Comparing H281DRAFT_03911 FitnessBrowser__Burk376:H281DRAFT_03911 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2bhtA Crystal structure of o-acetylserine sulfhydrylase b (see paper)
63% identity, 98% coverage: 5:298/300 of query aligns to 3:292/294 of 2bhtA
P16703 Cysteine synthase B; CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B; EC 2.5.1.47 from Escherichia coli (strain K12) (see paper)
63% identity, 98% coverage: 5:298/300 of query aligns to 3:292/303 of P16703
5xoqA Crystal structure of o-acetylserine sulfhydrylase with bound transcription factor peptide inhibitor from planctomyces limnophilus
46% identity, 99% coverage: 3:298/300 of query aligns to 5:306/310 of 5xoqA
8srvB Crystal structure of o-acetyl-l-serine sulfhydrylase a (cysk) from staphylococcus aureus nctc 8325 complexed with a transcriptional repressor (cymr) derived 10 amino acid peptide
41% identity, 99% coverage: 1:298/300 of query aligns to 7:312/314 of 8srvB
2q3dA 2.2 a resolution crystal structure of o-acetylserine sulfhydrylase (oass) from mycobacterium tuberculosis in complex with the reaction intermediate alpha-aminoacrylate (see paper)
44% identity, 98% coverage: 6:298/300 of query aligns to 7:305/306 of 2q3dA
P9WP55 O-acetylserine sulfhydrylase; OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase; EC 2.5.1.47 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
44% identity, 98% coverage: 6:298/300 of query aligns to 7:305/310 of P9WP55
P47998 Cysteine synthase 1; At.OAS.5-8; Beta-substituted Ala synthase 1;1; ARAth-Bsas1;1; CSase A; AtCS-A; Cys-3A; O-acetylserine (thiol)-lyase 1; OAS-TL A; O-acetylserine sulfhydrylase; Protein ONSET OF LEAF DEATH 3; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
43% identity, 99% coverage: 4:300/300 of query aligns to 7:310/322 of P47998
2isqA Crystal structure of o-acetylserine sulfhydrylase from arabidopsis thaliana in complex with c-terminal peptide from arabidopsis serine acetyltransferase (see paper)
43% identity, 99% coverage: 4:300/300 of query aligns to 5:308/320 of 2isqA
P9WP53 O-phosphoserine sulfhydrylase; OPS sulfhydrylase; CysO-thiocarboxylate-dependent cysteine synthase; Cysteine synthase B; CSase B; O-phosphoserine-specific cysteine synthase; [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase; EC 2.5.1.113 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
42% identity, 99% coverage: 3:298/300 of query aligns to 4:306/323 of P9WP53
Sites not aligning to the query:
3zeiA Structure of the mycobacterium tuberculosis o-acetylserine sulfhydrylase (oass) cysk1 in complex with a small molecule inhibitor (see paper)
44% identity, 96% coverage: 6:293/300 of query aligns to 7:300/300 of 3zeiA
2q3cA 2.1 a resolution crystal structure of o-acetylserine sulfhydrylase (oass) holoenzyme from mycobacterium tuberculosis in complex with the inhibitory peptide dfsi (see paper)
44% identity, 96% coverage: 6:293/300 of query aligns to 7:300/300 of 2q3cA
3dwgA Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of mycobacterium tuberculosis (see paper)
42% identity, 99% coverage: 3:298/300 of query aligns to 6:308/325 of 3dwgA
1z7yA Crystal structure of the arabidopsis thaliana o-acetylserine sulfhydrylase k46a mutant (see paper)
43% identity, 99% coverage: 4:300/300 of query aligns to 5:308/320 of 1z7yA
3bm5A Crystal structure of o-acetyl-serine sulfhydrylase from entamoeba histolytica in complex with cysteine (see paper)
41% identity, 99% coverage: 3:298/300 of query aligns to 13:318/338 of 3bm5A
4jbnA Crystal structure of o-acetyl serine sulfhydrylase from entamoeba histolytica in complex with serine acetyl transferase derived tetrapeptide, spsi (see paper)
41% identity, 99% coverage: 3:298/300 of query aligns to 13:318/336 of 4jbnA
4il5A Crystal structure of o-acetyl serine sulfhydrylase from entamoeba histolytica in complex with isoleucine (see paper)
41% identity, 99% coverage: 3:298/300 of query aligns to 13:318/336 of 4il5A
4jblB Crystal structure of o-acetyl serine sulfhydrylase from entamoeba histolytica in complex with methionine (see paper)
41% identity, 99% coverage: 3:298/300 of query aligns to 13:318/335 of 4jblB
3bm5B Crystal structure of o-acetyl-serine sulfhydrylase from entamoeba histolytica in complex with cysteine (see paper)
41% identity, 99% coverage: 3:298/300 of query aligns to 13:318/335 of 3bm5B
6kr5B Crystal structure of o-acetyl serine sulfhydrylase isoform 3 from entamoeba histolytica (see paper)
41% identity, 99% coverage: 3:298/300 of query aligns to 12:317/336 of 6kr5B
P0ABK5 Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; S-carboxymethylcysteine synthase; Sulfate starvation-induced protein 5; SSI5; EC 2.5.1.47; EC 4.5.1.5 from Escherichia coli (strain K12) (see 5 papers)
43% identity, 98% coverage: 4:298/300 of query aligns to 3:312/323 of P0ABK5
Sites not aligning to the query:
>H281DRAFT_03911 FitnessBrowser__Burk376:H281DRAFT_03911
MAYKTIEDTIGNTPLVQLVRLPDDEIRSRNNVVLAKLEGNNPAGSVKDRPALSMIKKAEA
RGRIKPGDTLIESTSGNTGIALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAQIILTP
VTGGMEYARDLAEQMQRDGKGIILDQFANPDNPAAHVEGTGPEIWRDTEGRITHFVSSMG
TTGTIMGVSSYLKQQNQAIEIVGAQPEEGSRIPGIRKWPEAYMPKIFDRSRVDRVENVSQ
AAAEAMARRLASVEGIFAGISSGGACEVALRVARQVENATIVFIVCDRGDRYLSTGVFPA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory