≠ L113), G110 (≠ S116), F156 (≠ S162), Q278 (≠ Y283), F282 (≠ S287), L442 (≠ F454), A444 (≠ I456)
- binding nicotinamide-adenine-dinucleotide: I151 (= I157), T152 (= T158), P153 (= P159), W154 (= W160), K178 (= K184), G211 (= G217), G215 (= G221), F229 (= F235), G231 (= G237), S232 (≠ G238), V235 (= V241)
4go2A Crystal structure of thE C-terminal domain of 10'formyltetrahydrofolate dehydrogenase in complex with thio-NADP (see paper)
38% identity, 95% coverage: 17:488/499 of query aligns to 20:496/498 of 4go2A
- active site: N170 (= N161), K193 (= K184), E269 (= E259), C303 (= C293), E400 (= E394), D479 (≠ E471)
- binding 7-thionicotinamide-adenine-dinucleotide phosphate: V166 (≠ I157), I167 (≠ T158), P168 (= P159), W169 (= W160), K193 (= K184), A195 (= A186), Q196 (≠ E187), S225 (≠ K216), G226 (= G217), G230 (= G221), Q231 (≠ D222), F244 (= F235), G246 (= G237), S247 (≠ G238), V250 (= V241), I254 (= I245), E269 (= E259), G271 (= G261), C303 (= C293), E400 (= E394), F402 (= F396)
Query Sequence
>H281DRAFT_03644 FitnessBrowser__Burk376:H281DRAFT_03644
MTDMTHFDTSLVPTGDIFIGGEWRQGRGNPYKSLYPADQSVNMEISTANADDAREAVEAA
DIAWRKSDWSGLKPHQRALILYRIADLIMARHEALAQLQRRDNGKPIGETRVLVASAANT
FRYFAACLETLDEEVTPSRGDYLTMSVYEPIGVIAAITPWNSPIASDAQKLAPALAGGNA
VVLKPAEVTPLVSLALARICEEAGVPKGVISVLPGKGSVIGDVLVRHPLVKKVSFTGGTE
VGRGIARIAADKLMPVSLELGGKSPTVVFDDADLDHAVNGVLYGIFSSSGEACIAGSRLF
VQRSVYDAFMKRLVEGARKLRVGDPSRVETQMGPLITQAHRETVERYVALGLEEGGRLLC
GGERPVGDGREQGTYFQPTILEGLSNNARICQEEIFGPVLVAMPFDDEASLLKEANNSVF
GLAAGIWTRDYKRAYRTARALEAGTIWINTYKLFSISTPFSGWKESGMGREKGRLGIREY
MQQKSLYWGLNDAPLAWAN
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory